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    • 2. 发明申请
    • SYNTHESIS OF EPIRUBICIN FROM 13-DIHYDRODAUNORUBICINE
    • 来自13-二氢异喹啉的EPIRUBICIN的合成
    • WO2007076345A2
    • 2007-07-05
    • PCT/US2006062286
    • 2006-12-19
    • SOLUX CORPZABUDKIN ALEXANDERMATVIENKO VICTORMATVEEV ALEXEYITKIN ALEKSANDR
    • ZABUDKIN ALEXANDERMATVIENKO VICTORMATVEEV ALEXEYITKIN ALEKSANDR
    • A61K31/704C07H15/24
    • C07H1/00C07H15/24C07H15/252
    • A method of preparing an anthracyclin such as epirubicin from a starting material comprising 13-dihydrodaunorubicine (13-daunorubicinol). The method comprises producing N-Trifluoroacetyl-13-daunorubicinol from 13-daunorubicinol by acylation. The N-Trifluoroacetyl-13-daunorubicinol is reacted with an aprotic solvent and an acylating agent to produce an intermediate sulfoxy salt which is treated with a strong base to produce 4'-keto-N-Trifluoroacetyldaunorubicin. The 4'-keto-N-Trifluoroacetyldaunorubicin is reacted with a reducing agent, such as borohydride of an alkaline metal, to produce N-Trifluoroacetyl-4'-epi-daunorubicin. The N-Trifluoroacetyl-4`-epi-daunorubicin is hydrolyzed in a basic solution to produce an intermediate compound. The intermediate compound is reacted with a halogenizing agent to produce a 14-Hal-derivative. The 14-Hal derivative is hydrolized in the presence of a formate of an alkaline metal to produce the desired final compound.
    • 从包含13-二氢阿柔比星(13-柔红霉素)的原料制备蒽环类似表柔比星的方法。 该方法包括通过酰化由13-柔红霉素生产N-三氟乙酰基-13-柔红霉素。 将N-三氟乙酰基-13-柔红霉素与非质子传递溶剂和酰化剂反应,生成中间体磺酰氧基盐,用强碱处理产生4'-酮 - 三氟乙酰基柔红霉素。 4'-酮-N-三氟乙酰基柔红霉素与还原剂如碱金属的硼氢化物反应,生成N-三氟乙酰基-4'-表柔比星。 将N-三氟乙酰基-4'-表柔比星在碱性溶液中水解以产生中间体化合物。 使中间体化合物与卤化剂反应生成14-Hal衍生物。 将14-Hal衍生物在碱金属甲酸盐存在下水解,得到所需的最终化合物。
    • 7. 发明申请
    • HIGH TORQUE DENSITY ELECTRICAL MACHINE
    • 高扭矩密度电机
    • WO2013022351A1
    • 2013-02-14
    • PCT/NO2012/050137
    • 2012-07-13
    • SMARTMOTOR ASMATVEEV, Alexey
    • MATVEEV, Alexey
    • H02K16/04
    • H02K16/00
    • Electrical machine (11) including at least three stator packets(12a-e) arranged to a common stator carrying structure and at least three rotor packets(14a-d) arranged to a common rotor carrying structure), where each of the rotor packets (14a-d) are electromagnetically interacting with at least one of the stator packets(12a-e),where: -either an inner rotor carrying structure (15) and rotor packets (14a-d) are rotating between an outer stator carrying structure (18a- b) and the stator packets(12a-e), and where at least one of the stator packets(12b-e)is arranged on each side of the rotor carrying structure (15), in axial direction,and where one of the stator packets (12a) is arranged at the periphery,in radial direction,of the electrical machine (11), -or an inner stator carrying structure (18) and stator packets (12a- e) are surrounded by a rotating outer rotor carrying structure (15a-b) and rotor packets(14a-d), where at least one of the rotor packets (14a-d) is arranged on each side of the rotor carrying structure (15a- b), in axial direction,and one of the rotor packets (14a-d) is arranged at the periphery, in radial direction, of the electrical machine (11).
    • 电机(11)包括布置在公共定子承载结构上的至少三个定子包(12a-e)和至少三个设置在公共转子承载结构上的转子包(14a-d)),其中每个转子包 14a-d)与至少一个定子包(12a-e)电磁相互作用,其中:内转子承载结构(15)和转子包(14a-d)都在外定子承载结构 18a-b)和定子包(12a-e),并且其中至少一个定子包(12b-e)在轴向方向上布置在转子承载结构(15)的每一侧上,并且其中 定子包(12a)布置在电机(11)的径向周边,或者内定子承载结构(18)和定子包(12a- e)被转动的外转子 结构(15a-b)和转子包(14a-d),其中至少一个转子包(14a-d)布置在每一侧 的转子承载结构(15a-b),并且其中一个转子包(14a-d)布置在电机(11)的径向周边。