专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006007392A1 METHOD AND MEDICAMENT FOR SULFATED POLYSACCHARIDE TREATMENT OF INFLAMMATION WITHOUT INDUCING PLATELET ACTIVATION AND HEPARIN-INDUCED THROMBOCYTOPENIA SYNDROME 审中-公开
标题翻译：硫酸化多糖治疗不诱导血小板活化和肝素诱导的血栓形成综合征的方法和药物
公开(公告)号：WO2006007392A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/021277
申请日：2005-06-15
申请人： PARINGENIX, INC. , KENNEDY, Thomas, Preston
发明人： KENNEDY, Thomas, Preston
IPC分类号： A61K31/727
CPC分类号： A61K31/727
摘要： A method and medicament for treating inflammation in a patient with a sulfated polysaccharide without inducing platelet activation or thrombosis in the presence of heparin- and platelet factor 4-complex reactive antibodies using a 2-O desulfated heparin with an average degree of sulfation of 0.6 sulfate groups per monosaccharide or greater and an average molecular weight or 2.4 kD or greater. The medicament preferably is administered intravenously, by aerosolization or orally. Preferably, the 2-O desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline, and distilled water. Additionally provided is a method of synthesizing 2-O desulfated heparin.
摘要翻译：使用平均硫酸化程度为0.6硫酸盐的2-O脱硫酸肝素，在肝素和血小板因子4-复合体抗体抗体存在下，用硫酸化多糖治疗患者的炎症的方法和药物，而不诱导血小板活化或血栓形成每个单糖或更大的基团，平均分子量或2.4kD或更大。药物优选通过雾化或口服静脉内施用。优选地，2-O脱硫酸盐的肝素药物包括生理上可接受的载体，其可以选自生理缓冲盐水，生理盐水和蒸馏水。另外提供了合成2-O脱硫酸肝素的方法。

2. 发明申请

WO2006023397A2 METHOD AND MEDICAMENT FOR ANTICOAGULATION USING A SULFATED POLYSACCHARIDE WITH ENHANCED ANTI-INFLAMMATORY ACTIVITY 审中-公开
标题翻译：使用磺化多糖与增强抗炎活性进行抗凝化的方法和药物
公开(公告)号：WO2006023397A2
公开(公告)日：2006-03-02
申请号：PCT/US2005028771
申请日：2005-08-12
申请人： PARINGENIX INC , KENNEDY THOMAS PRESTON
发明人： KENNEDY THOMAS PRESTON
IPC分类号： A61K31/727 , A61P7/02
CPC分类号： A61K31/727 , A61K2300/00
摘要： A method and medicament for anticoagulating a patient with a sulfated polysaccharide mixture that demonstrates enhanced anti-inflammatory activity compared to anticoagulation with unfractionated heparin comprising various combinations of fully anticoagulant unfractionated heparin with 2-O desulfated heparin demonstrating reduced anticoagulant activity but enhanced antiinflammatory actions. The medicament preferably is administered intravenously, by aerosolization or orally. Preferably, the 2-O desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline and distilled water. Additionally provided is a method of synthesizing 2-O desulfated heparin in commercially practical quantities for the formulation of an anticoagulant 2-O desulfated heparin and heparin mixture.
摘要翻译：一种用硫酸化多糖混合物抗凝的方法和药物，其与使用普通肝素的抗凝治疗相比具有增强的抗炎活性，其包括完全抗凝血剂未分级肝素与2-O脱硫酸肝素的各种组合，其表现出降低的抗凝血活性但增强的抗炎作用。药物优选通过雾化或口服静脉内施用。优选地，2-O脱硫酸盐的肝素药物包括生理上可接受的载体，其可以选自生理缓冲盐水，生理盐水和蒸馏水。另外提供了一种合成2-O脱硫酸肝素的方法，其用于制备抗凝血剂2-O脱硫酸盐肝素和肝素混合物的商业实用量。

3. 发明申请

WO2013016181A1 COMPOSITIONS AND METHODS FOR ANTI-COAGULATION 审中-公开
标题翻译：用于抗凝血的组合物和方法
公开(公告)号：WO2013016181A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047577
申请日：2012-07-20
申请人： PARINGENIX, INC. , GREINACHER, Andreas , KRAUEL, Krystin
发明人： GREINACHER, Andreas , KRAUEL, Krystin
IPC分类号： A61K31/727
CPC分类号： A61K31/727 , A61K9/0019 , A61K9/08 , A61K2300/00
摘要： The present application provides pharmaceutical compositions and unit dosage forms comprising ODSH and an anticoagulant heparin in an ODSH:anticoagulant heparin (ODSH:H) weight ratio ranging from about 1:1 to about 4:1. Also provided herein are methods of anticoagulating, comprising administering ODSH and an anticoagulant heparin to subjects in need of such treatment.
摘要翻译：本申请提供了包含ODSH和抗凝血剂肝素的药物组合物和单位剂型，其中ODSH：抗凝血剂肝素（ODSH：H）的重量比范围为约1:1至约4:1。本文还提供了抗凝方法，包括向需要这种治疗的受试者施用ODSH和抗凝血剂肝素。

