专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012122628A1 MICROFLUIDIC SYSTEM HAVING MONOLITHIC NANOPLASMONIC STRUCTURES 审中-公开
标题翻译：具有单层纳米结构的微流体系统
公开(公告)号：WO2012122628A1
公开(公告)日：2012-09-20
申请号：PCT/CA2012/000203
申请日：2012-03-12
申请人： NATIONAL RESEARCH COUNCIL OF CANADA , MALIC, Lidija , MORTON, Keith , VERES, Teodor
发明人： MALIC, Lidija , MORTON, Keith , VERES, Teodor
IPC分类号： B29C59/00 , B21D22/02 , B81C1/00 , B82Y30/00 , C12M1/34 , G01N21/77 , B22C7/04 , C08J5/18
CPC分类号： G01N21/65 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/044 , B01L2300/0654 , B01L2300/0822 , B01L2300/0861 , B01L2300/0887 , B01L2300/0896 , B01L2300/12 , B01L2400/086 , B82Y30/00 , C12M23/16 , G01N21/554 , G01N21/658 , Y10T137/8593
摘要： A microfluidic system, particularly suited as a cell culture system, is provided having a single monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements required for plasmonic response monitoring and a network of microchannels for precisely controlling cellular environment. The system has the additional advantages of low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, amenability to mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecu!ar binding using plasmonic techniques. A ratio of greater than 0.2 between the cross-sectional dimension and the spacing distance of the nano-scale elements is useful for plasmonic response monitoring. A process for producing such a system involves fabrication of a master mold containing the nano-scale elements etched into a hard substrate, and the micro-scale and meso-scale features, such as channels and chambers, provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold and then the features of the intended device transferred to a polymeric substrate using the stamp.
摘要翻译：提供了特别适合作为细胞培养系统的微流体系统，其具有单个整体生物相容性基底，其具有具有等离子体激发响应监测所需的纳米级元件的有序阵列的表面和用于精确控制细胞环境的微通道网络。该系统具有低体积消耗，快速低成本制造具有易于互换的微流体通道布局的模具，大规模生产的易于使用以及原位无标签的实时检测细胞反应，存活力，行为和生物分子的额外优点使用等离子体激元技术进行结合。横截面尺寸与纳米级元件的间距之间的比值大于0.2对于等离子体响应监测是有用的。制造这种系统的方法包括制造含有蚀刻到硬质基材中的纳米级元素的母模，以及提供在粘合到该柔性膜上的软膜中的微尺度和中尺度特征，例如通道和室硬质基材。可以通过设置放置在母模中的可固化液体聚合物或金属，然后使用印模将预期装置的特征转移到聚合物基底来形成印模。

2. 发明申请

WO2010011934A3 BUMP ARRAY DEVICE HAVING ASYMMETRIC GAPS FOR SEGREGATION OF PARTICLES 审中-公开
标题翻译：具有用于粒子分离的不对称孔的BUMP阵列装置
公开(公告)号：WO2010011934A3
公开(公告)日：2010-04-29
申请号：PCT/US2009051704
申请日：2009-07-24
申请人： UNIV PRINCETON , STURM JAMES C , AUSTIN ROBERT , LOUTHERBACK KEVIN , MORTON KEITH , PUCHALLA JASON
发明人： STURM JAMES C , AUSTIN ROBERT , LOUTHERBACK KEVIN , MORTON KEITH , PUCHALLA JASON
IPC分类号： G01N27/00
CPC分类号： B03B5/00 , B01L3/502753 , G01N27/44791 , G01N30/0005 , G01N30/6069 , G01N30/6095 , G01N2030/528
摘要： The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
摘要翻译：本公开涉及用于按尺寸分离颗粒群体的障碍物阵列装置（也称为凸块阵列装置）。通过使跨越障碍物之间的间隙的流体速度分布相对于平分间隙且平行于整体流体流动的方向的平面不对称来实现对先前障碍物阵列装置的改进。这种不对称可以通过选择限定间隙的障碍物的形状来实现，使得障碍物的上游，下游或桥接间隙的最窄部分的部分相对于该平面不对称。通过使用边界尖锐的障碍物也可以实现改进。其他改进通过选择障碍物形状来实现，使得由两个不同流体流动方向上的间隙限定的临界颗粒尺寸不同。

3. 发明申请

WO2010011934A2 BUMP ARRAY DEVICE HAVING ASYMMETRIC GAPS FOR SEGREGATION OF PARTICLES 审中-公开
标题翻译：具有不对称GAPS的BUG阵列设备用于分离颗粒
公开(公告)号：WO2010011934A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051704
申请日：2009-07-24
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , STURM, James, C. , AUSTIN, Robert , LOUTHERBACK, Kevin , MORTON, Keith , PUCHALLA, Jason
发明人： STURM, James, C. , AUSTIN, Robert , LOUTHERBACK, Kevin , MORTON, Keith , PUCHALLA, Jason
IPC分类号： G01N27/00
CPC分类号： B03B5/00 , B01L3/502753 , G01N27/44791 , G01N30/0005 , G01N30/6069 , G01N30/6095 , G01N2030/528
摘要： The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
摘要翻译：本公开涉及用于按尺寸分离颗粒群的障碍物阵列装置（也称为凸块阵列装置）。通过使跨越障碍物之间的间隙的流体速度分布相对于平分该间隙并且平行于体积流体流动方向的平面不对称来实现对先前障碍物阵列装置的改进。这种不对称性可以通过选择围绕间隙的障碍物的形状来实现，使得障碍物的上游，下游或桥接最窄部分的障碍物的部分相对于该平面是不对称的。通过使用具有边界限制边界的障碍物来实现改进。通过选择障碍物形状来实现其他改进，使得由两个不同流体流动方向上的间隙限定的临界粒子尺寸不同。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式