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1. 发明申请

WO2006080022A2 MRI CONTRAST AGENTS FOR DIAGNOSIS AND PROGNOSIS OF TUMORS 审中-公开
标题翻译： MRI对比剂用于诊断和预防肿瘤
公开(公告)号：WO2006080022A2
公开(公告)日：2006-08-03
申请号：PCT/IL2006000124
申请日：2006-01-31
申请人： YEDA RES & DEV , DEGANI HADASSA , MILSTEIN DAVID
发明人： DEGANI HADASSA , MILSTEIN DAVID
IPC分类号： A61K49/10
CPC分类号： A61K49/085 , A61K49/10
摘要： The invention relates to bifunctional conjugates comprising a receptor ligand moiety and a metal binding moiety and complexes thereof with paramagnetic lanthanide or transition metals, and to the use of the metal complexes as contrast agents in magnetic resonance imaging (MRI) of tumors and other abnormalities.
摘要翻译：本发明涉及包含受体配体部分和金属结合部分及其与顺磁镧系元素或过渡金属的复合物的双功能缀合物，以及在肿瘤和其他异常的磁共振成像（MRI）中使用金属络合物作为造影剂。

2. 发明申请

WO2012052996A2 NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF 审中-公开
标题翻译：新型氢氧化钠复合物及其用于形成和/或加氢酯，氨基和衍生物的方法中的用途
公开(公告)号：WO2012052996A2
公开(公告)日：2012-04-26
申请号：PCT/IL2011000817
申请日：2011-10-11
申请人： YEDA RES & DEV , MILSTEIN DAVID , BALARAMAN EKAMBARAM , GUNANATHAN CHIDAMBARAM , GNANAPRAKASAM BOOPATHY , ZHANG JING
发明人： MILSTEIN DAVID , BALARAMAN EKAMBARAM , GUNANATHAN CHIDAMBARAM , GNANAPRAKASAM BOOPATHY , ZHANG JING
IPC分类号： B01J31/18
CPC分类号： C07K5/12 , B01J31/18 , B01J31/189 , B01J31/2404 , B01J31/2409 , B01J31/248 , B01J31/2485 , B01J2231/40 , B01J2231/49 , B01J2231/643 , B01J2231/763 , B01J2531/0244 , B01J2531/821 , C07B41/02 , C07B41/08 , C07B41/12 , C07B43/04 , C07B43/06 , C07C29/136 , C07C29/149 , C07C29/177 , C07C41/16 , C07C41/26 , C07C45/002 , C07C45/006 , C07C51/00 , C07C51/02 , C07C51/23 , C07C51/295 , C07C67/00 , C07C67/03 , C07C67/297 , C07C209/00 , C07C209/62 , C07C213/00 , C07C213/02 , C07C231/02 , C07C231/10 , C07C2101/08 , C07C2101/10 , C07C2101/14 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D207/06 , C07D207/08 , C07D211/12 , C07D213/38 , C07D241/08 , C07D241/12 , C07D295/023 , C07D295/027 , C07D295/185 , C07D305/06 , C07D307/14 , C07D307/33 , C07D307/44 , C07D307/52 , C07D307/83 , C07D309/30 , C07D487/14 , C07F9/582 , C07F9/65583 , C07F15/0046 , C07F15/0053 , C07K1/00 , C08G69/00 , Y02P20/52 , C07C233/05 , C07C235/06 , C07C233/07 , C07C235/16 , C07C235/14 , C07C235/10 , C07C211/27 , C07C211/07 , C07C211/35 , C07C211/46 , C07C211/10 , C07C215/28 , C07C217/58 , C07C69/14 , C07C69/24 , C07C31/125 , C07C31/12 , C07C49/78 , C07C49/04 , C07C49/10 , C07C49/08 , C07C49/403 , C07C31/205 , C07C31/202 , C07C31/04 , C07C31/08 , C07C33/20 , C07C33/22 , C07C31/1355 , C07C31/10 , C07C43/13 , C07C69/78 , C07C69/75 , C07C53/124 , C07C53/126 , C07C59/125 , C07C57/32 , C07C61/08 , C07C57/30 , C07C65/21 , C07C63/08 , C07C63/06
摘要： The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.
摘要翻译：本发明涉及新的钌催化剂和相关的硼氢化物络合物，以及这种催化剂的用途，特别是（1）将酰胺（包括聚酰胺）氢化成醇和胺; （2）由醇与胺制备酰胺（包括通过使二醇和二胺反应和/或通过氨基醇的聚合反应制备聚酰胺（例如多肽）; （3）将酯氢化成醇（包括环酯（内酯）或环状二酯（二内酯）或聚酯）的氢化）; （4）将有机碳酸酯（包括聚碳酸酯）氢化成醇，并将氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物氢化成醇和胺; （5）醇与酯的脱氢偶联; （6）将仲醇醇化成酮类; （7）酯的酰胺化（即从酯和胺合成酰胺）; （8）使用酯酰化醇; （9）将醇与水偶联以形成羧酸; 和（10）β-氨基醇脱氢形成吡嗪。本发明还涉及某些吡啶钌催化剂的新用途。

