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1. 发明申请

WO2009150533A3 ANALYSIS OF VI SACCHARIDES 审中-公开
公开(公告)号：WO2009150533A3
公开(公告)日：2009-12-17
申请号：PCT/IB2009/006087
申请日：2009-06-12
申请人： NOVARTIS AG , BERTI, Francesco , MICOLI, Francesca , PROIETTI, Daniela
发明人： BERTI, Francesco , MICOLI, Francesca , PROIETTI, Daniela
IPC分类号： G01N33/15
摘要： Salmonella typhi Vi saccharide can be assayed in two new ways. First, its proton NMR spectrum can be used, with comparison to an internal Standard permitting quantitative analysis. Second, anion exchange chromatography with amperometric detection can be used on hydrolysed saccharide.

2. 发明申请

WO2011080595A2 POLYSACCHARIDE IMMUNOGENS CONJUGATED TO E. COLI CARRIER PROTEINS 审中-公开
标题翻译：多糖免疫调节蛋白与大肠杆菌载体蛋白结合
公开(公告)号：WO2011080595A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/003484
申请日：2010-12-30
申请人： NOVARTIS AG , COSTANTINO, Paolo , SERINO, Laura , ROMANO, Maria, Rosaria , TONTINI, Marta , BERTI, Francesco , MICOLI, Francesca , KABANOVA, Anna
发明人： COSTANTINO, Paolo , SERINO, Laura , ROMANO, Maria, Rosaria , TONTINI, Marta , BERTI, Francesco , MICOLI, Francesca , KABANOVA, Anna
IPC分类号： A61K47/48 , A61K39/02
CPC分类号： A61K47/4833 , A61K39/0002 , A61K39/0258 , A61K39/39 , A61K47/646 , A61K2039/6068 , Y02A50/401 , Y02A50/403 , Y02A50/41 , Y02A50/478 , Y02A50/484
摘要： E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sell repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
摘要翻译：已经鉴定出大肠杆菌蛋白质可用作载体蛋白，以改善对与这种蛋白质缀合的多糖免疫原的反应。特别地，已证明AcfD前体蛋白（orf3526多肽），Flu抗原43蛋白（orf1364多肽）和含Sell重复蛋白（upec-5211多肽）是有效的。此外，这些大肠杆菌蛋白质可增强对葡聚糖，特别是葡萄糖葡萄糖的免疫应答。

3. 发明申请

WO2013038375A3 METHODS FOR MAKING SACCHARIDE-PROTEIN GLYCOCONJUGATES 审中-公开
标题翻译：制备海草蛋白糖蛋白的方法
公开(公告)号：WO2013038375A3
公开(公告)日：2013-06-20
申请号：PCT/IB2012054805
申请日：2012-09-14
申请人： NOVARTIS AG , SAUL ALLAN , MICOLI FRANCESCA
发明人： SAUL ALLAN , MICOLI FRANCESCA
IPC分类号： A61K39/09 , C07K16/12 , C08B37/00
CPC分类号： C08B37/0006 , A61K39/02 , A61K39/0275 , A61K39/095 , A61K39/385 , A61K47/6415 , A61K47/646 , A61K2039/6037 , C07K14/34 , C07K16/1285 , C07K16/44 , C07K2317/734 , C08B37/0003 , C08B37/006 , C08B37/0063 , C08B37/0081
摘要： The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate of a polysaccharide and a carrier molecule, comprising the steps of: (a) coupling the polysaccharide to a linker, to form a polysaccharide-linker compound in which the free terminus of the linker is an ester group; and (b) reacting the ester group with a primary amine group in the carrier molecule, to form a polysaccharide-linker-carrier molecule conjugate in which the linker is coupled to the carrier molecule via an amide linkage. The invention also provides a process for reducing contamination of a polysaccharide-linker compound with unreacted linker, comprising a step of precipitating unreacted linker under aqueous conditions at a pH of less than 5. The invention also provides polysaccharide-linker-carrier molecule conjugates and intermediate compounds obtained or obtainable by these processes.
摘要翻译：本发明提供了在多糖的还原末端还原胺化羰基的方法，其中还原胺化在pH4至5之间进行。本发明还提供了制备多糖和载体分子，其包括以下步骤：（a）将多糖偶联至接头，以形成其中接头的游离末端为酯基的多糖 - 接头化合物; 和（b）在载体分子中使酯基与伯胺基反应，以形成多糖 - 连接体 - 载体分子缀合物，其中连接体经由酰胺键与载体分子偶联。本发明还提供了一种减少多糖 - 接头化合物与未反应接头的污染的方法，包括在pH小于5的水性条件下沉淀未反应的接头的步骤。本发明还提供多糖 - 接头 - 载体分子缀合物和中间体通过这些方法获得或可获得的化合物。

