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1. 发明申请

WO2007050572A2 DISPOSABLE PATIENT INTERFACE 审中-公开
标题翻译：一次性患者接口
公开(公告)号：WO2007050572A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041412
申请日：2006-10-24
申请人： INTRALASE CORP. , RAKSI, Ferenc , JUHASZ, Tibor , KURTZ, Ron , LUMMIS, Wes , DAVIS, Chris , NAGY, Laszlo
发明人： RAKSI, Ferenc , JUHASZ, Tibor , KURTZ, Ron , LUMMIS, Wes , DAVIS, Chris , NAGY, Laszlo
IPC分类号： A61B18/18 , A61F9/008
CPC分类号： A61F9/009 , A61B2017/306 , A61F9/008
摘要： A patient interface device adapted to provide an interface between a cornea and a surgical laser system. A frame has an applanation end and an attachment end which is adapted to couple to the surgical laser system. A skirt is affixed to the applanation end of the frame and is adapted to seal against the anterior surface of the cornea to form a chamber. A lens is disposed near the applanation end of the frame and is supported by a flexible support which affixes the lens to the frame.
摘要翻译：适于在角膜和手术激光系统之间提供界面的患者界面装置。框架具有扁平端部和适于耦合到手术激光系统的附接端部。裙边固定在框架的扁平端，并适于密封角膜的前表面以形成腔室。镜片被放置在框架的扁平端附近并由将镜片固定到框架的柔性支撑件支撑。

2. 发明申请

WO2013032993A1 EYE MANIPULATOR 审中-公开
标题翻译：眼睛操作员
公开(公告)号：WO2013032993A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052460
申请日：2012-08-27
申请人： ALCON LENSX, INC. , JUHASZ, Tibor , NAGY, Laszlo
发明人： JUHASZ, Tibor , NAGY, Laszlo
IPC分类号： A61F9/009 , A61F9/013
CPC分类号： A61F9/013 , A61F9/009 , A61F2009/00887
摘要： An eye-manipulator can include an applicator-arm and an eye-contact element, the applicator-arm providing mechanical control over the eye-contact element, and the eye-contact element, connected to the applicator-arm, can be configured to make contact with an eye. A method of manipulating an eye includes aligning the eye-contact element with an eye by adjusting the applicator-arm of the eye-manipulator; contacting the eye with the eye-contact element of the eye-manipulator; and manipulating the eye with the eye-manipulator to assist a docking of a patient interface of an ophthalmic system onto the eye.
摘要翻译：眼睛操纵器可以包括施用器臂和眼睛接触元件，施加器臂提供对眼睛接触元件的机械控制，并且连接到施用器臂的眼睛接触元件可以被配置为使与眼睛接触。操纵眼睛的方法包括通过调节眼睛操纵器的施用器臂来将眼睛接触元件与眼睛对准; 使眼睛与眼睛操纵器的眼睛接触元件接触; 并且用眼睛操纵器操纵眼睛以帮助眼科系统的患者接口对准眼睛。

3. 发明申请

WO2007050572A3 DISPOSABLE PATIENT INTERFACE 审中-公开
标题翻译：可疑患者界面
公开(公告)号：WO2007050572A3
公开(公告)日：2007-11-22
申请号：PCT/US2006041412
申请日：2006-10-24
申请人： INTRALASE CORP , RAKSI FERENC , JUHASZ TIBOR , KURTZ RON , LUMMIS WES , DAVIS CHRIS , NAGY LASZLO
发明人： RAKSI FERENC , JUHASZ TIBOR , KURTZ RON , LUMMIS WES , DAVIS CHRIS , NAGY LASZLO
IPC分类号： A61B18/18
CPC分类号： A61F9/009 , A61B2017/306 , A61F9/008
摘要： A patient interface device adapted to provide an interface between a cornea and a surgical laser system. A frame has an applanation end and an attachment end which is adapted to couple to the surgical laser system. A skirt is affixed to the applanation end of the frame and is adapted to seal against the anterior surface of the cornea to form a chamber. A lens is disposed near the applanation end of the frame and is supported by a flexible support which affixes the lens to the frame.
摘要翻译：一种适于提供角膜和外科激光系统之间的界面的患者接口装置。框架具有压平端和适于联接到手术激光系统的附接端。裙部固定在框架的压平端上并且适于密封角膜的前表面以形成腔室。透镜设置在框架的压平端附近，并且由将镜片固定到框架的柔性支撑件支撑。

