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1. 发明申请

WO2014160194A3 METHOD AND APPARATUS FOR SECURE COMMUNICATION 审中-公开
标题翻译：用于安全通信的方法和设备
公开(公告)号：WO2014160194A3
公开(公告)日：2014-12-04
申请号：PCT/US2014026015
申请日：2014-03-13
申请人： MASSACHUSETTS INST TECHNOLOGY , NAT UNIV IRELAND MAYNOOTH
发明人： CALMON FLAVIO DU PIN , MEDARD MURIEL , ZEGER LINDA M , CHRISTIANSEN MARK M , DUFFY KENNETH R
IPC分类号： H04K1/04
CPC分类号： G06F21/6209 , H03M13/1102 , H03M13/1515 , H04L9/065 , H04L63/0435 , H04L2209/30 , H04L2209/34
摘要： Secrecy scheme systems and associated methods using list source codes for enabling secure communications in communications networks are provided herein. Additionally, improved information-theoretic metrics for characterizing and optimizing said secrecy scheme systems and associated methods are provided herein. One method of secure communication comprises receiving a data file at a first location, encoding the data file using a list source code to generate an encoded file, encrypting a select portion of the data file using a key to generate an encrypted file, and transmitting the encoded file and the encrypted file to an end user at a destination location, wherein the encoded file cannot be decoded at the destination location until the encrypted file has been received and decrypted by the end user, wherein the end user possesses the key.
摘要翻译：本文提供了使用列表源代码来实现通信网络中的安全通信的保密方案系统和相关方法。此外，本文提供了用于表征和优化所述保密方案系统和相关方法的改进的信息理论度量。一种安全通信的方法包括：在第一位置处接收数据文件;使用列表源代码对数据文件进行编码以生成编码文件;使用密钥对数据文件的选择部分进行加密以生成加密文件; 编码文件和加密文件发送给目的地位置处的最终用户，其中编码文件不能在目的地位置被解码，直到最终用户接收和解密加密文件，其中最终用户拥有该密钥。

2. 发明申请

WO2013138563A1 GLYCOMIMETICS TO INHIBIT PATHOGEN-HOST INTERACTIONS 审中-公开
标题翻译： GLYCOMIMETICS来阻止病原体间的相互作用
公开(公告)号：WO2013138563A1
公开(公告)日：2013-09-19
申请号：PCT/US2013031238
申请日：2013-03-14
申请人： UNIV GEOGIA RES FOUNDATION INC , NAT UNIV IRELAND , GLYCOSENSORS AND DIAGNOSTICS LLC , WOODS ROBERT J , MURPHY PAUL V , YANG LORETTA , SMITH HANNAH M K , HENDEL JENNIFER
发明人： WOODS ROBERT J , MURPHY PAUL V , YANG LORETTA , SMITH HANNAH M K , HENDEL JENNIFER
IPC分类号： A61K31/7042 , C07H3/04
CPC分类号： C07H17/04 , C07D455/02 , C07H15/04 , C07H15/20 , C07H17/02 , C07H19/01 , C07H19/02 , C07H19/04 , C07H19/24 , G06F19/10
摘要： The present invention relates to novel glycomimetic compounds that are rationally designed to inhibit the binding of various pathogens to cell surface sialylated galactose and methods of use thereof. Specifically sialic acid glycosides and C-glycosides are disclosed that form a lactam ring structure or a cyclic ether/amine ring structure with the adjacent monosaccharide residue.
摘要翻译：本发明涉及合理设计以抑制各种病原体与细胞表面唾液酸化半乳糖结合的新型糖模拟化合物及其使用方法。具体而言，公开了与相邻的单糖残基形成内酰胺环结构或环醚/胺环结构的唾液酸糖苷和C-糖苷。

