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1. 发明申请

WO2007035798A2 APPARATUS AND METHODS FOR IMPLANTING OBJECTS, SUCH AS BRONCHOSCOPICALLY IMPLANTING MARKERS IN THE LUNG OF PATIENTS 审中-公开
标题翻译：用于植入对象的装置和方法，例如在患者肺中的人造牙植入标记
公开(公告)号：WO2007035798A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036585
申请日：2006-09-19
申请人： CALYPSO MEDICAL TECHNOLOGIES, INC. , MAYSE, Martin, L. , DIMMER, Steven, C. , HILDWEIN, Roger , NIELSON, Eric, D.
发明人： MAYSE, Martin, L. , DIMMER, Steven, C. , HILDWEIN, Roger , NIELSON, Eric, D.
IPC分类号： A61M25/09
CPC分类号： A61B90/39 , A61B1/018 , A61B1/2676 , A61B17/12104 , A61B17/12172 , A61B34/20 , A61B34/25 , A61B34/30 , A61B2017/00809 , A61B2017/00951 , A61B2034/2051 , A61B2034/252 , A61B2090/101 , A61B2090/3912 , A61B2090/3954 , A61B2090/3966 , A61B2090/397 , A61B2090/3987 , A61B2090/3991 , A61N2005/1009
摘要： Apparatuses and methods for implanting objects, such as a marker, in the lungs of patients. In one embodiment, a bronchoscopic catheter assembly for implanting an object in the lung of a patient includes a handle, a delivery catheter projecting outwardly from the handle, and a push wire contained within the catheter. In one aspect of this embodiment, the catheter can be configured to releasably hold a plurality of markers at a distal end. In another aspect of this embodiment, the push wire can be operably connected to the handle and axially moveable within the delivery catheter to eject the marker out of the catheter within the bronchi of the patient. In a further aspect of this embodiment, the marker can further include an anti-migration device associated with the marker for holding the marker in place once the marker is deployed in the bronchi. The anti-migration device can be integral with the marker or positioned proximate to the marker to prevent migration of the marker.
摘要翻译：用于在患者的肺中植入诸如标记物的物体的装置和方法。在一个实施例中，用于将物体植入患者肺部的支气管镜导管组件包括手柄，从手柄向外突出的输送导管以及容纳在导管内的推送线。在该实施例的一个方面中，导管可以被配置为可释放地将多个标记物保持在远端。在该实施例的另一方面，推动导线可以可操作地连接到手柄并且在输送导管内可轴向移动，以将患者的支气管内的标记物从导管中排出。在该实施例的另一方面，标记还可以包括与标记物相关联的抗迁移装置，一旦标记部署在支气管中，则将标记物保持在适当位置。抗迁移装置可以与标记物成一体或靠近标记物定位，以防止标记的迁移。

2. 发明申请

WO2005067563A2 INSTRUMENTS WITH LOCATION MARKERS AND METHODS FOR TRACKING INSTRUMENTS THROUGH ANATOMICAL PASSAGEWAYS 审中-公开
标题翻译：具有位置标记的仪器和通过解剖学通过跟踪仪器的方法
公开(公告)号：WO2005067563A2
公开(公告)日：2005-07-28
申请号：PCT/US2005001525
申请日：2005-01-12
申请人： CALYPSO MED TECHNOLOGIES INC , WRIGHT J NELSON , DIMMER STEVEN C
发明人： WRIGHT J NELSON , DIMMER STEVEN C
IPC分类号： A61B5/05 , A61B5/06 , A61B19/00 , A61M25/01
CPC分类号： A61M25/0127 , A61B5/06 , A61B5/062 , A61B34/20 , A61B90/36 , A61B2034/2051 , A61B2034/2072
摘要： Instruments and methods for tracking such instruments in a human patient. One embodiment of an instrument in accordance with the invention comprises an elongated body, such as an elongated flexible member, which has a distal section configured to be passed through a vessel or other passageway in a human. The instrument can further include a lumen through the distal section and a magnetic marker having a transponder at the distal section. The transponder includes a circuit configured to be energized by a wirelessly transmitted magnetic excitation energy and to wirelessly transmit a magnetic location signal in response to the excitation energy. The magnetic marker, for example, can be attached to or otherwise integral with the instrument.
摘要翻译：用于在人类患者中跟踪这些器械的仪器和方法。根据本发明的器械的一个实施例包括细长主体，例如细长的柔性构件，其具有构造成穿过人体中的血管或其它通道的远侧部分。仪器还可以包括通过远侧部分的内腔和在远侧部分具有应答器的磁性标记。应答器包括被配置为由无线传输的磁激发能量激励并且响应于激发能量无线地发送磁位置信号的电路。例如，磁性标记可以附着到仪器或以其他方式与仪器一体。

