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1. 发明申请

WO2004080296A1 METHOD AND KITS FOR MONITORING WOMEN’S HEALTH 审中-公开
标题翻译：监测妇女健康的方法和工具
公开(公告)号：WO2004080296A1
公开(公告)日：2004-09-23
申请号：PCT/EP2004/002529
申请日：2004-03-11
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , MORRIS, Carol, Ann
发明人： CARNEY, Fiona, Patricia , MORRIS, Carol, Ann
IPC分类号： A61B5/00
CPC分类号： A61B5/42 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/4306 , A61B10/0012 , A61B10/0045 , A61B2010/0067
摘要： The invention provides methods and kits for monitoring the status of women’s health, including HRT monitoring and determination or diagnosis of ovulation, contraception, pregnancy, menopause, polycystic ovarian disease, and female sexual dysfunction. The method comprises the steps of: (a) collecting a tear fluid from a female human; (b) determining the tear concentration of at least one hormone of relevance to female fertility, sexual differentiation of sexual dysfunction in a female human, wherein the tear concentration is diagnostics of the status of women’s health.
摘要翻译：本发明提供了监测妇女健康状况的方法和工具，包括HRT监测和排卵，避孕，怀孕，绝经，多囊卵巢疾病和女性性功能障碍的确定或诊断。该方法包括以下步骤：（a）从女性人体收集泪液; （b）确定与女性生育力相关的至少一种激素的泪液浓度，女性人类性功能障碍的性别分化，其中泪液浓度是对妇女健康状况的诊断。

2. 发明申请

WO2004030544A1 METHODS AND KITS FOR ASSAYS OF ANALYTES OF INTEREST IN TEARS 审中-公开
标题翻译：用于分析利益分析的方法和工具
公开(公告)号：WO2004030544A1
公开(公告)日：2004-04-15
申请号：PCT/EP2003/010972
申请日：2003-10-02
申请人： NOVARTIS AG. , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn , MORRIS, Carol, Ann
发明人： CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn , MORRIS, Carol, Ann
IPC分类号： A61B10/00
CPC分类号： A61B10/0045 , A61B2010/0067
摘要： The invention, in one aspect, provides a strip for tear collection. The strip has a first end and an opposite second end and preferably has substantially uniform crass-sections from the first end to the second end. The strip is made of a hydrogel material in substantially dry state. The strip is characterized by having a substantially uniform swelling along the hydrogel strip from the first end to the second end when fully wicked by a tear fluid and by having a correlation between the volume of tear uptake by said strip and the length of the wicked end portion of said strip. A strip of the invention is useful for assay of an analyte of interest in a tear fluid. The invention also provides a method and kits for assaying an analyte of interest (e.g., lactoferrin, glucose, herpes simplex virus, hormones, etc.).
摘要翻译：本发明在一个方面提供了一种用于撕裂收集的条带。带材具有第一端和相对的第二端，并且优选地具有从第一端到第二端的基本均匀的粗糙部分。条带由基本上干燥状态的水凝胶材料制成。该条带的特征在于，当被泪液完全弄脏时，沿着水凝胶条具有从第一端到第二端的基本上均匀的溶胀，并且通过所述带的撕裂吸收体积与邪恶端的长度之间的相关性所述条的一部分。本发明的条带可用于测定泪液中感兴趣的分析物。本发明还提供了用于测定所关注的分析物（例如乳铁蛋白，葡萄糖，单纯疱疹病毒，激素等）的方法和试剂盒。

