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1. 发明申请

WO2013038375A2 METHODS FOR MAKING SACCHARIDE-PROTEIN GLYCOCONJUGATES 审中-公开
标题翻译：制备糖化物 - 蛋白质糖苷酶的方法
公开(公告)号：WO2013038375A2
公开(公告)日：2013-03-21
申请号：PCT/IB2012/054805
申请日：2012-09-14
申请人： NOVARTIS AG , SAUL, Allan , MICOLI, Francesca
发明人： SAUL, Allan , MICOLI, Francesca
CPC分类号： C08B37/0006 , A61K39/02 , A61K39/0275 , A61K39/095 , A61K39/385 , A61K47/6415 , A61K47/646 , A61K2039/6037 , C07K14/34 , C07K16/1285 , C07K16/44 , C07K2317/734 , C08B37/0003 , C08B37/006 , C08B37/0063 , C08B37/0081 , Y02A50/482
摘要： The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate of a polysaccharide and a carrier molecule, comprising the steps of: (a) coupling the polysaccharide to a linker, to form a polysaccharide-linker compound in which the free terminus of the linker is an ester group; and (b) reacting the ester group with a primary amine group in the carrier molecule, to form a polysaccharide-linker-carrier molecule conjugate in which the linker is coupled to the carrier molecule via an amide linkage. The invention also provides a process for reducing contamination of a polysaccharide-linker compound with unreacted linker, comprising a step of precipitating unreacted linker under aqueous conditions at a pH of less than 5. The invention also provides polysaccharide-linker-carrier molecule conjugates and intermediate compounds obtained or obtainable by these processes.
摘要翻译：本发明提供了用于还原胺化在多糖的还原末端的羰基的方法，其中还原胺化在4-5的pH下进行。本发明还提供了一种方法用于制备多糖和载体分子的缀合物的方法，包括以下步骤：（a）将多糖与接头偶联，以形成其中接头的游离末端是酯基的多糖 - 接头化合物; 和（b）使酯基团与载体分子中的伯胺基团反应以形成多糖 - 接头 - 载体分子偶联物，其中接头通过酰胺键与载体分子偶联。本发明还提供了用于减少多糖 - 连接体化合物与未反应的连接体的污染的方法，其包括在小于5的pH的含水条件下沉淀未反应的连接体的步骤。本发明还提供了多糖 - 连接体 - 载体分子缀合物和中间体通过这些方法获得或可获得的化合物。

2. 发明申请

WO2011036562A1 PURIFICATION OF BACTERIAL VESICLES 审中-公开
标题翻译：细菌的净化
公开(公告)号：WO2011036562A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/002556
申请日：2010-09-28
申请人： NOVARTIS VACCINES INSTITUTE FOR GLOBAL HEALTH SRL , Dl CIOCCIO, Vito , COLUCCI, Anna Maria , SAUL, Allan
发明人： Dl CIOCCIO, Vito , COLUCCI, Anna Maria , SAUL, Allan
IPC分类号： A61K39/385 , B01D61/14
CPC分类号： A61K39/0283 , A61K9/1277 , A61K39/0275 , A61K39/385 , A61K2039/60 , A61K2039/6018 , B01D61/142 , B01D61/147 , B01D63/02 , B01D2315/10 , B01D2315/16 , B01D2317/025
摘要： A two stage size filtration process is used to purify immunogenic bacterial vesicles. A first step separates the vesicles from intact bacteria based on their different sizes, with the smaller vesicles passing into the filtrate (permeate). A second step then uses a finer filter to remove smaller contaminants, with the vesicles remaining in the retentate. This two stage process is extremely simple to operate but has been shown to give vesicles of high purity.
摘要翻译：使用两阶段大小的过滤方法来纯化免疫原性细菌泡。第一步是根据不同的大小将囊泡与完整的细菌分开，较小的囊泡通过滤液（渗透物）。然后第二步使用更精细的过滤器去除较小的污染物，其中囊泡残留在滞留物中。这两步过程操作非常简单，但已经显示出提供高纯度的囊泡。

