专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011156734A3 METHOD OF CHARACTERIZING VASCULAR DISEASES 审中-公开
标题翻译：表征血管疾病的方法
公开(公告)号：WO2011156734A3
公开(公告)日：2012-03-01
申请号：PCT/US2011040015
申请日：2011-06-10
申请人： HITACHI CHEMICAL CO LTD , HITACHI CHEMICAL RES CT INC , MITSUHASHI MASATO
发明人： MITSUHASHI MASATO
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： Embodiments of the invention relate generally to methods of diagnosing diseases and measuring homeostatic states. In particular, the methods described here are used to characterize RNA from vesicles for expression of disease related markers. Embodiments of the invention also relate generally to the characterization of RNA by using sensitive techniques such as PCR to internally sample organ health using whole blood.
摘要翻译：本发明的实施方案一般涉及诊断疾病和测量内稳态的方法。特别地，本文描述的方法用于表征囊泡中的RNA以表达与疾病相关的标记物。本发明的实施方案一般还涉及通过使用诸如PCR的敏感技术来使用全血对内部采样器官健康进行RNA的表征。

2. 发明申请

WO2011156734A2 METHOD OF CHARACTERIZING VASCULAR DISEASES 审中-公开
标题翻译：表征血管疾病的方法
公开(公告)号：WO2011156734A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/040015
申请日：2011-06-10
申请人： HITACHI CHEMICAL CO., LTD. , HITACHI CHEMICAL RESEARCH CENTER, INC. , MITSUHASHI, Masato
发明人： MITSUHASHI, Masato
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： Embodiments of the invention relate generally to methods of diagnosing diseases and measuring homeostatic states. In particular, the methods described here are used to characterize RNA from vesicles for expression of disease related markers. Embodiments of the invention also relate generally to the characterization of RNA by using sensitive techniques such as PCR to internally sample organ health using whole blood.
摘要翻译：本发明的实施方案一般涉及诊断疾病和测量内稳态的方法。特别地，本文描述的方法用于表征囊泡中的RNA以表达与疾病相关的标记物。本发明的实施方案一般还涉及通过使用诸如PCR的敏感技术来使用全血对内部采样器官健康进行RNA的表征。

3. 发明申请

WO2009018544A1 PATHOGEN DETECTION IN LARGE-VOLUME PARTICULATE SAMPLES 审中-公开
标题翻译：大容量样品中的病原体检测
公开(公告)号：WO2009018544A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/072007
申请日：2008-08-01
申请人： HITACHI CHEMICAL CO., LTD. , HITACHI CHEMICAL RESEARCH CENTER, INC. , MURAKAMI, Taku , LI, Jifan , MITSUHASHI, Masato , OAKES, Melanie
发明人： MURAKAMI, Taku , LI, Jifan , MITSUHASHI, Masato , OAKES, Melanie
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/24
摘要： Methods and filter systems for detecting microorganisms in a sample, such as a food sample, are disclosed. The filter is configured to attract the microorganism, for example by electrostatic charge. The filter containing the microorganism is incubated to grow the microorganism so that it may be detected. The filter may be degradable and the detection may involve extracting the microorganism or the molecular marker of the microorganism from the filter for detection. The filter system may also include a porous microbead component selected to trap dirt and other contaminants from the sample while allowing the microorganisms to pass among the microbeads. Methods are disclosed for detecting microorganisms in samples using the filter systems described. The methods may also include adding a polymer and/or a microorganism detection reagent to the filter to localize microorganism growth and prevent evaporation of reagents.
摘要翻译：公开了用于检测样品（例如食品样品）中的微生物的方法和过滤系统。过滤器被配置为吸引微生物，例如通过静电电荷。将含有微生物的过滤器温育以生长微生物，使其可以被检测。过滤器可以是可降解的，并且检测可能涉及从过滤器中提取微生物或微生物的分子标记物进行检测。过滤系统还可以包括多孔微珠组分，其被选择以从样品中捕获污垢和其它污染物，同时允许微生物在微珠之间通过。公开了使用所述过滤系统检测样品中的微生物的方法。所述方法还可以包括向过滤器中加入聚合物和/或微生物检测试剂以定位微生物生长并防止试剂的蒸发。

