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1. 发明申请

WO2010030697A1 LUNG CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：肺癌生物标志物及其用途
公开(公告)号：WO2010030697A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056399
申请日：2009-09-09
申请人： SOMALOGIC, INC. , GOLD, Larry , STANTON, Marty , BRODY, Edward, N. , OSTROFF, Rachel, M. , ZICHI, Dominic , STEWART, Alex A., E.
发明人： GOLD, Larry , STANTON, Marty , BRODY, Edward, N. , OSTROFF, Rachel, M. , ZICHI, Dominic , STEWART, Alex A., E.
IPC分类号： G06G7/58 , G01N33/50
CPC分类号： G01N33/57423 , G06F19/00 , Y02A90/26
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.
摘要翻译：本申请包括用于肺癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。在一个方面，该应用提供可以单独使用或以各种组合使用以诊断肺癌或允许肺结节的鉴别诊断为良性或恶性的生物标志物。在另一方面，提供了用于诊断个体中的肺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值，第2栏，其中基于所述至少一种生物标记值，将个体分类为具有肺癌或确定患有肺癌的个体的可能性。

2. 发明申请

WO2011043840A1 CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：癌症生物标志物及其用途
公开(公告)号：WO2011043840A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/029878
申请日：2010-04-03
申请人： SOMALOGIC, INC. , GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , RIEL-MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
发明人： GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , RIEL-MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
IPC分类号： G01N33/53 , C12Q1/68 , G06F17/18 , G06F19/00
CPC分类号： G01N33/57449 , G06F19/24 , Y10T436/143333
摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 24, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.
摘要翻译：本公开内容包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。一方面，本公开提供可以单独使用或以各种组合使用以诊断癌症的生物标志物。在另一方面，提供了用于诊断个体癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表24中提供的生物标志物组的生物标志物的生物标记值，其中基于所述至少一种生物标志物值将所述个体分类为具有癌症或确定患有癌症的个体的可能性。

3. 发明申请

WO2011031344A1 CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：癌症生物标志物及其用途
公开(公告)号：WO2011031344A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/026439
申请日：2010-03-05
申请人： SOMALOGIC, INC. , GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
发明人： GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
IPC分类号： A61B5/00 , G01N33/48 , G01N33/574
CPC分类号： G01N33/57423
摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 47, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.
摘要翻译：本公开包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。一方面，本公开提供可以单独使用或以各种组合使用以诊断癌症的生物标志物。在另一方面，提供了用于诊断个体癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一个对应于选自表47中提供的生物标志物组的生物标志物的生物标记值，其中所述个体基于所述至少一种生物标志物值被分类为具有癌症或确定个体患有癌症的可能性。

4. 发明申请

WO2013062515A3 LUNG CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：肺癌生物标志物及其用途
公开(公告)号：WO2013062515A3
公开(公告)日：2014-04-17
申请号：PCT/US2011057499
申请日：2011-10-24
申请人： SOMALOGIC INC , RIEL-MEHAN MICHAEL , STEWART ALEX A E , OSTROFF RACHEL M , WILLIAMS STEPHEN ALARIC , BRODY EDWARD N
发明人： RIEL-MEHAN MICHAEL , STEWART ALEX A E , OSTROFF RACHEL M , WILLIAMS STEPHEN ALARIC , BRODY EDWARD N
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N2800/60
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits tor the detection and diagnosis of non-small cell lung cancer and general cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose non-small cell lung cancer or general cancer. In another aspect, methods are provided for diagnosing non-small cell lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.
摘要翻译：本申请包括非小细胞肺癌和一般癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。在一个方面，本申请提供可以单独使用或以各种组合使用以诊断非小细胞肺癌或一般癌症的生物标志物。在另一方面，提供了用于诊断个体中的非小细胞肺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自生物标志物组的至少一种生物标志物的生物标记值如表1所示，其中，基于至少一种生物标志物值，将个体分类为具有肺癌或确定患有肺癌的个体的可能性。