3. 发明申请

WO2004061460A3 IMPLANTABLE MARKER WITH A WIRELESS SIGNAL TRANSMITTER COMPATIBLE FOR USE IN MAGNETIC RESONANCE IMAGING DEVICES AND/OR SUITABLE FOR USE IN RADIATION IMAGING PROCESSES 审中-公开
标题翻译：具有无磁信号发射器的可移动标记，用于磁共振成像装置和/或适用于辐射成像过程中
公开(公告)号：WO2004061460A3
公开(公告)日：2005-07-07
申请号：PCT/US0341329
申请日：2003-12-24
申请人： CALYPSO MED TECHNOLOGIES INC , DIMMER STEVEN C , HADFORD ERIC
发明人： DIMMER STEVEN C , HADFORD ERIC
IPC分类号： A61B5/055 , A61B5/06 , A61B5/00 , A61B19/00
CPC分类号： A61B5/06 , A61B5/055 , A61B5/062 , A61B2090/3975 , Y10T29/43 , Y10T29/4902 , Y10T29/49073 , Y10T29/49194
摘要： A wireless (e.g., leadless) marker for localizing the position of a target within a patient. In one embodiment, the marker includes a casing, a resonating circuit, and a ferromagnetic element. The ferromagnetic element can have a volume such that when the marker is in an imaging magnetic field having a field strength of 1.5 T and a gradient of 3 T/m, then the force exerted on the marker by the imaging magnetic field is not greater than gravitational force exerted on the marker. In an alternative embodiment, the ferromagnetic element need not have such a volume, but the marker further includes an imaging element incorporated with the casing and/or the magnetic transponder (e.g., resonating circuit). The imaging element produces a radiographic profile in a radiographic image such that the marker has a radiographic centroid at least approximately coincident with the magnetic centroid of the transponder.
摘要翻译：用于定位患者内的目标位置的无线（例如，无引线）标记。在一个实施例中，标记包括壳体，谐振电路和铁磁元件。铁磁元件可以具有这样的体积，使得当标记处于场强为1.5T和3T / m的梯度的成像磁场中时，由成像磁场施加在标记上的力不大于施加在标记上的重力。在替代实施例中，铁磁元件不需要具有这样的体积，但是标记还包括与壳体和/或磁转发器（例如谐振电路）结合的成像元件。成像元件在放射照相图像中产生放射照相轮廓，使得标记具有与应答器的磁性质心至少近似一致的射线照相质心。

