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1. 发明申请

WO2012052996A3 NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF 审中-公开
公开(公告)号：WO2012052996A3
公开(公告)日：2012-04-26
申请号：PCT/IL2011/000817
申请日：2011-10-11
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MILSTEIN, David , BALARAMAN, Ekambaram , GUNANATHAN, Chidambaram , GNANAPRAKASAM, Boopathy , ZHANG, Jing
发明人： MILSTEIN, David , BALARAMAN, Ekambaram , GUNANATHAN, Chidambaram , GNANAPRAKASAM, Boopathy , ZHANG, Jing
IPC分类号： B01J31/18 , C07C29/136 , C07C29/149 , C07C67/00 , C07C209/50 , C07C209/62 , C07C213/00 , C07C231/10 , C07D213/38 , C08G69/00 , C07F9/58 , C07F15/00
摘要： The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta- amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes.

2. 发明申请

WO2010018570A1 PROCESS FOR PREPARING AMINES FROM ALCOHOLS AND AMMONIA 审中-公开
标题翻译：从酒精和氨水制备氨基酸的方法
公开(公告)号：WO2010018570A1
公开(公告)日：2010-02-18
申请号：PCT/IL2009/000778
申请日：2009-08-10
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MILSTEIN, David , GUNANATHAN, Chidambaram
发明人： MILSTEIN, David , GUNANATHAN, Chidambaram
IPC分类号： C07F15/00 , C07F9/60 , C07F9/64 , C07C209/00
CPC分类号： C07C209/16 , B01J31/146 , C07B43/04 , C07C213/02 , C07C2601/14 , C07D213/38 , C07D305/06 , C07D307/52 , C07F9/60 , C07F9/64 , C07F15/0046 , C07C211/07 , C07C211/17 , C07C211/27 , C07C217/08 , C07C217/58
摘要： The present invention provides novel ruthenium based catalysts, and a process for preparing amines, by reacting a primary alcohol and ammonia in the presence of such catalysts, to generate the amine and water. According to the process of the invention, primary alcohols react directly with ammonia to produce primary amines and water in high yields and high turnover numbers. This reaction is catalyzed by novel ruthenium complexes, which are preferably composed of quinolinyl or acridinyl based pincer ligands.
摘要翻译：本发明提供新型的钌基催化剂，以及通过在这种催化剂存在下使伯醇和氨反应制备胺的方法，以产生胺和水。根据本发明的方法，伯醇直接与氨反应，以高产率和高的周转数产生伯胺和水。该反应由新的钌络合物催化，其优选由喹啉基或吖啶基的钳形配体组成。

3. 发明申请

WO2002083698A1 NEW METHOD FOR THE PREPARATION OF METAL CARBENE COMPLEXES 审中-公开
标题翻译：用于制备金属碳复合物的新方法
公开(公告)号：WO2002083698A1
公开(公告)日：2002-10-24
申请号：PCT/IL2002/000304
申请日：2002-04-15
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MILSTEIN, David , GANDELMAN, Mark , ASHKENAZI, Nissan , RYBTCHINSKI, Boris
发明人： MILSTEIN, David , GANDELMAN, Mark , ASHKENAZI, Nissan , RYBTCHINSKI, Boris
IPC分类号： C07F15/00
CPC分类号： C07F15/0046 , C07C381/00 , C07F15/002
摘要： The present invention provides a process for preparing a metal carbene complex of formula (I): wherein M is a transition metal atom selected from the group consisting of ruthenium, rhodium, iron , cobalt, osmium and iridium; L denotes neutral donor ligands ligated to said metal, such groups being the same or different; X is an anionic ligand; R1 and R2 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C20 alkyl, substituted or unsubstituted C2-C20 alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted vinyl, a is 2 or 3 and b is 1 or 2, such process comprising reacting a sulfur ylide of the formula Ar 2 S=CR 1 R 2 or its precursor with an appropriate metal complex comprising a transition metal atom selected from the group consisting of ruthenium, rhodium, iron, cobalt, osmium and iridium, said metal complex being also in dimeric form, at a temperature between +80 °C and -80 °C, in an inert solvent and under inert atmosphere.
摘要翻译：本发明提供了制备式（I）的金属卡宾络合物的方法：其中M是选自钌，铑，铁，钴，锇和铱的过渡金属原子; L表示与所述金属连接的中性供体配体，这些基团相同或不同; X是阴离子配体; R 1和R 2各自独立地选自氢，取代或未取代的C 1 -C 20烷基，取代或未取代的C 2 -C 20烯基，取代或未取代的环烷基，取代或未取代的杂环烷基，取代或未取代的芳基，取代或未取代的乙烯基，a为2或3，b为1或2，该方法包括使式Ar> 2 R 2或其前体的硫叶立德与合适的金属络合物反应，选自钌，铑，铁，钴，锇和铱的过渡金属原子，在惰性溶剂中，在+ 80℃至-80℃之间的温度下，所述金属络合物也是二聚体形式，和在惰性气氛下。

