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1. 发明申请

WO2008073193A3 OCULAR DEVICES AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译： OCULAR DEVICES AND METHODS OF MAKING AND USINGOFER
公开(公告)号：WO2008073193A3
公开(公告)日：2009-03-26
申请号：PCT/US2007023239
申请日：2007-11-05
申请人： NOVARTIS AG , PRUITT JOHN DALLAS , WINTERTON LYNN COOK , LALLY JOHN MARTIN
发明人： PRUITT JOHN DALLAS , WINTERTON LYNN COOK , LALLY JOHN MARTIN
IPC分类号： A61K9/00 , A61F9/00 , A61K31/35 , A61K31/445 , A61K31/728 , G02C7/04
CPC分类号： A61K9/0051 , A61K31/35 , A61K31/445 , A61K31/453 , A61K31/728
摘要： Described herein are stable ocular devices that immobilize and deliver bioactive agents to the eye over sustained periods of time. Also described herein are methods of making and using the ocular devices.
摘要翻译：本文描述的是稳定的眼睛装置，其在持续的时间段内将生物活性剂固定并递送至眼睛。本文还描述了制造和使用眼睛装置的方法。

2. 发明申请

WO2004025332A1 METHOD FOR APPLYING AN LBL COATING ONTO A MEDICAL DEVICE 审中-公开
标题翻译：将LBL涂层应用于医疗装置的方法
公开(公告)号：WO2004025332A1
公开(公告)日：2004-03-25
申请号：PCT/EP2003/010065
申请日：2003-09-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , MATSUZAWA, Yasuo
发明人： QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , MATSUZAWA, Yasuo
IPC分类号： G02B1/04
CPC分类号： A61L27/34 , B05D1/185 , G02B1/043
摘要： The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.
摘要翻译：本发明提供改进的LbL涂覆方法，用于改变医疗装置的表面，优选眼科装置，更优选隐形眼镜。根据本发明的方法制备的隐形眼镜上的LbL涂层可以具有增强的亲水性，其特征在于约80度或更小，优选约50度或更小的平均接触角，同时保持所需的松散性作为透镜材料的透氧性和离子透过性。

3. 发明申请

WO2008073193A2 OCULAR DEVICES AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译： OCULAR DEVICES AND METHODS OF MAKING AND USINGOFER
公开(公告)号：WO2008073193A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/023239
申请日：2007-11-05
申请人： NOVARTIS AG , PRUITT, John, Dallas , WINTERTON, Lynn, Cook , LALLY, John, Martin
发明人： PRUITT, John, Dallas , WINTERTON, Lynn, Cook , LALLY, John, Martin
IPC分类号： A61K9/00 , G02C7/04
CPC分类号： A61K9/0051 , A61K31/35 , A61K31/445 , A61K31/453 , A61K31/728
摘要： Described herein are stable ocular devices that immobilize and deliver bioactive agents to the eye over sustained periods of time. Also described herein are methods of making and using the ocular devices.
摘要翻译：本文描述的是稳定的眼睛装置，其在持续的时间段内将生物活性剂固定并递送至眼睛。本文还描述了制造和使用眼睛装置的方法。

4. 发明申请

WO2007020010A1 METHOD FOR MAKING CONTACT LENSES 审中-公开
标题翻译：制造接触镜的方法
公开(公告)号：WO2007020010A1
公开(公告)日：2007-02-22
申请号：PCT/EP2006/007924
申请日：2006-08-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , WANG, Guigui , SMITH, Dawn , VOGT, Jürgen , LALLY, John, Martin , DEVLIN, Brian, Gerrard
发明人： WANG, Guigui , SMITH, Dawn , VOGT, Jürgen , LALLY, John, Martin , DEVLIN, Brian, Gerrard
IPC分类号： G02B1/04
CPC分类号： B29C33/60 , B29C33/62 , B29D11/00134 , B29D11/00192 , G02B1/043
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a non-crosslinkable hydrophilic polymer into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the non-crosslinkable hydrophilic polymer and to provide a disparity of about 10 N or less in mold separation force. The non-crosslinkable hydrophilic polymer has a limited miscibility with the lens-forming material low enough to successfully and timely form an intact interfacial film with a sufficient thickness at an interface between the mold and the fluid composition therein, and has a structure that minimizes entanglement of the non-crosslinkable hydrophilic polymer in the interfacial film with the polymer matrix of the formed lens.
摘要翻译：本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。本发明的方法包括将不可交联的亲水性聚合物添加到包含透镜形成材料的流体组合物中，该透镜形成材料的量足以将平均的模具分离力减小至少约40％，与不使用不可交联的亲水性并且在模具分离力中提供约10N或更小的差异。不可交联的亲水性聚合物与透镜形成材料的混溶性有限，足够低以在模具和其中的流体组合物之间的界面处成功地及时地形成具有足够厚度的完整界面膜，并且具有最小化缠结的结构的界面膜中的不可交联的亲水聚合物与形成的透镜的聚合物基体。