5. 发明申请

WO2013062515A2 LUNG CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：肺癌生物标志物及其用途
公开(公告)号：WO2013062515A2
公开(公告)日：2013-05-02
申请号：PCT/US2011/057499
申请日：2011-10-24
申请人： SOMALOGIC, INC. , RIEL-MEHAN, Michael , STEWART, Alex, A.E. , OSTROFF, Rachel, M. , WILLIAMS, Stephen, Alaric , BRODY, Edward, N.
发明人： RIEL-MEHAN, Michael , STEWART, Alex, A.E. , OSTROFF, Rachel, M. , WILLIAMS, Stephen, Alaric , BRODY, Edward, N.
IPC分类号： G06F19/10
CPC分类号： G01N33/57423 , G01N2800/60
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of non-small cell lung cancer and general cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose non-small cell lung cancer or general cancer. In another aspect, methods are provided for diagnosing non-small cell lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.
摘要翻译：本申请包括用于非小细胞肺癌和一般癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。在一个方面，本申请提供可以单独使用或以各种组合使用以诊断非小细胞肺癌或一般癌症的生物标志物。在另一方面，提供了用于诊断个体中的非小细胞肺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自生物标志物组的至少一种生物标志物的生物标记值如表1所示，其中，基于至少一种生物标志物值，将个体分类为具有肺癌或确定患有肺癌的个体的可能性。在另一方面，提供了用于诊断个体中的癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表19中提供的生物标志物组的至少一种生物标志物的生物标记值，其中所述个体基于所述至少一种生物标志物值被分类为具有癌症或确定个体患有癌症的可能性。

6. 发明申请

WO2013028807A2 RENAL CELL CARCINOMA BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：肾细胞癌细胞生物标志物及其用途
公开(公告)号：WO2013028807A2
公开(公告)日：2013-02-28
申请号：PCT/US2012051944
申请日：2012-08-22
申请人： SOMALOGIC INC , OSTROFF RACHEL M , WILLIAMS STEPHEN ALARIC , RIEL-MEHAN MICHAEL , BRODY EDWARD N , STEWART ALEX A E , KATO SHINTARO
发明人： OSTROFF RACHEL M , WILLIAMS STEPHEN ALARIC , RIEL-MEHAN MICHAEL , BRODY EDWARD N , STEWART ALEX A E , KATO SHINTARO
IPC分类号： C40B30/04 , C12Q1/68 , C40B40/06 , C40B40/10 , G01N33/574 , G06F19/00
CPC分类号： G01N33/57438 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N2333/4703 , G01N2333/4706 , G01N2333/521 , G01N2333/70503 , G01N2333/78 , G01N2333/805 , G01N2333/8121 , G01N2333/96433 , G01N2333/96494 , G06F19/20
摘要： The subject disclosure concerns methods for evaluation of renal cell carcinoma (RCC). Such methods include a method of determining of a diagnosis of the individual as having or not having RCC; determination of a prognosis of a future course of RCC; determination of disease burden; or determination of recurrence of RCC in an individual who had been apparently cured of RCC. The methods each involve the detection of the value of at least one biomarker of Table 1. The biomarker value is used, in some of the methods, to determine whether the individual does or does not demonstrate evidence of disease, and in another method, to determine the degree or a score indicative of the individual's extent of disease.
摘要翻译：本发明涉及肾细胞癌（RCC）评估方法。这种方法包括确定个体具有或不具有RCC的诊断的方法; 确定RCC未来过程的预后; 确定疾病负担; 或确定RCC明显治愈RCC的个体复发。所述方法各自涉及检测表1的至少一种生物标志物的值。在一些方法中，使用生物标志物值来确定个体是否表现出疾病的证据，并且在另一种方法中，确定指示个体疾病程度的程度或得分。

7. 发明申请

WO2012047618A3 MESOTHELIOMA BIOMARKERS AND USES THEREOF 审中-公开
公开(公告)号：WO2012047618A3
公开(公告)日：2012-04-12
申请号：PCT/US2011/053377
申请日：2011-09-27
申请人： SOMALOGIC, INC. , OSTROFF, Rachel, M. , STEWART, Alex, A., E. , WILLIAMS, Stephen, Alaric , BRODY, Edward, N. , NIKRAD, Malti , RIEL-MEHAN, Michael
发明人： OSTROFF, Rachel, M. , STEWART, Alex, A., E. , WILLIAMS, Stephen, Alaric , BRODY, Edward, N. , NIKRAD, Malti , RIEL-MEHAN, Michael
IPC分类号： C12Q1/68 , G01N33/53
摘要： Biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and mesothelioma specifically are disclosed.

