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1. 发明申请

WO2014146019A3 HIGH VOLTAGE MONITORING SUCCESSIVE APPROXIMATION ANALOG TO DIGITAL CONVERTER 审中-公开
标题翻译：高电压监测模拟数字转换器
公开(公告)号：WO2014146019A3
公开(公告)日：2015-03-05
申请号：PCT/US2014030890
申请日：2014-03-17
申请人： MANN ALFRED E FOUND SCIENT RES
发明人： LEE EDWARD K F
IPC分类号： H03M1/12 , A61N1/36 , A61N1/372 , H03M1/46
CPC分类号： A61N1/36125 , A61N1/36071 , A61N1/37235 , H03M1/00 , H03M1/12 , H03M1/129 , H03M1/38 , H03M1/468 , H03M1/685 , H03M1/804
摘要： A successive approximation ADC made of a low voltage configurable differential amplifier and low voltage logic circuits which can convert a high voltage analog input to a digital equivalent. The differential amplifier can be configured as either an op amp or a comparator depending upon the mode of operation. An input capacitor C1 is switchably coupled to an electrode selected for voltage sampling. A switched capacitor array C2 is coupled across the differential amplifier input and output. A SAR coupled to the switched capacitor array provides a digital output corresponding to the sampled analog voltage. During a sampling interval and a charge transfer interval, the differential amplifier is configured as an op amp. During the transfer interval, the voltage on the input capacitor multiplied by the ratio C1/C2 is transferred to the switched capacitor array. During an analog to digital conversion interval, the ADC converts the analog voltage to an equivalent digital output.
摘要翻译：由低电压可配置差分放大器和低压逻辑电路组成的逐次逼近ADC，可将高压模拟输入转换为数字等效电路。根据操作模式，差分放大器可以配置为运算放大器或比较器。输入电容器C1可切换地耦合到选择用于电压采样的电极。开关电容器阵列C2跨差分放大器输入和输出耦合。耦合到开关电容器阵列的SAR提供对应于采样的模拟电压的数字输出。在采样间隔和电荷转移间隔期间，差分放大器被配置为运算放大器。在传输间隔期间，输入电容上乘以C1 / C2比的电压被传送到开关电容阵列。在模数转换间隔期间，ADC将模拟电压转换为等效的数字输出。

2. 发明申请

WO2015017475A2 MICROPROCESSOR CONTROLLED CLASS E DRIVER 审中-公开
标题翻译：微处理器控制类驱动程序
公开(公告)号：WO2015017475A2
公开(公告)日：2015-02-05
申请号：PCT/US2014048750
申请日：2014-07-29
申请人： MANN ALFRED E FOUND SCIENT RES
发明人： DEARDEN BRIAN R , WOLFE JAMES H , KHEMANI MANISH
IPC分类号： A61N1/378
CPC分类号： H02J7/025 , A61N1/36125 , A61N1/37223 , A61N1/3727 , A61N1/3787 , H02J7/0052 , H02J7/007 , H02J50/10 , H02J2007/0096 , H03C3/00 , H04B5/0037
摘要： A charger including a class E power driver, a frequency-shift keying ("FSK") module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.
摘要翻译：包括E类电源驱动器，频移键控（“FSK”）模块和处理器的充电器。处理器可以接收与E类功率驱动器的操作有关的数据，并且可以基于与E类功率驱动器的操作相关的接收数据来控制E类功率驱动器。处理器可以另外控制FSK模块来调制E类电力变压器的固有频率，从而允许可植入装置的同时充电和将数据传输到可植入装置。处理器可以通过调整切换时间来另外补偿传播延迟。

3. 发明申请

WO2014153216A3 MICROFLUIDIC FLOW RATE SENSOR 审中-公开
标题翻译：微流量流量传感器
公开(公告)号：WO2014153216A3
公开(公告)日：2014-12-04
申请号：PCT/US2014029672
申请日：2014-03-14
申请人： MANN ALFRED E FOUND SCIENT RES
发明人： BYERS CHARLES L , HETLINGER CHRIS J
IPC分类号： G01F1/74
CPC分类号： G01F1/56 , G01F1/7086 , G01F1/7088
摘要： A microfluidic flow rate sensor includes a droplet within a channel and a droplet movement detector that generates a signal based on the position and/or movement of the droplet within the channel. A processor determines the flow rate of a fluid through the channel based on the signal received from the droplet movement detector. In one example, the droplet movement detector is an optical detector, such as a combination of a lens and an image capturing device. In other examples, the droplet is electrically conductive, and at least a portion of the channel is conductive or includes electrical contacts. The position of the droplet within the channel is determined by observing the electrical characteristics of the channel.
摘要翻译：微流体流量传感器包括通道内的液滴和液滴移动检测器，其基于通道内液滴的位置和/或移动产生信号。处理器基于从液滴移动检测器接收的信号确定通过通道的流体的流速。在一个示例中，液滴移动检测器是诸如透镜和图像捕获装置的组合的光学检测器。在其他示例中，液滴是导电的，并且通道的至少一部分是导电的或包括电接触。通过观察通道的电气特性来确定液滴在通道内的位置。