5. 发明申请

WO2004056404A2 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004056404A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/014533
申请日：2003-12-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , KOTOV, Nicholas
发明人： QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , KOTOV, Nicholas
IPC分类号： A61L27/34
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选隐形眼镜，其中芯材和含抗微生物金属的LbL涂层不共价连接到医疗装置上，并且可以赋予医疗装置增加的亲水性。本发明的隐形眼镜上的抗微生物金属包衣对于包括革兰氏阳性和革兰氏阴性细菌在内的微生物具有很高的抗微生物效能，并且具有低毒性，同时保持所需的体积特性，如透氧性和透镜材料的离子渗透性。这种透镜可用作延长佩戴的隐形眼镜。另外，本发明提供了制造其上具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法。

6. 发明申请

WO2003075888A3 MATERIALS CONTAINING MULTIPLE LAYERS OF VESICLES 审中-公开
公开(公告)号：WO2003075888A3
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002564
申请日：2003-03-12
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , LALLY, John, Martin , KOTOV, Nicholas
发明人： LALLY, John, Martin , KOTOV, Nicholas
IPC分类号： A61K9/127
摘要： The present invention provides a composite material, preferably an opthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.

7. 发明申请

WO2006117228A3 OPHTHALMIC DEVICES FOR SUSTAINED DELIVERY OF ACTIVE COMPOUNDS 审中-公开
标题翻译：用于持续输送活性化合物的透明设备
公开(公告)号：WO2006117228A3
公开(公告)日：2007-02-01
申请号：PCT/EP2006004193
申请日：2006-05-04
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , WINTERTON LYNN COOK , LALLY JOHN MARTIN
发明人： WINTERTON LYNN COOK , LALLY JOHN MARTIN
IPC分类号： G02B1/04 , A61K9/00 , B29D11/00
CPC分类号： G02B1/043 , A61K9/0051 , B29D11/00038 , B29D11/00865 , C08L29/04
摘要： The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery of a drug or a lubricant.
摘要翻译：本发明涉及具有以时间控制释放方式输送客体材料（例如润滑剂或药物）的能力的眼用产品。本发明还提供了制备本发明的眼用产品的方法。此外，本发明提供了药物或润滑剂的时间控制递送的方法。

8. 发明申请

WO2005014074A1 ANTIMICROBIAL MEDICAL DEVICES 审中-公开
标题翻译：抗微生物医疗器械
公开(公告)号：WO2005014074A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/007927
申请日：2004-07-15
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , QIU, Yongxing , LALLY, John, Martin
发明人： QIU, Yongxing , LALLY, John, Martin
IPC分类号： A61L27/54
CPC分类号： G02B1/043 , A01N59/16 , A61L12/088 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/442 , A61L2300/624 , B29D11/00038 , B82Y30/00
摘要： The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extendedwear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.
摘要翻译：本发明提供了制备抗微生物医疗器械的方法，所述抗微生物医疗器件优选为抗微生物眼科装置，更优选地包含其中均匀分布有银纳米颗粒的抗微生物增长型隐形眼镜。抗微生物医疗装置可以在长时间内显示出抗菌活性。

9. 发明申请

WO2004056404A3 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004056404A3
公开(公告)日：2004-09-23
申请号：PCT/EP0314533
申请日：2003-12-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , KOTOV NICHOLAS
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , KOTOV NICHOLAS
IPC分类号： A61L27/34 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , G02B1/04
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.
摘要翻译：本发明提供了一种医疗装置，优选隐形眼镜，其中核心材料和含抗菌金属的LbL涂层不共价连接到医疗装置并且可以赋予医疗装置更高的亲水性。本发明的隐形眼镜上的抗微生物金属涂层对包括革兰氏阳性和革兰氏阴性细菌的微生物具有高抗微生物效力并且毒性低，同时保持期望的体积性质，例如透镜材料的透氧性和离子渗透性。这种镜片可用作长效隐形眼镜。此外，本发明提供了一种制造医疗装置，优选隐形眼镜的方法，其上具有抗微生物金属LbL涂层。

10. 发明申请

WO0216974A8 PROCESS FOR SURFACE MODIFYING SUBSTRATES AND MODIFIED SUBSTRATES RESULTING THEREFROM 审中-公开
标题翻译：表面修饰基板和改性基板的工艺
公开(公告)号：WO0216974A8
公开(公告)日：2004-04-08
申请号：PCT/EP0109712
申请日：2001-08-22
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , COMMW SCIENT IND RES ORG , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
IPC分类号： G02C7/04 , A61L27/34 , C08J7/04 , C08J7/16 , G02B1/04 , G02B1/14 , G02B1/10
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bond to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加包含聚离子材料的粘结层; （b）将包含烯键式不饱和双键的双官能化合物共价结合到连接层上; 和（c）将亲水性单体接枝聚合到包含烯属不饱和双键的化合物上。通过本发明的方法可获得的涂覆制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的所需特性，因此可用于制造生物医学制品如眼科装置。

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