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1. 发明申请

WO2014118542A1 CONTAINER FOR TRANSPORTING A BIOLOGICAL SAMPLE, KIT THEREWITH AND BLANK 审中-公开
标题翻译：用于运输生物样品的容器，套件和空白
公开(公告)号：WO2014118542A1
公开(公告)日：2014-08-07
申请号：PCT/GB2014/050248
申请日：2014-01-30
申请人： MAST GROUP LIMITED
发明人： MCELARNEY, Iain
IPC分类号： B65D5/50 , B65D5/54 , B65D5/70 , B65D81/113 , B65D81/26
CPC分类号： B65D5/5054 , B01L3/5055 , B01L9/06 , B01L2200/185 , B01L2300/043 , B01L2300/069 , B65D5/509 , B65D5/5475 , B65D5/70 , B65D81/113 , B65D81/264
摘要： A fluid impermeable container (10) for transporting a biological sample, the container (10) comprising folded sheet material having a fluid impermeable first layer and a rigid second layer, the folded sheet material defining a base (12), enclosing side walls (14, 16, 18a, 18b), an upper wall (20), and a container closing member (22), the upper wall (20) being configured to define an opening to a recess (24) for receiving a receptacle containing a biological sample to be transported, in which the recess (24) is sealingly enclosed by the container closing member (22) when the container (10) is in a closed configuration.
摘要翻译：用于输送生物样品的流体不可渗透容器（10），所述容器（10）包括具有流体不可渗透的第一层和刚性第二层的折叠片材，所述折叠片材限定基部（12），封闭侧壁，16，18a，18b），上壁（20）和容器封闭构件（22），所述上壁（20）构造成限定到凹部（24）的开口，用于容纳包含生物样品待运输时，当容器（10）处于关闭状态时，凹部24被容器封闭件22密封地封闭。

2. 发明申请

WO2019016562A1 APPARATUS FOR CONDUCTING AN ASSAY 审中-公开
公开(公告)号：WO2019016562A1
公开(公告)日：2019-01-24
申请号：PCT/GB2018/052054
申请日：2018-07-20
申请人： MAST GROUP LIMITED
发明人： WONG, Kenneth , WILLIAMS, David
IPC分类号： G01N35/00 , G01N27/74 , G01N21/07 , B01L3/00
摘要： The present invention provides an apparatus for conducting an assay in a microfluidic system comprising magnetic beads, said apparatus comprising: a platform upon which a microfluidic system can be mounted, one or more actuators having a magnet, configured to directly influence movement of magnetic beads housed within a microfluidic system when a microfluidic system is mounted on said platform, and a control means configured to control relative movement of the one or more magnets, and a microfluidic system when mounted, to enable the magnet to trace a desired path across a mounted microfluidic system, said magnet being positionable at any x- and y-coordinates of a mounted microfluidic system, wherein said apparatus further comprises: a) at least one rotary actuator configured to enable magnet movement in an x-axis, and/or b) a means for moving a mounted microfluidic system in a stepwise fashion.

3. 发明申请

WO2017098206A1 EXTRACTION DISC 审中-公开
标题翻译：提取光盘
公开(公告)号：WO2017098206A1
公开(公告)日：2017-06-15
申请号：PCT/GB2016/053732
申请日：2016-11-28
申请人： MAST GROUP LIMITED
发明人： BLUNDELL, Jamie , HOBSON, Jonathan Anthony
IPC分类号： C12Q1/04 , C12Q1/18 , C12Q1/34
CPC分类号： C12Q1/04 , C12Q1/18 , C12Q1/34
摘要： The present invention relates to a method for determining whether a microorganism produces a carbapenem or penem hydrolysing p-Iactamase, comprising: providing a reagent composition comprising a p-Iactam containing antibiotic, an extended-spectrum p-lactamase inhibitor and/or an AmpC inhibitor to which the carbapenem or penem hydrolysing p-lactamase is resistant, and a membrane permeabilizing agent which is ethylene glycol tetraacetic acid (EGTA) that permeabilizes the microorganism's outer membrane; contacting the microorganism suspected of producing a P-lactamase with the reagent composition; and culturing the microorganism with the reagent composition in a culture medium comprising a reporter microorganism wherein a positive test is determined by an increase in the growth of the reporter microorganism. The present invention also relates to an enzyme assay system and a kit for use in such a method.
摘要翻译：本发明涉及确定微生物是否产生碳青霉烯或青霉烯水解β-内酰胺酶的方法，包括：提供试剂组合物，所述试剂组合物包含含有抗生素的β-内酰胺， β-内酰胺酶抑制剂和/或其中碳青霉烯或青霉烯水解β-内酰胺酶耐受的AmpC抑制剂以及透膜化乙二醇四乙酸（EGTA）的膜透化剂，所述透膜剂使所述微生物的外膜透化; 使怀疑产生β-内酰胺酶的微生物与试剂组合物接触; 以及在含有报道微生物的培养基中用试剂组合物培养微生物，其中通过报道微生物生长的增加来确定阳性测试。本发明还涉及用于这种方法的酶测定系统和试剂盒。

