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1. 发明申请

WO2012135588A2 METHODS OF TREATING SEROSAL CANCER 审中-公开
标题翻译：治疗糖尿病的方法
公开(公告)号：WO2012135588A2
公开(公告)日：2012-10-04
申请号：PCT/US2012031390
申请日：2012-03-30
申请人： SLOAN KETTERING INST CANCER , MOORE MALCOLM A S , ERTEM SERVER A
发明人： MOORE MALCOLM A S , ERTEM SERVER A
IPC分类号： A61K31/16 , A61K31/23 , A61K31/365 , A61K47/30 , A61K47/48 , A61P35/00
CPC分类号： A61K38/4886 , A61K31/03 , A61K31/16 , A61K31/165 , A61K31/23 , A61K31/337 , A61K31/365 , A61K31/4045 , A61K31/5377 , A61K38/47 , A61K45/06 , A61K47/60 , A61N5/1001 , C12Y302/01035 , C12Y304/24007 , G01N33/5011 , G01N2800/52 , G01N2800/7028 , A61K2300/00
摘要： The discovery of clonally pure populations of serosal cancer stem cells (CSCs) as well as methods of producing CSCs, culturing the CSCs and using them in screening assays, has lead to the development of methods of treating serosal and ovarian cancers by targeting removal or inhibition of the glycocalyx coat surrounding such cells, and includes combination therapies using particular chemotherapeutics in conjunction with glycocalyx inhibitors, as well as the same new chemotherapy treatments without targeting the glycocalyx, where the chemotherapeutic agent is any one of LBH-589 (Panobinostat), NVP-AUY922, LAQ824 (NVP- LAQ824, Dacinostat), colchicine, brefeldin A, diphenyleneiodonium chloride, any combination thereof or another agent identified herein. These treatment methods of the invention can also be used in combination with radiation treatment or other conventional cancer therapy.
摘要翻译：克隆纯化的浆细胞癌干细胞（CSCs）的发现以及产生CSCs的方法，培养CSCs并在筛选测定中使用它们，导致通过靶向去除或抑制来治疗浆膜和卵巢癌的方法的发展包括围绕这样的细胞的糖萼胶衣，并且包括使用特定化学治疗剂结合糖萼抑制剂的组合疗法，以及不针对糖萼的相同的新化学疗法治疗，其中化学治疗剂是LBH-589（Panobinostat），NVP -AUY922，LAQ824（NVP-LAQ824，Dacinostat），秋水仙素，布雷菲德菌素A，二苯基碘鎓氯化物，其任何组合或本文鉴定的另一种药剂。本发明的这些治疗方法也可以与放射治疗或其他常规癌症治疗组合使用。

2. 发明申请

WO2006034478A3 ISOMIGRASTATIN ANALOGS IN THE TREATMENT OF CANCER 审中-公开
标题翻译：异烟肼在治疗癌症中的作用
公开(公告)号：WO2006034478A3
公开(公告)日：2006-11-30
申请号：PCT/US2005034305
申请日：2005-09-23
申请人： SLOAN KETTERING INST CANCER , DANISHEFSKY SAMUEL J , MANDAL MIHIRBARAN , DORN DAVID C , MOORE MALCOLM A S
发明人： DANISHEFSKY SAMUEL J , MANDAL MIHIRBARAN , DORN DAVID C , MOORE MALCOLM A S
IPC分类号： C07D313/00 , A61K31/365 , A61P35/00
CPC分类号： C07D313/00
摘要： The present invention provides compounds having formula (I): (I) wherein n, R 1 -R 5 , R a -R b , Q, Y 1 and Y 2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.
摘要翻译：本发明提供具有式（I）的化合物：（I）其中n，R 1 -R 5，R a，R a， Q 1，Y 1和Y 2 2如本文所定义; 并且另外提供其合成方法，其组合物及其用于治疗包括癌症，转移和涉及增加的血管发生的病症的各种疾病的方法。

3. 发明申请

WO2006001967A2 MIGRASTATIN ANALOGS IN THE TREATMENT OF CANCER 审中-公开
标题翻译：在治疗癌症中的莫比沙坦模拟物
公开(公告)号：WO2006001967A2
公开(公告)日：2006-01-05
申请号：PCT/US2005018603
申请日：2005-05-25
申请人： SLOAN KETTERING INST CANCER , DANISHEFSKY SAMUEL J , GAUL CHRISTOPH , NJARDARSON JON T , MOORE MALCOLM A S , WU KAIDA , DORN DAVID C , MANDAL MIHIRBARAN
发明人： DANISHEFSKY SAMUEL J , GAUL CHRISTOPH , NJARDARSON JON T , MOORE MALCOLM A S , WU KAIDA , DORN DAVID C , MANDAL MIHIRBARAN
IPC分类号： A61K31/00
CPC分类号： A61K31/395 , A61K31/365 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, ,-R,, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.
摘要翻译：一方面，本发明提供一种用于治疗受试者中结肠和/或卵巢癌的方法，其包括向有需要的受试者施用通式（I）的化合物：其中R 1 -R 6，R 1，R 7， Q，Y1，Y2和n如本文所定义，其中化合物以有效抑制结肠和/或卵巢肿瘤转移的量存在。

