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    • 4. 发明申请
    • NANOSTRUCTURES COMPRISING RADIOISOTOPES AND/OR METALS
    • 包含放射性物质和/或金属的纳米结构
    • WO2012027556A1
    • 2012-03-01
    • PCT/US2011/049119
    • 2011-08-25
    • WILLIAM MARSH RICE UNIVERSITYRADIOMEDIX INC.MACKEYEV, YuriTWOROWSKA, IzabelaWILSON, Lon, J.
    • MACKEYEV, YuriTWOROWSKA, IzabelaWILSON, Lon, J.
    • C08J9/00
    • A61K51/1251B82Y5/00
    • Nanostructure compositions comprising radioisotopes and/or metals, methods of their synthesis, and their use in cancer imaging and therapy are provided. The compositions may be used as multimodality probes for detection of disease-changed organs using different detection methods. These novel probes will allow for acquisition of different functional parameters with PET and SPECT techniques in addition to high-resolution anatomical and functional information that can be obtained with MRI and CT techniques. The compositions of the present disclosure can enhance the diagnostic information that can be acquired in a single imaging session. Compositions of the present disclosure can be detected by one or more imaging methods. In some embodiments, the compositions of the present disclosure may be used as dual modalityPET/CT, PET/MRI agents or multimodality PET/CT IMRI/SPECT agents.
    • 提供包含放射性同位素和/或金属的纳米结构组合物,其合成方法及其在癌症成像和治疗中的应用。 组合物可以用作多模式探针,用于使用不同的检测方法检测疾病变化的器官。 除了通过MRI和CT技术获得的高分辨率解剖和功能信息之外,这些新型探针将允许采用PET和SPECT技术获取不同的功能参数。 本公开的组合物可以增强可以在单个成像会话中获得的诊断信息。 本公开的组合物可以通过一种或多种成像方法检测。 在一些实施方案中,本公开的组合物可以用作双重模式PET / CT,PET / MRI试剂或多模态PET / CT IMRI / SPECT试剂。