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1. 发明申请

WO2007093310A3 DRY POWDER INHALER DEVICE 审中-公开
公开(公告)号：WO2007093310A3
公开(公告)日：2007-08-23
申请号：PCT/EP2007/001031
申请日：2007-02-07
申请人： JAGOTEC AG , MUELLER-WALZ, Rudi , EGGIMANN, Thomas
发明人： MUELLER-WALZ, Rudi , EGGIMANN, Thomas
IPC分类号： A61M15/00
摘要： A DPI device comprising a dispensing chamber (13) for receiving a discrete dose of medicament-containing powder and means for delivering said dose from the dispensing chamber to a patient in an air-flow that passes from the chamber to the patient via a mouth-piece (3) along a first air passage (4) that comprises de-agglomerating means, the device additionally comprises a second air passage (5) in fluid communication with the dispensing chamber and the mouth-piece and which by-passes the de- agglomerating means and which is located such that it receives a portion of said air-flow that is free, or substantially free, of powder.

2. 发明申请

WO2007068443A1 POWDER COMPOSITIONS FOR INHALATION 审中-公开
标题翻译：用于吸入的粉末组合物
公开(公告)号：WO2007068443A1
公开(公告)日：2007-06-21
申请号：PCT/EP2006/011941
申请日：2006-12-12
申请人： JAGOTEC AG , MUELLER-WALZ, Rudi
发明人： MUELLER-WALZ, Rudi
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K47/00
CPC分类号： A61K9/145 , A61K9/0075 , A61K9/0078 , A61K31/40 , Y02A50/465
摘要： A pharmacological powder for inhalation comprising fine particles of a drug and particles of a force-controlling agent, wherein the particles of said force-controlling agent are disposed on the surface of the active particles as either a particulate coating, or as a continuous or discontinuous film. The powder may further comprise particles of a carrier material for supporting the drug particles. The force-controlling agent may be selected from: amino acids, peptides and polypeptides having a molecular weight of from 0.25 to 1000 KDa; phospholipids; titanium dioxide; aluminium dioxide; silicon dioxide; starch; and salts of fatty acids. Also disclosed is a method of making such a powder for inhalation comprising mixing a force-controlling agent with particles of one or more pharmacologically active materials to obtain a mixture in which the particles of said force-controlling agent are disposed on the surface of the active particles as either a particulate coating, or as a continuous or discontinuous film. The mixing step may be achieved by sieving, mixing or blending, micronising and/or co-micronising the particles of one or more pharmacologically active material and particles of force-controlling agents.
摘要翻译：一种用于吸入的药物粉末，其包含药物的微粒和力控制剂的颗粒，其中所述力控制剂的颗粒设置在活性颗粒的表面上，作为颗粒涂层，或作为连续或不连续的电影。粉末还可以包含用于支撑药物颗粒的载体材料的颗粒。力控制剂可以选自：分子量为0.25至1000KDa的氨基酸，肽和多肽; 磷脂; 二氧化钛; 二氧化铝; 二氧化硅; 淀粉; 和脂肪酸的盐。还公开了制备这种用于吸入的粉末的方法，包括将力控制剂与一种或多种药理学活性物质的颗粒混合以获得其中所述力控制剂的颗粒设置在活性物质的表面上的混合物颗粒作为颗粒涂层，或作为连续或不连续膜。混合步骤可以通过筛选，混合或共混，微粉化和/或共微粉碎一种或多种药理学活性物质和力控制剂颗粒来实现。

3. 发明申请

WO2011045429A1 IMPROVED FORMULATIONS 审中-公开
标题翻译：改进配方
公开(公告)号：WO2011045429A1
公开(公告)日：2011-04-21
申请号：PCT/EP2010/065569
申请日：2010-10-15
申请人： JAGOTEC AG , MUELLER-WALZ, Rudi , FUEG, Lise-Marie
发明人： MUELLER-WALZ, Rudi , FUEG, Lise-Marie
IPC分类号： A61K9/00 , A61K31/00
CPC分类号： A61K9/008 , A61K31/045 , A61K31/167 , A61K31/56 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： In a metered dose inhaler, comprising a canister and metering valve, containing a suspension aerosol formulation comprising particles of formoterol fumarate dihydrate and fluticasone propionate suspended in an HFA propellant, a method of reducing deposition of particles on the surfaces of the canister and the metering valve, the method comprising the step of adding a wetting agent to the formulation.
摘要翻译：在包含罐和计量阀的计量剂量吸入器中，包含悬浮气溶胶制剂，其包含悬浮在HFA推进剂中的福莫特罗富马酸盐二水合物和氟酸氟替卡松的颗粒，减少颗粒沉积在罐和表面上的方法该方法包括向制剂中加入润湿剂的步骤。

