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1. 发明申请

WO2013141874A1 METHOD OF BUFFER MANAGEMENT FOR SYNCHRONIZATION OF CORRELATED MEDIA PRESENTATIONS 审中-公开
标题翻译：缓存管理方法对相关媒体演示进行同步化
公开(公告)号：WO2013141874A1
公开(公告)日：2013-09-26
申请号：PCT/US2012/030307
申请日：2012-03-23
申请人： THOMSON LICENSING , LI, Jun , MA, Xiao Jun , CHEN, Jian Feng
发明人： LI, Jun , MA, Xiao Jun , CHEN, Jian Feng
IPC分类号： H04N21/43 , H04N21/44 , H04N21/462
CPC分类号： H04N21/4307 , H04N21/4126 , H04N21/4305 , H04N21/43615 , H04N21/438 , H04N21/44004 , H04N21/4622 , H04N21/637
摘要： The present invention concerns synchronization of correlated media presentations among two or more media devices. Each device makes a determination as to whether inter-presentation synchronization may be outside of a predetermined tolerance. If so, the device making the determination communicates its buffer and playback status to the other device. Based upon comparison of the buffer and playback status of the local presentation with the buffer and playback status of the presentation at the other device, each device makes a determination as to whether to pause playback, so as to allow the other device to catch up, advance playback, so as to catch up with the other device, or take no action, allowing the other device to take action to correct the synchronization issue.
摘要翻译：本发明涉及两个或多个媒体设备之间的相关媒体呈现的同步。每个设备确定呈现间同步是否在预定公差之外。如果是这样，进行确定的设备将其缓冲区和播放状态传送给另一个设备。基于本地呈现与缓冲器的缓冲区和播放状态的比较以及在另一设备处的呈现的回放状态，每个设备确定是否暂停播放，以允许其他设备赶上，提前播放，以赶上其他设备，或不采取任何行动，允许其他设备采取行动来纠正同步问题。

2. 发明申请

WO2013002750A2 DETERMINING TUMOR ORIGIN 审中-公开
标题翻译：确定肿瘤起源
公开(公告)号：WO2013002750A2
公开(公告)日：2013-01-03
申请号：PCT/US2011/031870
申请日：2011-06-29
申请人： BIOTHERANOSTICS, INC. , ERLANDER, Mark , MA, Xiao-Jun
发明人： ERLANDER, Mark , MA, Xiao-Jun
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/158
摘要： The disclosure provides methods for the use of gene expression measurements to classify or identify among 54 cancer types in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.
摘要翻译：本公开提供了使用基因表达测量来分类或鉴定从临床背景中的受试者获得的样品中的54种癌症类型的方法，例如福尔马林固定，石蜡包埋（FFPE ）样本。

3. 发明申请

WO2010026223A1 METHOD AND DEVICE FOR ENCODING ELEMENTS 审中-公开
标题翻译：编码元素的方法和装置
公开(公告)号：WO2010026223A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/061479
申请日：2009-09-04
申请人： THOMSON LICENSING , CHEN, Ren Lei , ZHOU, Guang Hua , SONG, Wen Juan , MA, Xiao Jun
发明人： CHEN, Ren Lei , ZHOU, Guang Hua , SONG, Wen Juan , MA, Xiao Jun
IPC分类号： G06F17/22 , H03M7/30
CPC分类号： G06F17/2247 , G06F17/2252 , H03M7/3084
摘要： A method for encoding a set of elements wherein each element comprises a data structure of a type and at least one attribute value is provided. The method comprises the steps of: selecting a current element for encoding; determining whether the current element has the same data structure type as a previously encoded element; in the negative, encoding the data structure of the current element and the at least one attribute value of the current element; and in the affirmative, encoding the at least one attribute value of the current element and providing an indication value indicating the current element has the same data structure type as the previously encoded element. The method is used to reduce the encoding redundancy of the structure information.
摘要翻译：一种用于对一组元素进行编码的方法，其中每个元素包括类型的数据结构和至少一个属性值。该方法包括以下步骤：选择当前要编码的元素; 确定当前元素是否具有与先前编码的元素相同的数据结构类型; 负的是对当前元素的数据结构和当前元素的至少一个属性值进行编码; 并且肯定地，编码当前元素的至少一个属性值并且提供指示当前元素的指示值具有与先前编码的元素相同的数据结构类型。该方法用于减少结构信息的编码冗余度。

