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1. 发明申请

WO2009045653A3 BIOMASS TREATMENT METHOD 审中-公开
标题翻译：生物量处理方法
公开(公告)号：WO2009045653A3
公开(公告)日：2009-08-06
申请号：PCT/US2008073418
申请日：2008-08-18
申请人： DU PONT , MIDWEST RESEARCH INST , FRIEND JULIE , ELANDER RICHARD T , TUCKER III MELVIN P , LYONS ROBERT C
发明人： FRIEND JULIE , ELANDER RICHARD T , TUCKER III MELVIN P , LYONS ROBERT C
IPC分类号： C08B1/00 , C13K1/02
CPC分类号： C13K1/02 , C08H8/00 , Y02E50/16
摘要： A method for treating biomass was developed that uses an apparatus which moves a biomass and dilute aqueous ammonia mixture through reaction chambers without compaction. The apparatus moves the biomass using a non-compressing piston (34). The resulting treated biomass is saccharified to produce fermentable sugars.
摘要翻译：开发了一种处理生物质的方法，该方法使用移动生物质并将氨水混合物稀释成反应室而不进行压实的装置。该设备使用非压缩活塞（34）移动生物质。将所得处理的生物质糖化以产生可发酵糖。

2. 发明申请

WO2008133638A3 XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS FOR ETHANOL PRODUCTION 审中-公开
标题翻译：用于乙醇生产的XYLOSE-ZYMOMONAS的XYLITOL合成突变体
公开(公告)号：WO2008133638A3
公开(公告)日：2009-01-29
申请号：PCT/US2007020950
申请日：2007-09-28
申请人： DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
发明人： VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
IPC分类号： C12N1/22 , C12P7/06 , C12P7/10
CPC分类号： C12N1/22 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism.lt also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
摘要翻译：用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了一种利用木糖的酵母菌菌株，导致GFOR酶活性的降低。工程化的菌株表现出木糖代谢产物的减少，这是木糖代谢的有害副产物。在过程相关条件下，混合糖发酵过程中还会消耗更多的木糖并产生更多的乙醇。

3. 发明申请

WO2008051348A3 ETHANOL PRODUCTION USING XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS 审中-公开
标题翻译：用木糖醇合成突变型木糖醇突变株生产乙醇
公开(公告)号：WO2008051348A3
公开(公告)日：2008-09-12
申请号：PCT/US2007020945
申请日：2007-09-28
申请人： DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN
发明人： VIITANEN PAUL V , MCCUTCHEN CAROL M , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN
IPC分类号： C12P7/06 , C12N1/22 , C12P7/10
CPC分类号： C12P7/065 , Y02E50/16 , Y02E50/17
摘要： Production of ethanol using a strain of xylose-utilizing Zymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.
摘要翻译：发现使用具有葡萄糖 - 果糖氧化还原酶基因的遗传修饰的利用木糖的发酵单胞菌菌株生产乙醇，由于木糖醇的产生大大降低，木糖醇是发酵期间合成的木糖代谢的有害副产物，所以发现其得到改善。

4. 发明申请

WO2007001414A3 LOW THERMAL RESISTANCE POWER MODULE ASSEMBLY 审中-公开
标题翻译：低耐热功率模块组件
公开(公告)号：WO2007001414A3
公开(公告)日：2007-05-18
申请号：PCT/US2005037137
申请日：2005-10-18
申请人： MIDWEST RESEARCH INST , HASSANI VAHAB , VLAHINOS ANDREAS , BHARATHAN DESIKAN
发明人： HASSANI VAHAB , VLAHINOS ANDREAS , BHARATHAN DESIKAN
IPC分类号： H05K7/20 , H01L21/48
CPC分类号： H01L23/3677 , H01L23/473 , H01L25/072 , H01L2224/291 , H01L2224/32225 , H01L2924/1305 , H01L2924/13055 , H01L2924/13091 , Y10T29/49002 , H01L2924/014 , H01L2924/00
摘要： A power module assembly (400) with low thermal resistance and enhanced heat dissipation to a cooling medium. The assembly includes a heat sink or spreader plate (410) with passageways or openings (414) for coolant that extend through the plate from a lower surface (411) to an upper surface (412). A circuit substrate (420) is provided and positioned on the spreader plate (410) to cover the coolant passageways. The circuit substrate (420) includes a bonding layer (422) configured to extend about the periphery of each of the coolant passageways and is made up of a substantially nonporous material. The bonding layer (422) may be solder material which bonds to the upper surface (412) of the plate to provide a continuous seal around the upper edge of each opening (414) in the plate. The assembly includes power modules (430) mounted on the circuit substrate (420) on a surface opposite the bonding layer (422). The power modules (430) are positioned over or proximal to the coolant passageways.
摘要翻译：一种功率模块组件（400），其具有低热阻和对散热介质的增强散热。组件包括散热器或散热板（410），其具有用于冷却剂的通道或开口（414），其从所述板的下表面延伸到上表面（412）。电路基板（420）设置并定位在扩展板（410）上以覆盖冷却剂通道。电路基板（420）包括构造成围绕每个冷却剂通道的周边延伸并且由基本上无孔的材料构成的结合层（422）。接合层（422）可以是焊接材料，其粘合到板的上表面（412），以围绕板中的每个开口（414）的上边缘提供连续的密封。组件包括安装在电路基板（420）上的与结合层（422）相对的表面上的电源模块（430）。功率模块（430）位于冷却剂通道的上方或附近。