4. 发明申请

WO2019030519A1 DETECTION OF CARBAPENEMASE-PRODUCING ENTEROBACTERIALES, PSEUDOMONAS AND ACINETOBACTER SPECIES USING A CHROMOGEN 审中-公开
公开(公告)号：WO2019030519A1
公开(公告)日：2019-02-14
申请号：PCT/GB2018/052255
申请日：2018-08-07
申请人： MAST GROUP LIMITED
发明人： HOBSON, Jonathan Anthony , COLEBORN, Matilda May , DAVIES, Mya , ANYAKWO, Andrew Chuka
IPC分类号： C12Q1/04 , C12Q1/10 , C12Q1/25 , C12Q1/34
摘要： The present application relates to a method for detecting the presence of carbapenemase- producing Enterobacteriales, Pseudomonas and Ancinetobacter in a sample, comprising; providing a sample suspected of having carbapenemase-producing Enterobacteriales, Pseudomonas or Acinetobacter ; reacting the sample with a solution of (7R)-7-[(z)-2-(2- aminothiazol-4-yl)-(Z)-2(methoxyimino)acetamide]-3-(2,4-dinitrostyryl)-3-cephem-4 carboxylic acid) or a salt thereof, and detecting a color change in the reaction medium when carbapenemase-producing Enterobacteriales, Pseudomonas or Acinetobacter are present in the test sample.

5. 发明申请

WO2017089823A1 CARBAPENEMASE DETECTION METHOD 审中-公开
标题翻译：卡巴霉素检测方法
公开(公告)号：WO2017089823A1
公开(公告)日：2017-06-01
申请号：PCT/GB2016/053716
申请日：2016-11-25
申请人： MAST GROUP LIMITED
发明人： WILSON, Michelle
IPC分类号： C12Q1/04
CPC分类号： C12Q1/34 , C12Q1/04 , G01N2333/22 , G01N2333/32 , G01N2333/986
摘要： The present invention provides a method for detecting the presence of carbapenemase-producing bacteria in a sample, comprising: providing a sample suspected of having carbapenemase-producing bacteria; and reacting the sample with a reagent kit comprising: a) a carbapenemase substrate which is a penem; b) a pH color indicator which will change color when the pH of the reaction mixture is from 5.2 to 8.0, wherein a color change in the reaction medium indicates the presence of carbapenemase-producing bacteria in the test sample.
摘要翻译：本发明提供了检测样品中产生碳青霉烯酶的细菌的方法，包括：提供怀疑具有产生碳青霉烯酶的细菌的样品; 并使样品与试剂盒反应，所述试剂盒包含：a）青霉烯类碳青霉烯酶底物; b）pH颜色指示剂，当反应混合物的pH为5.2-8.0时，其会改变颜色，其中反应介质中的颜色变化表明测试样品中存在产生碳青霉烯酶的细菌。

6. 发明申请

WO2015063498A2 NUCLEIC ACID PROBE 审中-公开
标题翻译：核酸探针
公开(公告)号：WO2015063498A2
公开(公告)日：2015-05-07
申请号：PCT/GB2014/053238
申请日：2014-10-30
申请人： MAST GROUP LIMITED
发明人： SUWARA, Monika Iwona , JAVED, Sajid , GILLIES, Elizabeth Ann
CPC分类号： C12Q1/6825 , C12Q1/6816 , C12Q1/6844 , C12Q1/689 , C12Q2531/101 , C12Q2531/119 , C12Q2563/107 , C12Q2565/107 , C12Q2600/16
摘要： The present invention provides novel probes for use in LAMP detection methods. The probes are particularly useful in the detection of chlamydia and gonorrhea infections in a patient.
摘要翻译：本发明提供了用于LAMP检测方法的新型探针。探针在患者中检测衣原体和淋病感染中特别有用。

7. 发明申请

WO2006109005A1 DISPENSING DEVICE 审中-公开
标题翻译：分配设备
公开(公告)号：WO2006109005A1
公开(公告)日：2006-10-19
申请号：PCT/GB2005/001382
申请日：2005-04-09
申请人： MAST GROUP LIMITED , LOYNES, Clive
发明人： LOYNES, Clive
IPC分类号： C12M1/20
CPC分类号： C12M99/00
摘要： A dispensing device (10) for dispensing discrete items, such as antibiotic sensitivity discs, the device having an actuator (12) and a body (14) movable between a dispensing configuration and a non-dispensing configuration. The device is capable of carrying a plurality of magazines, each of which houses a plurality of discrete items.
摘要翻译：一种用于分配离散物品（例如抗生素敏感性盘）的分配装置（10），该装置具有致动器（12）和可在分配配置和非分配配置之间移动的主体（14）。该装置能够携带多个杂志，每个杂志容纳多个离散的物品。