3. 发明申请

WO2011069128A1 CONVERTING A MESSAGE VIA A POSTING CONVERTER 审中-公开
标题翻译：转换信息转换器
公开(公告)号：WO2011069128A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058991
申请日：2010-12-03
申请人： INTELLISIST, INC. , MILSTEIN, David
发明人： MILSTEIN, David
IPC分类号： G06F17/28 , G06Q10/00 , H04L12/58
CPC分类号： G06F17/2872 , G06Q10/10 , G06Q10/107 , H04L51/063 , H04L51/066
摘要： A system (10) and method (30) for converting a message via a posting converter (42) is provided. At least one incoming message is received from a composition device (41). Characteristics of the message are determined. The characteristics include a target device (43) to which the message is directed and an application through which the message will be presented. An appropriate template (44) is selected for the message based on at least one of the message characteristics. The message is converted to a different format using the selected template (44). The converted message is provided for display on the target device (43).
摘要翻译：提供了一种用于经由发布转换器（42）转换消息的系统（10）和方法（30）。从合成装置（41）接收至少一个传入消息。确定消息的特征。特征包括消息被引导到的目标设备（43）和消息将被呈现的应用。基于消息特征中的至少一个为消息选择适当的模板（44）。使用所选模板将消息转换为不同的格式（44）。转换的消息被提供用于在目标设备（43）上显示。

4. 发明申请

WO2002083698A1 NEW METHOD FOR THE PREPARATION OF METAL CARBENE COMPLEXES 审中-公开
标题翻译：用于制备金属碳复合物的新方法
公开(公告)号：WO2002083698A1
公开(公告)日：2002-10-24
申请号：PCT/IL2002/000304
申请日：2002-04-15
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MILSTEIN, David , GANDELMAN, Mark , ASHKENAZI, Nissan , RYBTCHINSKI, Boris
发明人： MILSTEIN, David , GANDELMAN, Mark , ASHKENAZI, Nissan , RYBTCHINSKI, Boris
IPC分类号： C07F15/00
CPC分类号： C07F15/0046 , C07C381/00 , C07F15/002
摘要： The present invention provides a process for preparing a metal carbene complex of formula (I): wherein M is a transition metal atom selected from the group consisting of ruthenium, rhodium, iron , cobalt, osmium and iridium; L denotes neutral donor ligands ligated to said metal, such groups being the same or different; X is an anionic ligand; R1 and R2 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C20 alkyl, substituted or unsubstituted C2-C20 alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted vinyl, a is 2 or 3 and b is 1 or 2, such process comprising reacting a sulfur ylide of the formula Ar 2 S=CR 1 R 2 or its precursor with an appropriate metal complex comprising a transition metal atom selected from the group consisting of ruthenium, rhodium, iron, cobalt, osmium and iridium, said metal complex being also in dimeric form, at a temperature between +80 °C and -80 °C, in an inert solvent and under inert atmosphere.
摘要翻译：本发明提供了制备式（I）的金属卡宾络合物的方法：其中M是选自钌，铑，铁，钴，锇和铱的过渡金属原子; L表示与所述金属连接的中性供体配体，这些基团相同或不同; X是阴离子配体; R 1和R 2各自独立地选自氢，取代或未取代的C 1 -C 20烷基，取代或未取代的C 2 -C 20烯基，取代或未取代的环烷基，取代或未取代的杂环烷基，取代或未取代的芳基，取代或未取代的乙烯基，a为2或3，b为1或2，该方法包括使式Ar> 2 R 2或其前体的硫叶立德与合适的金属络合物反应，选自钌，铑，铁，钴，锇和铱的过渡金属原子，在惰性溶剂中，在+ 80℃至-80℃之间的温度下，所述金属络合物也是二聚体形式，和在惰性气氛下。

