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1. 发明申请

WO2004017040A3 MULTI-DIMENSIONAL CHROMATOGRAPHY SYSTEM FOR PROTEOMICS 审中-公开
标题翻译：用于保护的多维色谱系统
公开(公告)号：WO2004017040A3
公开(公告)日：2004-10-21
申请号：PCT/US0325367
申请日：2003-08-13
申请人： GENEPROT INC , BAUSSANT THIERRY , BOEHM GUENTER , HELLER MANFRED , KUSSMANN MARTIN , MENIN LAURE , ROGERS JOHN , ROSE KEITH
发明人： BAUSSANT THIERRY , BOEHM GUENTER , HELLER MANFRED , KUSSMANN MARTIN , MENIN LAURE , ROGERS JOHN , ROSE KEITH
IPC分类号： G01N30/02 , G01N30/46 , G01N30/88 , G01N24/00 , G01N33/00 , G01N33/566
CPC分类号： G01N30/463 , G01N30/02 , G01N2030/8813 , G01N2030/884 , B01D15/3804
摘要： The present invention relates to multidimensional chromatography systems for proteomics and methods for identifying lower-abundance proteins in body fluids. Abundant proteins(s) is first removed by affinity chromatography utilizing affinity chromatographic column functionalized with ligand capable of selectively binding the abundant protein in the sample. Multidimensional chromatographic techniques are applied to the eluent with a reduced content of the abundant protein followed by mass spectrometric analysis.
摘要翻译：本发明涉及用于蛋白质组学的多维色谱系统和用于鉴定体液中低丰度蛋白质的方法。首先通过亲和层析法利用利用能够选择性结合样品中丰富蛋白质的配体官能化的亲和色谱柱来除去丰富的蛋白质。将多维色谱技术应用于具有降低的丰富蛋白质含量的洗脱液，然后进行质谱分析。

2. 发明申请

WO2004055176A3 TRANS-SIALIDASES OBTAINED FROM TRYPANOSOMA CONGOLENSE 审中-公开
标题翻译： TRANS -sialidases OFF刚果锥虫
公开(公告)号：WO2004055176A3
公开(公告)日：2005-05-26
申请号：PCT/EP0314079
申请日：2003-12-11
申请人： NUTRICIA NV , SCHMITT JOACHIM , BOEHM GUENTER , STAHL BERND , SCHAUER ROLAND , TIRALONGO EVELIN , SCHRADER SILKE
发明人： SCHMITT JOACHIM , BOEHM GUENTER , STAHL BERND , SCHAUER ROLAND , TIRALONGO EVELIN , SCHRADER SILKE
IPC分类号： C12N9/10 , A61K35/00 , C12N5/00
CPC分类号： C12N9/1081
摘要： The invention relates to novel enzymes, which transfer sialic acid from a donor molecule onto an acceptor molecule (trans-sialidases). The enzymes are isolated from the protozoan Trypanosoma congolense. The invention also relates to functional equivalents of said enzymes, to the nucleic acid sequences and amino acid sequences that code for the enzymes and their functional equivalents, to expression constructs and vectors that contain said sequences, to recombinant microorganisms that carry the inventive coding nucleic-acid sequences, to a method for the recombinant production of the inventive enzymes, to a method for isolating said enzyme from Trypanosoma congolense, to a method for the enzymatic sialization of acceptor molecules using the inventive enzymes, to effectors of the inventive trans-sialidases, to the use of the nucleic acid sequences, amino acid sequences, enzymes, effectors or sialization products for producing vaccines, medicaments, foodstuffs or food additives, in addition to the latter products obtained by the inventive method.
摘要翻译：本发明涉及的是从供体分子转移唾液酸到受体分子（反式唾液酸酶）新的酶。将酶从原生动物刚果锥虫隔离。本发明还涉及到这些酶的功能等价物; 需要这些酶和它们的功能等价物的编码核酸序列和氨基酸序列，表达构建体和含有这些序列的载体; 携带了本发明的核酸序列编码的重组微生物; 一种用于重组生产本发明的酶的方法; 一种用于根据来自刚果锥虫本发明的酶的分离方法; 过程用于使用根据本发明的酶受体的酶活sialization; 根据本发明的反式唾液酸酶效应; 根据本发明的核酸序列，氨基酸序列，酶，效应或sialization用于生产疫苗，药物，食品或食品补充剂的使用; 并根据自身生产的本发明的装置。

3. 发明申请

WO2004017040A2 MULTI-DIMENSIONAL CHROMATOGRAPHY SYSTEM FOR PROTEOMICS 审中-公开
标题翻译：用于保护的多维色谱系统
公开(公告)号：WO2004017040A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025367
申请日：2003-08-13
申请人： GENEPROT, INC. , BAUSSANT, Thierry , BOEHM, Guenter , HELLER, Manfred , KUSSMANN, Martin , MENIN, Laure , ROGERS, John , ROSE, Keith
发明人： BAUSSANT, Thierry , BOEHM, Guenter , HELLER, Manfred , KUSSMANN, Martin , MENIN, Laure , ROGERS, John , ROSE, Keith
IPC分类号： G01N
CPC分类号： G01N30/463 , G01N30/02 , G01N2030/8813 , G01N2030/884 , B01D15/3804
摘要： The present invention relates generally to methods and compositions for identifying biomolecules present in a biological sample. More specifically, the present invention relates to mass spectrometry-based methods and compositions for identifying proteins present in a body fluid.
摘要翻译：本发明一般涉及用于鉴定存在于生物样品中的生物分子的方法和组合物。更具体地，本发明涉及用于鉴定体液中存在的蛋白质的基于质谱法的方法和组合物。

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