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1. 发明申请

WO0177112A3 PHOTOCHROMIC SPIRO(INDOLINE)NAPHTHOXAZINES 审中-公开
标题翻译：光敏螺旋（吲哚）萘甲酰胺
公开(公告)号：WO0177112A3
公开(公告)日：2002-04-18
申请号：PCT/IL0100317
申请日：2001-04-05
申请人： YEDA RES & DEV , KRONGAUZ VALERI , CHIF ALEXANDRE , AIZIKOVICH ALEXANDER , TCHERNOIVANOV VLADIMIR
发明人： KRONGAUZ VALERI , CHIF ALEXANDRE , AIZIKOVICH ALEXANDER , TCHERNOIVANOV VLADIMIR
IPC分类号： G02B1/04 , C07D498/10 , C09B19/00 , C09K9/02 , G02B5/23 , G03C1/685 , A61K31/5386 , C08K5/357
CPC分类号： C07D498/10 , C09B19/00 , G02B5/23 , G03C1/685
摘要： A photochromic compound for incorporation into plastic articles, particularly into a plastic lens, is selected from a spiro(indoline)naphtho(2,1-b) (1,4)oxazine and a spiro(indoline)naphtho(1,2-b)(1,4)oxazine containing a group selected from: (a) -CH2-CnF2n+1 at the nitrogen atom in the 1-position on the indoline part of the molecule, wherein n is an integer of 1 to 6; (b) -COOR at the 3-position on the indoline part of the molecule, wherein R is (i) C1-C6 alkyl optionally substituted by fluoro, C1-C4 alkoxy or fluoroalkoxy, C1-C4 alkylcarbonyloxy, C2-C4 alkenylcarbonyloxy, C3-C6 cycloalkyl or aryl; (ii) C2-C6 alkenyl with a terminal double bond; (iii) C3-C6 cycloalkyl optionally substituted by fluoro; or (iv) aryl; (c) an -OCF3 group on the benzene ring of the indoline part of the molecule; (d) an aryl(dialkyl)methyl group of the formula -C(aryl)(CnH2n+1)(CmH2m+1), wherein n and m are integers from 1 to 5, linked to one of the benzene rings of the naphthoxazine part of the molecule; and (e) any combination of (a), (b), (c) and/or (d).
摘要翻译：选自螺（二氢吲哚）萘并（2,1-b）（1,4）恶嗪和螺（二氢吲哚）萘酚（1,2-b）的光致变色化合物，特别是掺入塑料透镜中的光致变色化合物）（1,4）恶嗪，其中n为1至6的整数;（a）在分子的二氢吲哚部分的1-位的氮原子上的选自：（a）-CH2-CnF2n + （b）在分子的二氢吲哚部分的3-位的-COOR，其中R是（i）任选被氟取代的C 1 -C 6烷基，C 1 -C 4烷氧基或氟代烷氧基，C 1 -C 4烷基羰基氧基，C 2 -C 4链烯基羰基氧基， C3-C6环烷基或芳基; （ii）具有末端双键的C 2 -C 6烯基; （iii）任选被氟取代的C 3 -C 6环烷基; 或（iv）芳基; （c）在分子的二氢吲哚部分的苯环上的-OCF 3基团; （d）与萘恶嗪的一个苯环连接的式-C（芳基）（C n H 2n + 1）（C m H 2n + 1）的芳基（二烷基）甲基，其中n和m为1至5的整数分子的一部分; 和（e）（a），（b），（c）和/或（d）的任何组合。

2. 发明申请

WO2006129318A3 BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES 审中-公开
公开(公告)号：WO2006129318A3
公开(公告)日：2006-12-07
申请号：PCT/IL2006/000641
申请日：2006-05-31
申请人： PHARMOS CORPORATION , YACOVAN, Avihai , GRYNSZPAN, Flavio , AIZIKOVICH, Alexander , BRODY, Marcus Stephen , BAR-JOSEPH, Avi , MEILIN, Sigal
发明人： YACOVAN, Avihai , GRYNSZPAN, Flavio , AIZIKOVICH, Alexander , BRODY, Marcus Stephen , BAR-JOSEPH, Avi , MEILIN, Sigal
IPC分类号： C07D307/91 , C07D307/93 , A61K31/343 , A61P25/00 , A61P37/02 , A61P1/00 , A61P27/06
摘要： The present invention relates to benzofuran derivatives , to pharmaceutical compositions comprising same, and to methods of usa thereof . Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of benef icial therapeutic indications . In particular, compounds or the invention are useful ae analgesic, neuroprotective, immunomodulatory and anfci - inf lammatory agents .