4. 发明申请

WO2009150543A3 CONJUGATED VI SACCHARIDES 审中-公开
标题翻译：结合六味
公开(公告)号：WO2009150543A3
公开(公告)日：2010-05-06
申请号：PCT/IB2009006285
申请日：2009-06-12
申请人： NOVARTIS AG , MICOLI FRANCESCA , COSTANTINO PAOLO , BERTI FRANCESCO
发明人： MICOLI FRANCESCA , COSTANTINO PAOLO , BERTI FRANCESCO
IPC分类号： A61K47/48 , A61P43/00
CPC分类号： C07K14/195 , A61K39/0275 , A61K47/6415 , A61K47/646
摘要： Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM197 (a non-toxic variant of diphtheria toxin) and tetanus toxoid, as carrier proteins.
摘要翻译：已经通过碳二亚胺介导的合成制备了两种Vi缀合物，其使用衍生化的CRM197（一种白喉毒素的无毒变体）和破伤风类毒素的己二酸二酰肼作为载体蛋白。

5. 发明申请

WO2009150533A2 ANALYSIS OF VI SACCHARIDES 审中-公开
标题翻译：六味子的分析
公开(公告)号：WO2009150533A2
公开(公告)日：2009-12-17
申请号：PCT/IB2009006087
申请日：2009-06-12
申请人： NOVARTIS AG , BERTI FRANCESCO , MICOLI FRANCESCA , PROIETTI DANIELA
发明人： BERTI FRANCESCO , MICOLI FRANCESCA , PROIETTI DANIELA
IPC分类号： G01N33/15
CPC分类号： G01R33/46 , G01N24/08 , G01N2333/255 , G01N2400/10 , Y10T436/143333
摘要： Salmonella typhi Vi saccharide can be assayed in two new ways. First, its proton NMR spectrum can be used, with comparison to an internal Standard permitting quantitative analysis. Second, anion exchange chromatography with amperometric detection can be used on hydrolysed saccharide.
摘要翻译：伤寒沙门氏菌Vi糖可以通过两种新方法进行测定。首先，可以使用其质子NMR谱，与允许定量分析的内部标准进行比较。第二，具有电流检测的阴离子交换层析可用于水解糖。

6. 发明申请

WO2015068129A1 SALMONELLA CONJUGATE VACCINES 审中-公开
标题翻译： SALMONELLA联合疫苗
公开(公告)号：WO2015068129A1
公开(公告)日：2015-05-14
申请号：PCT/IB2014/065869
申请日：2014-11-07
申请人： NOVARTIS AG , MACLENNAN, Calman Alexander , MARTIN, Laura Bartle , MICOLI, Francesca , SAUL, Allan James
发明人： MACLENNAN, Calman Alexander , MARTIN, Laura Bartle , MICOLI, Francesca , SAUL, Allan James
IPC分类号： A61K47/48 , A61P31/04
CPC分类号： A61K39/385 , A61K39/0275 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/627
摘要： The invention relates to a conjugate based on Vi polysaccharide which is fragmented and a carrier protein, to compositions comprising said conjugate and to methods for making said conjugates and compositions.
摘要翻译：本发明涉及一种基于片段化的Vi多糖和载体蛋白的缀合物，包含所述缀合物的组合物以及制备所述缀合物和组合物的方法。