4. 发明申请

WO2003024329A1 MINIATURE RESONATING MARKER ASSEMBLY 审中-公开
标题翻译：小型协调标志牌大会
公开(公告)号：WO2003024329A1
公开(公告)日：2003-03-27
申请号：PCT/US2002/029390
申请日：2002-09-16
申请人： CALYPSO MEDICAL TECHNOLOGIES, INC. , GISSELBERG, Margo , HADFORD, Eric , DIMMER, Steven, C. , GOLDBERG, Jack , PELTON, Jeff , ZUBLIN, Kurt
发明人： GISSELBERG, Margo , HADFORD, Eric , DIMMER, Steven, C. , GOLDBERG, Jack , PELTON, Jeff , ZUBLIN, Kurt
IPC分类号： A61B5/11
CPC分类号： A61B5/6883 , A61B5/055 , A61B5/06 , A61B5/062 , A61B90/39 , A61B2034/2051 , A61B2090/3958 , H01Q1/2208 , H01Q7/08
摘要： A miniature resonating marker assembly that includes, in one embodiment, a ferromagnetic core, a wire coil disposed around the core, and a capacitor connected to the wire coil adjacent to the magnetic core. The core, coil, and capacitor form a signal element that, when energized, generates a magnetic field at a selected resonant frequency. The magnetic field has a magnetic center point positioned along at least one axis of the signal element. An inert encapsulation member encapsulates the signal element therein and defines a geometric shape of the resonating marker assembly. The geometric shape has a geometric center point substantially coincident with the magnetic center point along at least a first axis of the signal element. The shape and configuration of the assembly also provides for a miniature signal element specifically tuned to resonate at a selected frequency with a high quality factor.
摘要翻译：一种微型谐振标记组件，在一个实施例中包括铁磁芯，设置在芯周围的线圈线圈和连接到与磁芯相邻的线圈线圈的电容器。核心，线圈和电容器形成信号元件，当被激励时，以选定的谐振频率产生磁场。磁场具有沿着信号元件的至少一个轴定位的磁中心点。惰性封装构件将信号元件封装在其中并限定谐振标记组件的几何形状。几何形状具有与信号元件的至少第一轴线的磁性中心点大致一致的几何中心点。该组件的形状和结构还提供了一种特别调谐为以选择的频率以高品质因数谐振的微型信号元件。

5. 发明申请

WO2011060201A1 METHODS AND SYSTEMS FOR SCREENING SUBJECTS 审中-公开
标题翻译：筛选物种的方法和系统
公开(公告)号：WO2011060201A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056425
申请日：2010-11-11
申请人： INNOVATIVE PULMONARY SOLUTIONS, INC. , MAYSE, Martin, L. , DIMMER, Steven, C.
发明人： MAYSE, Martin, L. , DIMMER, Steven, C.
IPC分类号： A61B5/087
CPC分类号： A61B5/087 , A61B5/411
摘要： A screening method can be used to determine whether a subject is a suitable candidate for interventional therapy. The method can be used to determine the likelihood the subject will receive a therapeutic effect from denervation therapy. The determination is based, at least in part, on lung information obtained by performing lung function tests with and without treating the subject's lungs with a test agent. Based on the response to a test agent, the subject's response to a therapy is predicted.
摘要翻译：可以使用筛选方法来确定受试者是否是介入治疗的合适候选者。该方法可用于确定受试者将从去神经治疗获得治疗效果的可能性。该测定至少部分地基于通过用或不用测试剂治疗受试者的肺进行肺功能测试而获得的肺信息。根据对试剂的反应，预测受试者对治疗的反应。

6. 发明申请

WO2009137819A1 SYSTEMS, ASSEMBLIES, AND METHODS FOR TREATING A BRONCHIAL TREE 审中-公开
标题翻译：系统，装配和方法，用于处理BRONCHIAL TREE
公开(公告)号：WO2009137819A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/043393
申请日：2009-05-08
申请人： INNOVATIVE PULMONARY SOLUTIONS, INC. , DIMMER, Steven, C. , MAYSE, Martin, L.
发明人： DIMMER, Steven, C. , MAYSE, Martin, L.
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B8/12 , A61B18/02 , A61B18/1206 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2018/00011 , A61B2018/00023 , A61B2018/00214 , A61B2018/0022 , A61B2018/00541 , A61B2018/00577 , A61B2018/0212 , A61B2018/143 , A61B2018/1432 , A61B2018/1861 , A61N7/022
摘要： Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.
摘要翻译：用于治疗肺部疾病的系统，组件和方法用于减少肺内支气管树远端区域的神经系统输入。治疗系统损伤神经组织以暂时或永久性减少神经系统输入。治疗系统能够加热神经组织，冷却神经组织，输送引起神经组织创伤，刺穿神经组织，撕裂神经组织，切割神经组织，向神经组织施加压力的可流动物质，施加超声波到神经组织，向神经组织施加电离辐射，用电能破坏神经组织的细胞膜，或向神经组织递送长效神经阻断化学物质。