4. 发明申请

WO2007133551A3 METHOD FOR TESTING DRUG SENSITIVITY IN SOLID TUMORS BY QUANTIFYING MRNA EXPRESSION IN THINLY-SLICED TUMOR TISSUE 审中-公开
标题翻译：通过在薄片肿瘤组织中定量检测MRNA表达来测定固体肿瘤中药物灵敏度的方法
公开(公告)号：WO2007133551A3
公开(公告)日：2008-01-10
申请号：PCT/US2007011121
申请日：2007-05-08
申请人： HITACHI CHEMICAL CO LTD , HITACHI CHEMICAL RES CT INC , MITSUHASHI MASATO , OBARA KAZUHIKO
发明人： MITSUHASHI MASATO , OBARA KAZUHIKO
IPC分类号： A61K49/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A method is disclosed for assaying the sensitivity of neoplastic tissue to therapeutic agents, and in particular, for the quantification of pro-apoptotic marker mRNA expression in cells obtained from thinly-sliced living tumor tissue in such methods. The method may comprise ascertaining a particular apoptosis marker mRNA for an individual tumor or tumor type as well as exposure of thin-sliced live cancer tissues from the individual tumor to candidate chemotherapeutic drug regimes in vitro, followed by an assessment of the level of the marker mRNA in the tissue.
摘要翻译：公开了一种用于测定肿瘤组织对治疗剂的敏感性的方法，特别是用于定量在这样的方法中从薄切片的活体肿瘤组织获得的细胞中促凋亡标记物mRNA表达。该方法可以包括确定个体肿瘤或肿瘤类型的特定凋亡标志物mRNA，以及将来自个体肿瘤的薄切活活组织从体外暴露于候选化疗药物方案，随后评估标志物的水平组织中的mRNA。

5. 发明申请

WO2005067646A2 PRIMERS AND PROBES FOR THE DETECTION OF HIV 审中-公开
标题翻译：检测艾滋病毒的前提和探索
公开(公告)号：WO2005067646A2
公开(公告)日：2005-07-28
申请号：PCT/US2005/000504
申请日：2005-01-07
申请人： HITACHI CHEMICAL RESEARCH CENTER, INC. , HITACHI CHEMICAL CO., LTD. , MITSUHASHI, Masato
发明人： MITSUHASHI, Masato
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2561/101
摘要： Provided herein are primer/probe sets useful for detecting HIV (HIV-1) in a test sample. The primer/probe sets can be employed according to nucleic acid amplification procedures including PCR, real-time quantitative PCR, or RT-PCR. The primer/probe sets can also be provided in the form of a kit with other reagents for performing a nucleic acid amplification reaction.
摘要翻译：本文提供了可用于检测测试样品中HIV（HIV-1）的引物/探针组。可以根据包括PCR，实时定量PCR或RT-PCR的核酸扩增方法使用引物/探针组。引物/探针组还可以以试剂盒的形式提供用于进行核酸扩增反应的其它试剂。

6. 发明申请

WO03091407A2 DEVICE AND METHOD FOR HIGH-THROUGHPUT QUANTIFICATION OF MRNA FROM WHOLE BLOOD 审中-公开
标题翻译：用于从全血中MRNA进行高通量定量的装置和方法
公开(公告)号：WO03091407A2
公开(公告)日：2003-11-06
申请号：PCT/US0312895
申请日：2003-04-24
申请人： HITACHI CHEMICAL RES CT INC , HITACHI CHEMICAL CO LTD , HITACHI LTD , MITSUHASHI MASATO
发明人： MITSUHASHI MASATO
IPC分类号： G01N33/48 , B01L3/00 , C12M1/00 , C12M1/26 , C12Q1/68 , G01N33/50 , C12N
CPC分类号： C12Q1/6806 , C12Q1/6837 , C12Q2600/158 , C12Q2565/501 , C12Q2525/173 , C12Q2523/308 , C12Q2547/101
摘要： Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.
摘要翻译：公开了一种用于从全血中简单，可重复和高通量定量mRNA的方法，装置试剂盒和自动化系统。更具体地，方法，装置，试剂盒和自动化系统涉及附着于寡聚（dT）活化的多孔板的白细胞过滤器的组合。

7. 发明申请

WO0198539A3 GENE MARKERS FOR LUNG CANCER 审中-公开
标题翻译：肺癌基因标记
公开(公告)号：WO0198539A3
公开(公告)日：2003-08-14
申请号：PCT/US0119980
申请日：2001-06-21
申请人： HITACHI CHEMICAL CO LTD , HITACHI CHEMICAL RES CT INC , HITACHI LTD , MITSUHASHI MASATO , KAMBARA HIDEKI , MATSUNAGA HIROKO , KAWAMURA MASAFUMI
发明人： MITSUHASHI MASATO , KAMBARA HIDEKI , MATSUNAGA HIROKO , KAWAMURA MASAFUMI
IPC分类号： G01N33/574 , C07H21/04 , C07K16/30 , C12N15/09 , C12Q1/68 , C07K14/47
CPC分类号： C07H21/04 , C07K16/30 , C12Q1/6809 , C12Q1/686 , C12Q1/6886 , C12Q2600/158 , G01N33/57423 , G01N33/57484 , C12Q2539/113 , C12Q2537/162 , C12Q2525/191 , C12Q2525/15
摘要： A method for the diagnosis and identification of new or residual lung cancer is disclosed which uses newly identified markers for lung cancer including syndecan 1, collagen 1 alpha 2, and two novel proteins, 7013 and 7018. The method involves identification of the lung cancer markers is blood from a patient. It is envisioned that at least one marker may be used or any mixture of the four. The method may also include the identification of cytokeratin-19.
摘要翻译：公开了用于诊断和鉴定新的或残留的肺癌的方法，其使用新鉴定的肺癌标志物，包括syndecan 1，胶原1α2和两种新型蛋白质，7013和7018.该方法涉及鉴定肺癌标志物是来自病人的血液。可以想象，可以使用至少一个标记物或四种的任何混合物。该方法还可以包括细胞角蛋白-19的鉴定。

