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1. 发明申请

WO2010104473A1 A METHOD FOR THE SYSTEMATIC EVALUATION OF THE PROGNOSTIC PROPERTIES OF GENE PAIRS FOR MEDICAL CONDITIONS, AND CERTAIN GENE PAIRS IDENTIFIED 审中-公开
标题翻译：用于医学条件的基因配对的预防性质的系统评估方法和鉴定的某些基因配对
公开(公告)号：WO2010104473A1
公开(公告)日：2010-09-16
申请号：PCT/SG2010/000079
申请日：2010-03-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MILLER, Lance, D. , KARUTURI, Krishna, Murthy
发明人： MILLER, Lance, D. , KARUTURI, Krishna, Murthy
IPC分类号： G06F17/18 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6886 , C12Q2600/118 , G06F19/18 , G06F19/20 , G06F19/24
摘要： A method is proposed identification of pairs of genes for which the respective gene expression values in a subject are statistically significant in relation to a medical condition, for example cancer, or more particularly breast cancer. Many pairs of genes are generated, and for each pair of genes clinical data is used to fit a statistical model to obtain the statistical significance of the ratio of the corresponding expression values. The clinical data characterizes for each of the patients the level of expressions of the genes and times until a clinical endpoint of interest.
摘要翻译：提出了一种方法，鉴定对象中各个基因表达值相对于医学状况（例如癌症，或更特别是乳腺癌）具有统计学意义的基因对。生成多对基因，对于每一对基因，临床资料用于拟合统计学模型，以获得相应表达值比值的统计学显着性。临床数据表征每个患者的基因表达水平和直到临床终点为止的时间。

2. 发明申请

WO2010101528A1 A BIOMARKER AND TREATMENT FOR CANCER 审中-公开
标题翻译：生物标记和癌症治疗
公开(公告)号：WO2010101528A1
公开(公告)日：2010-09-10
申请号：PCT/SG2010/000072
申请日：2010-03-02
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , DESAI, Kartik, V , LIU, Edison T , MILLER, Lance, David
发明人： DESAI, Kartik, V , LIU, Edison T , MILLER, Lance, David
IPC分类号： C12Q1/68 , A61K39/395 , C07K16/28 , C07K16/30 , C12N15/113
CPC分类号： C07K16/3015 , C07K16/40 , C12N9/00 , C12N9/0071 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Q2600/178 , C12Y114/11004 , G01N33/573 , G01N33/57415 , G01N33/57496
摘要： A correlation between expression of JMJD6 polypeptide and breast cancer metastasis exists accordingly the present invention relates a diagnostic, prognostic and therapeutic biomarker to distinguish between early and advanced/metastatic cancer particularly breast cancer, including compounds and methods to treat the same.
摘要翻译：因此，JMJD6多肽的表达与乳腺癌转移之间的相关性存在，因此本发明涉及诊断，预后和治疗性生物标志物，以区分早期/晚期/转移性癌症，特别是乳腺癌，包括化合物和治疗它们的方法。

3. 发明申请

WO2008048193A3 BREAST TUMOUR GRADING 审中-公开
公开(公告)号：WO2008048193A3
公开(公告)日：2008-04-24
申请号：PCT/SG2007/000357
申请日：2007-10-19
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MILLER, Lance, D. , KUZNETSOV, Vladimir , IVSHINA, Anna
发明人： MILLER, Lance, D. , KUZNETSOV, Vladimir , IVSHINA, Anna
IPC分类号： C12Q1/68
摘要： We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D1 (SWS Classifier 0).

