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2. 发明申请

WO2013074044A8 METHODS FOR DIAGNOSIS AND/OR PROGNOSIS OF GYNECOLOGICAL CANCER 审中-公开
标题翻译：妇科肿瘤的诊断和/或预后方法
公开(公告)号：WO2013074044A8
公开(公告)日：2013-07-04
申请号：PCT/SG2012000435
申请日：2012-11-19
申请人： AGENCY SCIENCE TECH & RES
发明人： BATAGOV ARSEN , IVSHINA ANNA , KUZNETSOV VLADIMIR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to an in vitro method for diagnosing epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and/or predisposition to epithelial ovarian cancer in a subject, the method comprising determining in a sample of the subject gene expression level of at least one gene in the MDS 1 and EVI1 complex (MECOM) locus; and/or copy number of at least one gene in the MECOM locus; wherein the level against at least one expression cutoff value and/or copy number against at least one copy number cutoff value are indicative of the subject having epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and/or a predisposition to epithelial ovarian cancer cervical cancer, endometriosis, clear cell renal carcinoma and/or determining whether the ovarian cancer in the subject is primary or secondary ovarian cancer and/or a risk of the disease progression after surgery treatment, and/or an effectiveness of post-surgery chemotherapy.
摘要翻译：本发明涉及用于诊断受试者的上皮卵巢癌，宫颈癌，子宫内膜异位，透明细胞肾癌和/或易患上皮卵巢癌的体外方法，所述方法包括确定受试者基因的样品中的表达水平 MDS1和EVI1复合物（MECOM）基因座中的至少一个基因; 和/或MECOM基因座中至少一个基因的拷贝数; 其中针对至少一个表达截断值和/或拷贝数相对于至少一个拷贝数截止值的水平指示受试者患有上皮卵巢癌，宫颈癌，子宫内膜异位，透明细胞肾癌和/或上皮卵巢癌倾向癌症宫颈癌，子宫内膜异位，透明细胞肾癌和/或确定受试者中的卵巢癌是原发性还是继发性卵巢癌和/或手术治疗后疾病进展的风险，和/或术后化疗的有效性。

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