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1. 发明申请

WO2008081334A2 ION TRAP 审中-公开
标题翻译：离子阱
公开(公告)号：WO2008081334A2
公开(公告)日：2008-07-10
申请号：PCT/IB2007/004434
申请日：2007-12-27
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , MONASTYRSKIY, Mikhail, A. , GRINFELD, Dmitry, E.
发明人： MAKAROV, Alexander , MONASTYRSKIY, Mikhail, A. , GRINFELD, Dmitry, E.
CPC分类号： H01J49/423 , H01J49/427
摘要： An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.
摘要翻译：离子阱包括基本上细长的电极10,20，其中一些电极10,10沿着其伸长轴线弯曲并且在它们之间限定捕获体积。该捕集体向伸长方向截面的横截面面积与远离其末端的截面积（例如朝向捕集阱的中部）不同。在优选实施例中，陷阱具有多个细长电极，其中相对电极具有不同的曲率半径，使得陷阱向其四肢展开。因此，可以捕获并喷射更宽质量范围的离子，提供更高的空间电荷容量（对于给定的陷阱长度），并且能够在喷射时聚焦更清晰的离子束。

2. 发明申请

WO2008081334A3 ION TRAP 审中-公开
标题翻译：离子阱
公开(公告)号：WO2008081334A3
公开(公告)日：2009-09-03
申请号：PCT/IB2007004434
申请日：2007-12-27
申请人： THERMO FISHER SCIENT BREMEN , MAKAROV ALEXANDER , MONASTYRSKIY MIKHAIL A , GRINFELD DMITRY E
发明人： MAKAROV ALEXANDER , MONASTYRSKIY MIKHAIL A , GRINFELD DMITRY E
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/423 , H01J49/427
摘要： An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.
摘要翻译：离子阱包括基本上细长的电极10,20，其中一些电极10,10沿着其伸长轴线弯曲并且在它们之间限定捕获体积。该捕集体向伸长方向截面的横截面面积与远离其末端的截面积（例如朝向捕集阱的中部）不同。在优选实施例中，陷阱具有多个细长电极，其中相对电极具有不同的曲率半径，使得陷阱向其四肢展开。因此，可以捕获并喷射更宽质量范围的离子，提供更高的空间电荷容量（对于给定的陷阱长度），并且能够在喷射时聚焦更清晰的离子束。

3. 发明申请

WO2009081143A3 MULTIREF LECTION TIME-OF -FLIGHT MASS SPECTROMETER 审中-公开
标题翻译： MULTIREF LECTION飞行时间质谱仪
公开(公告)号：WO2009081143A3
公开(公告)日：2010-03-25
申请号：PCT/GB2008004231
申请日：2008-12-22
申请人： THERMO FISHER SCIENT BREMEN , MAKAROV ALEXANDER , GRINFELD DMITRY E , MONASTYRSKIY MIKHAIL A
发明人： MAKAROV ALEXANDER , GRINFELD DMITRY E , MONASTYRSKIY MIKHAIL A
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： The present invention provides a method of reflecting ions in a multiref lection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.
摘要翻译：本发明提供了一种在多反射飞行时间质谱仪中反射离子的方法，包括提供具有多个电极的离子反射镜，所述离子反射镜具有具有第一短轴（Y）和第二主轴（Y）的横截面每个垂直于离子镜的纵向轴线（Z）的轴线（X），其通常位于反射镜中的离子的飞行时间分离方向上; 引导离子到离子镜; 向电极施加电压以产生电场：（a）使得离子的平均轨迹与包含纵向（Z）和长轴（X）的离子镜的对称平面相交，镜子; （b）使离子在离子反射镜中反射; 和（c）使得离子离开离子反射镜的方向，使得通过离子镜的离子的平均轨迹具有与所述对称平面垂直的方向（Y）和与其对称的发散方向的运动分量。