5. 发明申请

WO2005040170A3 PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO 审中-公开
标题翻译：吡咯烷酮衍生物，包含该衍生物的组合物及其相关方法
公开(公告)号：WO2005040170A3
公开(公告)日：2005-06-30
申请号：PCT/US2004035050
申请日：2004-10-22
申请人： US GOV HEALTH & HUMAN SERV , SPIROGEN LTD , STARKS ASS , MIDWEST RESEARCH INST , VISHNUVAJJALA B RAO , LIU PAUL S , SNADER KENNETH M , THURSTON DAVID , HOWARD PHILIP W , HSIAO LUKE Y , TURNER GREGORY
发明人： VISHNUVAJJALA B RAO , LIU PAUL S , SNADER KENNETH M , THURSTON DAVID , HOWARD PHILIP W , TURNER GREGORY , HSIAO LUKE Y
IPC分类号： C07D487/04 , A61K31/551 , A61P31/00
CPC分类号： C07D487/04
摘要： Disclosed are compounds of Formula (I) wherein X, Y, R 1 -R 7 , T 1 , T 2 , Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.
摘要翻译：公开了式（I）的化合物，其中X，Y，R 1 -R 7，T 1，T 2， SUP>，Z和p如本文所述; 包含式（I）化合物和载体的药物组合物; 抑制细胞生长的方法，该方法包括以有效抑制生长的量施用式（I）化合物; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的量施用式（I）化合物; 治疗细胞的病毒，寄生或细菌感染的方法，所述方法包括以有效治疗病毒，寄生或细菌感染的量施用式（I）化合物; 和制备本文所述的式（I）化合物的方法。

6. 发明申请

WO0183784A3 METHOD OF SITE-SPECIFIC INSERTION IN ZYMOMONAS MOBILIS 审中-公开
标题翻译： ZYMOMONAS MOBILIS中的特定插入方法
公开(公告)号：WO0183784A3
公开(公告)日：2003-10-02
申请号：PCT/US0111239
申请日：2001-04-06
申请人： MIDWEST RESEARCH INST
发明人： ZHANG MIN , CHOU YAT-CHEN
IPC分类号： C12N15/09 , C12N15/74 , C12N15/90
CPC分类号： C12N15/74 , C12N15/902
摘要： The present invention briefly provides a method of site-specific insertion in Zymomonas, comprising, providing a Zymomonas gene fragment, interrupting a DNA sequence the fragment, and transforming the Zymomonas through homologous recombination with the interrupted fragment.
摘要翻译：本发明简要提供在发酵单胞菌中特异性插入的方法，其包括：提供酵母单胞菌属基因片段，中断DNA序列片段，并通过与中断片段的同源重组转化酵母单胞菌。

7. 发明申请

WO03012090A3 THERMAL TOLERANT AVICELASE FROM ACIDOTHERMUS CELLULOLYTICUS 审中-公开
标题翻译：来自ACIDOTHERMUS CELLULOLYTICUS的耐热AVICELASE
公开(公告)号：WO03012090A3
公开(公告)日：2003-03-27
申请号：PCT/US0123818
申请日：2001-07-28
申请人： MIDWEST RESEARCH INST
发明人： DING SHI-YOU , ADNEY WILLIAM S , VINZANT TODD B , HIMMEL MICHAEL E
IPC分类号： C12N1/21 , C12N9/42 , C12N15/56 , C07K16/40 , C11D3/386 , C12N15/62 , C12Q1/68 , D06M16/00
CPC分类号： C12N9/2437 , C07K2319/00 , C12Y302/01004 , C12Y302/01091
摘要： The invention provides a thermal tolerant (thermostable) cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as AviIII. AviIII has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified AviIII. Methods of making and using AvIII polypeptides, including fusions, variants, and derivatives, are also disclosed.
摘要翻译：本发明提供了作为糖苷水解酶家族成员的耐热（热稳定的）纤维素酶。本发明还公开了该纤维素酶作为AviIII。 AviIII已经被分离并表征为酸热解纤溶液。本发明还提供了鉴定的AviIII的重组形式。还公开了制备和使用AvIII多肽，包括融合体，变体和衍生物的方法。

