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1. 发明申请

WO2013106563A1 APPLICATION OF ENERGY IN MEDICAL TREATMENTS 审中-公开
标题翻译：能源在医疗治疗中的应用
公开(公告)号：WO2013106563A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/021021
申请日：2013-01-10
申请人： MULLER, David , MARSHALL, John
发明人： MULLER, David , MARSHALL, John
IPC分类号： A61F9/007 , A61N5/06
CPC分类号： A61F9/0079 , A61F9/00736 , A61F9/008 , A61F2009/0087 , A61F2009/00887 , A61N5/062 , A61N2005/0661
摘要： Embodiments apply light energy in medical treatments. To enhance or control the effect of the light energy, embodiments apply the light energy after tissue has been treated, e.g., with a photosensitizing agent. For example, embodiments may treat target tissue with riboflavin before exposure to ultraviolet light. For example, a system for cataract surgery includes a removal system configured to remove a first lens from an eye, wherein a capsular bag remains in the eye after removal of the first lens. The system includes an application system configured to treat lenticular epithelial cells in the capsular bag with the photosensitizing agent. The system includes a delivery system with a light source and an optical device. The optical device delivers light to the treated lenticular epithelial cells. Energy from the light destroys the lenticular epithelial cells in the capsular bag to reduce the growth of epithelial cells that cause posterior capsule opacification.
摘要翻译：实施例在光疗中应用光能。为了增强或控制光能的效果，实施例在组织被处理之后例如用光敏剂施加光能。例如，实施方案可以在暴露于紫外线之前用核黄素治疗靶组织。例如，用于白内障手术的系统包括被配置为从眼睛去除第一透镜的去除系统，其中在移除第一透镜之后，囊袋保留在眼睛中。该系统包括被配置成用光敏剂治疗囊袋中的透镜上皮细胞的应用系统。该系统包括具有光源和光学装置的传送系统。光学器件将光递送到经处理的透镜上皮细胞。来自光的能量破坏囊袋中的透镜上皮细胞以减少导致后囊不透明的上皮细胞的生长。

2. 发明申请

WO2012145159A1 CONTROLLED CROSS-LINKING INITIATION AND CORNEAL TOPOGRAPHY FEEDBACK SYSTEMS FOR DIRECTING CROSS-LINKING 审中-公开
标题翻译：控制交叉引导和导向交叉连接的角度反射系统
公开(公告)号：WO2012145159A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/032024
申请日：2012-04-03
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Stephen , KAMAEV, Pavel , PERTAUB, Radha
发明人： MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Stephen , KAMAEV, Pavel , PERTAUB, Radha
IPC分类号： A61F9/01 , A61F9/008
CPC分类号： A61N5/062 , A61B2018/00619 , A61F9/0079 , A61F2009/00844 , A61F2009/00872 , A61F2009/00882
摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
摘要翻译：用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。提供反馈系统以获取测量并将反馈信息传递给控制器。反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。反馈系统的方面也可用于监测和诊断眼睛的特征。还提供了根据反馈系统提供的信息激活交联的方法，以提高交联疗法的准确性和安全性。

3. 发明申请

WO2011130356A9 SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
公开(公告)号：WO2011130356A9
公开(公告)日：2011-10-20
申请号：PCT/US2011/032234
申请日：2011-04-13
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , TROKEL, Stephen L. , HERSH, Peter , KAMAEV, Pavel
发明人： MULLER, David , MARSHALL, John , TROKEL, Stephen L. , HERSH, Peter , KAMAEV, Pavel
IPC分类号： A61F9/00 , A61N5/00 , A61K31/525 , A61P27/02 , A61N5/08

4. 发明申请

WO2012158991A2 CONTROLLED APPLICATION OF CROSS-LINKING AGENT 审中-公开
标题翻译：交联剂的控制应用
公开(公告)号：WO2012158991A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/038483
申请日：2012-05-18
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , TROKEL, Stephen L. , HERSH, Peter , KAMAEV, Pavel
发明人： MULLER, David , MARSHALL, John , TROKEL, Stephen L. , HERSH, Peter , KAMAEV, Pavel
CPC分类号： A61K31/525 , A61F9/0079 , A61F9/008 , A61F9/00804 , A61F2009/00844 , A61F2009/00851 , A61F2009/00853 , A61F2009/00857 , A61F2009/00872
摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
摘要翻译：用于激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，使交联在该至少一种眼睛部件内活化。本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制加强组织的三维区域。方法允许将交联剂输送到角膜表面下方的深度，使得在角膜表面下方激活交联。