4. 发明申请

WO2006052218A1 METHODS, SYSTEMS, AND ARRAYS BASED ON CORRELATING P53 STATUS WITH GENE EXPRESSION PROFILES, FOR CLASSIFICATION, PROGNOSIS, AND DIAGNOSIS OF CANCERS 审中-公开
标题翻译：基于与基因表达谱相关的P53状态的方法，系统和阵列，用于分类，预防和诊断癌症
公开(公告)号：WO2006052218A1
公开(公告)日：2006-05-18
申请号：PCT/SG2005/000338
申请日：2005-10-05
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MILLER, Lance D. , GEORGE, Joshy , VEGA, Vinsensius B.
发明人： MILLER, Lance D. , GEORGE, Joshy , VEGA, Vinsensius B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/00 , G06F19/20 , G16H50/20 , Y02A90/22 , Y02A90/26
摘要： The present invention provides methods, systems and compositions for predicting disease susceptibility in a patient based on correlating p53 mutational status and gene expression profiles for a set of predetermined genes. In some embodiments, methods for the classification, prognosis, and diagnosis of cancers are provided. In other embodiments, the present invention provides statistical methods for building a gene-expression-based classifier that may be employe for predicting disease susceptibility in a patient, for classifying carcinomas, and for the prognosis of clinical outcomes
摘要翻译：本发明提供了基于一组预定基因的p53突变状态和基因表达谱的相关性来预测患者中疾病易感性的方法，系统和组合物。在一些实施方案中，提供了分类，预后和诊断癌症的方法。在其它实施方案中，本发明提供了用于构建基因表达的分类器的统计方法，所述分类器可用于预测患者的疾病易感性，用于分类癌症和预后的临床结果

5. 发明申请

WO9746971A8 A METHOD FOR AUTOMATICALLY DETECTING OBJECTS OF PREDEFINED SIZE WITHIN AN IMAGE, E.G. A MAMOGRAPHIC IMAGE 审中-公开
标题翻译：一种用于自动检测图像中预定尺寸的物体的方法，E.G. 马克思图像
公开(公告)号：WO9746971A8
公开(公告)日：1999-11-11
申请号：PCT/EP9702963
申请日：1997-06-03
申请人： AGFA GEVAERT NV , PARTICLE PHYSICS AND ASTRONOMY , MILLER LANCE
发明人： MILLER LANCE
IPC分类号： G06T7/00 , G06T5/00 , G06T7/60
CPC分类号： G06T7/168 , G06T7/11 , G06T2207/10116 , G06T2207/20056 , G06T2207/30068 , G06T2207/30096
摘要： The digital representation of the image is sequentially subjected to the following steps: (i) applying the Fourier transform to the original image; (ii) defining a critical Fourier wavelength equal to the predefined size of the objects; (iii) applying one of the techniques of entropy maximisation or cross-entropy minimisation to the original image to create the new image wherein (a) the amplitudes and the phases of the Fourier components of the new image with wavelengths that are shorter than the critical Fourier wavelength are substantially the same as the amplitudes and the phases of the Fourier components of the original image, and wherein (b) for the amplitudes and the phases of Fourier components having wavelengths that are longer than the critical wavelength, new values are estimated so that either image cross-entropy is minimised or image entropy is maximised.
摘要翻译：图像的数字表示依次进行以下步骤：（i）将傅里叶变换应用于原始图像; （ii）定义等于对象的预定义大小的关键傅立叶波长; （iii）将熵最大化或交叉熵最小化的技术之一应用于原始图像以产生新图像，其中（a）新图像的傅立叶分量的幅度和相位的波长比临界值更短傅立叶波长基本上与原始图像的傅立叶分量的幅度和相位相同，并且其中（b）对于具有比临界波长长的波长的傅立叶分量的幅度和相位，新估计值图像交叉熵最小化或图像熵最大化。

6. 发明申请

WO2011044513A1 DIAGNOSTIC AND PROGNOSTIC MARKERS FOR CANCER 审中-公开
标题翻译：癌症的诊断和预测标记
公开(公告)号：WO2011044513A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/052072
申请日：2010-10-08
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES , TORTI, Frank, M. , TORTI, Suzy, V. , MILLER, Lance
发明人： TORTI, Frank, M. , TORTI, Suzy, V. , MILLER, Lance
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/57415 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N33/57496 , G01N2500/10 , G01N2800/54 , G01N2800/60
摘要： Compositions and methods useful for diagnosis and prognosis of cancer are provided.
摘要翻译：提供了用于诊断和预后癌症的组合物和方法。