8. 发明申请

WO0217359B1 HIGH CARRIER CONCENTRATION P-TYPE TRANSPARENT CONDUCTING OXIDE FILMS 审中-公开
标题翻译：高载体浓度P型透明导电氧化膜
公开(公告)号：WO0217359B1
公开(公告)日：2003-03-20
申请号：PCT/US0125874
申请日：2001-08-17
申请人： MIDWEST RESEARCH INST , YAN YANFA , ZHANG SHENGBAI
发明人： YAN YANFA , ZHANG SHENGBAI
IPC分类号： C01G9/02 , C23C16/40 , H01L21/00 , H01L31/0224 , H01L31/0296 , H01L31/18
CPC分类号： H01L31/022466 , C01G9/02 , C23C16/407 , H01L31/022483 , H01L31/02963 , H01L31/1884 , Y02E10/50 , Y10T428/12681
摘要： A p-type transparent conducting oxide film is provided which is consisting essentially of, the transparent conducting oxide and a molecular doping source, the oxide and doping source grown under conditions sufficient to deliver the doping source intact onto the oxide.
摘要翻译：提供了一种p型透明导电氧化物膜，其主要由透明导电氧化物和分子掺杂源组成，氧化物和掺杂源在足以将掺杂源完整地输送到氧化物上的条件下生长。

9. 发明申请

WO02088918A2 MULTI-FUNCTIONAL ERGONOMIC INTERFACE 审中-公开
标题翻译：多功能人体界面
公开(公告)号：WO02088918A2
公开(公告)日：2002-11-07
申请号：PCT/US0213645
申请日：2002-05-02
申请人： MIDWEST RESEARCH INST
发明人： DOYNOV PLAMEN
IPC分类号： G06F3/00 , G06F3/01 , G06F3/033
CPC分类号： G06F3/014 , G06F3/033 , G06F2203/0331
摘要： A wearable control apparatus is provided for implementing desired user commands on an electronic device. The apparatus comprises a mounting frame for attaching to one or more of the user's fingers, various sensors for generating a command signal in response to user initiated input, and a physical link layer for performing processing on the command signals generated by the sensors and transmitting such processed signals to the electronic device to allow for control and navigation of such device. Preferably, the mounting frame is biometrically shaped to be ergonomically worn on the user's index finger or embedded in a "smart-glove", such that the wearer's thumb can manipulated the sensors with minimal physical movement. The control apparatus can interface with the electronic device through a wire based or wireless connection, with an optional antenna for transmitting signals and power supply preferably attached to a user's wrist to maximise ergonomics and the range of use of the invention.
摘要翻译：提供一种用于在电子设备上实现期望的用户命令的可佩戴控制装置。该装置包括用于附接到用户的一个或多个手指的安装框架，用于响应于用户启动的输入而产生命令信号的各种传感器，以及用于对由传感器产生的命令信号进行处理的物理链路层处理的信号到电子设备，以允许这种设备的控制和导航。优选地，安装框架被生物计量形成为符合人体工程学地佩戴在使用者的食指上或嵌入在“智能手套”中，使得佩戴者的拇指可以以最小的物理运动来操纵传感器。控制装置可以通过有线或无线连接与电子设备接口，其中可选的天线用于传输信号和电源，优选地附接到用户的手腕上，以最大化人体工程学和本发明的使用范围。

10. 发明申请

WO0186258A9 PD/NI-WO3 ANODIC DOUBLE LAYER COLORMETRIC GAS SENSOR 审中-公开
标题翻译： PD / NI-WO3阳极双层COLORMETRIC气体传感器
公开(公告)号：WO0186258A9
公开(公告)日：2002-07-11
申请号：PCT/US0114381
申请日：2001-05-05
申请人： MIDWEST RESEARCH INST , LEE SE-HEE , TRACY C EDWIN , PITTS J ROLAND , LIU PING
发明人： LEE SE-HEE , TRACY C EDWIN , PITTS J ROLAND , LIU PING
IPC分类号： G01N21/77 , G01N21/78 , G01N33/00
CPC分类号： G01N21/78 , G01N21/7703 , G01N21/783 , G01N33/005 , Y10T436/22
摘要： An anodic double layer gasochromic sensor structure for optical detection of hydrogen in improved response time and with improved optical absorption real time constants, comprising: a glass substrate; a tungsten-doped nickel oxide layer coated on the glass substrate; and a palladium layer coated on the tungsten-doped nickel oxide layer.
摘要翻译：一种用于光学检测氢气的阳极双层气致变色传感器结构，其具有改进的响应时间和改进的光吸收实时常数，包括：玻璃基底; 涂覆在玻璃基板上的钨掺杂氧化镍层; 以及涂覆在钨掺杂的氧化镍层上的钯层。

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