4. 发明申请

WO2010096589A1 PARTIALLY IMPLANTABLE MEDICAL DEVICES, FLUID CARTRIDGES FOR USE WITH SAME, AND ASSOCIATED APPARATUS AND METHODS 审中-公开
标题翻译：部分可植入医疗器械，与其一起使用的流体容器及相关装置和方法
公开(公告)号：WO2010096589A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/024628
申请日：2010-02-18
申请人： INCUMED, LLC , MANN, Alfred, E. , HE, Tom, Xiaohai
发明人： MANN, Alfred, E. , HE, Tom, Xiaohai
IPC分类号： A61M31/00
CPC分类号： A61M5/14244 , A61M5/14276 , A61M5/16854 , A61M39/0247 , A61M39/04 , A61M2205/12 , A61M2205/50 , A61M2205/6054 , A61M2205/8206
摘要： Partially implantable medical devices and methods associated with partially implantable medical devices.
摘要翻译：部分可植入的医疗设备和与部分可植入医疗设备相关的方法。

5. 发明申请

WO2014146016A2 CURRENT SENSING MULTIPLE OUTPUT CURRENT STIMULATORS WITH FAST TURN ON TIME 审中-公开
标题翻译：电流传感器多输出电流刺激器快速打开时间
公开(公告)号：WO2014146016A2
公开(公告)日：2014-09-18
申请号：PCT/US2014030886
申请日：2014-03-17
申请人： MANN ALFRED E FOUND SCIENT RES
发明人： LEE EDWARD K F
IPC分类号： H03K3/012
CPC分类号： A61N1/36125 , A61N1/36003 , A61N1/3605 , A61N1/36071 , A61N1/36146 , H03K3/012 , H03K3/023 , Y10T307/406
摘要： A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
摘要翻译：描述了具有快速打开时间的多输出电流刺激器电路。至少一对输入侧和输出侧晶体管布置在通过共源共栅耦合连接到电源晶体管的电流镜中。输出侧晶体管向与组织接触的电极提供刺激电流。连接到参考电压的运算放大器和输出侧晶体管驱动电源晶体管以将输出侧晶体管处的电压保持在等于参考电压。至少一对晶体管包括多对晶体管，其输出侧晶体管以刺激电流驱动相应的电极。刺激器确定提供给每个电极的刺激电流脉冲的起始和持续时间。在电路激活时，产生大的电流，从而使输出侧晶体管中的电容放电，导致快速的输出侧晶体管导通。

6. 发明申请

WO2009094166A1 PROTHESIS ATTACHMENT METHOD AND APPARATUS WITH SOFT TISSUE INTEGRATING SEAL 审中-公开
标题翻译：具有软组织密封性能的附件方法和装置
公开(公告)号：WO2009094166A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/000415
申请日：2009-01-21
申请人： MEDICAL RESEARCH PRODUCTS-B, INC , MANN, Alfred, E. , MORAN, Byron, L. , JANIS, Abram, D. , KALUZNIAK, Paul
发明人： MANN, Alfred, E. , MORAN, Byron, L. , JANIS, Abram, D. , KALUZNIAK, Paul
IPC分类号： A61B17/86
CPC分类号： A61B17/8625 , A61B17/60 , A61F2/2814 , A61F2/30749 , A61F2/78 , A61F2002/0086 , A61F2002/30013 , A61F2002/30029 , A61F2002/30434 , A61F2002/30448 , A61F2002/30451 , A61F2002/3093 , A61F2002/7887 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2250/0024 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00149
摘要： A method and apparatus for reducing the incident of infection proximate to an exit site where a prosthesis fastener, e.g., a bone screw, percutaneously penetrates a patient's skin/soft tissue. Infection reduction is achieved in accordance with the invention by growing a tissue integrating seal around the fastener proximate to the exit site.
摘要翻译：用于减少接近出口部位的感染事件的方法和装置，其中假体紧固件（例如骨螺钉）经皮穿透患者的皮肤/软组织。根据本发明通过在邻近出口部位附近围绕紧固件生长组织集成密封来实现感染减少。