7. 发明申请

WO2008048193A2 BREAST TUMOUR GRADING 审中-公开
标题翻译：乳腺肿瘤分级
公开(公告)号：WO2008048193A2
公开(公告)日：2008-04-24
申请号：PCT/SG2007000357
申请日：2007-10-19
申请人： AGENCY SCIENCE TECH & RES , MILLER LANCE D , KUZNETSOV VLADIMIR , IVSHINA ANNA
发明人： MILLER LANCE D , KUZNETSOV VLADIMIR , IVSHINA ANNA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , Y02A90/26
摘要： We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D1 (SWS Classifier 0).
摘要翻译：我们描述了将等级分配给乳腺肿瘤的方法，该等级指示肿瘤的侵袭性，该方法包括检测从表D1中列出的基因（SWS分类器0）中选出的基因的表达。

8. 发明申请

WO2007021250A3 METHOD AND/OR APPARATUS OF OLIGONUCLEOTIDE DESIGN AND/OR NUCLEIC ACID DETECTION 审中-公开
标题翻译：寡核苷酸设计和/或核酸检测的方法和/或装置
公开(公告)号：WO2007021250A3
公开(公告)日：2007-07-05
申请号：PCT/SG2006000224
申请日：2006-08-08
申请人： AGENCY SCIENCE TECH & RES , WONG CHRISTOPHER WING CHEONG , SUNG WING-KIN , LEE CHARLIE , MILLER LANCE DAVID
发明人： WONG CHRISTOPHER WING CHEONG , SUNG WING-KIN , LEE CHARLIE , MILLER LANCE DAVID
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6813 , G06F19/20
摘要： It is provided a method of designing at least one oligonucleotide for nucleic acid detection comprising the following steps in any order: (I) identifying and/or selecting region(s) of at least one target nucleic acid to be amplified, the region(s) having an efficiency of amplification (AE) higher than the average AE; and (II) designing at least one oligonucleotide capable of hybridizing to the selected region(s). It is also provided a method of detecting at least one target nucleic acid comprising the steps of: (i) providing at least one biological sample; (ii) amplifying nucleic acid(s) comprised in the biological sample; (iii) providing at least one oligonucleotide capable of hybridizing to at least one target nucleic acid, if present in the biological sample; and (iv) contacting the oligonucleotide(s) with the amplified nucleic acids and detecting the oligonucleotide(s) hybridized to the target nucleic acid(s). In particular, the method is for detecting the presence of at least one pathogen, for example a virus, in at least one human biological sample. The probes may be placed on a support, for example a microarray.
摘要翻译：提供了设计用于核酸检测的至少一种寡核苷酸的方法，其包括以下步骤：（I）鉴定和/或选择待扩增的至少一种靶核酸的区域，所述区域）具有比平均AE高的放大效率（AE）; 和（II）设计至少一种能够与选定区域杂交的寡核苷酸。还提供了检测至少一种靶核酸的方法，包括以下步骤：（i）提供至少一种生物样品; （ii）扩增生物样品中包含的核酸; （iii）提供至少一种能够与至少一种靶核酸杂交的寡核苷酸，如果存在于生物样品中; 和（iv）使寡核苷酸与扩增的核酸接触并检测与靶核酸杂交的寡核苷酸。特别地，该方法用于在至少一种人类生物样品中检测至少一种病原体，例如病毒的存在。探针可以放置在载体上，例如微阵列。