4. 发明申请

WO1993021936A1 LIGAND FOR THE c-KIT RECEPTOR AND METHODS OF USE THEREOF 审中-公开
标题翻译： c-kit接收者的配体及其使用方法
公开(公告)号：WO1993021936A1
公开(公告)日：1993-11-11
申请号：PCT/US1993003640
申请日：1993-04-16
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , BESMER, Peter , BUCK, Jochen , MOORE, Malcolm, A., S. , NOCKA, Karl
发明人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
IPC分类号： A61K35/16
CPC分类号： C07K14/715 , A61K38/18 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K48/00 , C07K14/71 , A61K2300/00
摘要： A pharmaceutical composition which comprises the c-kit ligand (KL) purified by applicants or produced by applicants' recombinant methods in combination with other hematopoietic factors and a pharmaceutically acceptable carrier is provided as well as methods of treating patients which comprise administering to the patient the pharmaceutical composition of this invention. This invention provides combination therapies using c-kit ligand (KL) and a purified c-kit ligand (KL) polypeptide, or a soluble fragment thereof and other hematopoietic factors. It also provides methods and compositions for ex-vivo use of KL alone or in combination therapy. A mutated KL antagonist is also described. Such an antagonist may also be a small molecule. Antisense nucleic acids to KL as therapeutics are also described. Lastly, compositions and methods are described that take advantage of the role of KL in germ cells, mast cells and melanocytes.
摘要翻译：提供了包含通过申请人纯化或由申请人的重组方法与其他造血因子组合产生的c-kit配体（KL）和药学上可接受的载体的药物组合物，以及治疗患者的方法，其包括向患者施用本发明的药物组合物。本发明提供了使用c-kit配体（KL）和纯化的c-kit配体（KL）多肽或其可溶性片段和其他造血因子的组合疗法。它还提供单独使用KL或联合治疗的离体使用KL方法和组合物。还描述了突变的KL拮抗剂。这样的拮抗剂也可以是小分子。还描述了作为治疗剂的KL的反义核酸。最后，描述了利用KL在生殖细胞，肥大细胞和黑素细胞中的作用的组合物和方法。

5. 发明申请

WO2006001967A3 MIGRASTATIN ANALOGS IN THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2006001967A3
公开(公告)日：2006-01-05
申请号：PCT/US2005/018603
申请日：2005-05-25
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , DANISHEFSKY, Samuel, J. , GAUL, Christoph , NJARDARSON, Jón, T. , MOORE, Malcolm , A., S. , WU, Kaida , DORN, David, C. , MANDAL, Mihirbaran
发明人： DANISHEFSKY, Samuel, J. , GAUL, Christoph , NJARDARSON, Jón, T. , MOORE, Malcolm , A., S. , WU, Kaida , DORN, David, C. , MANDAL, Mihirbaran
IPC分类号： A61K31/365 , A61P35/00 , A61P35/04 , A61K31/395 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, ,-R,, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.

6. 发明申请

WO2005084222A3 SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF 审中-公开
公开(公告)号：WO2005084222A3
公开(公告)日：2005-11-24
申请号：PCT/US2005006051
申请日：2005-02-28
申请人： SLOAN KETTERING INST CANCER , DANISHEFSKY SAMUEL J , RIVKIN ALEXEY , YOSHIMURA FUMIHIKO , CHOU TING-CHAO , GABARDA ORTEGA ANA ESTHER , DONG HUAJIN , WU KAIDA , MOORE MALCOLM A S , DORN DAVID
发明人： DANISHEFSKY SAMUEL J , RIVKIN ALEXEY , YOSHIMURA FUMIHIKO , CHOU TING-CHAO , GABARDA ORTEGA ANA ESTHER , DONG HUAJIN , WU KAIDA , MOORE MALCOLM A S , DORN DAVID
IPC分类号： A61K31/426 , C07D277/20 , C07D417/06 , C07D493/04
CPC分类号： C07D417/06 , C07D413/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

