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1. 发明申请

WO2009091478A1 TARGETED THERAPEUTIC AGENT RELEASE FOR WEIGHT LOSS THERAPY 审中-公开
标题翻译：针对重量损失治疗的针对性治疗药物释放
公开(公告)号：WO2009091478A1
公开(公告)日：2009-07-23
申请号：PCT/US2008/087607
申请日：2008-12-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WALAK, Steven , MADDEN, Michael , SMITH, Paul
发明人： WALAK, Steven , MADDEN, Michael , SMITH, Paul
IPC分类号： A61F5/00 , A61M31/00
CPC分类号： A61M31/002 , A61F5/0013
摘要： A method for treating obesity comprises anchoring at a first target site within a body a first therapeutic agent delivery device (120) including a first therapeutic agent reservoir (122) coupled to a first outlet (126) which, when the first device is anchored at the first target site, is positioned adjacent to a first target treatment location within a GI tract of a patient and releasing a first therapeutic agent from the first reservoir via the first outlet.
摘要翻译：治疗肥胖症的方法包括在体内的第一靶部位处锚定第一治疗剂递送装置（120），所述第一治疗剂递送装置包括联接到第一出口（126）的第一治疗剂储存器（122），当第一装置被锚定在第一目标部位位于患者胃肠道内的第一目标治疗位置附近，并经由第一出口从第一储存器释放第一治疗剂。

2. 发明申请

WO2009049148A1 DEVICE AND METHOD FOR DETECTING AND TREATING LESIONS 审中-公开
标题翻译：用于检测和处理伤口的装置和方法
公开(公告)号：WO2009049148A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079506
申请日：2008-10-10
申请人： BOSTON SCIENTIFIC SCIMED, INC. , OSTROVSKY, Isaac , MCINTYRE, Jon T. , FAIRNENY, Ty , SHUKHAT, Victor , MADDEN, Michael
发明人： OSTROVSKY, Isaac , MCINTYRE, Jon T. , FAIRNENY, Ty , SHUKHAT, Victor , MADDEN, Michael
IPC分类号： A61B5/00 , A61B7/02
CPC分类号： A61N7/022 , A61B5/0084 , A61B5/4325 , A61B2017/00061 , A61B2018/00023 , A61B2090/306
摘要： A device for treating tissue comprises an enlongate probe (200) and a light delivery unit (222, 212) illuminating a target area (206) with light within a first wavelength band selected to enhance identification of target tissue in combination with an ultrasound crystal (210) mounted at a distal end of the probe, the crystal being stimulated to treat target tissue identified using the light delivery unit.
摘要翻译：用于处理组织的装置包括用选择的增强的探针（200）和用于照射目标区域（206）的光在第一波长带内，以增强与超声波晶体的组合的目标组织的识别（ 210），所述晶体被刺激以治疗使用所述光输送单元识别的目标组织。