4. 发明申请

WO2006080022A3 MRI CONTRAST AGENTS FOR DIAGNOSIS AND PROGNOSIS OF TUMORS 审中-公开
公开(公告)号：WO2006080022A3
公开(公告)日：2006-08-03
申请号：PCT/IL2006/000124
申请日：2006-01-31
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , DEGANI, Hadassa , MILSTEIN, David
发明人： DEGANI, Hadassa , MILSTEIN, David
IPC分类号： A61K31/555
摘要： The invention relates to bifunctional conjugates comprising a receptor ligand moiety and a metal binding moiety and complexes thereof with paramagnetic lanthanide or transition metals, and to the use of the metal complexes as contrast agents in magnetic resonance imaging (MRI) of tumors and other abnormalities.

5. 发明申请

WO2016035081A1 LIQUID-ORGANIC HYDROGEN CARRIER SYSTEMS BASED ON CATALYTIC PEPTIDE FORMATION AND HYDROGENATION 审中-公开
标题翻译：基于催化肽形成和加氢的液体有机氢载体系统
公开(公告)号：WO2016035081A1
公开(公告)日：2016-03-10
申请号：PCT/IL2015/050888
申请日：2015-09-03
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： MILSTEIN, David , HU, Peng , FOGLER, Eran
IPC分类号： C01B3/00 , C07C209/50 , C07C213/00 , C07C29/149 , C07C31/08
CPC分类号： C01B3/0015 , C01B3/00 , C07C29/149 , C07C209/50 , C07C211/00 , C07C211/10 , C07C213/00 , C07C215/08 , C07C231/08 , C07C231/10 , C07C233/36 , C07C237/08 , C07C249/02 , C07C251/08 , C07D241/08 , Y02E60/327 , Y02E60/328 , C07C31/08
摘要： The present invention provides a system and method of storing hydrogen (H 2 ) and releasing it on demand, comprising and making use of diaminoalkanes and alcohols, or aminoalcohols as liquid-organic hydrogen carrier systems (LOHC). 2-aminoethanol (AE) or its N-methyl derivative 2-(methylamino)ethanol undergo catalytic dehydrogenation to form a cyclic dipeptide (glycine anhydride - GA) or its N,N-dimethyl derivative ( N,N- dimethyl GA) with release of hydrogen. Similarly, ethylenediamine (ED) and ethanol undergo catalytic dehydrogenation to form N,N '-diacetylethylenediamine (DAE) with release of hydrogen. Glycine anhydride (GA) or N,N -dimethyl-GA may be hydrogenated back to 2-aminoethanol (AE) or 2-(methylamino)ethanol, respectively, each of which functions as a hydrogen storage system. N,N'-diacetylethylenediamine (DAE) may be hydrogenated back to ED and ethanol, which functions as a hydrogen storage system. These reactions may be catalyzed by a variety of compounds or complexes, including Ruthenium complexes as described herein.
摘要翻译：本发明提供一种存储氢（H 2）并根据需要释放的系统和方法，包括并利用二氨基烷烃和醇，或氨基醇作为液 - 有机氢载体系统（LOHC）。 2-氨基乙醇（AE）或其N-甲基衍生物2-（甲基氨基）乙醇进行催化脱氢以形成环状二肽（甘氨酸酐-GA）或其N，N-二甲基衍生物（N，N-二甲基氨基）的氢。类似地，乙二胺（ED）和乙醇经历催化脱氢以形成N，N'-二乙酰基乙二胺（DAE），释放氢气。甘氨酸酐（GA）或N，N-二甲基-GA可以分别氢化回2-氨基乙醇（AE）或2-（甲基氨基）乙醇，它们各自用作储氢体系。 N，N'-二乙酰基乙二胺（DAE）可以被氢化回ED和乙醇，其用作氢存储系统。这些反应可以由各种化合物或络合物催化，包括本文所述的钌络合物。