7. 发明申请

WO1992003459A1 LIGAND FOR THE c-KIT RECEPTOR AND METHODS OF USE THEREOF 审中-公开
标题翻译： c-kit接收者的配体及其使用方法
公开(公告)号：WO1992003459A1
公开(公告)日：1992-03-05
申请号：PCT/US1991006130
申请日：1991-08-27
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , BESMER, Peter , NOCKA, Karl , BUCK, Jochen , MOORE, Malcolm, A., S.
发明人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
IPC分类号： C07H15/12
CPC分类号： A61K31/7072 , A61K38/00 , A61K38/193 , A61K38/202 , C07K14/475 , C07K14/52 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/22 , C12N15/87 , A61K2300/00
摘要： The invention provides an isolated nucleic acid molecule which encodes an amino acid sequence corresponding to a c-kit ligand (KL) and a purified c-kit ligand (KL) polypeptide, or a soluble fragment thereof. A pharmaceutical composition which comprises the c-kit ligand (KL) purified by applicants or produced by applicants' recombinant methods and a pharmaceutically acceptable carrier is further provided as well as methods of treating patients which comprise administering to the patient the pharmaceutical composition of this invention.
摘要翻译：本发明提供了分离的核酸分子，其编码对应于c-kit配体（KL）和纯化的c-kit配体（KL）多肽或其可溶性片段的氨基酸序列。进一步提供包含通过申请人纯化或由申请人的重组方法产生的c-kit配体（KL）和药学上可接受的载体的药物组合物以及治疗患者的方法，所述方法包括向患者施用本发明的药物组合物。

8. 发明申请

WO2005084222A2 SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF 审中-公开
标题翻译： EPOTHILONES的合成，其中间体，其模拟物及其用途
公开(公告)号：WO2005084222A2
公开(公告)日：2005-09-15
申请号：PCT/US2005/006051
申请日：2005-02-28
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , DANISHEFSKY, Samuel, J. , RIVKIN, Alexey , YOSHIMURA, Fumihiko , CHOU, Ting-Chao , GABARDA ORTEGA, Ana, Esther , DONG, Huajin , WU, Kaida , MOORE, Malcolm, A., S. , DORN, David
发明人： DANISHEFSKY, Samuel, J. , RIVKIN, Alexey , YOSHIMURA, Fumihiko , CHOU, Ting-Chao , GABARDA ORTEGA, Ana, Esther , DONG, Huajin , WU, Kaida , MOORE, Malcolm, A., S. , DORN, David
IPC分类号： A61K31/426 , C07D277/20 , C07D417/06 , C07D493/04
CPC分类号： C07D417/06 , C07D413/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译：本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。本发明另外提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。

9. 发明申请

WO2011057034A2 CATENAE: SEROSAL CANCER STEM CELLS 审中-公开
标题翻译： CATENAE：血清癌症干细胞
公开(公告)号：WO2011057034A2
公开(公告)日：2011-05-12
申请号：PCT/US2010055538
申请日：2010-11-05
申请人： SLOAN KETTERING INST CANCER , MOORE MALCOLM A S , ERTEM SERVER A
发明人： MOORE MALCOLM A S , ERTEM SERVER A
IPC分类号： C12N5/0797 , C12N15/12 , C12Q1/68 , G01N33/15
CPC分类号： C12N5/0695 , A01K2207/12 , A01K2267/0331 , C12N9/1051
摘要： The present invention relates to a clonally pure population of serosal cancer stem cells (CSCs) as well as methods of producing and culturing the CSCs and uses thereof. The CSCs form catenae (free floating chains of cells) which have a glycocalyx coat of hyaluronan and proteoglycans. This discovery has lead to the development of methods of treating serosal and ovarian cancers by targeting removal or inhibition of glycocalyx formation, including combination therapies using chemotherapeutics in conjunction with glycocalyx inhibitors. The invention also provides drug screening assays for identifying compounds effective against these CSCs as well as other serosal cancer cells. Methods to use catena gene signatures, protein and surface antigens are provided for monitoring patient samples for the presence of serosal cancer stem cells.
摘要翻译：本发明涉及克隆纯化的浆膜癌干细胞（CSC）群体以及生产和培养CSC的方法及其用途。 CSCs形成具有乙酰透明质酸和蛋白多糖的糖衣壳的连锁（细胞的自由浮动链）。这一发现导致开发了通过靶向去除或抑制糖萼形成来治疗浆膜癌和卵巢癌的方法，包括使用化学治疗剂与糖萼抑制剂联合治疗。本发明还提供了用于鉴定对这些CSC以及其他浆膜癌细胞有效的化合物的药物筛选测定法。提供使用连环蛋白基因特征，蛋白质和表面抗原的方法用于监测患者样品中浆膜癌干细胞的存在。

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