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1. 发明申请

WO2005100402A1 ANTI-P-SELECTIN ANTIBODIES 审中-公开
标题翻译：抗P-选择素抗体
公开(公告)号：WO2005100402A1
公开(公告)日：2005-10-27
申请号：PCT/EP2005/003581
申请日：2005-04-05
申请人： F.HOFFMANN-LA ROCHE AG , GRAUS, Yvo , HIMBER, Jacques , JANSEN-MOLENAAR, Miranda , KLING, Dorothee , KOPETZKY, Erhard , PARREN, Paul , REBERS, Frank , STEINER, Beat , STERN, Anne , STREIN, Pamela , STUBENRAUCH, Kay-Gunnar , VAN DE WINKEL, Jan , VAN VUGT, Martine
发明人： GRAUS, Yvo , HIMBER, Jacques , JANSEN-MOLENAAR, Miranda , KLING, Dorothee , KOPETZKY, Erhard , PARREN, Paul , REBERS, Frank , STEINER, Beat , STERN, Anne , STREIN, Pamela , STUBENRAUCH, Kay-Gunnar , VAN DE WINKEL, Jan , VAN VUGT, Martine
IPC分类号： C07K16/28
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor Clq. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译：本发明涉及抗P-选择素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子Clq的抗P-选择蛋白抗体及其变体。这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。

2. 发明申请

WO2007000169A3 NON-HUMAN MAMMALIAN ARTHRITIS MODEL FEATURING HUMAN ANTIBODIES AGAINST CITRULLINATED PROTEINS 审中-公开
标题翻译：非人类哺乳动物模型特异性抗体蛋白质人类抗体
公开(公告)号：WO2007000169A3
公开(公告)日：2007-03-01
申请号：PCT/DK2006000384
申请日：2006-06-29
申请人： GENMAB AS , TOES RENE , HUIZINGA THOMAS , MOLENAAR MIRANDA , PARREN PAUL , VAN DE WINKEL JAN
发明人： TOES RENE , HUIZINGA THOMAS , MOLENAAR MIRANDA , PARREN PAUL , VAN DE WINKEL JAN
IPC分类号： A01K67/027 , G01N33/50
CPC分类号： G01N33/5088
摘要： Use of a non-human mammalian disease model, wherein the non-human mammal has been implanted with human synovial tissue or other human inflamed tissue containing anti-CCP (cyclic citrullinated peptide) antibody producing cells for (i) analyzing cellular processes in a disease associated with anti-CCP antibodies in such human synovial tissue or other human inflamed tissue, (ii) studying the role of anti- CCP antibodies in the induction and progression of a disease associated with anti- CCP antibodies, (iii) testing the efficacy of a therapeutic agent for the prevention or treatment of a disease associated with anti-CCP antibodies, and (iv) identifying a therapeutic agent useful for the prevention or treatment of a disease associated with anti-CCP antibodies. In one embodiment the non-human mammalian disease model is a mouse, such as a SCID mouse, and the disease associated with anti-CCP antibodies is arthritis, such as RA (rheumatoid arthritis).
摘要翻译：使用非人哺乳动物疾病模型，其中所述非人哺乳动物已经植入人滑膜组织或其它含有抗CCP（环状瓜氨酸化肽）抗体产生细胞的人发炎组织，用于（i）分析疾病中的细胞过程与这种人滑膜组织或其他人发炎组织中的抗CCP抗体相关联，（ii）研究抗CCP抗体在与抗CCP抗体相关的疾病的诱导和进展中的作用，（iii）测试抗CCP抗体的功效用于预防或治疗与抗CCP抗体相关的疾病的治疗剂，和（iv）鉴定可用于预防或治疗与抗CCP抗体相关的疾病的治疗剂。在一个实施方案中，非人哺乳动物疾病模型是小鼠，例如SCID小鼠，并且与抗CCP抗体相关的疾病是关节炎，例如RA（类风湿性关节炎）。

3. 发明申请

WO2007000169A2 NON-HUMAN MAMMALIAN ARTHRITIS MODEL 审中-公开
标题翻译：非人类玛雅人神经元模型
公开(公告)号：WO2007000169A2
公开(公告)日：2007-01-04
申请号：PCT/DK2006/000384
申请日：2006-06-29
申请人： GENMAB A/S , TOES, Rene , HUIZINGA, Thomas , MOLENAAR, Miranda , PARREN, Paul , VAN DE WINKEL, Jan
发明人： TOES, Rene , HUIZINGA, Thomas , MOLENAAR, Miranda , PARREN, Paul , VAN DE WINKEL, Jan
IPC分类号： A01K67/027 , G01N33/50
CPC分类号： G01N33/5088
摘要： Use of a non-human mammalian disease model, wherein the non-human mammal has been implanted with human synovial tissue or other human inflamed tissue containing anti-CCP (cyclic citrullinated peptide) antibody producing cells for (i) analyzing cellular processes in a disease associated with anti-CCP antibodies in such human synovial tissue or other human inflamed tissue, (ii) studying the role of anti- CCP antibodies in the induction and progression of a disease associated with anti- CCP antibodies, (iii) testing the efficacy of a therapeutic agent for the prevention or treatment of a disease associated with anti-CCP antibodies, and (iv) identifying a therapeutic agent useful for the prevention or treatment of a disease associated with anti-CCP antibodies. In one embodiment the non-human mammalian disease model is a mouse, such as a SCID mouse, and the disease associated with anti-CCP antibodies is arthritis, such as RA (rheumatoid arthritis).
摘要翻译：使用非人哺乳动物疾病模型，其中所述非人哺乳动物已经植入人滑膜组织或其它含有抗CCP（环状瓜氨酸化肽）抗体产生细胞的人发炎组织，用于（i）分析疾病中的细胞过程与这种人滑膜组织或其他人发炎组织中的抗CCP抗体相关联，（ii）研究抗CCP抗体在与抗CCP抗体相关的疾病的诱导和进展中的作用，（iii）测试抗CCP抗体的功效用于预防或治疗与抗CCP抗体相关的疾病的治疗剂，和（iv）鉴定可用于预防或治疗与抗CCP抗体相关的疾病的治疗剂。在一个实施方案中，非人哺乳动物疾病模型是小鼠，例如SCID小鼠，并且与抗CCP抗体相关的疾病是关节炎，例如RA（类风湿性关节炎）。

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