6. 发明申请

WO2020161723A1 REVERSIBLE LIQUID ORGANIC SYSTEM, METHOD AND PROCESS FOR LOADING AND DISCHARGING HYDROGEN BASED ON N-HETEROCYCLES 审中-公开
公开(公告)号：WO2020161723A1
公开(公告)日：2020-08-13
申请号：PCT/IL2020/050153
申请日：2020-02-06
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： MILSTEIN, David , XIE, Yinjun
IPC分类号： C01B3/00 , C01B3/22
摘要： The present invention provides a system, a process and a method of storing hydrogen (H 2 ) and releasing it on demand, comprising and making use of N -heterocycles as liquid organic hydrogen carriers (LOHCs).

7. 发明申请

WO2023062633A1 PROCESS FOR THE PREPARATION OF A SALBUTAMOL INTERMEDIATE 审中-公开
公开(公告)号：WO2023062633A1
公开(公告)日：2023-04-20
申请号：PCT/IL2022/051083
申请日：2022-10-12
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： MILSTEIN, David , UTTAM, Kumar Das , SAYAN, Kar
IPC分类号： C07C209/52 , C07C217/70 , B01J23/34 , B01J23/46
摘要： This invention is directed to a catalytic hydrogenation process for the preparation of l-(4- (benzyloxy)-3-(hydroxymethyl)phenyl)-2-(tert-butylamino)ethanol, which is an intermediate for the preparation of Salbutamol.

8. 发明申请

WO2023012789A1 IRON-CATALYZED METATHESIS POLYMERIZATION OF OLEFINS 审中-公开
公开(公告)号：WO2023012789A1
公开(公告)日：2023-02-09
申请号：PCT/IL2022/050830
申请日：2022-08-01
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： MILSTEIN, David , TAKEBAYASH, Satoshi
IPC分类号： B01J31/00 , C07F9/58 , C07F15/02 , C08F4/00 , C08G61/00
摘要： This invention is directed to iron-based complexes, and uses thereof for catalytic olefin metathesis reaction, including ring opening metathesis polymerization of olefins.

9. 发明申请

WO2022136476A1 ELECTROCATALYTIC OXIDATION OF ALCOHOLS USING ACCEPTOR-LESS DEHYDROGENATION CATALYSTS 审中-公开
公开(公告)号：WO2022136476A1
公开(公告)日：2022-06-30
申请号：PCT/EP2021/087164
申请日：2021-12-21
申请人： UNIVERSITÉ DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： VON WOLFF, Niklas , MILSTEIN, David
IPC分类号： C25B1/02 , C25B1/23 , C25B3/07 , C25B3/23 , C25B9/15 , C25B11/054 , C25B11/065 , C25B11/085
摘要： The present invention relates to the use of an acceptor-less dehydrogenation catalyst for an electrocatalytic oxidation of an alcohol to an ester or/and an acid under electrochemical conditions, the acceptor-less dehydrogenation catalyst being represented by formula (I).

10. 发明申请

WO2020141520A1 REVERSIBLE LIQUID ORGANIC SYSTEM FOR LOADING AND DISCHARGING HYDROGEN BASED ON ETHYLENE GLYCOL 审中-公开
公开(公告)号：WO2020141520A1
公开(公告)日：2020-07-09
申请号：PCT/IL2019/051440
申请日：2019-12-30
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： MILSTEIN, David , ZOU, You-Quan , ANABY, Aviel
IPC分类号： C01B3/00 , B01J23/46 , B01J31/22 , B01J31/24 , C07F15/00
摘要： This invention provides a reversible hydrogen loading and discharging system and a reversible method for loading and discharging hydrogen. The system and the methods of this invention comprise ethylene glycol as a liquid organic hydrogen carrier and at least one transition metal. By reacting ethylene glycol with at least one transition metal; at least one hydrogen molecule and at least one oligoester of ethylene glycol are formed (hydrogen releasing)·, and by reacting at least one oligoester of ethylene glycol with at least one transition metal and at least one hydrogen molecule, at least one ethylene glycol is formed (hydrogen loading).

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