4. 发明申请

WO2005034927A3 AEROSOL FORMULATION COMPRISING FORMOTEROL IN SUSPENSION 审中-公开
标题翻译：包含FORMOTEROL在悬浮液中的气溶胶制剂
公开(公告)号：WO2005034927A3
公开(公告)日：2005-06-02
申请号：PCT/IB2004003465
申请日：2004-10-08
申请人： JAGOTEC AG , MUELLER-WALZ RUDI
发明人： MUELLER-WALZ RUDI
IPC分类号： A61K9/00 , A61K31/00 , A61K31/58 , A61K31/67 , A61K9/72
CPC分类号： A61K9/008 , A61K31/58 , A61K31/67 , A61K2300/00
摘要： A pharmaceutical aerosol formulation comprising formoterol fumarate di-hydrate in suspension, and a steroid in solution, and a propellant, ethanol, and optionally a surfactant, wherein the formoterol fumarate di-hydrate has a water content of about 4.8 to 4.28 % by weight, more particularly about 4.5 to 4.28%. A method of producing the formulation characterized in that the formoterol is dried beforehand to a water content of 4.8 to 4.28%.
摘要翻译：包含富马酸富马酸二水合物悬浮液和溶液中类固醇的药物气溶胶制剂，以及推进剂，乙醇和任选的表面活性剂，其中富马酸福莫特罗二水合物的水含量为约4.8至4.28重量％更特别是约4.5〜4.28％。制备该制剂的方法，其特征在于福莫特罗预先干燥至含水量为4.8至4.28％。

5. 发明申请

WO2005046636A1 DRY POWDER FORMULATIONS 审中-公开
标题翻译：干粉配方
公开(公告)号：WO2005046636A1
公开(公告)日：2005-05-26
申请号：PCT/IB2004/003804
申请日：2004-11-04
申请人： JAGOTEC AG , MUELLER-WALZ, Rudi , STEINER, Roland
发明人： MUELLER-WALZ, Rudi , STEINER, Roland
IPC分类号： A61K9/00
CPC分类号： A61K9/0075
摘要： A dry powder suitable for inhalation in a dry powder inhaler, the powder comprising a carrier, an active agent and at least 0.5% by weight of magnesium stearate, the powder being further characterized in that the less than 10% of the surface of the carrier material is covered with particles of magnesium stearate . The invention is also directed to a method of making dry powders by blending together the ingredients mentioned in a diffusion blender for a period time that is less than 60 minutes.
摘要翻译：一种适用于吸入干粉吸入器的干燥粉末，该粉末包含载体，活性剂和至少0.5重量％的硬脂酸镁，该粉末进一步的特征在于载体表面的小于10％材料被硬脂酸镁颗粒覆盖。本发明还涉及通过将扩散混合器中提及的成分混合在一起的时间小于60分钟来制备干粉的方法。

6. 发明申请

WO2011045432A1 IMPROVED MEDICINAL AEROSOL FORMULATIONS 审中-公开
标题翻译：改进药物制剂
公开(公告)号：WO2011045432A1
公开(公告)日：2011-04-21
申请号：PCT/EP2010/065573
申请日：2010-10-15
申请人： JAGOTEC AG , MUELLER-WALZ, Rudi , FUEG, Lise-Marie
发明人： MUELLER-WALZ, Rudi , FUEG, Lise-Marie
IPC分类号： A61K9/00 , A61K31/00
CPC分类号： A61K31/58 , A61K9/008 , A61K9/124 , A61K31/137 , A61K31/167 , A61K31/56 , A61K45/06 , A61K47/10 , A61K47/22 , A61K2300/00
摘要： The present invention provides a medicinal aerosol suspension formulation for MDl administration, comprising: a) micronised pa-agonist; b) micronised corticosteroid; c) a siib-therapexrtic quantity of a moisture-scavenger excipient; and d) a HFA propellaπt; wherein (a), (b) and (c) and their respective relative amounts are selected such that they associate to form floccules having a density substantially the same as that of the HFA propellant.
摘要翻译：本发明提供用于MD1给药的药用气溶胶悬浮液制剂，其包含：a）微粉化的pa-激动剂; b）微粉化皮质类固醇; c）一种可溶解量的除湿剂赋形剂; 和d）HFA推进剂; 其中（a），（b）和（c）和它们各自的相对量被选择为使得它们结合形成具有与HFA推进剂基本上相同密度的絮凝物。

