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    • 3. 发明申请
    • DEVICE FOR SLOW LIBERATION VIA TRANSDERMIC PROCESS OF A MEDICINE FOR EXCESS OF CHOLESTEROL AND METHOD OF PRODUCTION OF A TRANSDERMIC DEVICE.
    • 用于通过用于超过胆固醇的药物的转移过程的慢速释放装置和生产转换装置的方法。
    • WO2006119598A2
    • 2006-11-16
    • PCT/BR2006/000090
    • 2006-05-10
    • MILLET, Jean Marc
    • MILLET, Jean Marc
    • A61K31/40A61K31/20A61K9/70
    • A61K9/7023A61K31/20A61K31/40
    • Device for slow liberation via transdermic process of a medicine for excess of cholesterol and method of production of a transdermic device, which is characterized for contemplating a bi-laminate device for slow transdermic liberation comprising a flexible macromolecular matrix (2) of thickness 0,15 to 0,6 cm and the surface from 10 to 100 square cm and presents a posterior coating (1) on one side which allows a considerable reduction (more than 15 times) of the doses to be administered in the treatment for excess of cholesterol; the macromolecular matrix contains and liberates in a continuous way for a period between 1 to 4 months from 0,05 to 0,18% a day of its total weight in Omega 3 and/or statin by its surface in contact with the patient's skin without being necessary the device to be adhered in a fix and permanent way to the his/her skin, which is characterized for contemplating a bi-laminate device for slow transdermic liberation comprising a flexible macromolecular matrix (2) of thickness 0,15 to 0,6 cm and the surface from 10 to 100 square cm and presents a posterior coating (1) on one side which allows a considerable reduction (more than 15 times) of the doses to be administered in the treatment for excess of cholesterol; the macromolecular matrix contains and liberates in a continuous way for a period between 1 to 4 months from 0,05 to 0,18% a day of its total weight in Omega 3 and/or statin by its surface in contact with the patient's skin without being necessary the device to be adhered in a fix and permanent way to the his/her skin.
    • 用于通过用于过量胆固醇的药物的经皮操作缓慢释放的装置和经皮装置的生产方法,其特征在于考虑用于缓慢经皮解放的双层压装置,其包括厚度为0.15的柔性高分子基质(2) 至0.6cm,表面为10至100平方厘米,并且在一侧具有后涂层(1),其允许在用于治疗过量胆固醇时施用的剂量显着降低(超过15倍) 大分子基质含有并以连续的方式释放1至4个月之间的时间,其从Ω-3和/或他汀类药物的总重量的每天的0.05至0.18%,其与患者皮肤接触的表面没有 需要将装置以固定和永久的方式粘附到他/她的皮肤上,其特征在于考虑用于缓慢经皮解放的双层压装置,其包括厚度为0.15至0的柔性大分子矩阵(2) 6厘米,表面10至100平方厘米,并且在一侧具有后涂层(1),其允许在治疗过量胆固醇时施用相当大量的剂量(超过15倍) 大分子基质含有并以连续的方式释放1至4个月之间的时间,其从Ω-3和/或他汀类药物的总重量的每天的0.05至0.18%,其与患者皮肤接触的表面没有 需要将装置固定并固定在他/她的皮肤上。
    • 5. 发明申请
    • METHOD FOR PREPARING ACROLEIN FROM GLYCEROL OR GLYCERINE
    • 从甘油或甘油制备阿拉伯糖的方法
    • WO2010076510A3
    • 2010-10-14
    • PCT/FR2009052577
    • 2009-12-16
    • ADISSEO FRANCE SASCENTRE NAT RECH SCIENTBELLIERE-BACA VIRGINIELORIDANT STEPHANEMILLET JEAN-MARCLAURIOL-GARBEY PASCALINE
    • BELLIERE-BACA VIRGINIELORIDANT STEPHANEMILLET JEAN-MARCLAURIOL-GARBEY PASCALINE
    • C07C45/52C07C47/22
    • C07C45/66B01J23/20B01J23/92B01J38/12C07C45/52C07C319/18Y02P20/584C07C47/22C07C323/22C07C323/52C07C323/58
    • The invention relates to a method for preparing acrolein from glycerol or glycerine, comprising dehydrating glycerol or glycerine in the presence of a catalyst consisting of at least a) a mixed oxide of zirconium and at least one metal, said metal being selected from niobium, tantalum and vanadium, b) a zirconium oxide and at least one metal oxide, the metal being selected from niobium, tantalum and vanadium, c) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, d) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, vanadium and titanium, e) a titanium oxide and a mixed oxide of zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, f) a titanium oxide and a mixed oxide or zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon. The method can be used for producing -3-(methylthio)propionic (MMP) aldehyde, 2-hydroxy-4-methylthiobutyronitrile (HMTBN), methionine and analogues thereof from acrolein.