4. 发明申请

WO2007122383A2 ION ENERGY SPREAD REDUCTION FOR MASS SPECTROMETER 审中-公开
标题翻译：离子能量减少大量光谱仪
公开(公告)号：WO2007122383A2
公开(公告)日：2007-11-01
申请号：PCT/GB2007/001370
申请日：2007-04-13
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , MONASTYRSKIY, Mikhail , GRINFIELD, Dmitry, E.
发明人： MAKAROV, Alexander , MONASTYRSKIY, Mikhail , GRINFIELD, Dmitry, E.
CPC分类号： H01J49/06
摘要： A method for reducing the energy spread of ions over a specific and limited mass to charge ratio range is disclosed, along with an ion deceleration arrangement for implementing such a method. An electric field, having an electric field strength E is generated by a deceleration electrode arrangement (250). Ions of a specific and limited mass to charge ratio range, but having a spread of energies, are directed into the decelerating electric field generated by the deceleration electrode arrangement (250). The decelerating electric field is then removed, once substantially all of the ions of the specific mass to charge ratio range have entered the decelerating electric field. By matching the electric field strength E to the energy spread of the ions upon entry into the electric field, the energy spread of the said ions is reduced. Preferred embodiments of the invention employ energy dispersion upstream of the ion deceleration arrangement. For example, an ion mirror arrangement (200) may be used, the ions reflecting off an ion mirror (220) within that ion mirror arrangement (200) to promote energy defocusing.
摘要翻译：公开了一种用于在特定且有限的质荷比范围内减小离子的能量扩散的方法，以及用于实现这种方法的离子减速布置。具有电场强度E的电场由减速电极装置（250）产生。特定且有限的质荷比范围但具有能量扩散的离子被引导到由减速电极装置（250）产生的减速电场。然后，除去减速电场，一旦基本上所有特定质荷比的离子进入减速电场。通过将电场强度E与进入电场的离子的能量扩散相匹配，所述离子的能量扩散减小。本发明的优选实施例在离子减速装置的上游采用能量分散。例如，可以使用离子镜装置（200），离子反射离开反射镜装置（200）内的离子反射镜（220）以促进能量散焦。

5. 发明申请

WO2009081143A2 MULTIREF LECTION TIME-OF -FLIGHT MASS SPECTROMETER 审中-公开
标题翻译： MULTIREF LECTION飞行时间质谱仪
公开(公告)号：WO2009081143A2
公开(公告)日：2009-07-02
申请号：PCT/GB2008/004231
申请日：2008-12-22
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , GRINFELD, Dmitry, E. , MONASTYRSKIY, Mikhail, A.
发明人： MAKAROV, Alexander , GRINFELD, Dmitry, E. , MONASTYRSKIY, Mikhail, A.
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： The present invention provides a method of reflecting ions in a multiref lection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.
摘要翻译：本发明提供了一种在多反射飞行时间质谱仪中反射离子的方法，包括提供具有多个电极的离子反射镜，所述离子反射镜具有具有第一短轴（Y）和第二主轴（Y）的横截面每个垂直于离子镜的纵向轴线（Z）的轴线（X），其通常位于反射镜中的离子的飞行时间分离方向上; 引导离子到离子镜; 向电极施加电压以产生电场：（a）使得离子的平均轨迹与包含纵向（Z）和长轴（X）的离子镜的对称平面相交，镜子; （b）使离子在离子反射镜中反射; 和（c）使得离子离开离子反射镜的方向，使得通过离子镜的离子的平均轨迹具有与所述对称平面垂直的方向（Y）和与其对称的发散方向的运动分量。

6. 发明申请

WO2007122383A3 ION ENERGY SPREAD REDUCTION FOR MASS SPECTROMETER 审中-公开
标题翻译：离子能量减少大量光谱仪
公开(公告)号：WO2007122383A3
公开(公告)日：2008-10-02
申请号：PCT/GB2007001370
申请日：2007-04-13
申请人： THERMO FISHER SCIENT BREMEN , MAKAROV ALEXANDER , MONASTYRSKIY MIKHAIL , GRINFIELD DMITRY E
发明人： MAKAROV ALEXANDER , MONASTYRSKIY MIKHAIL , GRINFIELD DMITRY E
IPC分类号： H01J49/06
CPC分类号： H01J49/06
摘要： A method for reducing the energy spread of ions over a specific and limited mass to charge ratio range is disclosed, along with an ion deceleration arrangement for implementing such a method. An electric field, having an electric field strength E is generated by a deceleration electrode arrangement (250). Ions of a specific and limited mass to charge ratio range, but having a spread of energies, are directed into the decelerating electric field generated by the deceleration electrode arrangement (250). The decelerating electric field is then removed, once substantially all of the ions of the specific mass to charge ratio range have entered the decelerating electric field. By matching the electric field strength E to the energy spread of the ions upon entry into the electric field, the energy spread of the said ions is reduced. Preferred embodiments of the invention employ energy dispersion upstream of the ion deceleration arrangement. For example, an ion mirror arrangement (200) may be used, the ions reflecting off an ion mirror (220) within that ion mirror arrangement (200) to promote energy defocusing.
摘要翻译：公开了一种用于在特定且有限的质荷比范围内减小离子的能量扩散的方法，以及用于实现这种方法的离子减速布置。具有电场强度E的电场由减速电极装置（250）产生。特定且有限的质荷比范围但具有能量扩散的离子被引导到由减速电极装置（250）产生的减速电场。然后，除去减速电场，一旦基本上所有特定质荷比的离子进入减速电场。通过将电场强度E与进入电场的离子的能量扩散相匹配，所述离子的能量扩散减小。本发明的优选实施例在离子减速装置的上游采用能量分散。例如，可以使用离子镜装置（200），离子反射离开反射镜装置（200）内的离子反射镜（220）以促进能量散焦。

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