4. 发明申请

WO2007120643A2 SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) USING HELICAL SCANNINIG WITH MULTIPLEXING MULTI-PINHOLE APERTURES 审中-公开
标题翻译：单光子发射计算机图像（SPECT）使用具有多重复合孔径的螺旋扫描
公开(公告)号：WO2007120643A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008812
申请日：2007-04-11
申请人： BIOSCON, INC. , HOPPIN, John , VANCAUTER, Staf , LACKAS, Christian , NAGY, Laszlo
发明人： HOPPIN, John , VANCAUTER, Staf , LACKAS, Christian , NAGY, Laszlo
IPC分类号： G01T1/166
CPC分类号： G01T1/1648 , A61B6/027
摘要： The reconstruction of artifact free images is made possible by the implementation of a SPECT imaging device that employs helical scanning. The SPECT imaging device includes a detector configured to detect photons, such as photons, that are projected onto it. A collimator is axially aligned with the detector and includes a plurality of pinholes configured to create overlapping projections of the photons. An object support structure is configured to move in a direction that is axially aligned with. the detector and collimator. The detector and collimator are configured to rotate around the object support structure in a transaxial plane to the object support structure while the object support structure moves in an axial direct to the collimator and detector.
摘要翻译：通过实施采用螺旋扫描的SPECT成像装置，可以实现无伪影图像的重建。 SPECT成像装置包括检测器，其被配置为检测投影到其上的光子，例如光子。准直器与检测器轴向对准并且包括被配置为产生光子的重叠投影的多个针孔。物体支撑结构构造成沿与轴向对准的方向移动。检测器和准直仪。检测器和准直器构造成在对象支撑结构的轴向平面内围绕物体支撑结构旋转，同时物体支撑结构在轴向上直接移动到准直器和检测器。

5. 发明申请

WO2012027011A1 REPLACEABLE LIGHT EMITTING DIODE MODULE WITH HIGH OPTICAL PRECISION 审中-公开
标题翻译：具有高光学精度的可更换的发光二极管模块
公开(公告)号：WO2012027011A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/040441
申请日：2011-06-15
申请人： GENERAL ELECTRIC COMPANY , GALLAI, Jozsef , BAKO, Zoltan , MUDRA, Istvan , MOLNAR, Imre , NAGY, Laszlo , KOVÁCS, Krisztián Mihály
发明人： GALLAI, Jozsef , BAKO, Zoltan , MUDRA, Istvan , MOLNAR, Imre , NAGY, Laszlo , KOVÁCS, Krisztián Mihály
IPC分类号： F21V19/00 , F21V19/02 , F21S8/10 , F21S8/12 , F21V29/00 , F21Y101/02
CPC分类号： F21V29/503 , F21S41/143 , F21S41/192 , F21S43/14 , F21S43/195 , F21V19/001 , F21V19/02 , F21Y2115/10
摘要： A replaceable lighting module in an LED light source is provided. The module improves thermal, mechanical, and electrical connection with an associated fixture. The replaceable module also provides for precise positioning and improves on optical properties of the light distribution.
摘要翻译：提供LED光源中的可更换照明模块。该模块改善了与相关固定装置的热连接，机械连接和电气连接。可替换模块还提供了精确的定位，并改善了光分布的光学性能。

6. 发明申请

WO2007120643A3 SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) USING HELICAL SCANNINIG WITH MULTIPLEXING MULTI-PINHOLE APERTURES 审中-公开
标题翻译：单光子发射计算机图像（SPECT）使用具有多重复合孔径的螺旋扫描
公开(公告)号：WO2007120643A3
公开(公告)日：2008-08-28
申请号：PCT/US2007008812
申请日：2007-04-11
申请人： BIOSCON INC , HOPPIN JOHN , VANCAUTER STAF , LACKAS CHRISTIAN , NAGY LASZLO
发明人： HOPPIN JOHN , VANCAUTER STAF , LACKAS CHRISTIAN , NAGY LASZLO
IPC分类号： G01T1/166
CPC分类号： G01T1/1648 , A61B6/027
摘要： The reconstruction of artifact free images is made possible by the implementation of a SPECT imaging device that employs helical scanning. The SPECT imaging device includes a detector configured to detect photons, such as photons, that are projected onto it. A collimator is axially aligned with the detector and includes a plurality of pinholes configured to create overlapping projections of the photons. An object support structure is configured to move in a direction that is axially aligned with. the detector and collimator. The detector and collimator are configured to rotate around the object support structure in a transaxial plane to the object support structure while the object support structure moves in an axial direct to the collimator and detector.
摘要翻译：通过实施采用螺旋扫描的SPECT成像装置，可以实现无伪影图像的重建。 SPECT成像装置包括检测器，其被配置为检测投影到其上的光子，例如光子。准直器与检测器轴向对准并且包括被配置为产生光子的重叠投影的多个针孔。物体支撑结构构造成沿与轴向对准的方向移动。检测器和准直仪。检测器和准直器被构造成在对象支撑结构沿直轴移动到准直器和检测器的同时沿轴向平面旋转对象支撑结构。