3. 发明申请

WO2010041140A3 TREATMENT OF PROLIFERATIVE DISORDERS WITH A DEATH RECEPTOR AGONIST 审中-公开
标题翻译：用死亡受体激动剂治疗增生性疾病
公开(公告)号：WO2010041140A3
公开(公告)日：2010-07-29
申请号：PCT/IB2009007170
申请日：2009-10-09
申请人： NAT UNIV IRELAND , SAMALI AFSHIN , SZEGEZDI EVA , MAHALINGAM DEVALINGAM , NATONI ALESSANDRO
发明人： SAMALI AFSHIN , SZEGEZDI EVA , MAHALINGAM DEVALINGAM , NATONI ALESSANDRO
IPC分类号： A61K31/7105 , A61K38/17 , A61K38/19 , A61K39/395 , A61K45/06 , A61P35/00
CPC分类号： A61K45/06 , A61K31/7105 , A61K38/1709 , A61K38/177 , A61K38/191 , A61K39/395 , C12N15/113 , C12N2310/14 , A61K2300/00
摘要： A method of treating a proliferative disorder, and a pharmaceutical composition for use in such a method, comprises administering to the patient a combination of an agonist of a death receptor and an antagonist of Egr-1. The death receptor agonist and the Egr-1 antagonist may be administered sequentially, separately or in combination
摘要翻译：治疗增殖性疾病的方法和用于该方法的药物组合物包括向患者施用死亡受体激动剂和Egr-1拮抗剂的组合。死亡受体激动剂和Egr-1拮抗剂可以顺序，单独或组合施用

4. 发明申请

WO2010052342A2 CHEMICAL MESSENGER SENSOR 审中-公开
标题翻译：化学传感器
公开(公告)号：WO2010052342A2
公开(公告)日：2010-05-14
申请号：PCT/EP2009064942
申请日：2009-11-10
申请人： NAT UNIV IRELAND MAYNOOTH , COLLERAN JOHN , HARLEY CLAIRE , ALCOCK BERNADETTE , BRESLIN CARMEL , FINNERTY NIALL
发明人： COLLERAN JOHN , HARLEY CLAIRE , ALCOCK BERNADETTE , BRESLIN CARMEL , FINNERTY NIALL
IPC分类号： G01N33/487 , G01N33/543
CPC分类号： G01N33/5438 , G01N33/942
摘要： A sensor for the detection of chemical messengers is described herein. In particular, a sensor for the detection of serotonin is reported. Serotonin plays a pivotal role as a neurotransmitter in the modulation of a myriad of physiological responses including anger, aggression, mood, sleep, sexuality, and appetite. An electrode for detecting serotonin comprising a conducting or semi-conducting substrate, and a polymer material on said substrate is disclosed. Said polymer comprises a conducting polymer doped with a cyclodextrin macrocycle. Suitable polymer materials include polypyrroles and polythiophenes, e.g. PEDOT. Suitable cyclodextrin macrocycles include anionic cyclodextrin macrocycles, for example sulfonated ß-cyclodextrins (CDs). Also disclosed is a sensor capable of selectively detecting serotonin in the presence of ascorbic acid, epinephrine, norepinephrine and dopamine.
摘要翻译：本文描述了用于检测化学信使的传感器。特别地，报道了用于检测5-羟色胺的传感器。 5-羟色胺作为神经递质在调节无数生理反应（包括愤怒，侵略，情绪，睡眠，性欲和食欲）方面起关键作用。公开了一种用于检测血清素的电极，其包含导电或半导体衬底，以及在所述衬底上的聚合物材料。所述聚合物包含掺杂有环糊精大环的导电聚合物。合适的聚合物材料包括聚吡咯和聚噻吩。 PEDOT。合适的环糊精大环化合物包括阴离子环糊精大环化合物，例如磺化β-环糊精（CD）。还公开了能够在抗坏血酸，肾上腺素，去甲肾上腺素和多巴胺存在下选择性检测5-羟色胺的传感器。

5. 发明申请

WO2009115580A3 DENDRIMERS AND DENDRIMER APPLICATIONS 审中-公开
标题翻译： DENDRIMERS和DENDRIMER应用
公开(公告)号：WO2009115580A3
公开(公告)日：2010-03-18
申请号：PCT/EP2009053259
申请日：2009-03-19
申请人： NAT UNIV IRELAND , PANDIT ABHAY , RETHORE GILDAS , NAIK HEMANTKUMAR
发明人： PANDIT ABHAY , RETHORE GILDAS , NAIK HEMANTKUMAR
IPC分类号： C08G83/00 , C08J3/24 , C08L5/00 , C08L89/00
CPC分类号： C08G83/003 , C08J3/246 , C08J2305/00 , C08J2389/00
摘要： An activatable functionalised Nth generation dendrimer having: a core comprising a first monomer having at least two carboxylic acid functional groups; and N successive generations, where N = 0 to 10, wherein each generation comprises: a second monomer having at least two alcohol functional groups, wherein at least one alcohol group is bonded to a carboxylic acid group of the first monomer of the prior generation, and an additional first monomer attached to a second alcohol function group of said second monomer of that generation; and the final generation having attached thereto at said second alcohol functional group of said second monomer, a moiety having a dicarboxylic acid functional group, activatable by treatment with a carboxylic acid activating reagent such that reactivity of the carboxylic acid functional group is increased. The dendrimer, when activated, may be used in applications such as polymer crosslinking and/or nanoshell production.
摘要翻译：一种可活化的官能化第N代树枝状聚合物，其具有：包含具有至少两个羧酸官能团的第一单体的芯; 和N个连续世代，其中N = 0至10，其中每一代包含：具有至少两个醇官能团的第二单体，其中至少一个醇基键合到上一代的第一单体的羧酸基团，和附加到该代第二单体的第二醇官能团的另外的第一单体; 并且在所述第二单体的所述第二醇官能团上附着的最后一代，具有二羧酸官能团的部分，可通过用羧酸活化剂处理而活化，使得羧酸官能团的反应性增加。树枝状大分子当被活化时可用于诸如聚合物交联和/或纳米壳生产的应用中。