7. 发明申请

WO2008058691A3 POWDER FORMULATION FOR INHALATION 审中-公开
标题翻译：用于吸入的粉末配方
公开(公告)号：WO2008058691A3
公开(公告)日：2008-10-23
申请号：PCT/EP2007009761
申请日：2007-11-12
申请人： JAGOTEC AG , MUELLER-WALZ RUDI
发明人： MUELLER-WALZ RUDI
IPC分类号： A61K9/72
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/145 , A61K38/193 , A61K38/28 , A61K38/47 , A61K38/48 , A61K38/4826 , A61K38/50 , A61K39/0015 , A61K39/13 , A61K39/292
摘要： A powder formulation for inhalation comprising a macromolecule and a crystalline carrier material.
摘要翻译：一种用于吸入的粉末制剂，其包含高分子和结晶载体材料。

8. 发明申请

WO2007093310A2 IMPROVEMENTS IN OR RELATING TO DRY POWDER INHALER DEVICES 审中-公开
标题翻译：干燥粉末吸入装置的改进或相关
公开(公告)号：WO2007093310A2
公开(公告)日：2007-08-23
申请号：PCT/EP2007001031
申请日：2007-02-07
申请人： JAGOTEC AG , MUELLER-WALZ RUDI , EGGIMANN THOMAS
发明人： MUELLER-WALZ RUDI , EGGIMANN THOMAS
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M11/002 , A61M15/0025 , A61M15/0026 , A61M15/0065 , A61M15/0076 , A61M15/0081 , A61M15/0093 , A61M15/0096 , A61M2202/064
摘要： A DPI device comprising a dispensing chamber for receiving a discrete dose of medicament-containing powder and means for delivering said dose from the dispensing chamber to a patient in an air-flow that passes from the chamber to the patient via a mouth-piece along a first air passage that comprises de-agglomerating means, the device additionally comprises a second air passage in fluid communication with the dispensing chamber and the mouth-piece and which by-passes the de- agglomerating means and which is located such that it receives a portion of said air-flow that is free, or substantially free, of powder.
摘要翻译： DPI装置，其包括用于接收离散剂量的药物含有粉末的分配室和用于将空气流中的剂量从所述分配室输送到患者的装置，所述气流从所述腔室经由口腔沿着第一空气通道包括去聚集装置，该装置另外包括与分配腔和口件流体连通的第二空气通道，并且旁通除去凝聚装置并且被定位成使得其接收部分的所述气流，其是游离的或基本上不含的粉末。

9. 发明申请

WO2008058691A2 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的改善或有关
公开(公告)号：WO2008058691A2
公开(公告)日：2008-05-22
申请号：PCT/EP2007/009761
申请日：2007-11-12
申请人： JAGOTEC AG , MUELLER-WALZ, Rudi
发明人： MUELLER-WALZ, Rudi
IPC分类号： A61K9/72
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/145 , A61K38/193 , A61K38/28 , A61K38/47 , A61K38/48 , A61K38/4826 , A61K38/50 , A61K39/0015 , A61K39/13 , A61K39/292
摘要： A powder formulation for inhalation comprising a macromolecule and a crystalline carrier material.
摘要翻译：用于吸入的粉末制剂，其包含高分子和结晶载体材料。

10. 发明申请

WO2005034927A2 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物或相关化合物的改进
公开(公告)号：WO2005034927A2
公开(公告)日：2005-04-21
申请号：PCT/IB2004/003465
申请日：2004-10-08
申请人： JAGOTEC AG , MUELLER-WALZ, Rudi
发明人： MUELLER-WALZ, Rudi
IPC分类号： A61K9/72
CPC分类号： A61K9/008 , A61K31/58 , A61K31/67 , A61K2300/00
摘要： A pharmaceutical aerosol formulation comprising formoterol fumarate di-hydrate in suspension, and a steroid in solution, and a propellant, ethanol, and optionally a surfactant, wherein the formoterol fumarate di-hydrate has a water content of about 4.8 to 4.28 % by weight, more particularly about 4.5 to 4.28%.
摘要翻译：包含悬浮液中富马酸富马酸二水合物和溶液中类固醇的药物气溶胶制剂，以及推进剂，乙醇和任选的表面活性剂，其中富马酸福莫特罗二水合物的水含量为约4.8至4.28重量％更特别地约4.5〜4.28％。

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