3. 发明申请

WO2004106037A1 METHOD FOR FORMING COVER FOR INDUSTRIAL ROLL 审中-公开
标题翻译：工业轧辊成型方法
公开(公告)号：WO2004106037A1
公开(公告)日：2004-12-09
申请号：PCT/US2004/007085
申请日：2004-03-08
申请人： STOWE WOODWARD, LLC , MADDEN, Michael, D. , VOSIKA, Matthew
发明人： MADDEN, Michael, D. , VOSIKA, Matthew
IPC分类号： B29C53/58
CPC分类号： D21G1/0233 , B29C47/0023 , B29C47/0052 , B29C47/025 , B29C47/065 , B29C53/581 , B29K2007/00 , B29K2009/06 , B29K2019/00 , B29K2023/06 , B29K2075/00 , Y10T29/49551 , Y10T29/49563
摘要： A process for forming a cover for an industrial roll includes the steps of: providing an elongate cylindrical core (20) having a longitudinal axis (A1); rotating the core (20) about the longitudinal axis (A1); providing a nozzle (22) movable along a nozzle path (N) that is substantially parallel to and above the core longitudinal axis, the nozzle (22) having at least an upstream outlet (24) and a downstream outlet (26), the nozzle outlets being longitudinally offset a distance (d) from each other; and applying multiple strips of polymeric material to the core through the nozzle outlets as the nozzle moves along the nozzle path such that the downstream strip (28) forms an overlapping spiral inner layer and the upstream strip (36) forms an overlapping spiral outer layer that overlies the inner layer, the inner and outer layers being adhered with the core (20).
摘要翻译：一种用于形成用于工业辊的盖的方法包括以下步骤：提供具有纵向轴线（A1）的细长圆柱形芯（20）; 使所述芯部（20）围绕所述纵向轴线（A1）旋转; 提供沿着基本上平行于芯纵向轴线并在其上方的喷嘴路径（N）可移动的喷嘴（22），喷嘴（22）至少具有上游出口（24）和下游出口（26），喷嘴出口纵向偏离距离（d）; 以及当所述喷嘴沿着所述喷嘴路径移动时，通过所述喷嘴出口将多个聚合材料条带施加到所述芯部，使得所述下游条带（28）形成重叠的螺旋内层，并且所述上游条带（36）形成重叠的螺旋外层，覆盖在内层上，内层和外层与芯（20）粘合。

4. 发明申请

WO2004080286A2 DILATOR WITH EXPANDABLE MEMBER 审中-公开
标题翻译：具有可扩展会员的DILATOR
公开(公告)号：WO2004080286A2
公开(公告)日：2004-09-23
申请号：PCT/US2004007134
申请日：2004-03-09
申请人： SCIMED LIFE SYSTEMS INC , BRASINGTON EVAN , MADDEN MICHAEL
发明人： BRASINGTON EVAN , MADDEN MICHAEL
IPC分类号： A61M29/00 , A61B
CPC分类号： A61M29/02 , A61M2025/0004 , A61M2025/0006 , A61M2025/1081
摘要： A dilator and access sheath assembly (2) including a first conduit which includes a wall (21) defining a lumen therethrough and which is sufficiently rigid to dilate tissue in a body vessel; a member (14) coaxially surrounding a first section of the first conduit, where the member is capable of expanding; and a second conduit (30) coaxially surrounding a second section of the first conduit.
摘要翻译：包括第一导管的扩张器和进入护套组件（2），所述第一导管包括限定通过其中的腔的壁（21），所述壁足够刚性以膨胀身体容器中的组织; 构件（14）同轴地围绕第一导管的第一部分，其中构件能够膨胀; 以及同轴地围绕第一导管的第二部分的第二导管（30）。

5. 发明申请

WO2015009718A1 SYSTEMS AND METHODS FOR CALIBRATING READ AND WRITE OPERATIONS IN TWO DIMENSIONAL MAGNETIC RECORDING 审中-公开
标题翻译：用于在两维磁记录中校准读取和写入操作的系统和方法
公开(公告)号：WO2015009718A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/046690
申请日：2014-07-15
申请人： MARVELL WORLD TRADE LTD. , ZOU, Qiyue , MADDEN, Michael , BURD, Gregory
发明人： ZOU, Qiyue , MADDEN, Michael , BURD, Gregory
IPC分类号： G11B20/10
CPC分类号： G11B5/455 , G11B5/012 , G11B5/4886 , G11B5/58 , G11B5/59627 , G11B5/59683 , G11B20/10
摘要： Systems and methods are provided for calibrating signals retrieved from a storage device using a first reader and a second reader. The systems and methods further include reading a first signal using the first reader and a second signal using the second reader. Control circuitry computes a calibration metric associated with the first reader and the second reader based on the combination of the first signal and the second signal. At least one of the first signal and the second signal is subsequently decoded based in part on the computed calibration metric.
摘要翻译：提供了用于使用第一读取器和第二读取器校准从存储设备检索的信号的系统和方法。系统和方法还包括使用第一读取器读取第一信号和使用第二读取器读取第二信号。控制电路基于第一信号和第二信号的组合来计算与第一读取器和第二读取器相关联的校准度量。部分地基于所计算的校准度量，随后对第一信号和第二信号中的至少一个进行解码。