9. 发明申请

WO2007021250A2 METHOD AND/OR APPARATUS OF OLIGONUCLEOTIDE DESIGN AND/OR NUCLEIC ACID DETECTION 审中-公开
标题翻译：寡核苷酸设计和/或核酸检测的方法和/或装置
公开(公告)号：WO2007021250A2
公开(公告)日：2007-02-22
申请号：PCT/SG2006/000224
申请日：2006-08-08
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WONG, Christopher, Wing Cheong , SUNG, Wing-Kin , LEE, Charlie , MILLER, Lance, David
发明人： WONG, Christopher, Wing Cheong , SUNG, Wing-Kin , LEE, Charlie , MILLER, Lance, David
CPC分类号： C12Q1/6813 , G06F19/20
摘要： It is provided a method of designing at least one oligonucleotide for nucleic acid detection comprising the following steps in any order: (I) identifying and/or selecting region(s) of at least one target nucleic acid to be amplified, the region(s) having an efficiency of amplification (AE) higher than the average AE; and (II) designing at least one oligonucleotide capable of hybridizing to the selected region(s). It is also provided a method of detecting at least one target nucleic acid comprising the steps of: (i) providing at least one biological sample; (ii) amplifying nucleic acid(s) comprised in the biological sample; (iii) providing at least one oligonucleotide capable of hybridizing to at least one target nucleic acid, if present in the biological sample; and (iv) contacting the oligonucleotide(s) with the amplified nucleic acids and detecting the oligonucleotide(s) hybridized to the target nucleic acid(s). In particular, the method is for detecting the presence of at least one pathogen, for example a virus, in at least one human biological sample. The probes may be placed on a support, for example a microarray.
摘要翻译：提供了设计用于核酸检测的至少一种寡核苷酸的方法，其包括以任何顺序的以下步骤：（I）鉴定和/或选择至少一种靶核酸的区域扩增效率（AE）高于平均AE的区域; 和（II）设计至少一种能够与选择的区域杂交的寡核苷酸。还提供了检测至少一种靶核酸的方法，其包括以下步骤：（i）提供至少一种生物样品; （ii）扩增包含在生物样品中的核酸; （iii）如果存在于生物样品中，则提供至少一种能够与至少一种靶核酸杂交的寡核苷酸; （iv）将寡核苷酸与扩增的核酸接触并检测与靶核酸杂交的寡核苷酸。特别地，该方法用于检测至少一种人类生物学样品中是否存在至少一种病原体，例如病毒。探针可以放置在支架上，例如微阵列。

10. 发明申请

WO0173134A2 GENE PROFILING ARRAYS 审中-公开
标题翻译：基因分布阵列
公开(公告)号：WO0173134A2
公开(公告)日：2001-10-04
申请号：PCT/US0109993
申请日：2001-03-28
申请人： US HEALTH , WANG ENA , MARINCOLA FRANCESCO M , MILLER LANCE D
发明人： WANG ENA , MARINCOLA FRANCESCO M , MILLER LANCE D
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/513
摘要： Ordered arrays of mixtures of nucleic acid molecules are provided, which mixtures reflect the expression profile of one or more specimens, such as different cells or tissues. In particular embodiments, complete mRNA mixtures from specimens are separately arrayed on a substrate. Specimens from which such mixtures of nucleic acid molecules are produced can be taken from any source, including animal, plant and/or microbial cells, and can be assembled in any collection desired. The collections can, for instance, include different cell types, different phenotypes, cells grown under different conditions, cells of different ages or developmental stages, and so forth. The nucleic acid arrays are provided in both macro- and microarray formats, and are suitable for gene profiling in which relative quantitative expression from a single source or multiple sources may be determined. Techniques are also disclosed for producing high-fidelity, amplified mixtures of nucleic acid molecules using a combination of anti-sense RNA amplification and template-switching synthesis. Amplified mixtures produced using this method can, for instance, be applied to the disclosed arrays. The disclosed arrays allow high throughput analysis of differential gene expression in a specimen (such as a tumor) or a variety of specimens (such as a variety of tumors), and are suitable for automated preparation and analysis.
摘要翻译：提供了核酸分子混合物的有序阵列，其混合物反映了一个或多个样品（例如不同细胞或组织）的表达谱。在具体实施方案中，将来自样品的完整mRNA混合物分别排列在基底上。产生核酸分子的这种混合物的样品可以从任何来源（包括动物，植物和/或微生物细胞）获取，并且可以以任何所需的收集物组装。例如，这些集合可以包括不同的细胞类型，不同的表型，在不同条件下生长的细胞，不同年龄或发育阶段的细胞等等。核酸阵列以宏阵列和微阵列格式提供，并且适用于可以确定来自单个来源或多个来源的相对定量表达的基因分析。还公开了使用反义RNA扩增和模板切换合成的组合产生高保真，扩增的核酸分子混合物的技术。使用该方法制备的扩增混合物可以例如应用于所公开的阵列。所公开的阵列允许在样品（例如肿瘤）或多种标本（例如多种肿瘤））中差异基因表达的高通量分析，并且适用于自动化制备和分析。

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