3. 发明申请

WO2008075353A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS 审中-公开
标题翻译：具有治疗适应症的磺胺衍生物
公开(公告)号：WO2008075353A1
公开(公告)日：2008-06-26
申请号：PCT/IL2007/001569
申请日：2007-12-19
申请人： PHARMOS CORPORATION , YACOVAN, Avihai , ALROY, Iris , AIZIKOVICH, Alexander , MIRILASHVILI, Sima , GRYNSZPAN, Flavio
发明人： YACOVAN, Avihai , ALROY, Iris , AIZIKOVICH, Alexander , MIRILASHVILI, Sima , GRYNSZPAN, Flavio
IPC分类号： C07C311/39 , A61K31/18 , A61P29/00 , C07C311/40 , C07C311/48 , C07C311/51 , C07D207/48 , C07D209/08 , C07D213/42 , C07D213/74 , C07D217/02 , C07D231/38 , C07D239/52 , C07D295/12 , C07D307/14 , C07D307/52 , C07D309/04 , C07D317/58 , C07D319/18 , C07D405/12 , C07D471/08 , C07D295/26 , C07D295/30
CPC分类号： C07C311/39 , C07C311/40 , C07C311/48 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/48 , C07D213/38 , C07D213/42 , C07D217/04 , C07D231/38 , C07D295/12 , C07D295/13 , C07D295/22 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D405/12 , C07D471/08
摘要： The present invention relates to sulfonamide derivatives of formula (I) (wherein R 1 , R 2 , R 3 , R 3' , R 4 and R 5 are as defined in the claims), to pharmaceutical compositions comprising the same, and to uses thereof. Compounds of the invention have a common wide range of beneficial therapeutic indications. In particular, compounds of the invention are useful analgesic and anti-inflammatory agents.
摘要翻译：本发明涉及式（I）的磺酰胺衍生物（其中R 1，R 2，R 3，R 3，R 3， R 4，R 4和R 5如权利要求中所定义），包含其的药物组合物及其用途。本发明的化合物具有普遍广泛的有益治疗适应症。特别地，本发明的化合物是有用的止痛剂和抗炎剂。

4. 发明申请

WO2006129318A2 BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES 审中-公开
标题翻译：具有治疗活性的苯唑嘌呤衍生物
公开(公告)号：WO2006129318A2
公开(公告)日：2006-12-07
申请号：PCT/IL2006000641
申请日：2006-05-31
申请人： PHARMOS CORP , YACOVAN AVIHAI , GRYNSZPAN FLAVIO , AIZIKOVICH ALEXANDER , BRODY MARCUS STEPHEN , BAR-JOSEPH AVI , MEILIN SIGAL
发明人： YACOVAN AVIHAI , GRYNSZPAN FLAVIO , AIZIKOVICH ALEXANDER , BRODY MARCUS STEPHEN , BAR-JOSEPH AVI , MEILIN SIGAL
IPC分类号： C07D307/91 , A61K31/343 , A61P25/00 , A61P37/02 , C07D307/93
CPC分类号： C07D307/91 , C07D307/93
摘要： The present invention relates to novel benzofuran derivatives, to pharmaceutical compositions comprising same, and to methods of use thereof. Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of beneficial therapeutic indications. In particular, compounds of the invention are useful as analgesic, neuroprotective, immunomodulatory and anti-inflammatory agents.
摘要翻译：本发明涉及新的苯并呋喃衍生物，包含其的药物组合物及其使用方法。本发明的某些化合物与大麻素具有一些药理学性质，并且具有普遍广泛的有益治疗适应症。特别地，本发明的化合物可用作止痛剂，神经保护剂，免疫调节剂和抗炎剂。

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