3. 发明申请

WO1990008783A1 RECEPTOR MEMBRANES AND IONOPHORE GATING 审中-公开
标题翻译：受体膜和离子加成
公开(公告)号：WO1990008783A1
公开(公告)日：1990-08-09
申请号：PCT/AU1990000025
申请日：1990-01-29
申请人： AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH ... , CORNELL, Bruce, Andrew , BRAACH-MAKSVYTIS, Vijoleta, Lucija, Bronislava , PACE, Ronald, John , KING, Lionel, George , RAGUSE, Burkhard , BAXTER, Claire, Rosemary , HALL, Ruth, Milna , MORRIS, Carol, Ann , OSMAN, Peter, Damien, John
发明人： AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH ...
IPC分类号： C07K17/08
CPC分类号： B82Y30/00 , A61B5/14546 , A61L27/22 , A61L27/28 , A61L27/54 , A61L33/0082 , A61L2300/256 , A61L2300/438 , A61L2300/442 , A61L2300/606 , A61L2300/608 , A61L2300/802 , B01D69/02 , B01D69/122 , B01D69/141 , B01D2325/48 , G01N33/5432 , G01N33/566 , Y10S977/89 , Y10S977/931
摘要： The present invention provides a membrane the conductivity of which is dependent on the presence or absence of an analyte. The membrane comprises a closely packed array of self-assembling amphiphilic molecules and two ionophore components. A receptor molecule reactive with the analyte is provided on one of the ionophore components. The binding of the analyte to the receptor molecule causes a change in the relationship between the ionophore components such that the flow of ion across the membrane is prevented or allowed. The ionophore components are preferably selected from the group consisting of amphotericin B, gramicidin A monomers and combinations thereof, with gramicidin A monomers being particularly preferred. The present invention also provides a membrane including receptors directed against the Fc region of antibodies. These receptors are preferably derived from polyclonal antibodies. These membranes provide a ''generic'' surface which will bind antibodies in a manner such that the antigen binding regions of the antibody are not hindered. The present invention further provides a device adapted for implantation in a mammalian body, the device being characterised in that it is coated with a membrane comprising a closely packed array of self-assembling amphiphilic molecules and receptor molecules, the receptor molecules being such that the attachment of specific cells to the membrane is enhanced or avoided. It is particularly preferred that the receptor molecules are directed against fibronectin, vitronectin, endothelial cells, or epithelial cells. It is further preferred that the membrane coating the device also includes a plurality of ion channels such as gramicidin.
摘要翻译：本发明提供了其导电性取决于分析物的存在或不存在的膜。膜包括紧密堆积的自组装两亲分子和两个离子载体组分的阵列。在离子载体组分之一上提供与分析物反应的受体分子。分析物与受体分子的结合导致离子载体组分之间的关系发生变化，从而防止或允许穿过膜的离子流。离子载体组分优选选自两性霉素B，短杆菌肽A单体及其组合，特别优选短节杆菌肽A单体。本发明还提供了包含针对抗体Fc区的受体的膜。这些受体优选衍生自多克隆抗体。这些膜提供了“通用”表面，其将以使得抗体的抗原结合区不受阻碍的方式结合抗体。本发明还提供一种适于植入哺乳动物体内的装置，该装置的特征在于其涂覆有包含紧密堆积的自组装两亲分子阵列和受体分子的膜，受体分子使得附着物的特定细胞被增强或避免。特别优选的是受体分子针对纤连蛋白，玻连蛋白，内皮细胞或上皮细胞。进一步优选的是，涂覆该装置的膜还包括多个离子通道，例如短杆菌肽。

4. 发明申请

WO2004046726A2 METHODS AND KITS FOR ASSAYS OF RAPID SCREENING OF DIABETES 审中-公开
标题翻译：用于糖尿病快速筛选的方法和试剂盒
公开(公告)号：WO2004046726A2
公开(公告)日：2004-06-03
申请号：PCT/EP2003/012958
申请日：2003-11-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MORRIS, Carol, Ann , CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn
发明人： MORRIS, Carol, Ann , CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn
IPC分类号： G01N33/66
CPC分类号： G01N33/6893 , G01N33/66 , G01N2800/042
摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
摘要翻译：本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间内测定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。本发明的方法通过使用本发明的试剂盒进行。试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

5. 发明申请

WO2010118474A1 COMPOUNDS AFFECTING GLYCEMIC INDEX 审中-公开
标题翻译：影响糖化指数的化合物
公开(公告)号：WO2010118474A1
公开(公告)日：2010-10-21
申请号：PCT/AU2010/000427
申请日：2010-04-16
申请人： SUGAR INDUSTRY INNOVATION PTY LTD , PAYN, Dionne Nadine , LEACH, David Norman , DESEO, Myrna A. , MORRIS, Carol Ann
发明人： PAYN, Dionne Nadine , LEACH, David Norman , DESEO, Myrna A. , MORRIS, Carol Ann
IPC分类号： C07D311/30 , A61K36/899 , A61P3/04 , A61P3/10 , A61K31/352 , C07D311/40
CPC分类号： C07D311/30 , A61K31/352
摘要： Compounds of formula I are disclosed which are useful as glycemic index lowering agents and/or, as α-amylase and/or α-glucosidase inhibitors. Also disclosed are nutritional and/or pharmaceutical compositions and supplements comprising one or more of these compounds. The compounds will be beneficial to patients who require stabilization of their postprandial glucose levels.
摘要翻译：公开了可用作血糖指数降低剂和/或作为α-淀粉酶和/或α-葡糖苷酶抑制剂的式I化合物。还公开了包含这些化合物中的一种或多种的营养和/或药物组合物和补充剂。这些化合物对于需要稳定其餐后葡萄糖水平的患者将是有益的。