7. 发明申请

WO2009015104A3 IMPLANTABLE DEVICES AND METHODS FOR EXTERNAL BEAM RADIATION TREATMENTS 审中-公开
标题翻译：可植入装置和用于外部束辐射治疗的方法
公开(公告)号：WO2009015104A3
公开(公告)日：2009-08-13
申请号：PCT/US2008070682
申请日：2008-07-21
申请人： CALYPSO MED TECHNOLOGIES INC , NIELSON ERIC D , DIMMER STEVEN C , KRAG DAVID N , MATE TIMOTHY P , PEREZ ROLAND , QUIGLEY FERGUS
发明人： NIELSON ERIC D , DIMMER STEVEN C , KRAG DAVID N , MATE TIMOTHY P , PEREZ ROLAND , QUIGLEY FERGUS
IPC分类号： A61B19/00
CPC分类号： A61N5/1049 , A61N2005/1051
摘要： Implantable devices and methods for external beam radiation treatments are disclosed. One embodiment of an implantable device for guided radiation therapy comprises an active marker configured to be positioned within the patient and to transmit a non-ionizing wireless signal in response to a non-ionizing wirelessly transmitted source energy. The device further includes a fastening unit coupled to the active marker and configured to (a) hold the marker within a desired distance of a target in the tissue and (b) inhibit deformation of tissue from moving the active marker relative to the target.
摘要翻译：公开了用于外部射束辐射处理的可植入装置和方法。用于引导放射治疗的可植入装置的一个实施例包括被配置为定位在患者体内并且响应于非电离无线传输的源能量而传输非电离无线信号的有源标记器。该装置进一步包括紧固单元，该紧固单元联接到有源标记并且被配置为（a）将标记保持在组织中目标的期望距离内，以及（b）抑制组织相对于目标移动有源标记的变形。

8. 发明申请

WO2006094156B1 SYSTEMS AND METHODS FOR TREATING A PATIENT USING GUIDED RADIATION THERAPY OR SURGERY 审中-公开
标题翻译：使用引导辐射治疗或手术治疗患者的系统和方法
公开(公告)号：WO2006094156B1
公开(公告)日：2007-12-21
申请号：PCT/US2006007508
申请日：2006-03-02
申请人： CALYPSO MED TECHNOLOGIES INC , MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
发明人： MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
IPC分类号： A61B19/00
CPC分类号： A61B90/16 , A61B34/20 , A61B34/25 , A61B90/14 , A61B90/39 , A61B2034/2051 , A61B2090/101 , A61B2090/363 , A61B2090/374 , A61B2090/3975 , A61B2090/3995
摘要： Systems and methods for locating and tracking a target, i.e., measuring the position and/or rotation of a target during setup and treatment of a patient in guided radiation therapy applications for the head and neck. One embodiment is directed toward a device having a body and markers, such as excitable transponders and/or radiographic fiducials, fixable in or on the body for localizing the body. For example, the body can be a mouthpiece body having a channel configured to receive a patient's teeth such that the mouthpiece is repeatedly and consistently placed in the same relative position in the patient when the patient bites down on the mouthpiece. The transponders can be alternating magnetic transponders and the fiducials can be gold seeds. Other embodiments include a device having a two-piece body, a first piece of the body having excitable transponders and a second piece of the body having radiographic fiducials.
摘要翻译：用于定位和跟踪目标的系统和方法，即在用于头颈部的引导放射治疗应用中，在患者的建立和治疗期间测量目标的位置和/或旋转。一个实施例涉及具有身体和标记的装置，例如可固定在体内或身体上用于定位身体的可兴奋的应答器和/或射线照相基准。例如，身体可以是具有通道的接口管体，该通道被配置为接收患者的牙齿，使得当患者咬在嘴件上时，接口管被重复且一致地放置在患者的相同相对位置。应答器可以是交替磁转发器，基准可以是金种子。其他实施例包括具有两件式主体的装置，具有可兴奋的应答器的本体的第一部分和具有放射照相基准的本体的第二部分。