8. 发明申请

WO2010042525A9 OVARIAN CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：卵巢癌生物标志物及其用途
公开(公告)号：WO2010042525A9
公开(公告)日：2010-11-18
申请号：PCT/US2009059706
申请日：2009-10-06
申请人： SOMALOGIC INC , GOLD LARRY , STANTON MARTY , BRODY EDWARD N , OSTROFF RACHEL M , ZICHI DOMINIC , STEWART ALEX A E
发明人： GOLD LARRY , STANTON MARTY , BRODY EDWARD N , OSTROFF RACHEL M , ZICHI DOMINIC , STEWART ALEX A E
IPC分类号： G06G7/58 , G01N33/50
CPC分类号： G01N33/57449 , G06F19/24
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value.
摘要翻译：本申请包括用于检测和诊断卵巢癌的生物标志物，方法，装置，试剂，系统和试剂盒。在一个方面，本申请提供了可以单独或以各种组合使用来诊断卵巢癌或允许盆腔肿块鉴别诊断为良性或恶性的生物标志物。另一方面，提供了用于诊断个体卵巢癌的方法，其中所述方法包括在来自个体的生物样品中检测对应于选自表1中提供的生物标记组中的至少一种生物标记物的至少一种生物标记物值其中所述个体被分类为患有卵巢癌，或基于所述至少一个生物标志物值确定所述个体患有卵巢癌的可能性。

9. 发明申请

WO2010042525A1 OVARIAN CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译： OVARIAN癌症生物标志物及其用途
公开(公告)号：WO2010042525A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/059706
申请日：2009-10-06
申请人： SOMALOGIC, INC. , GOLD, Larry , STANTON, Marty , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E.
发明人： GOLD, Larry , STANTON, Marty , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E.
IPC分类号： G06G7/58 , G01N33/50
CPC分类号： G01N33/57449 , G06F19/24
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value.
摘要翻译：本申请包括用于卵巢癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。一方面，本申请提供可以单独使用或以各种组合使用以诊断卵巢癌或允许骨盆块的鉴别诊断为良性或恶性的生物标志物。在另一方面，提供了用于诊断个体中的卵巢癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值，其中基于所述至少一种生物标志物值将所述个体分类为具有卵巢癌或确定具有卵巢癌的个体的可能性。

10. 发明申请

WO2013028807A3 RENAL CELL CARCINOMA BIOMARKERS AND USES THEREOF 审中-公开
公开(公告)号：WO2013028807A3
公开(公告)日：2013-02-28
申请号：PCT/US2012/051944
申请日：2012-08-22
申请人： SOMALOGIC, INC. , OSTROFF, Rachel M. , WILLIAMS, Stephen Alaric , RIEL-MEHAN, Michael , BRODY, Edward N. , STEWART, Alex A.E. , KATO, Shintaro
发明人： OSTROFF, Rachel M. , WILLIAMS, Stephen Alaric , RIEL-MEHAN, Michael , BRODY, Edward N. , STEWART, Alex A.E. , KATO, Shintaro
IPC分类号： G01N33/53 , G01N33/48
摘要： Biomarkers for the detecion of Renal Cell Carcinoma (RCC) in an individual are provided. More specifically, one or more biomarkers, methods, devices, reagents, systems, and kits for the evaluation of RCC are provided, wherein the evaluation may comprise diagnosis, prognosis, determination of disease burden or determination of recurrence of RCC in an individual.

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