6. 发明申请

WO2009150244A1 SW15 GENE AS A DIAGNOSTIC TARGET FOR THE IDENTIFICATION OF FUNGAL AND YEAST SPECIES 审中-公开
标题翻译： SW15基因作为鉴定真菌和YEAST物种的诊断目标
公开(公告)号：WO2009150244A1
公开(公告)日：2009-12-17
申请号：PCT/EP2009057346
申请日：2009-06-15
申请人： NAT UNIV IRELAND , BARRY THOMAS GERARD , MAHER MAJELLA , SMITH TERRY JAMES , JANKIEWICZ MARCIN , O'CONNOR LOUISE , TUITE NINA , LAHIFF SINEAD
发明人： BARRY THOMAS GERARD , MAHER MAJELLA , SMITH TERRY JAMES , JANKIEWICZ MARCIN , O'CONNOR LOUISE , TUITE NINA , LAHIFF SINEAD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895
摘要： The invention relates to the SWI5 gene, the corresponding RNA, specific probes, primers and oligonucleotides related thereto and their use in diagnostic assays to detect and/ or discriminate between fungal and yeast species.
摘要翻译：本发明涉及SWI5基因，相应的RNA，特异性探针，与之相关的引物和寡核苷酸及其在诊断测定中用于检测和/或区分真菌和酵母物种的用途。

7. 发明申请

WO2007096850A3 USE OF SINGLE-CHANNEL SEISMIC-REFLECTION PROFILING DATA USABLE FOR THE QUANTITATIVE DETERMINATION OF SEDIMENT PHYSICAL PROPERTIES OF THE SEABED AND THE LAYERED SUBBOTTOM 审中-公开
标题翻译：使用单通道地震反射分析数据可用于定量确定海床和层状物质的物理特性
公开(公告)号：WO2007096850A3
公开(公告)日：2008-10-09
申请号：PCT/IE2007000022
申请日：2007-02-21
申请人： NAT UNIV IRELAND , LEURER KLAUS CHRISTIAN , BROWN COLIN
发明人： LEURER KLAUS CHRISTIAN , BROWN COLIN
IPC分类号： G01V1/30
CPC分类号： G01V1/306
摘要： The present invention discloses a method for the quantitative characterisation of a seabed sediment composition and a seabed's layered subbottom structure from at least one normal-incidence, single-channel reflection acoustic amplitude time series seismogram. The method detects a plurality of reflections from subbottom interfaces in said seismograms, determines the traveltime, the polarity and the reflectivity of each detected reflection, determines the intrinsic attenuation of the sediment layer between pairs of adjacent reflections, and determines the acoustic properties, layer thicknesses and material properties of the seabed's layered subbottom structure as a function of said traveltimes, polarities and reflectivities of the detected reflections and said intrinsic attenuation of the sediment layer between pairs of adjacent reflections. The invention also discloses a forward model describing the physical relationship between the material properties and the acoustic properties of seabed sediments.
摘要翻译：本发明公开了一种用于从至少一个法向入射单声道反射声振幅时间序列地震图定量表征海底沉积物组成和海床分层底板结构的方法。该方法在所述地震图中检测来自底部界面的多次反射，确定每个检测反射的行进时间，极性和反射率，确定相邻反射对之间的沉积物层的固有衰减，并确定声学性质，层厚度以及作为所检测的反射的所述旅行时间，极性和反射率以及相邻反射对之间的沉积物层的固有衰减的函数的海床分层底部结构的材料性质。本发明还公开了一种描述海底沉积物的材料性质和声学性质之间的物理关系的前向模型。

