基本信息:
- 专利标题： MAGNETIC MICROGEL BEADS, METHODS OF MAKING AND USES THEREOF
- 申请号：PCT/CA2022/051679 申请日：2022-11-14
- 公开(公告)号：WO2023082021A1 公开(公告)日：2023-05-19
- 发明人： SOLEYMANI, Leyla , HOARE, Todd , LI, Yingfu , LU, Yang , PANDEY, Richa
- 申请人： MCMASTER UNIVERSITY
- 申请人地址： 1280 Main Street West
- 专利权人： MCMASTER UNIVERSITY
- 当前专利权人： MCMASTER UNIVERSITY
- 当前专利权人地址： 1280 Main Street West
- 代理机构： MCMANUS, Kimberly A. et al.
- 优先权： US63/279,417 2021-11-15
- 主分类号： G01N33/553
- IPC分类号： G01N33/553 ; C12Q1/68 ; G01N33/531 ; G01N21/66 ; G01N21/76 ; G01N27/416
摘要：
This disclosure relates to magnetic microgel beads, and in particular to magnetic microgel beads for biofunctionalization and methods of making and uses thereof, for example, in biosensing assays. In an embodiment, a magnetic microparticle comprising a magnetic nanoparticle encapsulated by a polymer hydrogel. In another embodiment, an assay for detecting the presence of a target analyte in a sample comprising a) the magnetic microparticle disclosed herein, wherein the biorecognition agent further comprises a reporter moiety; b) an electrochemical chip comprising a working electrode, a counter electrode and a reference electrode; and c) a capture probe functionalized on the working electrode; wherein binding of the biorecognition agent to the target analyte results in production of an electrochemical, electroluminescent or photoelectrochemical signal.
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N33/00 | 利用不包括在G01N1/00至G01N31/00组中的特殊方法来研究或分析材料 |
| --------G01N33/48 | .生物物质，例如血、尿（G01N33/02至G01N33/14，G01N33/26，G01N33/44，G01N33/46优先；种子发芽能力测定入A01C1/02）；血球计数器 |
| ----------G01N33/483 | ..生物物质的物理分析 |
| ------------G01N33/53 | ...免疫测定法；生物特有的结合方法的测定；相应的生物物质 |
| --------------G01N33/531 | ....免疫化学试验物质的制备 |
| ----------------G01N33/544 | .....载体为有机物 |
| ------------------G01N33/553 | ......金属或被包敷的金属 |