5. 发明申请

WO1998018107A1 APPARATUS AND METHODS FOR COLLECTING VALUE 审中-公开
标题翻译：收集价值的手段和方法
公开(公告)号：WO1998018107A1
公开(公告)日：1998-04-30
申请号：PCT/IL1997000337
申请日：1997-10-22
申请人： FORTRESS U & T LTD. , GRESSEL, Carmi, David , MILSTEIN, David , SANDER, Avi , HADAD, Isaac , GRANOT, Ran
发明人： FORTRESS U & T LTD.
IPC分类号： G07F07/08
CPC分类号： G07F7/0866 , G06Q20/105 , G06Q20/363
摘要： This invention discloses a system for safe collection of payment in return for goods, values or services, the system including a multiplicity of electronic system elements wherein each individual one of the elements has a purse storing an amount of credit for value receivable granted to the individual system element, each purse including a purse monitor operative to sign and authenticate a transaction record of each transaction in which the purse uses some of the credit for value receivable which it has been granted, and a purse control unit operative to prevent the purse, off-line, from exceeding the credit for value receivable which it has been granted.
摘要翻译：本发明公开了一种用于安全收取货物，价值或服务的付款的系统，该系统包括多个电子系统元件，其中每个单独的一个元件具有储存授予个人的应收值的信用额的钱包系统元件，每个钱包包括操作用于对每个交易的交易记录进行签名和验证的钱包监控器，其中钱包使用其已经被授予的可接收值的一部分的信用，以及用于防止钱包关闭的钱包控制单元不超过其已经获得的应收票据抵免额。

6. 发明申请

WO1993001173A1 PRODUCTION OF AROMATIC OLEFINS 审中-公开
标题翻译：生产芳香油
公开(公告)号：WO1993001173A1
公开(公告)日：1993-01-21
申请号：PCT/US1992005709
申请日：1992-07-07
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MILSTEIN, David , BEN DAVID, Yehoshua
发明人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
IPC分类号： C07D213/127
CPC分类号： C07D213/06 , C07B37/04 , C07C2/861 , C07C41/30 , C07C45/68 , C07C47/575 , C07C49/784 , C07C49/84 , C07C67/343 , C07C201/12 , C07C2531/24 , C07C15/40 , C07C69/618 , C07C69/76 , C07C205/06 , C07C43/215
摘要： Aromatic olefins are produced by catalytic vinylation of aryl chlorides in the presence of a base and of a palladium complex catalyst of the formula: [R6R7P(CH2)nPR8R9]2 Pd wherein n is 3 or 4 and R6 to R9 are selected from hydrogen, alkyl, cycloalkyl, unsubstituted carbocyclic aryl or aralkyl and carbocyclic aryl or aralkyl substituted by alkyl, alkoxy or phenoxy.
摘要翻译：芳基烯烃通过芳基氯化物在碱存在下和下式的钯络合物催化剂的催化乙烯基化制备：[R6R7P（CH2）nPR8R9] 2 Pd，其中n为3或4，R6至R9选自氢，烷基，环烷基，未取代的碳环芳基或芳烷基，碳环芳基或被烷基，烷氧基或苯氧基取代的芳烷基。

7. 发明申请

WO2012012247A1 EFFICIENTLY REDUCING TRANSCRIPTION ERROR USING HYBRID VOICE TRANSCRIPTION 审中-公开
标题翻译：使用混合语音转换功能有效减少转录错误
公开(公告)号：WO2012012247A1
公开(公告)日：2012-01-26
申请号：PCT/US2011/043889
申请日：2011-07-13
申请人： INTELLISIST, INC. , MILSTEIN, David
发明人： MILSTEIN, David
IPC分类号： G10L15/06
CPC分类号： G10L15/26 , G10L15/01 , G10L15/06 , G10L15/063 , G10L15/10 , G10L15/1822 , G10L15/19 , G10L15/22 , G10L2015/0631 , G10L2015/0638 , H04M3/42221 , H04M3/51 , H04M3/5183
摘要： A system (10) and method (40) for efficiently reducing transcription error using hybrid voice transcription is provided. A voice stream (22) is parsed into utterances. An initial transcribed value and corresponding recognition score (113) are assigned to each utterance. A transcribed message (23) is generated and includes the initial transcribed values. A threshold is applied to the recognition scores (113) to identify those utterances with recognition scores (113) below the threshold as questionable utterances (111). At least one questionable utterance (111) is compared to other questionable utterances (111) from other calls and a group of similar questionable utterances (111) is formed. One or more of the similar questionable utterances (111) is selected from the group. A common manual transcription value (124) is received for the selected similar questionable utterances (111). The common manual transcription value (124) is assigned to the remaining similar questionable utterances (111) in the group.
摘要翻译：提供了一种使用混合语音转录有效降低转录错误的系统（10）和方法（40）。语音流（22）被解析为话语。初始转录值和相应的识别分数（113）分配给每个发音。生成转录消息（23）并包括初始转录值。对识别分数（113）应用阈值，以将具有低于阈值的识别分数（113）的那些话语识别为可疑话语（111）。至少有一个有问题的话语（111）与来自其他呼叫的其他可疑话语（111）进行比较，并形成一组类似的可疑话语（111）。从组中选择一个或多个相似的可疑话语（111）。对于所选择的类似的可疑话语（111），接收到常见的手动转录值（124）。共同手动转录值（124）被分配给组中剩余的类似的可疑话语（111）。

