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1. 发明申请

WO2004017040A2 MULTI-DIMENSIONAL CHROMATOGRAPHY SYSTEM FOR PROTEOMICS 审中-公开
标题翻译：用于保护的多维色谱系统
公开(公告)号：WO2004017040A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025367
申请日：2003-08-13
申请人： GENEPROT, INC. , BAUSSANT, Thierry , BOEHM, Guenter , HELLER, Manfred , KUSSMANN, Martin , MENIN, Laure , ROGERS, John , ROSE, Keith
发明人： BAUSSANT, Thierry , BOEHM, Guenter , HELLER, Manfred , KUSSMANN, Martin , MENIN, Laure , ROGERS, John , ROSE, Keith
IPC分类号： G01N
CPC分类号： G01N30/463 , G01N30/02 , G01N2030/8813 , G01N2030/884 , B01D15/3804
摘要： The present invention relates generally to methods and compositions for identifying biomolecules present in a biological sample. More specifically, the present invention relates to mass spectrometry-based methods and compositions for identifying proteins present in a body fluid.
摘要翻译：本发明一般涉及用于鉴定存在于生物样品中的生物分子的方法和组合物。更具体地，本发明涉及用于鉴定体液中存在的蛋白质的基于质谱法的方法和组合物。

2. 发明申请

WO2007066179A3 PEPTIDES FOR ANTAGONISATION OF ANTICOAGULANTS AND USES THEREOF 审中-公开
标题翻译：抗凝剂拮抗剂的用途及其用途
公开(公告)号：WO2007066179A3
公开(公告)日：2007-10-04
申请号：PCT/IB2006003018
申请日：2006-10-26
申请人： PENTAPHARM AG , PERCHUC ANNA , HEIDL MARC , BUEHLER BEATRICE , SCHOENI RETO , WILMER MARIANNE , STOECKLIN RETO , MENIN LAURE
发明人： PERCHUC ANNA , HEIDL MARC , BUEHLER BEATRICE , SCHOENI RETO , WILMER MARIANNE , STOECKLIN RETO , MENIN LAURE
IPC分类号： A61K38/10 , A61K38/46
CPC分类号： A61K38/465 , C07K7/08 , C07K14/46 , C12Y301/01004
摘要： The present invention relates to peptides and compositions, in particular pharmaceutical compositions, in particular those of the general formula (I) R 1 -(B 1 ) m -(B 2 ) n -Tyr-(B 3a ) o -(B 3b ) p -Asn q -Asn r -Tyr s -Leu t -B 4 -(Pro) u -Phe-Abu-B 5 -(B 6 ) v -R 2 (I) wherein R 1 represents hydrogen or (C 1 -C 8 )-acyl, R 2 represents OH, O-(C 1 -C 8 )-alkyl, NH 2 or Ala-Asp-Pro-OH, B 1 to B 6 represent, independent of one another, a basic amino acid, such as arginine, homoarginine, lysine, ornithine, 2,4-diaminobutyric acid or 2,3-diaminopropionic acid, m,n,o,p,q,r,s,t,u,v represent, independent of one another, zero or 1, and their salts as well as pharmaceutical compositions characterized by containing a myotoxic phospholipase A2 (PLA 2 ) or an other snake venom containing the common peptide sequence KKYKNNYLKPFCKK. The peptides and the pharmaceutical compositions can be used for the antagonisation of heparins and heparin-based anticoagulants. Reagent kits for in vitro analysis of blood or blood components are also described.
摘要翻译：本发明涉及肽和组合物，特别是药物组合物，特别是通式（I）中的肽 - （B 1） / SUB> - （B ^{2 ）_{名词 -Tyr-（B ^{图3a ）_{0 - （B ^{图3b ）_{p -Asn _{q -Asn _{- [R -Tyr _{取值 -Leu _{吨 -B ^{4 - （Pro）的_{û -Phe-阿布-B ^{5 - （B ⁶}}}}}}}}}}}}}

3. 发明申请

WO0206324A3 ANTIFUNGAL AND/OR ANTIBACTERIAL PEPTIDES, PREPARATION METHODS AND COMPOSITION CONTAINING SAME 审中-公开
标题翻译：抗真菌和/或抗细菌肽，制备方法和含有相同成分的组合物
公开(公告)号：WO0206324A3
公开(公告)日：2002-05-23
申请号：PCT/FR0102164
申请日：2001-07-05
申请人： ENTOMED S A , DIMARCQ JEAN LUC , LEGRAIN MICHELE , MENIN LAURE
发明人： DIMARCQ JEAN-LUC , LEGRAIN MICHELE , MENIN LAURE
IPC分类号： C12N15/09 , A01N37/46 , A01N63/02 , A61K38/00 , A61P31/00 , A61P31/04 , A61P31/10 , C07K14/435 , C12N5/10 , C12N15/12 , A61K38/17 , C12N15/82
CPC分类号： C07K14/43563 , A01N37/46 , A01N63/02 , A61K38/00
摘要： The invention concerns peptides derived from heliomicine by substitution of one or several amino acids, characterised in that said peptides correspond to formula (I): X1, X2, X3, X4, X5, X6, C7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, C18, X19, X20, X21, C22 X23, X24, X25, X26, X27, X28, X29, X30, X31, X32, X33, X34, X35, X36, X37, X38, X39, C40, X41, C42, X43, X44 wherein: X1, X17, X21 X43 are amino acids; X16, X44 are small polar amino acids; X19 is a large polar amino acid; X36 is a small or lightly hydrophobic amino acid; X38 is a lightly hydrophobic or small amino acid; said substitutions being such that: at least one of X1, X17, X21, X43 is a basic or polar, advantageously large polar amino acid, and/or at least one of the amino acids X16, X44 is a basic amino acid or a large polar amino acid, and/or X19 is a basic amino acid, and/or at least one of the amino acids X36, X38 is a strongly hydrophobic amino acid. The invention also concerns antifungal and/or antibacterial compositions comprising at least one of said peptides.
摘要翻译：本发明涉及通过取代一个或几个氨基酸衍生自heliomicine的肽，其特征在于所述肽对应于式（I）：X1，X2，X3，X4，X5，X6，C7，X8，X9，X10，X11， X12，X13，X14，X15，X16，X17，C18，X19，X20，X21，C22 X23，X24，X25，X26，X26，X27，X28，X29，X30，X31，X32，X33，，X38，X39，C40，X41，C42，X43，X44，其中：X1，X17，X21，X43是氨基酸; X16，X44是小极性氨基酸; X19是一种大型极性氨基酸; X36是一种小的或轻度疏水的氨基酸; X38是轻度疏水或小氨基酸; 所述取代是这样的：X1，X17，X21，X43中的至少一个是碱性或极性的，有利的是大的极性氨基酸，和/或至少一个氨基酸X16，X44是碱性氨基酸或大的和/或X19是碱性氨基酸，和/或至少一个氨基酸X36，X38是强疏水性氨基酸。本发明还涉及包含至少一种所述肽的抗真菌和/或抗菌组合物。