6. 发明申请

WO2010033617A3 STAPLED PEPTIDES AND METHOD OF SYNTHESIS 审中-公开
公开(公告)号：WO2010033617A3
公开(公告)日：2010-09-23
申请号：PCT/US2009057189
申请日：2009-09-16
申请人： UNIV NEW YORK STATE RES FOUND , LIN QING , MADDEN MICHAEL , RIVERA VERA CLAUDIA IVETTE
发明人： LIN QING , MADDEN MICHAEL , RIVERA VERA CLAUDIA IVETTE
IPC分类号： A61K38/00 , B01J19/12 , C07D213/61
CPC分类号： C07K1/045 , C07K1/107 , C07K1/1136
摘要： A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.
摘要翻译：一种制备缝合肽的方法。根据光化学方法[3 + 2]环加成反应制备包装螺旋缝合肽的缝合肽。螺旋缝合肽表现出增加的螺旋度，热稳定性和细胞渗透性。

7. 发明申请

WO2006011124A1 PORTABLE MEDICAL MOTORING AND DIAGNOSTIC SYSTEM 审中-公开
标题翻译：便携式医疗电机和诊断系统
公开(公告)号：WO2006011124A1
公开(公告)日：2006-02-02
申请号：PCT/IE2004/000102
申请日：2004-07-28
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY , CHAMBERS, Desmond , LYONS, Gerard , MADDEN, Michael , SCHUKAT, Michael
发明人： CHAMBERS, Desmond , LYONS, Gerard , MADDEN, Michael , SCHUKAT, Michael
IPC分类号： G06F19/00
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H50/20 , G16H50/30
摘要： A patient care distribution and management system (1) is provided. The system (1) allows for the seamless roaming of a patient within a particular medical facility or between medical facilities. The system (1) includes body area network (BAN), management agents (4) which process data within specified parts of a defined operational remit of a medical facility; a BAN hub agent (7) associated with each patient (10) that communicates with a BAN management agent (4) and stores patient data delivered thereto by medical telemetry monitor diagnostic devices (MTMDD's) (8) connected to each patient (10). The essential feature of the system is that the BAN hub agent (7) has relatively little processing power compared to the BAN management agent (4) which feeds it with patient monitoring rules to monitor the patient condition and to enable the BAN hub agent (7) to set off alarms etc. as required.
摘要翻译：提供病人护理分配和管理系统（1）。系统（1）允许在特定医疗设施内或医疗设施之间的病人的无缝漫游。系统（1）包括身体局域网（BAN），管理代理（4），其处理医疗设施的定义的操作职能的指定部分内的数据; 与每个患者（10）相关联的与BAN管理代理（4）通信并存储通过连接到每个患者（10）的医疗遥测监视器诊断设备（MTMDD）（8）传递给其的患者数据的BAN中枢代理（7）。该系统的基本特征是与BAN管理代理（4）相比，BAN中枢代理（7）具有相对较小的处理能力，其向其馈送患者监视规则以监视患者状况并使能BAN中枢代理（7 ）根据需要设置报警等。