8. 发明申请

WO2017085472A1 APPARATUS FOR CONDUCTING AN ASSAY 审中-公开
标题翻译：用于进行测定的装置
公开(公告)号：WO2017085472A1
公开(公告)日：2017-05-26
申请号：PCT/GB2016/053568
申请日：2016-11-15
申请人： MAST GROUP LIMITED
发明人： WILLIAMS, David , ROSE, Howard , WONG, Ken
IPC分类号： B01L9/00 , B01L7/00
CPC分类号： B01L7/52 , B01L9/527 , B01L2200/025 , B01L2300/023 , B01L2300/0806 , B01L2300/1811 , B01L2300/1827 , B01L2300/1844
摘要： The present invention discloses an apparatus for conducting an assay, wherein the apparatus comprises a turntable (1) for receiving an assay disc (100) and to control an assay on said assay disc by rotational movement of said turntable, wherein said turntable comprises: one or more heater modules (4) to apply heat to one or more specific parts of said assay disc during rotation; a heater controller (54) to select a required heater and to control the temperature thereof, and an IR transceiver (30, 55) to allow instructions and/or heating parameters to be transferred to the heater controller wirelessly. More specifically, the present invention discloses, an apparatus for conducting an assay, wherein the heating location and rate of heating/cooling at a particular location on the assay disc may be controlled.
摘要翻译：本发明公开了一种用于进行测定的装置，其中所述装置包括用于接收测定盘（100）并通过所述测定盘（100）的旋转运动来控制所述测定盘上的测定的转盘（1）其中所述转盘包括：一个或多个加热器模块（4），用于在旋转期间将热量施加到所述化验盘的一个或多个特定部分; 选择所需加热器并控制其温度的加热器控制器（54），以及允许指令和/或加热参数无线传输到加热器控制器的IR收发器（30,55）。更具体地，本发明公开了一种用于进行测定的设备，其中可以控制测定盘上特定位置处的加热位置和加热/冷却速率。

9. 发明申请

WO2014111719A1 MODULAR ASSAY SYSTEM 审中-公开
标题翻译：模块化测试系统
公开(公告)号：WO2014111719A1
公开(公告)日：2014-07-24
申请号：PCT/GB2014/050124
申请日：2014-01-16
申请人： MAST GROUP LIMITED
发明人： JIN WONG, Dr. Ken , WILLIAMS, David Hugh , MCELARNEY, Iain , GILLIES, Elizabeth
IPC分类号： G01N35/00 , B01L3/00 , G01N21/07
CPC分类号： G01N21/6428 , B01L3/5027 , B01L3/545 , B01L2300/021 , B01L2300/0803 , G01J3/46 , G01J5/605 , G01J2003/466 , G01N33/487 , G01N35/00 , G01N35/00871 , G01N35/04 , G01N2021/6439 , G01N2035/00158 , G01N2035/00306 , G01N2035/00326 , G01N2035/00752 , G01N2035/00851 , G01N2035/0441 , G01N2201/024 , G01N2201/0256 , G01N2201/0407
摘要： A system for conducting an assay comprises a power source (16), a controller (13) for controlling the assay and a plurality of assay units (14) operatively connected to one another such that the controller can communicate with the assay units and the system is capable of conducting the assay. An assay device comprises a substantially circular body (24) having a plurality of chambers in fluid connection such that fluid can pass between said chambers and a central hub (200) having a sample inlet (202) disposed therein for receiving a sample.
摘要翻译：用于进行测定的系统包括电源（16），用于控制测定的控制器（13）和可操作地彼此连接的多个测定单元（14），使得控制器可以与测定单元和系统能够进行测定。测定装置包括具有流体连接的多个腔室的基本上圆形的本体（24），使得流体可以在所述室之间通过，并且具有设置在其中的用于接收样品的样品入口（202）的中心毂（200）。

10. 发明申请

WO2011010139A1 ASSAY AND ASSAY DEVICE 审中-公开
标题翻译：测定和测定装置
公开(公告)号：WO2011010139A1
公开(公告)日：2011-01-27
申请号：PCT/GB2010/051185
申请日：2010-07-20
申请人： MAST GROUP LIMITED , ROSE, Howard
发明人： ROSE, Howard
IPC分类号： C12Q1/04 , C12Q1/14 , C12M1/30 , B01L3/00
CPC分类号： C12Q1/045 , B01L3/502 , B01L9/06 , B01L2300/043 , B01L2300/0654 , B01L2300/0681 , C12Q1/14
摘要： The present invention relates generally to methods of pathogen detection. In particular, the present invention relates to methods of detecting MRSA in a biological sample.
摘要翻译：本发明一般涉及病原体检测方法。特别地，本发明涉及在生物样品中检测MRSA的方法。

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