7. 发明申请

WO1998029113A1 TREATMENT OF DISEASE STATES WHICH RESULT FROM NEOPLASTIC CELL PROLIFERATION USING PPAR-GAMMA ACTIVATORS AND COMPOSITIONS USEFUL THEREFOR 审中-公开
标题翻译：使用PPAR-GAMMA激活剂和组合物治疗由神经细胞增殖引起的疾病状态
公开(公告)号：WO1998029113A1
公开(公告)日：1998-07-09
申请号：PCT/US1997024190
申请日：1997-12-29
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , EVANS, Ronald, M. , TONTONOZ, Peter , NAGY, Laszlo
发明人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
IPC分类号： A61K31/20
CPC分类号： A61K31/44 , A61K31/12 , A61K31/19 , A61K31/192 , A61K31/205 , A61K31/445 , A61K31/557 , A61K31/5575 , A61K2300/00
摘要： In accordance with the present invention, it has been discovered that PPAR gamma is expressed consistently in tissues associated with each of a variety of disease states which result from neoplastic cell proliferation. It has further been discovered that maximal activation of PPAR gamma with exogenous ligand promotes terminal differentiation of primary cells which are otherwise subject to neoplastic cell proliferation. In accordance with another aspect of the invention, it has been discovered that RXR-specific ligands are also potent agents for induction of differentiation of cells expressing the PPAR gamma /RXR alpha heterodimer, and that simultaneous treatment of cells subject to neoplastic cell proliferation with a PPAR gamma -selective ligand, in combination with an RXR-specific ligand, results in an additive stimulation of differentiation. Thus, the effect of neoplastic cell proliferation can be ameliorated by treatment of cells undergoing neoplastic cell proliferation with PPAR gamma agonists, optionally in the further presence of RXR agonists, thereby blocking further proliferation thereof. Accordingly, compounds and compositions which are useful for the treatment of a variety of disease states which result from neoplastic cell proliferation have been identified and are described herein.
摘要翻译：根据本发明，已经发现PPARγ在与由肿瘤细胞增殖引起的多种疾病状态中的每一种相关的组织中一致地表达。进一步发现，外源性配体的PPARγ的最大活化促进原始细胞的终末分化，否则其将受到肿瘤细胞增殖的影响。根据本发明的另一方面，已经发现RXR特异性配体也是用于诱导表达PPARγ/RXRα异二聚体的细胞分化的有效试剂，并且同时处理具有赘生性细胞增殖的细胞 PPARγ选择性配体与RXR特异性配体组合导致分化的加性刺激。因此，可以通过用任选地在RXR激动剂的进一步存在下治疗与PPARγ激动剂进行肿瘤细胞增殖的细胞来改善肿瘤细胞增殖的作用，从而阻止其进一步增殖。因此，已经鉴定并描述了可用于治疗由肿瘤细胞增殖引起的各种疾病状态的化合物和组合物。

8. 发明申请

WO2007144679A3 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION 审中-公开
标题翻译：化合物，作用和方法进行细胞周期调控
公开(公告)号：WO2007144679A3
公开(公告)日：2009-06-18
申请号：PCT/HU2007000055
申请日：2007-06-14
申请人： UNIV DEBRECEN , NAGY LASZLO , SZATMARI ISTVAN
发明人： NAGY LASZLO , SZATMARI ISTVAN
IPC分类号： A61K45/06 , A61P35/00
CPC分类号： A61K45/06 , A61K49/0021
摘要： ABCG2, a member of the ATP-Binding Cassette transporters has been identified as a protective pump against endogenous and exogenous toxic agents. ABCG2 was shown to be expressed at high levels in stem cells, and variably regulated during cell differentation. It is demonstrated herein that functional ABCG2 is expressed in human monocyte-derived dendritic cells by the activation of a nuclear hormone receptor, PPARg. The present results uncovered a mechanism by which up-regulation of functional ABCG2 expression can be achieved via exogenous or endogenous activation of the lipid activated transcription factor, PPARg. Thus the invention relates to combined treatments by PPARg agonists and cytotoxic drugs transportable by ABCG2, various treatments in the field of neoplastic diseases as well as cell therapy, including autologous cell therapy, as well as kits and composition therefor. Method for protecting cells against cytotoxic drugs are also provided.
摘要翻译： ABCG2是ATP结合盒转运蛋白的成员，已被确定为针对内源性和外源性毒性物质的保护性泵。显示ABCG2在干细胞中以高水平表达，并且在细胞分化期间可变地调节。本文证明功能性ABCG2通过激活核激素受体PPARg在人单核细胞衍生的树突状细胞中表达。本研究结果揭示了通过脂质激活转录因子PPARg的外源或内源激活可以实现功能性ABCG2表达上调的机制。因此，本发明涉及PPARg激动剂和可通过ABCG2运输的细胞毒性药物，肿瘤疾病领域的各种治疗以及包括自体细胞治疗在内的细胞治疗以及试剂盒及其组合物的组合治疗。还提供了用于保护细胞免受细胞毒性药物的方法。