8. 发明申请

WO2004082735A2 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2004082735A2
公开(公告)日：2004-09-30
申请号：PCT/US2004007435
申请日：2004-03-12
申请人： SCIMED LIFE SYSTEMS INC , GELLMAN GARY N , MADDEN MICHAEL
发明人： GELLMAN GARY N , MADDEN MICHAEL
IPC分类号： A61M25/00 , A61M
CPC分类号： A61M27/008
摘要： A stent with rapid return and strong shape memory prevents migration of the stent out of a desired site within a patient's body due to peristaltic actions. One particular stent includes an elongated member which defines an eccentric lumen extending longitudinally therethrough such that a first wall portion of the elongated member is thicker than a second wall portion of the elongated member. The first wall has a stronger shape memory than the second wall, and it recoils faster than the second wall. Another particular stent includes a co-extruded elongated member. The elongated member comprises a first material co-extruded with a second material where the second material forms at least a portion of a wall of the elongated member. The second material can have a higher modulus of elasticity than the first material. Additionally or alternatively, the second material can include a shape memory material.
摘要翻译：具有快速返回和强壮形状记忆的支架防止由于蠕动作用使支架从患者体内的期望位置迁移。一个特定的支架包括细长构件，该细长构件限定了纵向穿过其中延伸的偏心腔，使得细长构件的第一壁部分比细长构件的第二壁部分更厚。第一个墙壁具有比第二个墙壁更强的形状记忆，并且它比第二个墙壁反弹更快。另一种具体的支架包括共挤出的细长构件。细长构件包括与第二材料共挤出的第一材料，其中第二材料形成细长构件的壁的至少一部分。第二种材料可以具有比第一种材料更高的弹性模量。另外或替代地，第二材料可以包括形状记忆材料。

9. 发明申请

WO2003047722A3 FILTER ELEMENT USING CORRUGATED MEDIA SHEET 审中-公开
公开(公告)号：WO2003047722A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/037200
申请日：2002-11-19
申请人： DONALDSON COMPANY, INC. , GOLDEN, Patrick , MADDEN, Michael, A.
发明人： GOLDEN, Patrick , MADDEN, Michael, A.
IPC分类号： B01D46/52
摘要： A corrugated web having tapered flutes is usable in straight-through flow filter elements. The corrugated web can be made by passage between a pair of corrugated rollers having tapered teeth. Methods of making usable corrugated rollers include methods for generating the tapered teeth at the end points and the extension between the end points. Corrugated webs may be made from a variety of media, including certain media that stretches in the machine direction. Methods of forming the corrugated web into filter elements (e.g., air filter elements) includes forming filter media by securing a flat sheet to the corrugated web. The filter media may then be wound into a filter element, including application of sealant during the winding process to close selected flutes.

10. 发明申请

WO2008151175A1 RESISTANCE EXERCISE DEVICE 审中-公开
标题翻译：电阻锻炼装置
公开(公告)号：WO2008151175A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065608
申请日：2008-06-03
申请人： SPRI PRODUCTS, INC. , MADDEN, Michael J.
发明人： MADDEN, Michael J.
IPC分类号： A63B21/02
CPC分类号： A63B21/0552 , A63B21/0004 , A63B21/0555 , A63B21/0557 , A63B21/4035 , A63B21/4043 , A63B23/12 , A63B2208/0204
摘要： A resistance exercise device comprising at least one handle and a cord having a pair of ends and a length extending between the pair of ends, the handle being secured to one of the ends of the cord, the cord being stretchable to extend the length and comprising a plurality of tubes extending substantially the entire length of the cord, the tubes being conjoined together along substantially the entire length of the cord by means of braiding. The tubes are conjoined together such that the tubes are snug along substantially the entire length of the cord and such that each of the tubes is in contact with at least one of the other tubes substantially along the entire length of the cord. The resistance exercise device may further comprise a plug and sleeve for securing the handle to the end of the cord.
摘要翻译：一种阻力锻炼装置，包括至少一个手柄和一根绳索，所述手柄和绳索具有一对端部和在所述一对端部之间延伸的长度，所述手柄固定到所述绳索的一端之一，所述绳索可拉伸以延长所述长度并且包括基本上沿着绳索的整个长度延伸的多个管，通过编织，沿着帘线的整个长度将管连接在一起。管被结合在一起，使得管沿着帘线的大致整个长度紧贴，并且使得每个管基本上沿着帘线的整个长度与至少一个其它管接触。抵抗运动装置还可以包括用于将手柄固定到绳索的端部的塞子和套筒。

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