7. 发明申请

WO2006091808A2 FULLY IMPLANTABLE HEARING AID SYSTEM 审中-公开
标题翻译：全面可植入助听系统
公开(公告)号：WO2006091808A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006588
申请日：2006-02-23
申请人： MEDICAL RESEARCH PRODUCTS-B, INC. , SLATTERY, William, III. , MANN, Alfred, E. , MORAN, Byron, L.
发明人： SLATTERY, William, III. , MANN, Alfred, E. , MORAN, Byron, L.
IPC分类号： H04R25/00
CPC分类号： H04R25/604 , H04R25/554 , H04R25/558 , H04R2225/67
摘要： A fully implantable hearing aid system comprised of an implantable sound generator module and an implantable sound receiver module connected by an implantable electric cable. The system includes: a) a sound generator module configured for implantation in subcutaneous tissue to place an output electric/acoustic (E/A) transducer, e.g., a speaker, immediately adjacent to, or preferably, extending percutaneously into, a patient's outer ear canal; b) a sound receiver module configured for implantation proximate to a patient's pinna to place an input acoustic/electric (AJE) transducer, e.g., a microphone, so that it is acoustically isolated from the E/A transducer; and c) an electric cable configured for implantation in subcutaneous tissue for directly electrically connecting said sound receiver module and said sound generator module.
摘要翻译：一种完全可植入的助听器系统，包括由可植入电缆连接的可植入声音发生器模块和可植入声音接收器模块。该系统包括：a）声音发生器模块，其配置用于植入皮下组织以将输出的电/声（E / A）换能器，例如扬声器紧邻或优选地经皮延伸到患者的外耳运河; b）声音接收器模块，其配置用于在患者的耳廓附近植入以放置例如麦克风的输入声/电（AJE）换能器，使得其与E / A换能器声学隔离; 以及c）配置用于植入皮下组织以直接电连接所述声音接收器模块和所述声音发生器模块的电缆。

8. 发明申请

WO2004073491A2 BATTERY-POWERED PATIENT IMPLANTABLE DEVICE 审中-公开
标题翻译：电池供电患者可植入器件
公开(公告)号：WO2004073491A2
公开(公告)日：2004-09-02
申请号：PCT/US2004004088
申请日：2004-02-11
申请人： MANN ALFRED E FOUND SCIENT RES
发明人： SCHULMAN JOSEPH H , DELL ROBERT DAN , GORD JOHN C
IPC分类号： A61B20060101 , A61B5/00 , A61B5/053 , A61B5/07 , A61F2/50 , A61F2/70 , A61F2/72 , A61N1/372 , A61N1/378 , A61B
CPC分类号： A61N1/3787 , A61B5/0031 , A61B5/053 , A61B5/07 , A61B5/145 , A61B5/14532 , A61B5/4519 , A61B2560/0219 , A61B2562/08 , A61F2/72 , A61F2002/5058 , A61F2002/704 , A61F2002/705 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37288
摘要： A device configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing, typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm, having a non-circular, e.g., an oval or polygon shaped, cross-section containing a power source for powering electronic circuitry within including a controller, an address storage means, a data signal receiver and an input/output transducer. When used as a stimulator, such a device is useful in a wide variety of applications to stimulate nerves and associated neural pathways. Alternatively, devices of the present invention are configurable to monitor a biological parameter. Furthermore, a placement structure is shown for facilitating placement of the implantable device proximate to neural / muscular tissue.
摘要翻译：一种被配置为植入患者皮肤下面以用于组织例如神经或肌肉，刺激和/或参数监测和/或数据通信的装置。根据本发明的装置包括通常具有小于60mm的轴向尺寸和小于6mm的横向尺寸的密封外壳，其具有非圆形例如椭圆形或多边形横截面包括用于为包括控制器，地址存储装置，数据信号接收器和输入/输出换能器的电子电路供电的电源。当用作刺激剂时，这种装置可用于各种应用以刺激神经和相关的神经通路。或者，本发明的装置可配置为监测生物参数。此外，示出了放置结构，以便于将可植入装置置于靠近神经/肌肉组织的位置。