5. 发明申请

WO2011053768A2 SYSTEM AND METHOD FOR STABILIZING CORNEAL TISSUE AFTER TREATMENT 审中-公开
标题翻译：用于稳定治疗后角膜组织的系统和方法
公开(公告)号：WO2011053768A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054673
申请日：2010-10-29
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John
发明人： MULLER, David , MARSHALL, John
IPC分类号： A61N5/02 , A61F9/007 , A61M35/00 , A61F7/00 , A61K38/20 , A61K38/18 , A61P27/02
CPC分类号： A61F9/007 , A61B18/1815 , A61B2018/00029 , A61F9/0079 , A61F9/013 , A61F2009/00872 , A61K38/1841 , A61M35/00 , A61M2210/0612
摘要： Embodiments according to aspects of the present invention provide systems and methods for stabilizing corneal tissue after treatment of the corneal tissue. For example, thermokeratoplasty may be applied to the corneal tissue to address disorders associated with abnormal shaping of the cornea. To stabilize the desired structural changes caused by the treatment, embodiments apply ophthalmic formulations that help to inhibit wound healing. Wound healing may occur in response to the application of the treatment and may produce further structural changes that mitigate or alter the desired effects of the treatment.
摘要翻译：根据本发明的各方面的实施例提供用于在治疗角膜组织之后稳定角膜组织的系统和方法。例如，热角膜成形术可以应用于角膜组织以解决与角膜异常成形相关的病症。为了稳定治疗引起的所需结构变化，实施例应用有助于抑制伤口愈合的眼科制剂。响应于治疗的应用可能会发生伤口愈合，并可能产生进一步的结构改变，从而减轻或改变治疗的预期效果。

6. 发明申请

WO2011050164A1 EYE THERAPY 审中-公开
标题翻译：眼睛治疗
公开(公告)号：WO2011050164A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053551
申请日：2010-10-21
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc, D.
发明人： MULLER, David , MARSHALL, John , FRIEDMAN, Marc, D.
IPC分类号： A61F9/013
CPC分类号： A61N5/062 , A61F9/0008 , A61F9/013 , A61K31/14
摘要： Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O 2 into singlet oxygen which causes cross-linking within the corneal tissue. The rate of cross-linking in the cornea is related to the concentration of O 2 present when the cross-linking agent is irradiated with photoactivating light. Accordingly, the embodiments control the concentration of O 2 during irradiation to increase or decrease the rate of cross-linking and achieve a desired amount of cross-linking.
摘要翻译：实施例将交联剂应用于角膜组织的区域。交联剂改善了角膜组织抵抗不良结构变化的能力。例如，交联剂可以是核黄素或玫瑰红，并且起始元件可以是光活化的光，例如紫外（UV）光。在这些实施方案中，光活化光通过照射所施加的交联剂以释放角膜组织中的活性氧自由基引发交联活性。交联剂用作敏化剂以将O 2转化为单线态氧，其导致角膜组织内的交联。角膜中的交联速率与交联剂用光活化光照射时存在的O 2浓度有关。因此，实施例控制照射期间的O 2浓度以增加或降低交联速率并达到所需量的交联。

7. 发明申请

WO2011116306A3 SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 审中-公开
公开(公告)号：WO2011116306A3
公开(公告)日：2011-09-22
申请号：PCT/US2011/029033
申请日：2011-03-18
申请人： AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Ronald , KAMAEV, Pavel , PERTAUB, Radha
发明人： MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Ronald , KAMAEV, Pavel , PERTAUB, Radha
IPC分类号： A61F9/00 , A61B3/10 , A61N5/06 , A61M35/00 , A61B3/107
摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