8. 发明申请

WO2007144711A2 METHOD AND APPARATUS FOR EVOKING A RESPONSE FROM A SUBJECT 审中-公开
标题翻译：用于从主体回应的方法和装置
公开(公告)号：WO2007144711A2
公开(公告)日：2007-12-21
申请号：PCT/IB2007001431
申请日：2007-05-31
申请人： NAT UNIV IRELAND MAYNOOTH , UNIV DUBLIN , REILLY RICHARD , LALOR EDMUND C , PEARLMUTTER BARAK A
发明人： REILLY RICHARD , LALOR EDMUND C , PEARLMUTTER BARAK A
IPC分类号： G06F19/00
CPC分类号： A61B5/04842 , G06F19/3481
摘要： A method of evoking a response from a subject is disclosed. The method comprises modulating a characteristic of a stimulus with a signal comprising a non-binary sequence, and measuring the subject's response to the stimulus. The subjects measured response is correlated with the modulated signal to produce an impulse response for the subject.
摘要翻译：公开了一种唤起受试者的反应的方法。该方法包括用包括非二进制序列的信号调制刺激的特征，以及测量受试者对刺激的反应。受试者测量的响应与调制信号相关，以产生受试者的脉冲响应。

9. 发明申请

WO0042168A2 BIFIDOBACTERIUM IN THE TREATMENT OF INFLAMMATORY DISEASE 审中-公开
标题翻译：双歧杆菌治疗炎症性疾病
公开(公告)号：WO0042168A2
公开(公告)日：2000-07-20
申请号：PCT/IE0000008
申请日：2000-01-17
申请人： ENTPR IE TRD AS BIORESEARCH IE , NAT UNIV IRELAND CORK , COLLINS JOHN KEVIN , SULLIVAN GERALD CHRISTOPHER O , MAHONY LIAM O , SHANAHAN FERGUS
发明人： COLLINS JOHN KEVIN , O'SULLIVAN GERALD CHRISTOPHER , O'MAHONY LIAM , SHANAHAN FERGUS
IPC分类号： A23L1/30 , A23C9/123 , A61K9/14 , A61K9/20 , A61K9/48 , A61K47/02 , A61K47/04 , A61K47/06 , A61K47/08 , A61K47/18 , A61K47/26 , A61K47/42 , A61K47/44 , A61K47/46 , A61P1/00 , A61P1/04 , A61P1/12 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C12N1/20 , C12R1/01 , C12R1/225 , A61K35/74 , C12N1/21
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译：从切除和洗涤的人类胃肠道中分离的双歧杆菌菌株在人类口服消耗后是显着的免疫调节。该菌株可用于预防和/或治疗不期望的炎症活性，特别是胃肠炎症活动如炎症性肠病或肠易激综合征。炎性活动也可能是由于癌症。

10. 发明申请

WO2010097471A3 PROTEIN TARGETS IN DISEASE 审中-公开
标题翻译：蛋白质在疾病中的目标
公开(公告)号：WO2010097471A3
公开(公告)日：2010-11-11
申请号：PCT/EP2010052504
申请日：2010-02-26
申请人： NAT UNIV IRELAND , SAMALI AFSHIN , GUPTA SANJEEV
发明人： SAMALI AFSHIN , GUPTA SANJEEV
IPC分类号： C12Q1/68 , A61K31/7052 , C12N15/113
CPC分类号： C12Q1/6883 , C12N15/111 , C12N2310/141 , C12N2320/11 , C12N2330/10 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G06F19/16 , G06F19/18 , G06F19/22
摘要： MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte apoptosis, it is envisaged that protein targets involved in same can be identified through specifically selected microRNAs. The microRNAs targeted are miR-351, miR-322, miR-125, miR-424 and miR-7a. Furthermore, the potential application of these identified proteins in the treatment of cardiovascular disease, in particular congestive heart failure, is disclosed.
摘要翻译：已显示微小RNA参与控制细胞存活和细胞死亡决定。通过鉴定涉及内质网应激诱导的心肌细胞凋亡的微RNA，设想通过特定选择的微RNA可以鉴定涉及其中的蛋白靶标。靶向的微RNA是miR-351，miR-322，miR-125，miR-424和miR-7a。此外，公开了这些鉴定的蛋白质在治疗心血管疾病，特别是充血性心力衰竭中的潜在应用。

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