    • 本发明涉及由甘油或甘油制备丙烯醛的方法,包括在催化剂存在下使甘油或甘油脱水,所述催化剂由至少a)锆和至少一种金属的混合氧化物组成,所述金属选自铌,钽 和钒,b)氧化锆和至少一种金属氧化物,所述金属选自铌,钽和钒,c)氧化硅和锆与至少一种金属的混合氧化物,所述金属选自钨, 铈,锰,铌,钽,钛,钒和硅,d)氧化硅和锆与至少一种金属的混合氧化物,所述金属选自钨,铈,锰,铌,钽,钒和钛, e)氧化钛和锆与至少一种金属的混合氧化物,所述金属选自钨,铈,锰,铌,钽,钛,钒和硅,f)氧化钛和混合氧化物或z (irconium)和至少一种金属,所述金属选自钨,铈,锰,铌,钽,钛,钒和硅。 该方法可用于由丙烯醛生产3-(甲硫基)丙酸(MMP)醛,2-羟基-4-甲硫基丁腈(HMTBN),甲硫氨酸及其类似物。
    • 7. 发明申请
    • PROCEDE DE PREPARATION D'ACROLEINE A PARTIR DE GLYCEROL OU DE GLYCERINE
    • 从甘油或甘油制备丙烯酸的方法
    • WO2010076510A2
    • 2010-07-08
    • PCT/FR2009/052577
    • 2009-12-16
    • ADISSEO FRANCE S.A.S.CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEBELLIERE-BACA, VirginieLORIDANT, StéphaneMILLET, Jean-MarcLAURIOL-GARBEY, Pascaline
    • BELLIERE-BACA, VirginieLORIDANT, StéphaneMILLET, Jean-MarcLAURIOL-GARBEY, Pascaline
    • C07C45/52C07C47/22
    • C07C45/66B01J23/20B01J23/92B01J38/12C07C45/52C07C319/18Y02P20/584C07C47/22C07C323/22C07C323/52C07C323/58
    • L'i nvention concerne un procédé de préparation d'acroléine à partir de glycérol ou de glycérine, selon lequel on réalise la déshydratation du glycérol ou glycérine en présence d'un catalyseur consistant en au moins a) un oxyde mixte de zirconium et d'au moins un métal, le dit métal étant choisi parmi le niobium, le tantale et le vanadium, b) un oxyde de zi rconi um et a u moins un oxyde de métal, le dit métal étant choisi parmi le niobium, le tantale et le vanadium, c) un oxyde de silicium et un oxyde mixte de zirconium et d'a u moins un métal, le dit métal étant choisi parmi le tungstène, le cérium, le manganèse, le niobium, le tantale, le titane, le vanadium et le silicium, d) un oxyde de silicium et un oxyde mixte de zirconium et d'au moins un méta l, le dit méta l étant choisi parmi le tungstène, le cérium, le manganèse, le niobium, le tantale, le vanadium et le titane, e) un oxyde de titane et un oxyde mixte de zirconium et d'au moins un méta l, le dit méta l éta nt choisi pa rmi le tungstène, le céri um, le ma nga nèse, le niobium, le tantale, le titane, le vanadium et le silicium, f) un oxyde de titane et un oxyde mixte de zirconium et d'au moins un méta l, le dit méta l éta nt choisi pa rmi le tu ngstène, le cériu m, le ma nga nèse, le niobium, le tantale, le titane, le vanadium et le silicium. Ce procédé peut être ut i l i s é p o u r l a fabrication de l 'a l dé hyde- 3-(méthylthio)propionique (M M P), du 2-hydroxy-4méthylthiobutyronitrile (HMTBN), de la méthionine et de ses analogues, à partir d'acroléine.
    • 本发明涉及一种由甘油或甘油制备丙烯醛的方法,包括在由至少一种锆和至少一种金属的混合氧化物组成的催化剂存在下使甘油或甘油脱水,所述金属选自铌,钽 和钒,b)氧化锆和至少一种金属氧化物,所述金属选自铌,钽和钒,c)氧化硅和锆与至少一种金属的混合氧化物,所述金属选自钨, 铈,锰,铌,钽,钛,钒和硅,d)氧化锆和锆与至少一种金属的混合氧化物,所述金属选自钨,铈,锰,铌,钽,钒和钛, e)氧化钛和锆与至少一种金属的混合氧化物,所述金属选自钨,铈,锰,铌,钽,钛,钒和硅,f)氧化钛和混合氧化物或z 所述金属选自钨,铈,锰,铌,钽,钛,钒和硅。 该方法可用于由丙烯醛生产3-(甲硫基)丙酸(MMP)醛,2-羟基-4-甲基硫代丁腈(HMTBN),甲硫氨酸及其类似物。
    • 9. 发明申请
    • TRANSDERMAL DEVICE FOR THE SLOW DELIVERY OF AN OMEGA-3-FATTY ACID, OPTIONALLY IN COMBINATION WITH A HMG COA REDUCTASE INHIBITOR
    • 用于缓慢递送欧米茄-3-脂肪酸的转换装置,可选地与HMG COA还原抑制剂组合
    • WO2006119598A3
    • 2007-03-01
    • PCT/BR2006000090
    • 2006-05-10
    • MILLET JEAN MARC
    • MILLET JEAN MARC
    • A61K9/70A61K31/20A61K31/401
    • A61K9/7023A61K31/20A61K31/40
    • Device for slow liberation via transdermal process of a medicine for reducing an excess of cholesterol and method of production of a transdermic device, which is characterized by a bi-laminate device comprising a flexible macromolecular matrix (2) providing a thickness from 0,15 to 0,6 cm and a surface from 10 to 100 square cm and a posterior coating (1) on one side which allows a considerable reduction (more than 15 times) of the doses to be administered in the treatment of an excess of cholesterol; the macromolecular matrix contains and liberates in a continuous way for a period between 1 to 4 months from 0,05 to 0,18% per day of its total weight of Omega-3 follyocid and / or statin by its surface in contact with the patient's skin without being necessarily the device to be adhered in a fix and permanent way to his / her skin.
    • 用于通过用于减少过量胆固醇的药物的经皮过程缓慢释放的装置和通透装置的生产方法,其特征在于包含柔性高分子基质(2)的双层压装置,其提供从0.15到 0.6厘米,10至100平方厘米的表面和一侧的后涂层(1),其允许在治疗过量胆固醇时施用的剂量显着减少(超过15倍) 大分子基质含有并以连续的方式释放1至4个月之间的时间,其总重量为0-55%至0.18%,其总重量为Omega-3的疱疹和/或他汀类与其与患者接触的表面 皮肤,而不一定是固定并固定在他/她的皮肤上的装置。