3. 发明申请

WO2011036564A2 HYPERBLEBBING SHIGELLA STRAINS 审中-公开
标题翻译： HYPERBLEBBING SHIGELLA菌株
公开(公告)号：WO2011036564A2
公开(公告)日：2011-03-31
申请号：PCT/IB2010/002582
申请日：2010-09-28
申请人： NOVARTIS VACCINES INSTITUTE FOR GLOBAL HEALTH SRL , GERKE, Christiane , BERLANDA SCORZA, Francesco , SAUL, Allan , MAGGIORE, Luana
发明人： GERKE, Christiane , BERLANDA SCORZA, Francesco , SAUL, Allan , MAGGIORE, Luana
IPC分类号： C12N1/20 , C12N1/21 , C07K14/25 , A61K35/74 , A61K39/02 , C12N9/12
CPC分类号： C12N1/20 , A61K39/00 , A61K2035/122 , C07K14/25 , Y02A50/476
摘要： Hyperblebbing Shigella strains are generated by disrupting one or more components of the Tol-Pal system. The blebs from these strains are useful immunogens for vaccination. The individual proteins found in these blebs can also be used as immunogens.
摘要翻译：通过破坏Tol-Pal系统的一种或多种组分产生超级结合志贺氏菌菌株。来自这些菌株的泡是有用的免疫原用于疫苗接种。在这些泡中发现的单个蛋白质也可以用作免疫原。

4. 发明申请

WO2012049662A1 HYPERBLEBBING SALMONELLA STRAINS 审中-公开
标题翻译：超轻度沙门氏菌菌株
公开(公告)号：WO2012049662A1
公开(公告)日：2012-04-19
申请号：PCT/IB2011/054569
申请日：2011-10-14
申请人： NOVARTIS VACCINES INSTITUTE FOR GLOBAL HEALTH SRL , MARTIN, Laura , SAUL, Allan , GERKE, Christiane , SA SILVA, Sara
发明人： MARTIN, Laura , SAUL, Allan , GERKE, Christiane , SA SILVA, Sara
IPC分类号： C12N1/20 , C07K14/255
CPC分类号： C07K14/255 , A61K39/0275 , A61K2039/522 , A61K2039/543 , C12P1/04 , Y02A50/482 , Y02A50/484
摘要： Hyperblebbing Salmonella strains are generated by disrupting one or more components of the Tol-Pal system, such as TolR. The blebs from these strains are useful immunogens for vaccination. The individual proteins found in these blebs can also be used as immunogens.
摘要翻译：超嗜性沙门菌属菌株是通过破坏Tol-Pal系统的一种或多种组分，如TolR产生的。这些菌株的泡沫是免疫接种的有用免疫原。这些泡中发现的各种蛋白质也可以用作免疫原。

5. 发明申请

WO2006124712A2 A METHOD FOR IMPROVING THE IMMUNOGENICITY OF PLASMODIUM ANTIGENS 审中-公开
标题翻译：一种改善PLASMODIUM抗原免疫原性的方法
公开(公告)号：WO2006124712A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/018615
申请日：2006-05-15
申请人： MERCK & CO., INC. , NATIONAL INSTITUTES OF HEALTH , SHAW, Alan , PRZYSIECKI, Craig, T. , FLANAGAN, Elizabeth , IONESCU, Roxana , SHI, Li , WU, Yimin , SAUL, Allan , MILLER, Louis
发明人： SHAW, Alan , PRZYSIECKI, Craig, T. , FLANAGAN, Elizabeth , IONESCU, Roxana , SHI, Li , WU, Yimin , SAUL, Allan , MILLER, Louis
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/6031 , A61K2039/6037 , Y02A50/412
摘要： The present invention provides a Malaria antigen-carrier conjugate, which comprises a carrier protein and a plurality of Plasmodium antigen polypeptides. Each of the antigen polypeptides is a wild-type antigen protein of Plasmodium or a derivative of the wild-type antigen protein, and each of the antigen polypeptides may be the same, or different. The plurality of Plasmodium antigen polypeptides are covalently linked to the carrier protein. The present invention further provides a vaccine against malaria, which comprises the conjugate absorbed on an aluminum adjuvant.
摘要翻译：本发明提供了一种疟疾抗原 - 载体缀合物，其包含载体蛋白和多个疟原虫抗原多肽。抗原多肽中的每一种都是疟原虫的野生型抗原蛋白或野生型抗原蛋白的衍生物，各抗原多肽可以相同也可以不同。多个疟原虫抗原多肽与载体蛋白共价连接。本发明还提供了一种抗疟疾疫苗，其包含在铝佐剂上吸收的缀合物。

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