4. 发明申请

WO2008106584A1 O-DESULFATED HEPARINS TREATING ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：治疗慢性阻塞性肺疾病急性发作的O型解冻型肝炎
公开(公告)号：WO2008106584A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/055249
申请日：2008-02-28
申请人： PARINGENIX, INC. , KENNEDY, Thomas, P.
发明人： KENNEDY, Thomas, P.
IPC分类号： A61K31/727 , A61P11/12
CPC分类号： A61K31/727
摘要： The present invention provides methods for treating and preventing acute exacerbations of Chronic Obstructive Pulmonary Disease. The methods particularly comprise administering to a patient have COPD a composition comprising O- desulfated heparin. The administration can be after onset of one or more symptoms indicating an exacerbation of COPD or prior to onset of such symptoms. After onset of an acute exacerbation, administration of the O-desulfated heparin is particularly beneficial for reducing the time of hospitalization of the patient and for reducing lung inflammation.
摘要翻译：本发明提供治疗和预防慢性阻塞性肺疾病急性加重的方法。所述方法特别包括向具有COPD的患者施用包含O-脱硫酸肝素的组合物。给药可以在发生一种或多种症状之后，表明COPD恶化或发生此类症状之前。在急性加重发作后，给予O-脱硫酸肝素特别有利于减少患者的住院时间和减少肺部炎症。

5. 发明申请

WO2013169355A1 TREATMENT OF MYELOSUPPRESSION 审中-公开
标题翻译：治疗关节炎
公开(公告)号：WO2013169355A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/031053
申请日：2013-03-13
申请人： PARINGENIX, INC.
发明人： MARCUS, Stephen
IPC分类号： A61K31/727 , A61K31/715 , C08B37/10
CPC分类号： A61K31/727 , A61K35/28 , A61K39/395 , A61K45/06 , A61N5/00
摘要： Methods are presented for attenuating myelosuppressive side effects of treatment regimens, promoting thrombopoiesis and neutrophil production, and increasing efficacy of treatment regimens, by administering PF4-interacting heparinoids.
摘要翻译：提出了通过施用PF4相互作用的类肝素来减轻治疗方案的骨髓抑制副作用，促进血小板生成和嗜中性粒细胞产生以及增加治疗方案的功效的方法。

6. 发明申请

WO2006047755A2 METHOD AND MEDICAMENT FOR SULFATED POLYSACCHARIDE TREATMENT OF HEPARIN-INDUCED THROMBOCYTOPENIA (HIT) SYNDROME 审中-公开
标题翻译：盐酸多巴胺治疗肝素诱导的血栓形成（HIT）综合征的方法与药物
公开(公告)号：WO2006047755A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/039011
申请日：2005-10-26
申请人： PARINGENIX, INC. , WALENGA, Jeanine, M. , KENNEDY, Thomas, Preston
发明人： WALENGA, Jeanine, M. , KENNEDY, Thomas, Preston
IPC分类号： A61K31/737
CPC分类号： A61K31/727 , A61K31/737 , C08B37/0075 , C08L5/10
摘要： A method and medicament for treating and preventing platelet activation or thrombosis in the presence of heparin- and platelet factor 4-complex reactive antibodies using a 2-O desulfated heparin with an average degree of sulfation of 0.6 sulfate groups per monosaccharide or greater and an average molecular weight or 2.4 kD or greater. The medicament preferably is administered intravenously, by aerosolization or orally. Preferably, the 2-0 desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline, and distilled water. Additionally provided is a method of synthesizing 2-O desulfated heparin.
摘要翻译：在肝素和血小板因子4复合体抗体抗体存在下，使用平均硫酸化度为0.6个硫酸盐基团的单糖或更高的平均硫酸盐化肝素的2-O脱硫肝素来治疗和预防血小板活化或血栓形成的方法和药物分子量或2.4kD以上。药物优选通过雾化或口服静脉内施用。优选地，2-0脱硫酸盐的肝素药物包括生理上可接受的载体，其可以选自生理缓冲盐水，生理盐水和蒸馏水。另外提供了合成2-O脱硫酸肝素的方法。