9. 发明申请

WO02102590A8 CERAMIC TO METAL SEAL 审中-公开
标题翻译：陶瓷到金属密封
公开(公告)号：WO02102590A8
公开(公告)日：2003-01-23
申请号：PCT/US0218949
申请日：2002-06-12
申请人： MANN ALFRED E FOUND SCIENT RES
发明人： FEY KATE E , JIANG GUANGQIANG
IPC分类号： B23K35/02 , B23K35/30 , C04B35/10 , C04B35/46 , C04B35/48 , B32B15/04 , B22F3/00 , B23K1/19 , B23K31/02 , B32B9/00 , C25D11/02
CPC分类号： C04B37/026 , B23K35/0244 , B23K35/3033 , B23K2203/14 , B23K2203/18 , B23K2203/52 , B32B2311/18 , C04B2235/3206 , C04B2235/3208 , C04B2235/3225 , C04B2235/3229 , C04B2237/123 , C04B2237/343 , C04B2237/346 , C04B2237/348 , C04B2237/403 , C04B2237/60 , C04B2237/708 , Y10T428/1259 , Y10T428/265
摘要： The invention is a method of bonding a ceramic part (6) to a metal part (4) by heating a component assembly (2) comprised of the metal part (4), the ceramic part (6), and a very thin essentially pure interlayer material (8) of a compatible interlayer material (8) placed between the two parts and heated at a temperature that is greater than the temperature of the eutectic formed between the metal part (4) and the metal interlayer material, but that is less than the melting point of either the interlayer material, the ceramic part (6) or the metal part (4). The component assembly (2) is held in intimate contact at temperature in a non-reactive atmosphere for a sufficient time to develop a homogeneous and strong bond between the ceramic part (6) and the metal part (4). The bonded component assembly (2) is optionally treated with acid to remove any residual free nickel and nickel salts, to assure a biocompatible component assembly (2) for implantation in living tissue.
摘要翻译：本发明是一种通过加热由金属部件（4），陶瓷部件（6）组成的部件组件（2）和非常薄的基本上纯的陶瓷部件（6）而将陶瓷部件（6）接合到金属部件（4）中间层材料（8）位于两个部分之间并在比金属部件（4）和金属中间层材料之间形成的共晶的温度大的温度下加热，但是较少比中间层材料，陶瓷部件（6）或金属部件（4）的熔点高。组件组件（2）在非反应性气氛中的温度下保持紧密接触足够的时间以在陶瓷部件（6）和金属部件（4）之间形成均匀且牢固的结合。任选地用酸处理粘合组分组件（2）以除去任何残留的游离镍和镍盐，以确保用于植入生物组织的生物相容性组分组件（2）。

10. 发明申请

WO02102452A2 MINIATURE IMPLANTABLE CONNECTORS 审中-公开
标题翻译：微型可插拔连接器
公开(公告)号：WO02102452A2
公开(公告)日：2002-12-27
申请号：PCT/US0217353
申请日：2002-05-31
申请人： MANN ALFRED E FOUND SCIENT RES , ADVANCED BIONICS CORP
发明人： SCHULMAN JOSEPH H , FEY KATE E , BYERS CHARLES L , ZILBERMAN YITZHAK , DELL ROBERT D , KUZMA JANUSZ
IPC分类号： A61N1/05 , A61N1/375 , A61N
CPC分类号： A61N1/3752 , A61N1/05 , A61N1/37205
摘要： The invention discloses methods of making electrical connections in living tissue between an electrically conductive wire and an implantable miniature device. The device may either stimulate muscles or nerves in the body or detect signals and transmit these signals outside the body or transmit the signals for use at another location within the body. The device is comprised of an electrically insulating or electrically conductive case with at least one electrode for transmitting electrical signals. The electrodes and the wire-electrode connections are protected from the aggressive environment within the body to avoid corrosion of the electrode and to avoid damage to the living tissue surrounding the device.
摘要翻译：本发明公开了在导电线和可植入微型装置之间的生物组织中进行电连接的方法。该装置可以刺激身体中的肌肉或神经，或者检测信号并将这些信号传输到身体外部，或者传输信号以在体内的另一位置使用。该装置由具有至少一个用于传输电信号的电极的电绝缘或导电壳体组成。电极和线电极连接被保护免受身体内的侵蚀性环境，以避免电极的腐蚀并且避免损坏设备周围的活体组织。

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