8. 发明申请

WO2011156763A1 METHODS FOR CHARACTERIZING KIDNEY FUNCTION 审中-公开
标题翻译：表征KIDNEY函数的方法
公开(公告)号：WO2011156763A1
公开(公告)日：2011-12-15
申请号：PCT/US2011/040057
申请日：2011-06-10
申请人： HITACHI CHEMICAL CO., LTD. , HITACHI CHEMICAL RESEARCH CENTER, INC. , SAPPORO CITY GENERAL HOSPITAL , MITSUHASHI, Masato , HARADA, Hiroshi
发明人： MITSUHASHI, Masato , HARADA, Hiroshi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2525/207 , C12Q2600/142 , C12Q2600/158 , C12Q2600/178
摘要： Embodiments of the invention relate generally to methods of characterizing kidney function. In particular, several embodiments quantify kidney-associated marker RNA isolated from vesicles contained in patient urine samples. In some embodiments, the quantified RNA from urine vesicles is compared to a normal population and in some embodiments is compared to the patient to evaluate kidney function over time
摘要翻译：本发明的实施方案一般涉及表征肾功能的方法。具体地，几个实施方案定量从患者尿样中包含的囊泡中分离的肾相关标记RNA。在一些实施方案中，将来自尿泡的定量RNA与正常群体进行比较，并且在一些实施方案中与患者进行比较以评估肾功能随时间变化

9. 发明申请

WO2011084333A1 METHOD FOR CHARACTERIZING HOST IMMUNE FUNCTION BY EX VIVO INDUCTION OF OFFENSIVE AND DEFENSIVE IMMUNE MARKERS 审中-公开
标题翻译：通过EXVIVO诱导有害和免疫免疫标记表征宿主免疫功能的方法
公开(公告)号：WO2011084333A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/059552
申请日：2010-12-08
申请人： HITACHI CHEMICAL CO., LTD. , HITACHI CHEMICAL RESEARCH CENTER, INC , MITSUHASHI, Masato
发明人： MITSUHASHI, Masato
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N33/57496 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： A host's immune function can be characterized by quantifying changes in offensive and defensive immune function associated markers. Certain methods can be used to identify a potentially efficacious therapy for a subject based on the induction of expression of offensive and defensive immune function-associated markers. Additionally, some methods can be used to identify drugs that allow the stimulation of either the offensive or defensive immune response while inhibiting the other of offensive or defensive immune response.
摘要翻译：宿主的免疫功能可以通过量化进攻性和防御性免疫功能相关标志物的变化来表征。可以使用某些方法基于进攻性和防御性免疫功能相关标志物的表达的诱导来鉴定受试者的潜在有效治疗。此外，一些方法可用于鉴定允许刺激进攻性或防御性免疫应答同时抑制另一种进攻性或防御性免疫应答的药物。

10. 发明申请

WO2007117611A2 ENHANCED T CELL RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY AND CHEMOKINE MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH CROHN'S DISEASE 审中-公开
标题翻译：增强T细胞受体介导的肿瘤坏死因子超家族和CHEMOKINE在外周血白细胞介素的表达与患有慢性疾病的患者
公开(公告)号：WO2007117611A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/008597
申请日：2007-04-05
申请人： HITACHI CHEMICAL CO., LTD. , HITACHI CHEMICAL RESEARCH CENTER, INC. , CEDARS-SINAI MEDICAL CENTER , MITSUHASHI, Masato , TARGAN, Stephan, R.
发明人： MITSUHASHI, Masato , TARGAN, Stephan, R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed.
摘要翻译：公开了一种用于通过测量响应于刺激的某些mRNA的水平来确定克罗恩病患者是否可能对靶向TNFSF成员或细胞因子的治疗作出反应的方法。还公开了评估人类克罗恩病治疗有效性的方法。此外，公开了一种筛选用于治疗克罗恩病的化合物的方法。还公开了一种在克罗恩病患者中随时间监测疾病状态的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式