8. 发明申请

WO2008039252A2 MULTIMODAL OCULAR BIOMETRIC SYSTEM 审中-公开
标题翻译：多模式眼睛生物测量系统
公开(公告)号：WO2008039252A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/011507
申请日：2007-05-14
申请人： RETICA SYSTEMS, INC. , FRIEDMAN, Marc, D. , CASAVERDE, Pablo , YANSEN, Don , MCNERNEY, Tim , TOSA, Yasunari , USHER, David , ACCOMANDO, Nicholas, A. , MULLER, David , HEACOCK, Greg , MARSHALL, John
发明人： FRIEDMAN, Marc, D. , CASAVERDE, Pablo , YANSEN, Don , MCNERNEY, Tim , TOSA, Yasunari , USHER, David , ACCOMANDO, Nicholas, A. , MULLER, David , HEACOCK, Greg , MARSHALL, John
IPC分类号： A61B3/14 , A61B3/15 , G06K9/62
CPC分类号： H04N7/18 , A61B3/1216 , A61B3/14 , G06K9/00597
摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.
摘要翻译：多模式生物统计识别系统捕获并处理虹膜和视网膜的图像以进行生物统计识别。另一种多模式眼部系统捕捉和处理虹膜和/或来自对象双眼的图像。基于这些系统提供的数据的生物特征识别比使用生物特征识别更加准确和可靠，这些生物特征包括仅来自虹膜或仅来自单眼的视网膜的数据。示例性实施例向双眼的虹膜和视网膜发射光子，当虹膜反射发射的光时捕获虹膜图像的虹膜图像传感器，视网膜图像传感器，其在视网膜反射时捕获视网膜的图像发出的光线以及控制虹膜和视网膜照射源的控制器，其中虹膜的拍摄图像和视网膜的拍摄图像包含生物统计数据。

9. 发明申请

WO2010056848A1 EYE THERAPY SYSTEM 审中-公开
标题翻译：眼睛治疗系统
公开(公告)号：WO2010056848A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064189
申请日：2009-11-12
申请人： AVEDRO, INC. , RYAN, Thomas , PERTAUB, Radha , MEYERS, Steven , DRESHER, Russ , MULLER, David , SCHARF, Ronald
发明人： RYAN, Thomas , PERTAUB, Radha , MEYERS, Steven , DRESHER, Russ , MULLER, David , SCHARF, Ronald
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1815 , A61B2090/065 , A61F9/0079
摘要： Systems and methods improve operation of an applicator that delivers heat- generating energy to an eye as a part of an eye therapy. For example, reflected power may be measured to determine whether sufficient contact has been established between the applicator and the eye for accurate and precise delivery of energy to the eye. In addition, at least one of forward and reflected power may be measured to monitor the application of coolant pulses that control the generation of heat in the eye when the applicator delivers energy to the eye. Further, the forward and reflected power may be measured to determine an efficiency of energy transfer or an impedance mismatch. Based on the efficiency of energy transfer or the impedance mismatch, an adjustable parameter of a tuning element may be modified.
摘要翻译：系统和方法改善了作为眼部治疗的一部分向眼睛提供热量产生能量的施用器的操作。例如，可以测量反射功率以确定施用器和眼睛之间是否已经建立足够的接触，以准确和精确地将能量递送到眼睛。此外，可以测量正向和反射功率中的至少一个以监测当施用器向眼睛递送能量时控制眼睛中的热量产生的冷却剂脉冲的应用。此外，可以测量正向和反射功率以确定能量传递的效率或阻抗失配。基于能量传递的效率或阻抗失配，可以修改调谐元件的可调参数。

10. 发明申请

WO2010039979A1 EYE THERAPY SYSTEM 审中-公开
标题翻译：眼睛治疗系统
公开(公告)号：WO2010039979A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/059260
申请日：2009-10-01
申请人： AVEDRO, INC. , MULLER, David
发明人： MULLER, David
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B2018/00005 , A61B2018/00755 , A61B2018/00875 , A61F9/0079 , A61F9/013
摘要： A system includes a conducting element that conducts energy from an energy source to apply therapy to an eye. The system includes a covering configured to be removably attached to the conducting element. The covering has an interface surface that is positionable at an eye. At least a portion of the interface surface includes one or more dielectric materials. Energy is deliverable to the eye through the interface surface. In one aspect, the covering provides an electrical insulator to minimize the concentration of electrical current in the area of contact with the eye. In another aspect, the covering allows the eye to be cooled during the application of energy without directly applying coolant to the eye. In another aspect, the covering includes a dielectric layer that may provide varying impedances that allow different patterns for energy delivery. In another aspect, the sheath promotes hygienic use of the conducting element.
摘要翻译：一种系统包括从能量源传导能量以将治疗应用于眼睛的导电元件。该系统包括构造成可移除地附接到导电元件的覆盖物。覆盖物具有可在眼睛处定位的界面。界面表面的至少一部分包括一种或多种介电材料。能量通过界面可传递给眼睛。在一个方面，覆盖物提供电绝缘体以最小化与眼睛接触的区域中的电流的浓度。另一方面，覆盖物允许眼睛在施加能量期间被冷却，而不直接将冷却剂施加到眼睛。在另一方面，覆盖物包括可提供允许不同图案用于能量输送的变化阻抗的介电层。另一方面，护套促进卫生使用导电元件。

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