8. 发明申请

WO2010018570A1 PROCESS FOR PREPARING AMINES FROM ALCOHOLS AND AMMONIA 审中-公开
标题翻译：从酒精和氨水制备氨基酸的方法
公开(公告)号：WO2010018570A1
公开(公告)日：2010-02-18
申请号：PCT/IL2009/000778
申请日：2009-08-10
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MILSTEIN, David , GUNANATHAN, Chidambaram
发明人： MILSTEIN, David , GUNANATHAN, Chidambaram
IPC分类号： C07F15/00 , C07F9/60 , C07F9/64 , C07C209/00
CPC分类号： C07C209/16 , B01J31/146 , C07B43/04 , C07C213/02 , C07C2601/14 , C07D213/38 , C07D305/06 , C07D307/52 , C07F9/60 , C07F9/64 , C07F15/0046 , C07C211/07 , C07C211/17 , C07C211/27 , C07C217/08 , C07C217/58
摘要： The present invention provides novel ruthenium based catalysts, and a process for preparing amines, by reacting a primary alcohol and ammonia in the presence of such catalysts, to generate the amine and water. According to the process of the invention, primary alcohols react directly with ammonia to produce primary amines and water in high yields and high turnover numbers. This reaction is catalyzed by novel ruthenium complexes, which are preferably composed of quinolinyl or acridinyl based pincer ligands.
摘要翻译：本发明提供新型的钌基催化剂，以及通过在这种催化剂存在下使伯醇和氨反应制备胺的方法，以产生胺和水。根据本发明的方法，伯醇直接与氨反应，以高产率和高的周转数产生伯胺和水。该反应由新的钌络合物催化，其优选由喹啉基或吖啶基的钳形配体组成。

9. 发明申请

WO2012052996A3 NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF 审中-公开
公开(公告)号：WO2012052996A3
公开(公告)日：2012-04-26
申请号：PCT/IL2011/000817
申请日：2011-10-11
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MILSTEIN, David , BALARAMAN, Ekambaram , GUNANATHAN, Chidambaram , GNANAPRAKASAM, Boopathy , ZHANG, Jing
发明人： MILSTEIN, David , BALARAMAN, Ekambaram , GUNANATHAN, Chidambaram , GNANAPRAKASAM, Boopathy , ZHANG, Jing
IPC分类号： B01J31/18 , C07C29/136 , C07C29/149 , C07C67/00 , C07C209/50 , C07C209/62 , C07C213/00 , C07C231/10 , C07D213/38 , C08G69/00 , C07F9/58 , C07F15/00
摘要： The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta- amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes.

10. 发明申请

WO2006080022A3 MRI CONTRAST AGENTS FOR DIAGNOSIS AND PROGNOSIS OF TUMORS 审中-公开
公开(公告)号：WO2006080022A3
公开(公告)日：2006-08-03
申请号：PCT/IL2006/000124
申请日：2006-01-31
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , DEGANI, Hadassa , MILSTEIN, David
发明人： DEGANI, Hadassa , MILSTEIN, David
IPC分类号： A61K31/555
摘要： The invention relates to bifunctional conjugates comprising a receptor ligand moiety and a metal binding moiety and complexes thereof with paramagnetic lanthanide or transition metals, and to the use of the metal complexes as contrast agents in magnetic resonance imaging (MRI) of tumors and other abnormalities.

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