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1. 发明申请

WO2012106379A1 SENSITIZATION OF CANCER CELLS TO TREATMENT 审中-公开
标题翻译：癌细胞对治疗的敏感性
公开(公告)号：WO2012106379A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023402
申请日：2012-01-31
申请人： PARINGENIX, INC. , MARCUS, Stephen
发明人： MARCUS, Stephen
IPC分类号： A61K31/727
CPC分类号： A61K31/727 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present application provides methods for the treatment of cancer, comprising administering substantially non-anticoagulant 2-O, 3-O desulfated heparin to patients suffering from cancer that is, or can become resistant to, cancer treatment, such as chemotherapy, targeted cancer therapy, or radiation therapy. The compositions can be administered to sensitize, or to reverse resistance to, cancer treatment, and can be administered alone or in combination with cancer treatment to subjects with solid tumors including, but not limited to, pancreatic, breast, renal, colorectal, gastric, or esophageal cancer, and subjects with hematologic malignancies, including but not limited to leukemia and lymphoma.
摘要翻译：本申请提供了用于治疗癌症的方法，其包括向患有癌症的癌症患者施用基本上非抗凝血的2-O，3-O脱硫酸肝素，所述癌症治疗或可能对癌症治疗如化疗，靶向癌症治疗，或放射治疗。可以施用组合物以敏化或抵抗癌症治疗的抗性，并且可以单独施用或与癌症治疗组合施用于具有实体瘤的受试者，包括但不限于胰腺，乳腺，肾脏，结肠直肠癌，胃癌，或食管癌，以及具有血液恶性肿瘤的受试者，包括但不限于白血病和淋巴瘤。

2. 发明申请

WO2006129318A3 BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES 审中-公开
公开(公告)号：WO2006129318A3
公开(公告)日：2006-12-07
申请号：PCT/IL2006/000641
申请日：2006-05-31
申请人： PHARMOS CORPORATION , YACOVAN, Avihai , GRYNSZPAN, Flavio , AIZIKOVICH, Alexander , BRODY, Marcus Stephen , BAR-JOSEPH, Avi , MEILIN, Sigal
发明人： YACOVAN, Avihai , GRYNSZPAN, Flavio , AIZIKOVICH, Alexander , BRODY, Marcus Stephen , BAR-JOSEPH, Avi , MEILIN, Sigal
IPC分类号： C07D307/91 , C07D307/93 , A61K31/343 , A61P25/00 , A61P37/02 , A61P1/00 , A61P27/06
摘要： The present invention relates to benzofuran derivatives , to pharmaceutical compositions comprising same, and to methods of usa thereof . Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of benef icial therapeutic indications . In particular, compounds or the invention are useful ae analgesic, neuroprotective, immunomodulatory and anfci - inf lammatory agents .

3. 发明申请

WO2004077103A3 POROUS OPTICAL SWITCH FILMS 审中-公开
标题翻译：多孔光开关膜
公开(公告)号：WO2004077103A3
公开(公告)日：2005-01-20
申请号：PCT/US2004004894
申请日：2004-02-19
申请人： EASTMAN KODAK CO , BERMEL MARCUS STEPHEN , COURNOYER ROBERT FREDERICK
发明人： BERMEL MARCUS STEPHEN , COURNOYER ROBERT FREDERICK
IPC分类号： G02B6/00 , G02B26/02 , G02B26/08 , G09F9/37
CPC分类号： G02B26/02 , G02B6/0001 , G02B26/0825 , Y10S385/901
摘要： A porous optical switching film is situated between at least two plates that have an electrical bias between them.
摘要翻译：多孔光学切换膜位于至少两个在它们之间具有电偏压的板之间。

