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1. 发明申请

WO2012030436A3 SYMMETRICAL PHYSIOLOGICAL SIGNAL SENSING WITH A MEDICAL DEVICE 审中-公开
标题翻译：与医疗设备的对称生理信号感知
公开(公告)号：WO2012030436A3
公开(公告)日：2013-04-04
申请号：PCT/US2011043965
申请日：2011-07-14
申请人： MEDTRONIC INC , MOLNAR GABRIELA C , STANSLASKI SCOTT R
发明人： MOLNAR GABRIELA C , STANSLASKI SCOTT R
IPC分类号： A61N1/05 , H03F3/45
CPC分类号： A61N1/0534 , A61N1/0553 , A61N1/36125
摘要： A physiological signal of a patient is sensed with sense electrodes symmetrically arranged relative to a stimulation electrode. In some examples, a member includes a plurality of relatively small electrodes that are configured to function as both sense and stimulation electrodes. One or more of the electrodes may be selected as stimulation electrodes and two or more different electrodes of the member may be selected as sense electrodes that are symmetrically arranged relative to the one or more selected stimulation electrodes. In some examples, a member includes a plurality of levels of segmented sense electrodes and a plurality of levels of stimulation electrodes. The levels of sense electrodes are arranged such that each level of stimulation electrodes is adjacent at least two levels of sense electrodes symmetrically arranged relative to the level of stimulation electrodes.
摘要翻译：用相对于刺激电极对称布置的感测电极感测患者的生理信号。在一些示例中，构件包括被配置为用作感测电极和刺激电极的多个相对较小的电极。可以选择一个或多个电极作为刺激电极，并且可以选择构件的两个或更多个不同的电极作为相对于一个或多个所选择的刺激电极对称布置的感测电极。在一些示例中，构件包括多个级别的分段感测电极和多个级别的刺激电极。感测电极的电平被布置成使得每个级别的刺激电极相邻于相对于刺激电极的水平对称布置的至少两个感测电极级。

2. 发明申请

WO2012030436A2 SYMMETRICAL PHYSIOLOGICAL SIGNAL SENSING WITH A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的对称生理信号检测
公开(公告)号：WO2012030436A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/043965
申请日：2011-07-14
申请人： MEDTRONIC, INC. , MOLNAR, Gabriela C. , STANSLASKI, Scott R.
发明人： MOLNAR, Gabriela C. , STANSLASKI, Scott R.
IPC分类号： A61N1/05 , A61B5/04
CPC分类号： A61N1/0534 , A61N1/0553 , A61N1/36125
摘要： A physiological signal of a patient is sensed with sense electrodes symmetrically arranged relative to a stimulation electrode. In some examples, a member includes a plurality of relatively small electrodes that are configured to function as both sense and stimulation electrodes. One or more of the electrodes may be selected as stimulation electrodes and two or more different electrodes of the member may be selected as sense electrodes that are symmetrically arranged relative to the one or more selected stimulation electrodes. In some examples, a member includes a plurality of levels of segmented sense electrodes and a plurality of levels of stimulation electrodes. The levels of sense electrodes are arranged such that each level of stimulation electrodes is adjacent at least two levels of sense electrodes symmetrically arranged relative to the level of stimulation electrodes.
摘要翻译：利用相对于刺激电极对称布置的感测电极来感测患者的生理信号。在一些示例中，构件包括配置成充当感测电极和刺激电极两者的多个相对较小的电极。可以选择一个或多个电极作为刺激电极，并且可以选择该构件的两个或更多个不同的电极作为相对于一个或多个选择的刺激电极对称地布置的感测电极。在一些示例中，构件包括多个级别的分段感测电极和多个级别的刺激电极。感测电极的水平被布置为使得每个刺激电极水平相邻于相对于刺激电极的水平对称地布置的至少两个水平的感测电极。

