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    • 5. 发明申请
    • METHODS AND COMPOSITIONS FOR DIFFERENTIAL EXPANSION OF FETAL CELLS IN MATERNAL BLOOD AND THEIR USE
    • 方法和组合物在宫颈细胞中的差异扩大及其使用
    • WO2008048931A1
    • 2008-04-24
    • PCT/US2007/081396
    • 2007-10-15
    • CELULA INC.MCNEELEY, PatriciaMARCHAND, PhilippeDIVER, Jonathan
    • MCNEELEY, PatriciaMARCHAND, PhilippeDIVER, Jonathan
    • C12N5/06C12N5/00
    • C12N5/0634C12N2500/90C12N2500/98C12N2501/125C12N2501/23
    • Disclosed is a method and compositions for the differential expansion of fetal cells over maternal cells. In the method, cells from a sample of maternal blood containing CD34+ cells of both maternal and fetal origin are incubated in the presence of Stem Cell Factor in serum free media. It has been discovered that incubation of fetal cells in the presence of SCF will preferentially expand the fetal cells relative to adult cells. Fetal cells can also be identified, enriched or obtained by differential expansion of the fetal cells during colony formation. It has been discovered that differential expansion of fetal cells can result in colonies of fetal cells that are larger than colonies of adult cells. The fetal CD34+ cells can be expanded without generation of significant clonal genetic artifacts during expansion. Also disclosed is a method and compositions for producing differentiated fetal cells. It has been discovered that differentiated fetal cells have markers that distinguish the fetal cells from adult cells. Also disclosed are fetal cells made or obtained using the disclosed methods. For example, disclosed are expanded and/or differentiated fetal cells. The disclosed fetal cells can be used for any purpose and in any way that fetal cells can be used. The disclosed fetal cells are particularly useful for prenatal analysis of a gestating fetus.
    • 公开了胎儿细胞在母细胞上差异扩增的方法和组合物。 在该方法中,含有母体和胎儿来源的含有CD34 +细胞的母体血液样品的细胞在无血清培养基中的干细胞因子存在下孵育。 已经发现,在SCF存在下胎儿细胞的孵育将相对于成体细胞优先扩张胎儿细胞。 胎儿细胞也可以在菌落形成期间通过胎儿细胞的差异扩增来鉴定,富集或获得。 已经发现,胎儿细胞的差异扩增可导致比成体细胞的集落大的胎儿细胞的集落。 胎儿CD34 +细胞可以在扩增期间扩增而不产生显着的克隆遗传伪像。 还公开了用于产生分化的胎儿细胞的方法和组合物。 已经发现,分化的胎儿细胞具有区分胎儿细胞和成体细胞的标记。 还公开了使用所公开的方法制造或获得的胎儿细胞。 例如,所公开的是扩增和/或分化的胎儿细胞。 所公开的胎儿细胞可以用于任何目的,并且可以以任何方式使用胎儿细胞。 所公开的胎儿细胞特别可用于孕胎分娩。
    • 8. 发明申请
    • DISPLAY APPARATUS
    • 显示设备
    • WO2008028743A2
    • 2008-03-13
    • PCT/EP2007/058251
    • 2007-08-08
    • THOMSON LICENSINGPLOQUIN, DidierMARCHAND, PhilippeMORIZOT, Gérard
    • PLOQUIN, DidierMARCHAND, PhilippeMORIZOT, Gérard
    • H05B33/0815G09G3/3426H05B33/083
    • A circuit for controlling illumination means in a display includes illumination means arranged in a series-connection that are supplied with an essentially constant current. For individually controlling the illumination means, switches are provided for bypassing individual illumination means, maintaining the essentially constant current in the series-connection. The switches are floating with respect to a ground potential. A coupling means is thus provided for proper control of the switches. In a development of the invention a floating local power supply is provided with each illumination means and switch for operating the switch. The local power supply is, in one embodiment, powered by the control signal that is used for controlling the bypass switch. In another embodiment provision is made for supplying power to the floating local power supply. A driving method according to the embodiments of the circuit is also described.