4. 发明申请

WO2004017040A3 MULTI-DIMENSIONAL CHROMATOGRAPHY SYSTEM FOR PROTEOMICS 审中-公开
标题翻译：用于保护的多维色谱系统
公开(公告)号：WO2004017040A3
公开(公告)日：2004-10-21
申请号：PCT/US0325367
申请日：2003-08-13
申请人： GENEPROT INC , BAUSSANT THIERRY , BOEHM GUENTER , HELLER MANFRED , KUSSMANN MARTIN , MENIN LAURE , ROGERS JOHN , ROSE KEITH
发明人： BAUSSANT THIERRY , BOEHM GUENTER , HELLER MANFRED , KUSSMANN MARTIN , MENIN LAURE , ROGERS JOHN , ROSE KEITH
IPC分类号： G01N30/02 , G01N30/46 , G01N30/88 , G01N24/00 , G01N33/00 , G01N33/566
CPC分类号： G01N30/463 , G01N30/02 , G01N2030/8813 , G01N2030/884 , B01D15/3804
摘要： The present invention relates to multidimensional chromatography systems for proteomics and methods for identifying lower-abundance proteins in body fluids. Abundant proteins(s) is first removed by affinity chromatography utilizing affinity chromatographic column functionalized with ligand capable of selectively binding the abundant protein in the sample. Multidimensional chromatographic techniques are applied to the eluent with a reduced content of the abundant protein followed by mass spectrometric analysis.
摘要翻译：本发明涉及用于蛋白质组学的多维色谱系统和用于鉴定体液中低丰度蛋白质的方法。首先通过亲和层析法利用利用能够选择性结合样品中丰富蛋白质的配体官能化的亲和色谱柱来除去丰富的蛋白质。将多维色谱技术应用于具有降低的丰富蛋白质含量的洗脱液，然后进行质谱分析。

5. 发明申请

WO2007066179A2 COMPOUNDS FOR ANTAGONISATION OF ANTICOAGULANTS AND USES THEREOF 审中-公开
标题翻译：化合物用于抗凝剂及其用途
公开(公告)号：WO2007066179A2
公开(公告)日：2007-06-14
申请号：PCT/IB2006/003018
申请日：2006-10-26
申请人： PENTAPHARM AG , PERCHUC, Anna , HEIDL, Marc , BÜHLER, Beatrice , SCHÖNI, Reto , WILMER, Marianne , STÖCKLIN, Reto , MENIN, Laure
发明人： PERCHUC, Anna , HEIDL, Marc , BÜHLER, Beatrice , SCHÖNI, Reto , WILMER, Marianne , STÖCKLIN, Reto , MENIN, Laure
CPC分类号： A61K38/465 , C07K7/08 , C07K14/46 , C12Y301/01004
摘要： The present invention relates to peptides and compositions, in particular pharmaceutical compositions, in particular those of the general formula (I) R 1 -(B 1 ) m -(B 2 ) n -Tyr-(B 3a ) o -(B 3b ) p -Asn q -Asn r -Tyr s -Leu t -B 4 -(Pro) u -Phe-Abu-B 5 -(B 6 )v-R 2 (I) wherein R 1 represents hydrogen or (C 1 -C 8 )-acyl, R 2 represents OH, O-(C 1 -C 8 )-alkyl, NH 2 or Ala-Asp-Pro-OH, B 1 to B 6 represent, independent of one another, a basic amino acid, such as arginine, homoarginine, lysine, ornithine, 2,4-diaminobutyric acid or 2,3-diaminopropionic acid, m,n,o,p,q,r,s,t,u,v represent, independent of one another, zero or 1 , and their salts as well as pharmaceutical compositions characterized by containing a myotoxic phospholipase A2 (PLA 2 ) or an other snake venom containing the common peptide sequence KKYKNNYLKPFCKK. The peptides and the pharmaceutical compositions can be used for the antagonisation of heparins and heparin-based anticoagulants. Reagent kits for in vitro analysis of blood or blood components are also described.
摘要翻译：本发明涉及肽和组合物，特别是药物组合物，特别是通式（I）R 1 - （B 1） / SUB> - （B ^{2 ）_{名词 -Tyr-（B ^{图3a ）_{0 - （B ^{图3b ）_{p -Asn _{q -Asn _{- [R -Tyr _{取值 -Leu _{吨 -B ^{4 - （Pro）的_{û -Phe-阿布-B ^{5 - （B ⁶}}}}}}}}}}}}}

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