3. 发明申请

WO2011136870A1 STIMULATION ELECTRODE SELECTION 审中-公开
标题翻译：刺激电极选择
公开(公告)号：WO2011136870A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/027060
申请日：2011-03-03
申请人： MEDTRONIC, INC. , MOLNAR, Gabriela C. , GOETZ, Steven M. , CSAVOY, Andrew N.
发明人： MOLNAR, Gabriela C. , GOETZ, Steven M. , CSAVOY, Andrew N.
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/0529 , A61N1/08 , A61N1/37247
摘要： One or more stimulation electrodes may be selected based on a bioelectrical signal sensed in a brain of a patient with a sense electrode combination that comprises at least one electrode and a physiological model that indicates one or more anatomical structures of the brain of the patient that are proximate the implanted at least one electrode. In some examples, the bioelectrical brain signal indicates which electrodes are located closest to a target tissue site. The physiological model can be generated based on a location of implanted at least one electrode within a patient and patient anatomy data, which can, for example, indicate one or more characteristics of patient tissue proximate to the implanted at least one electrode. In some example, the physiological model includes a therapy field model that represents a region of the tissue of the patient to which therapy is delivered via a selected set of electrodes.
摘要翻译：可以基于在具有感测电极组合的患者的脑中感测的生物电信号来选择一个或多个刺激电极，所述感测电极组合包括至少一个电极和生理模型，其指示患者的脑的一个或多个解剖结构邻近植入的至少一个电极。在一些实例中，生物电脑信号指示哪个电极位于最靠近目标组织部位。可以基于在患者内植入至少一个电极的位置和患者解剖数据来生成生理模型，其可以例如指示邻近植入的至少一个电极的患者组织的一个或多个特征。在一些示例中，生理模型包括治疗场模型，其表示通过所选择的一组电极递送治疗的患者的组织区域。

4. 发明申请

WO2010044989A3 STIMULATION ELECTRODE SELECTION 审中-公开
公开(公告)号：WO2010044989A3
公开(公告)日：2010-04-22
申请号：PCT/US2009/057862
申请日：2009-09-22
申请人： MEDTRONIC, INC. , CARLSON, David L. , JENSEN, Randy M. , DENISON, Timothy J. , WU, Jianping , MOLNAR, Gabriela C. , STANSLASKI, Scott R. , MARKS, William J.
发明人： CARLSON, David L. , JENSEN, Randy M. , DENISON, Timothy J. , WU, Jianping , MOLNAR, Gabriela C. , STANSLASKI, Scott R. , MARKS, William J.
IPC分类号： A61N1/36 , A61N1/372
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.

5. 发明申请

WO2011084341A1 STIMULATION ELECTRODE SELECTION 审中-公开
标题翻译：刺激电极选择
公开(公告)号：WO2011084341A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/059624
申请日：2010-12-09
申请人： MEDTRONIC, INC. , MOLNAR, Gabriela, C. , WU, Jianping
发明人： MOLNAR, Gabriela, C. , WU, Jianping
IPC分类号： A61B5/048 , A61N1/36
CPC分类号： A61B5/048 , A61B5/4082 , A61N1/0534 , A61N1/36139 , A61N1/36171 , A61N1/36185
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测的生物电信号的频域特性来选择用于将刺激递送到患者以管理患者状况的刺激电极组合。在一些示例中，基于确定哪个感测电极位于最靠近目标组织位置的位置来选择刺激电极组合，如感测出具有相对较高值的生物电脑信号的一个或多个感测电极所示频域特性。在一些示例中，确定哪个感测电极位于最靠近目标组织位置的位置可以包括使用频域特性的相对值来执行算法。

6. 发明申请

WO2010044989A2 STIMULATION ELECTRODE SELECTION 审中-公开
标题翻译：刺激电极选择
公开(公告)号：WO2010044989A2
公开(公告)日：2010-04-22
申请号：PCT/US2009057862
申请日：2009-09-22
申请人： MEDTRONIC INC , CARLSON DAVID L , JENSEN RANDY M , DENISON TIMOTHY J , WU JIANPING , MOLNAR GABRIELA C , STANSLASKI SCOTT R , MARKS WILLIAM J
发明人： CARLSON DAVID L , JENSEN RANDY M , DENISON TIMOTHY J , WU JIANPING , MOLNAR GABRIELA C , STANSLASKI SCOTT R , MARKS WILLIAM J
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency band characteristics may also be used to select the stimulation electrode combination.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。也可以使用其他频带特性来选择刺激电极组合。