7. 发明申请

WO2012106379A1 SENSITIZATION OF CANCER CELLS TO TREATMENT 审中-公开
标题翻译：癌细胞对治疗的敏感性
公开(公告)号：WO2012106379A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023402
申请日：2012-01-31
申请人： PARINGENIX, INC. , MARCUS, Stephen
发明人： MARCUS, Stephen
IPC分类号： A61K31/727
CPC分类号： A61K31/727 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present application provides methods for the treatment of cancer, comprising administering substantially non-anticoagulant 2-O, 3-O desulfated heparin to patients suffering from cancer that is, or can become resistant to, cancer treatment, such as chemotherapy, targeted cancer therapy, or radiation therapy. The compositions can be administered to sensitize, or to reverse resistance to, cancer treatment, and can be administered alone or in combination with cancer treatment to subjects with solid tumors including, but not limited to, pancreatic, breast, renal, colorectal, gastric, or esophageal cancer, and subjects with hematologic malignancies, including but not limited to leukemia and lymphoma.
摘要翻译：本申请提供了用于治疗癌症的方法，其包括向患有癌症的癌症患者施用基本上非抗凝血的2-O，3-O脱硫酸肝素，所述癌症治疗或可能对癌症治疗如化疗，靶向癌症治疗，或放射治疗。可以施用组合物以敏化或抵抗癌症治疗的抗性，并且可以单独施用或与癌症治疗组合施用于具有实体瘤的受试者，包括但不限于胰腺，乳腺，肾脏，结肠直肠癌，胃癌，或食管癌，以及具有血液恶性肿瘤的受试者，包括但不限于白血病和淋巴瘤。

8. 发明申请

WO2006047755A3 METHOD AND MEDICAMENT FOR SULFATED POLYSACCHARIDE TREATMENT OF HEPARIN-INDUCED THROMBOCYTOPENIA (HIT) SYNDROME 审中-公开
标题翻译：盐酸多巴胺治疗肝素诱导的血栓形成（HIT）综合征的方法与药物
公开(公告)号：WO2006047755A3
公开(公告)日：2007-02-01
申请号：PCT/US2005039011
申请日：2005-10-26
申请人： PARINGENIX INC , WALENGA JEANINE M , KENNEDY THOMAS PRESTON
发明人： WALENGA JEANINE M , KENNEDY THOMAS PRESTON
IPC分类号： A61K31/727
CPC分类号： A61K31/727 , A61K31/737 , C08B37/0075 , C08L5/10
摘要： A method and medicament for treating and preventing platelet activation or thrombosis in the presence of heparin- and platelet factor 4-complex reactive antibodies using a 2-O desulfated heparin with an average degree of sulfation of 0.6 sulfate groups per monosaccharide or greater and an average molecular weight or 2.4 kD or greater. The medicament preferably is administered intravenously, by aerosolization or orally. Preferably, the 2-0 desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline, and distilled water. Additionally provided is a method of synthesizing 2-O desulfated heparin.
摘要翻译：在肝素和血小板因子4复合体抗体抗体存在下，使用平均硫酸化度为0.6个硫酸盐基团的单糖或更高的平均硫酸盐化肝素的2-O脱硫肝素来治疗和预防血小板活化或血栓形成的方法和药物分子量或2.4kD以上。药物优选通过雾化或口服静脉内施用。优选地，2-0脱硫酸盐的肝素药物包括生理上可接受的载体，其可以选自生理缓冲盐水，生理盐水和蒸馏水。另外提供了合成2-O脱硫酸肝素的方法。

9. 发明申请

WO2006023397A3 METHOD AND MEDICAMENT FOR ANTICOAGULATION USING A SULFATED POLYSACCHARIDE WITH ENHANCED ANTI-INFLAMMATORY ACTIVITY 审中-公开
公开(公告)号：WO2006023397A3
公开(公告)日：2006-03-02
申请号：PCT/US2005/028771
申请日：2005-08-12
申请人： PARINGENIX, INC. , KENNEDY, Thomas, Preston
发明人： KENNEDY, Thomas, Preston
IPC分类号： A61K31/727 , A61P7/02
摘要： A method and medicament for anticoagulating a patient with a sulfated polysaccharide mixture that demonstrates enhanced anti-inflammatory activity compared to anticoagulation with unfractionated heparin comprising various combinations of fully anticoagulant unfractionated heparin with 2-O desulfated heparin demonstrating reduced anticoagulant activity but enhanced antiinflammatory actions. The medicament preferably is administered intravenously, by aerosolization or orally. Preferably, the 2-O desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline and distilled water. Additionally provided is a method of synthesizing 2-O desulfated heparin in commercially practical quantities for the formulation of an anticoagulant 2-O desulfated heparin and heparin mixture.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式