9. 发明申请

WO2009035438A1 POLYMERIC NANOPARTICLES BY ION-ION INTERACTIONS 审中-公开
标题翻译：由离子相互作用的聚合纳米粒子
公开(公告)号：WO2009035438A1
公开(公告)日：2009-03-19
申请号：PCT/US2007/019954
申请日：2007-09-13
申请人： BORBELY, Janos , BODNAR, Magdolna , HAJDU, Istvan , HARTMAN, John, F. , KERESZTESSY, Zsolt , NAGY, Laszlo , VAMOSI, Gyorgy
发明人： BORBELY, Janos , BODNAR, Magdolna , HAJDU, Istvan , HARTMAN, John, F. , KERESZTESSY, Zsolt , NAGY, Laszlo , VAMOSI, Gyorgy
IPC分类号： A61K31/715 , A61K47/36
CPC分类号： A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/715 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/551 , A61K47/6931 , A61K47/6933 , A61K47/6939
摘要： The present invention relates to biocompatible and biodegradable stimuli-sensitive polymeric nanoparticles, which were formed by ion-ion interaction in aqueous media. Synthetic and biological macromolecules with ionizable functional groups are capable of forming nanoparticles whose size and surface properties are sensitive to environmental influences such as pH, temperature and salt concentration. Nanodevices are designed for therapeutic applications as drug and nucleic acid carriers, and/or for MRI diagnosis as contrast agents. These nanodevices are designed for therapeutic applications as targeted drug carriers. Additionally, they can be used as contrast agents for MRI diagnosis. These nanosystems are also potential carriers for delivery of active ingredients as DNA, RNA, short interfering RNA (siRNA), antisense oligonucleotides (AS-ON), and triple helix forming oligonucleotides (TFO) etc. for pharmaceutical applications. Their adjustable size offers yet another advantage.
摘要翻译：本发明涉及生物相容性和生物可降解的刺激性敏感的聚合物纳米粒子，其通过在水性介质中的离子 - 离子相互作用而形成。具有可离子化官能团的合成和生物大分子能够形成尺寸和表面性质对pH，温度和盐浓度等环境影响敏感的纳米颗粒。纳米设备设计用作药物和核酸载体的治疗应用，和/或作为造影剂的MRI诊断。这些纳米设备被设计用作靶向药物载体的治疗应用。此外，它们可以用作MRI诊断的造影剂。这些纳米系统也是作为药物应用的DNA，RNA，短干扰RNA（siRNA），反义寡核苷酸（AS-ON）和三螺旋形成寡核苷酸（TFO）等递送活性成分的潜在载体。它们的可调节尺寸提供了另一个优点。

10. 发明申请

WO2007120643A9 SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) USING HELICAL SCANNINIG WITH MULTIPLEXING MULTI-PINHOLE APERTURES 审中-公开
标题翻译：单光子发射计算机图像（SPECT）使用具有多重复合孔径的螺旋扫描
公开(公告)号：WO2007120643A9
公开(公告)日：2007-12-27
申请号：PCT/US2007008812
申请日：2007-04-11
申请人： BIOSCON INC , HOPPIN JOHN , VANCAUTER STAF , LACKAS CHRISTIAN , NAGY LASZLO
发明人： HOPPIN JOHN , VANCAUTER STAF , LACKAS CHRISTIAN , NAGY LASZLO
IPC分类号： G01T1/166
CPC分类号： G01T1/1648 , A61B6/027
摘要： The reconstruction of artifact free images is made possible by the implementation of a SPECT im
摘要翻译：通过实施SPECT im可以实现无伪影图像的重建

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