7. 发明申请

WO2012054451A1 STEREO DATA REPRESENTATION OF BIOMEDICAL SIGNALS ALONG A LEAD 审中-公开
标题翻译：生物医学信号的立场数据表示
公开(公告)号：WO2012054451A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/056666
申请日：2011-10-18
申请人： MEDTRONIC, INC. , LAZAREWICZ, Maciej , MOLNAR, Gabriela C. , DIXON, Jeffrey R. , McCONNELL, Deborah A.
发明人： LAZAREWICZ, Maciej , MOLNAR, Gabriela C. , DIXON, Jeffrey R. , McCONNELL, Deborah A.
IPC分类号： A61B5/053 , A61B5/048 , A61N1/36 , A61B5/04
CPC分类号： A61B5/0476 , A61B5/0484 , A61B5/686 , A61B5/6868 , A61B5/743 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/37247
摘要： Various embodiments concern sensing bioelectrical signals using electrodes along a lead, the electrodes having a spatial configuration along the lead, generating signal data sets, one signal data set being generated for each bioelectrical signal, and graphically representing the electrodes and data representations of the signal data sets on a display. In various embodiments, each data representation indicates a parameter of a respective one of the data sets, the electrodes are graphically represented on the display in a spatial configuration representative of the spatial configuration of the electrodes along the lead, and each data representation is graphically represented on the display in spatial association with at least one electrode through which the bioelectrical signal on which the signal data set is based was sensed. The parameter can be indicative of the relative presence of a biomarker in the bioelectrical signals.
摘要翻译：各种实施例涉及使用沿着引线的电极来感测生物电信号，电极具有沿着引线的空间配置，产生信号数据集，为每个生物电信号产生一个信号数据集，并以图形方式表示信号数据的电极和数据表示设置在显示屏上。在各种实施例中，每个数据表示指示数据集中的相应一个的参数，电极在显示器上以表示沿着引线的电极的空间配置的空间配置图形地表示，并且每个数据表示以图形方式表示在与至少一个电极空间关联的显示器上，感测到信号数据集所基于的生物电信号。该参数可以指示生物标志物在生物电信号中的相对存在。

8. 发明申请

WO2012030437A1 SYMMETRICAL PHYSIOLOGICAL SIGNAL SENSING WITH A MEDICAL DEVICE 审中-公开
标题翻译：与医疗设备的对称生理信号感知
公开(公告)号：WO2012030437A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/043967
申请日：2011-07-14
申请人： MEDTRONIC, INC. , MOLNAR, Gabriela, C. , STANSLASKI, Scott, R.
发明人： MOLNAR, Gabriela, C. , STANSLASKI, Scott, R.
IPC分类号： A61N1/36 , A61N1/05 , H03F3/45 , A61B5/04
CPC分类号： A61N1/025 , A61B5/04004 , A61B5/0428 , A61B5/7217 , A61N1/0534 , A61N1/3605
摘要： A physiological signal of a patient is sensed with sense electrodes symmetrically arranged relative to a stimulation electrode. In some examples, a member includes a plurality of relatively small electrodes that are configured to function as both sense and stimulation electrodes. One or more of the electrodes may be selected as stimulation electrodes and two or more different electrodes of the member may be selected as sense electrodes that are symmetrically arranged relative to the one or more selected stimulation electrodes. In some examples, a member includes a plurality of levels of segmented sense electrodes and a plurality of levels of stimulation electrodes. The levels of sense electrodes are arranged such that each level of stimulation electrodes is adjacent at least two levels of sense electrodes symmetrically arranged relative to the level of stimulation electrodes.
摘要翻译：用相对于刺激电极对称布置的感测电极感测患者的生理信号。在一些示例中，构件包括被配置为用作感测电极和刺激电极的多个相对较小的电极。可以选择一个或多个电极作为刺激电极，并且可以选择构件的两个或更多个不同的电极作为相对于一个或多个所选择的刺激电极对称布置的感测电极。在一些示例中，构件包括多个级别的分段感测电极和多个级别的刺激电极。感测电极的电平被布置成使得每个级别的刺激电极相邻于相对于刺激电极的水平对称布置的至少两个感测电极级。

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