7. 发明申请

WO2013038375A2 METHODS FOR MAKING SACCHARIDE-PROTEIN GLYCOCONJUGATES 审中-公开
标题翻译：制备糖化物 - 蛋白质糖苷酶的方法
公开(公告)号：WO2013038375A2
公开(公告)日：2013-03-21
申请号：PCT/IB2012/054805
申请日：2012-09-14
申请人： NOVARTIS AG , SAUL, Allan , MICOLI, Francesca
发明人： SAUL, Allan , MICOLI, Francesca
CPC分类号： C08B37/0006 , A61K39/02 , A61K39/0275 , A61K39/095 , A61K39/385 , A61K47/6415 , A61K47/646 , A61K2039/6037 , C07K14/34 , C07K16/1285 , C07K16/44 , C07K2317/734 , C08B37/0003 , C08B37/006 , C08B37/0063 , C08B37/0081 , Y02A50/482
摘要： The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate of a polysaccharide and a carrier molecule, comprising the steps of: (a) coupling the polysaccharide to a linker, to form a polysaccharide-linker compound in which the free terminus of the linker is an ester group; and (b) reacting the ester group with a primary amine group in the carrier molecule, to form a polysaccharide-linker-carrier molecule conjugate in which the linker is coupled to the carrier molecule via an amide linkage. The invention also provides a process for reducing contamination of a polysaccharide-linker compound with unreacted linker, comprising a step of precipitating unreacted linker under aqueous conditions at a pH of less than 5. The invention also provides polysaccharide-linker-carrier molecule conjugates and intermediate compounds obtained or obtainable by these processes.
摘要翻译：本发明提供了用于还原胺化在多糖的还原末端的羰基的方法，其中还原胺化在4-5的pH下进行。本发明还提供了一种方法用于制备多糖和载体分子的缀合物的方法，包括以下步骤：（a）将多糖与接头偶联，以形成其中接头的游离末端是酯基的多糖 - 接头化合物; 和（b）使酯基团与载体分子中的伯胺基团反应以形成多糖 - 接头 - 载体分子偶联物，其中接头通过酰胺键与载体分子偶联。本发明还提供了用于减少多糖 - 连接体化合物与未反应的连接体的污染的方法，其包括在小于5的pH的含水条件下沉淀未反应的连接体的步骤。本发明还提供了多糖 - 连接体 - 载体分子缀合物和中间体通过这些方法获得或可获得的化合物。

8. 发明申请

WO2011080595A3 POLYSACCHARIDE IMMUNOGENS CONJUGATED TO E. COLI CARRIER PROTEINS 审中-公开
标题翻译：多糖免疫调节蛋白与大肠杆菌载体蛋白结合
公开(公告)号：WO2011080595A3
公开(公告)日：2012-07-26
申请号：PCT/IB2010003484
申请日：2010-12-30
申请人： NOVARTIS AG , COSTANTINO PAOLO , SERINO LAURA , ROMANO MARIA ROSARIA , TONTINI MARTA , BERTI FRANCESCO , MICOLI FRANCESCA , KABANOVA ANNA
发明人： COSTANTINO PAOLO , SERINO LAURA , ROMANO MARIA ROSARIA , TONTINI MARTA , BERTI FRANCESCO , MICOLI FRANCESCA , KABANOVA ANNA
IPC分类号： A61K47/48 , A61K39/02
CPC分类号： A61K47/4833 , A61K39/0002 , A61K39/0258 , A61K39/39 , A61K47/646 , A61K2039/6068
摘要： E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sell repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
摘要翻译：已经鉴定出大肠杆菌蛋白质可用作载体蛋白，以改善对与这种蛋白质缀合的多糖免疫原的反应。特别地，已证明AcfD前体蛋白（orf3526多肽），Flu抗原43蛋白（orf1364多肽）和含Sell重复蛋白（upec-5211多肽）是有效的。此外，这些大肠杆菌蛋白质可增强对葡聚糖，特别是葡萄糖葡萄糖的免疫应答。

9. 发明申请

WO2009150543A2 CONJUGATED VI SACCHARIDES 审中-公开
标题翻译：结合六味
公开(公告)号：WO2009150543A2
公开(公告)日：2009-12-17
申请号：PCT/IB2009/006285
申请日：2009-06-12
申请人： NOVARTIS AG , MICOLI, Francesca , COSTANTINO, Paolo , BERTI, Francesco
发明人： MICOLI, Francesca , COSTANTINO, Paolo , BERTI, Francesco
IPC分类号： A61K47/48 , A61P43/00
CPC分类号： C07K14/195 , A61K39/0275 , A61K47/6415 , A61K47/646
摘要： Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM 197 (a non-toxic variant of diphtheria toxin) and tetanus toxoid, as carrier proteins.
摘要翻译：已经通过碳二亚胺介导的合成制备了两种Vi缀合物，其使用衍生化的CRM197（一种白喉毒素的无毒变体）和破伤风类毒素的己二酸二酰肼作为载体蛋白。

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