6. 发明申请

WO2004080297A1 DEVICES FOR COLLECTING ANALYTES OF INTEREST IN TEARS 审中-公开
标题翻译：收集利益分析的设备
公开(公告)号：WO2004080297A1
公开(公告)日：2004-09-23
申请号：PCT/EP2004/002543
申请日：2004-03-11
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , MORRIS, Carol, Ann , QIU, Yongxing
发明人： CARNEY, Fiona, Patricia , MORRIS, Carol, Ann , QIU, Yongxing
IPC分类号： A61B5/00
CPC分类号： A61B5/42 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/411 , A61B5/4306 , A61B10/0045 , A61B2010/0067
摘要： The present invention provides a contact lens, preferably a daily disposable contact lens, which can be used to collect one or more analytes of interest in a tear fluid, and in turn, determine the physiological state or health of an individual.
摘要翻译：本发明提供一种隐形眼镜，优选为每日一次性隐形眼镜，其可用于在泪液中收集一种或多种感兴趣的分析物，并且进而确定个体的生理状况或健康状况。

7. 发明申请

WO2004050132A2 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004050132A2
公开(公告)日：2004-06-17
申请号：PCT/EP2003/013598
申请日：2003-12-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , GABRIEL, Manal, M. , MORRIS, Carol, Ann , LALLY, John, Martin
发明人： CARNEY, Fiona, Patricia , GABRIEL, Manal, M. , MORRIS, Carol, Ann , LALLY, John, Martin
IPC分类号： A61L27/34
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/608
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial peptides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.
摘要翻译：本发明提供医疗装置，优选隐形眼镜，其包含含有一种或多种抗微生物肽的抗微生物LbL涂层。本发明的抗微生物涂层可赋予医学以增加的表面亲水性和相对高的抗微生物活性以及低细胞毒性。本发明的抗微生物涂层对隐形眼镜的所需整体性质（例如透氧性，离子渗透性和光学性质）具有最小的不利影响。本发明的抗微生物涂层可以特别用于长效隐形眼镜。另外，本发明提供了一种用于制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

8. 发明申请

WO2003041754A1 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2003041754A1
公开(公告)日：2003-05-22
申请号：PCT/EP2002/012710
申请日：2002-11-13
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MORRIS, Carol, Ann , GABRIEL, Manal, M. , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , ASH, Marcia, Kay , CARNEY, Fiona, Patricia , MORGAN, Courtney, Flem
发明人： MORRIS, Carol, Ann , GABRIEL, Manal, M. , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , ASH, Marcia, Kay , CARNEY, Fiona, Patricia , MORGAN, Courtney, Flem
IPC分类号： A61L27/34
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.
摘要翻译：本发明提供一种医疗装置，优选隐形眼镜，其包括抗微生物涂层，其包含至少一层式（I）或（II）的聚四氢叶酸。本发明的医疗装置上的抗微生物涂层对微生物具有高抗微生物效果，包括革兰氏阳性和革兰氏阴性细菌，低毒性，低摩擦系数和增加的亲水性，同时保持所需的体积特性如氧气渗透性和透镜材料的离子透过率。这种透镜可用作延长佩戴的隐形眼镜。此外，本发明提供了制造其上具有抗微生物涂层的医疗装置，优选隐形眼镜的方法。

9. 发明申请

WO2004046726A3 METHODS AND KITS FOR ASSAYS OF RAPID SCREENING OF DIABETES 审中-公开
标题翻译：用于糖尿病快速筛选的方法和试剂盒
公开(公告)号：WO2004046726A3
公开(公告)日：2005-01-06
申请号：PCT/EP0312958
申请日：2003-11-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MORRIS CAROL ANN , CARNEY FIONA PATRICIA , LANE JENNIFER DAWN
发明人： MORRIS CAROL ANN , CARNEY FIONA PATRICIA , LANE JENNIFER DAWN
IPC分类号： A61B5/00 , C12Q1/54 , G01N33/66 , G01N33/68 , A61B10/00 , G01N33/52 , G01N33/542
CPC分类号： G01N33/6893 , G01N33/66 , G01N2800/042
摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
摘要翻译：本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间内测定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。本发明的方法通过使用本发明的试剂盒进行。试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

10. 发明申请

WO2004050132A3 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004050132A3
公开(公告)日：2004-10-14
申请号：PCT/EP0313598
申请日：2003-12-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY FIONA PATRICIA , GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN
发明人： CARNEY FIONA PATRICIA , GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , G02B1/04
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/608
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial peptides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.
摘要翻译：本发明提供一种医疗装置，优选隐形眼镜，其包括含有一种或多种抗微生物肽的抗微生物LbL涂层。本发明的抗微生物涂层可以赋予医学更高的表面亲水性和相对高的抗微生物活性以及低的细胞毒性。本发明的抗微生物涂层对隐形眼镜的期望体积特性具有最小的不利影响，例如透氧性，离子渗透性和光学性质。本发明的抗微生物涂层可以在延长佩戴的隐形眼镜中发现特别的用途。此外，本发明提供了制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

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