9. 发明申请

WO2006023055A2 SYSTEMS AND METHODS FOR REAL TIME TRACKING OF TARGETS IN RADIATION THERAPY AND OTHER MEDICAL APPLICATIONS 审中-公开
标题翻译：用于实时跟踪辐射治疗目标的系统和方法及其他医疗应用
公开(公告)号：WO2006023055A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/022374
申请日：2005-06-24
申请人： CALYPSO MEDICAL TECHNOLOGIES, INC. , WRIGHT, J., Nelson , DIMMER, Steven, C.
发明人： WRIGHT, J., Nelson , DIMMER, Steven, C.
IPC分类号： A61B6/00
CPC分类号： A61B5/06 , A61B5/055 , A61B6/12 , A61B8/0833 , A61B34/20 , A61B34/25 , A61B90/36 , A61B90/39 , A61B2034/2051 , A61B2034/252 , A61B2090/3908 , A61B2090/3954 , A61B2090/3958 , A61B2090/3995 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1051
摘要： Systems and methods for tracking targets in real time for radiation therapy and other applications. In one embodiment, a method includes collecting position information of a marker implanted within a patient at a site relative to the target at a time t n , and providing an objective output indicative of the location of the target based on the position information collected at time t n . The objective output is provided to a memory device, user interface, and/or radiation delivery machine within 1 ms to 2 seconds of the time t n when the position information was collected. This embodiment of the method can further include providing the objective output at a periodicity of 10-200 ms during at least a portion of a treatment procedure. For example, the method can further include generating a beam of ionizing radiation and directing the beam to a machine isocenter, and continuously repeating the collecting procedure and the providing procedure every 10-200 ms while irradiating the patient with the ionizing radiation beam.
摘要翻译：用于实时跟踪靶向放射治疗和其他应用的系统和方法。在一个实施例中，一种方法包括在时间t n n处收集在相对于目标的位置处植入在患者内的标记的位置信息，并且提供指示基于目标的位置的客观输出关于在时间t 收集的位置信息。当收集位置信息时，目标输出被提供给存储器设备，用户界面和/或辐射递送机器，在时间t n n n 1的1秒至2秒内。该方法的该实施例还可以包括在至少一部分治疗过程期间以10-200ms的周期提供目标输出。例如，该方法可以进一步包括产生电离辐射束并将光束引导到机器等角点，并且在每隔10-200毫秒同时持续地重复采集过程和提供过程，同时用电离辐射束照射患者。

10. 发明申请

WO2005037167A2 PATIENT SUPPORT SYSTEMS FOR USE WITH RADIATION THERAPY SYSTEMS AND OTHER APPLICATIONS 审中-公开
标题翻译：患者支持系统使用辐射治疗系统和其他应用
公开(公告)号：WO2005037167A2
公开(公告)日：2005-04-28
申请号：PCT/US2004034523
申请日：2004-10-18
申请人： CALYPSO MED TECHNOLOGIES INC , DIMMER STEVEN C , HERRON MATTHEW A , VERTATSCHITSCH EDWARD J
发明人： DIMMER STEVEN C , HERRON MATTHEW A , VERTATSCHITSCH EDWARD J
IPC分类号： A61B5/06 , A61B6/04 , A61G20060101 , A61G
CPC分类号： A61B5/06 , A61B6/0442
摘要： An apparatus for supporting a patient in radiation therapy and other applications. In one embodiment, the apparatus includes a support structure and a panel carried by the support structure. The support structure can have first and second support members, such as rigid girders or other structures comprising substantially dielectric materials. The panel is also a rigid structure comprising substantially dielectric materials. The panel can further include a pass-through zone or other type of zone that is compatible with an ionizing radiation beam. For example, the panel can have a grid or solid low-density structure that mitigates beam contamination. The support structure and the panel together are configured to position a magnetic marker implanted in the patient in a navigational zone in which a magnetic field transmitted from the marker is not affected by conductive components or loops of conductive material in the pedestals or cantilevered support structures of conventional patient systems.
摘要翻译：一种用于在放射治疗和其他应用中支持患者的装置。在一个实施例中，该装置包括支撑结构和由支撑结构承载的面板。支撑结构可以具有第一和第二支撑构件，例如刚性梁或包括基本介电材料的其他结构。面板也是包括基本介电材料的刚性结构。面板还可以包括与电离辐射束相容的通过区域或其他类型的区域。例如，面板可以具有减轻束污染的网格或固体低密度结构。支撑结构和面板一起构造成将植入患者体内的磁性标记定位在导航区域中，其中从标记物传输的磁场不受基座或悬臂支撑结构中的导电材料的导电部件或环的影响常规患者系统。

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