    • 用于控制显示器中的照明装置的电路包括以串联方式布置的被提供有基本恒定电流的照明装置。 为了单独控制照明装置,提供了用于旁路各个照明装置的开关,保持串联连接中基本恒定的电流。 开关相对于地电位浮动。 因此,提供耦合装置用于适当地控制开关。 在本发明的开发中,浮置本地电源设置有用于操作开关的每个照明装置和开关。 在一个实施例中,本地电源由用于控制旁路开关的控制信号供电。 在另一个实施例中,提供用于向浮动本地电源供电。 还描述了根据电路实施例的驱动方法。
    • 9. 发明申请
    • CRYOABLATION CATHETER HANDLE
    • CRYOABLATION CATHETER手柄
    • WO2007028232A1
    • 2007-03-15
    • PCT/CA2006/001361
    • 2006-08-18
    • CRYOCATH TECHNOLOGIES INC.ABBOUD, MarwanSANTOIANNI, DomenicMARCHAND, PhilippeMAHROUCHE, RachidST-LOUIS, Patrick
    • ABBOUD, MarwanSANTOIANNI, DomenicMARCHAND, PhilippeMAHROUCHE, RachidST-LOUIS, Patrick
    • A61B18/02A61M39/10
    • A61B18/02A61B2017/00292A61B2018/0212A61M25/0136A61M25/0147A61M39/1011A61M39/105
    • A thermal treatment medical system including an umbilical having a first portion and a second portion, and a connector including a male coupling body connected to the first portion, the male coupling body having a central shank defining first and second lumens, a female coupling body connected to the second portion, the female coupling body, matable with the male coupling body and defining third and fourth lumens matable to be in fluid communication with the first and second lumens, respectively, to define first and second fluid flow pathways, respectively, through the connector when the male coupling body is mated with the female coupling body. The second fluid flow pathway is co-axially disposed about a central axis coincident with the first fluid flow pathway. The connector includes a mating mechanism for spatially locking the male and female coupling bodies with respect to each other. Additionally, the thermal treatment medical system includes a multiple lumen co-axial connector for connecting the catheter flow pathways with a fluid source and control console.
    • 一种热处理医疗系统,包括具有第一部分和第二部分的脐带,以及包括连接到第一部分的阳联接体的连接器,阳联接体具有限定第一和第二腔的中心柄,连接到阴连接体 所述阴联结体分别与所述阳连接体配合并且限定可分别与所述第一和第二腔流体连通的第三和第四腔,以分别限定第一和第二流体流动通道 阳联接器与阴联结体配合时的连接器。 第二流体流动路径围绕与第一流体流动路径重合的中心轴线同轴设置。 连接器包括用于相对于彼此空间地锁定阳联结体和阴联结体的配合机构。 此外,热处理医疗系统包括用于将导管流动路径与流体源和控制台连接的多管腔同轴连接器。
    • 10. 发明申请
    • METHOD FOR MOUNTING FROM MODULAR ELEMENTS A DIRECT VOLTAGE CONVERTER CAPABLE OF DIFFERENT CONFIGURATIONS AND RESULTING CONVERTER
    • 用于安装模块化元件的方法直接电压转换器可配置不同配置和转换器
    • WO1998021812A1
    • 1998-05-22
    • PCT/FR1997001982
    • 1997-11-05
    • GAIA CONVERTERBONILLA, FrédéricMARCHAND, PhilippeHUILLET, HenriBOISROND, Pascal
    • GAIA CONVERTER
    • H02M03/00
    • H02M3/00H05K1/0286H05K1/18
    • The invention concerns a direct voltage converter. The object of the invention is a method for mounting from modular elements a direct voltage converter capable of different configurations. characterised in that it consists in constituting each of said elements in the form of a direct /direct elementary converter carried by a medium (1, 1') provided with connecting pins (2 to 10) and in constituting a motherboard in the form of a printed circuit (11) arranged for receiving several of said elements (1, 1') depending on the configuration of the desired voltage output, said configuration being produced by the choice and the interconnection of the elements (1, 1') between them and with the motherboard (11) by establishing and/or suppressing connections (14 to 19). said motherboard being further provided with different basic functions (12, 13) required by the final multiple output converter to be produced. The invention is applicable to direct voltage converters in particular with multiple output.
    • 本发明涉及直流电压转换器。 本发明的目的是从模块化元件安装能够具有不同结构的直流电压转换器的方法。 其特征在于,它包括以由设置有连接销(2至10)的介质(1,1')承载的形式的直接/直接元件转换器的形式构成每个元件,并且构成主板的形式为 印刷电路(11),其布置成根据所需电压输出的配置接收几个所述元件(1,1'),所述配置是通过它们之间的元件(1,1')和 与主板(11)通过建立和/或抑制连接(14至19)。 所述主板进一步具有要生产的最终多输出转换器所需的不同的基本功能(12,13)。 本发明特别适用于具有多重输出的直流电压转换器。