4. 发明申请

WO2006129318A2 BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES 审中-公开
标题翻译：具有治疗活性的苯唑嘌呤衍生物
公开(公告)号：WO2006129318A2
公开(公告)日：2006-12-07
申请号：PCT/IL2006000641
申请日：2006-05-31
申请人： PHARMOS CORP , YACOVAN AVIHAI , GRYNSZPAN FLAVIO , AIZIKOVICH ALEXANDER , BRODY MARCUS STEPHEN , BAR-JOSEPH AVI , MEILIN SIGAL
发明人： YACOVAN AVIHAI , GRYNSZPAN FLAVIO , AIZIKOVICH ALEXANDER , BRODY MARCUS STEPHEN , BAR-JOSEPH AVI , MEILIN SIGAL
IPC分类号： C07D307/91 , A61K31/343 , A61P25/00 , A61P37/02 , C07D307/93
CPC分类号： C07D307/91 , C07D307/93
摘要： The present invention relates to novel benzofuran derivatives, to pharmaceutical compositions comprising same, and to methods of use thereof. Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of beneficial therapeutic indications. In particular, compounds of the invention are useful as analgesic, neuroprotective, immunomodulatory and anti-inflammatory agents.
摘要翻译：本发明涉及新的苯并呋喃衍生物，包含其的药物组合物及其使用方法。本发明的某些化合物与大麻素具有一些药理学性质，并且具有普遍广泛的有益治疗适应症。特别地，本发明的化合物可用作止痛剂，神经保护剂，免疫调节剂和抗炎剂。

5. 发明申请

WO2006039140A1 OPTICAL FILMS AND PROCESS FOR MAKING THEM 审中-公开
标题翻译：光学薄膜及其制造方法
公开(公告)号：WO2006039140A1
公开(公告)日：2006-04-13
申请号：PCT/US2005/033551
申请日：2005-09-19
申请人： EASTMAN KODAK COMPANY , GREENER, Jehuda , ANDERSON, Charles Chester , BERMEL, Marcus Stephen
发明人： GREENER, Jehuda , ANDERSON, Charles Chester , BERMEL, Marcus Stephen
IPC分类号： G02B1/10
CPC分类号： C08J5/18 , B05C5/007 , B05C9/06 , B29C41/26 , B29C41/32 , B29D11/00788 , B29K2001/00 , B29K2001/12 , B29K2027/00 , B29K2029/00 , B29K2067/00 , B29K2995/0032 , B29L2009/001 , B29L2011/00 , B32B27/08 , C08J2301/12 , C08J2369/00 , G02B1/14 , G02B5/208 , Y10T428/10
摘要： A method of film fabrication is taught that uses a coating and drying apparatus to fabricate resin films suitable for optical applications. In particular, resin films are prepared by simultaneous application of multiple liquid layers to a moving carrier substrate having low surface energy. After solvent removal, the resin films are peeled from the sacrificial carrier substrate. Films prepared by the current invention exhibit good dimensional stability and low out-of-plane retardation.
摘要翻译：教导了一种薄膜制造方法，其使用涂覆和干燥装置来制造适用于光学应用的树脂薄膜。特别地，通过将多个液体层同时施加到具有低表面能的移动载体衬底来制备树脂膜。除去溶剂后，树脂膜从牺牲载体基材上剥离。由本发明制备的薄膜表现出良好的尺寸稳定性和低的平面外延迟。

6. 发明申请

WO2004077103A2 POROUS OPTICAL SWITCH FILMS 审中-公开
标题翻译：多孔光开关膜
公开(公告)号：WO2004077103A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/004894
申请日：2004-02-19
申请人： EASTMAN KODAK COMPANY , BERMEL, Marcus, Stephen , COURNOYER, Robert, Frederick
发明人： BERMEL, Marcus, Stephen , COURNOYER, Robert, Frederick
IPC分类号： G02B
CPC分类号： G02B26/02 , G02B6/0001 , G02B26/0825 , Y10S385/901
摘要： A porous optical switching film is situated between at least two plates that have an electrical bias between them.
摘要翻译：多孔光学切换膜位于至少两个在它们之间具有电偏压的板之间。

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