4. 发明申请

WO2005118879A3 IDENTIFICATION OF TUMORS 审中-公开
标题翻译：肿瘤鉴定
公开(公告)号：WO2005118879A3
公开(公告)日：2006-04-13
申请号：PCT/US2005019736
申请日：2005-06-03
申请人： ARCTURUS BIOSCIENCE INC , ERLANDER MARK G , MA XIAO-JUN
发明人： ERLANDER MARK G , MA XIAO-JUN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , G06F19/20 , G06F19/24 , G06Q50/22
摘要： The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.
摘要翻译：本发明提供了使用基因表达测量来分类或鉴定在临床环境中从受试者获得的样品中的肿瘤的方法，例如在福尔马林固定的石蜡包埋（FFPE）样品的情况下。

5. 发明申请

WO2004085681A3 GLOBAL LINEAR NON-BIASED NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：全球线性非偏心核酸放大
公开(公告)号：WO2004085681A3
公开(公告)日：2005-04-21
申请号：PCT/US2004008553
申请日：2004-03-19
申请人： ARCTURUS BIOSCIENCE INC , ERLANDER MARK G , SALUNGA RANELLE C , MA XIAO-JUN , ENRIGHT EDDY
发明人： ERLANDER MARK G , SALUNGA RANELLE C , MA XIAO-JUN , ENRIGHT EDDY
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2521/119 , C12Q2521/131 , C12Q2521/107 , C12Q2521/101 , C12Q2525/173
摘要： The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucloetides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products.
摘要翻译：本发明提供了扩增核酸分子的方法。提供了使用寡核苷酸，DNA和RNA聚合酶扩增靶多核苷酸（包括mRNA）的方法。本发明还提供了用于实施该方法的组合物和试剂盒，以及使用扩增产物的方法。

6. 发明申请

WO2004079014A3 SIGNATURES OF ER STATUS IN BREAST CANCER 审中-公开
标题翻译：乳腺癌ER状态的标志
公开(公告)号：WO2004079014A3
公开(公告)日：2005-03-31
申请号：PCT/US2004006736
申请日：2004-03-04
申请人： ARCTURUS BIOSCIENCE INC , ERLANDER MARK G , MA XIAO-JUN , WANG WEI , WITTLIFF JAMES L
发明人： ERLANDER MARK G , MA XIAO-JUN , WANG WEI , WITTLIFF JAMES L
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The invention relates to the identification and use of gene expression profiles, or patterns, suitable for identification of populations that are positive and negative for estrogen receptor expression. The gene expression profiles may be embodied in nucleic acid expression, protein expression, or other expression formats, and may be used in the study and/or diagnosis of cells and tissue in breast cancer as well as for the study and/or determination of prognosis of a patient, including breast cancer survival.
摘要翻译：本发明涉及鉴定和使用适合于鉴定雌激素受体表达阳性和阴性的群体的基因表达谱或模式。基因表达谱可以体现在核酸表达，蛋白质表达或其他表达形式中，并且可以用于乳腺癌细胞和组织的研究和/或诊断以及用于预后的研究和/或测定的患者，包括乳腺癌的存活。

7. 发明申请

WO2005001135A3 3' BIASED DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译： 3'偏核酸的检测
公开(公告)号：WO2005001135A3
公开(公告)日：2005-02-03
申请号：PCT/US2004017572
申请日：2004-06-02
申请人： ARCTURUS BIOSCIENCE INC , ELANDER MARK G , MA XIAO-JUN , BAER THOMAS M
发明人： ELANDER MARK G , MA XIAO-JUN , BAER THOMAS M
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
摘要： The invention provides materials and methods for the detection of nucleic acid expression via the 3' portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3' end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3' end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a "transcriptome").
摘要翻译：本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。本发明的实施方案包括使用包含核酸探针的微阵列，所述核酸探针与表达序列的3'末端互补，并且通过使用基于定量PCR（Q-PCR）的扩增在表达的3'末端或附近发现的序列序列。本发明可用于检测编码特定基因产物（存在于“转录组”中的序列）的表达核酸的存在。

8. 发明申请

WO2005001138A3 BREAST CANCER SURVIVAL AND RECURRENCE 审中-公开
公开(公告)号：WO2005001138A3
公开(公告)日：2005-01-06
申请号：PCT/US2004/019451
申请日：2004-06-18
申请人： ARCTURUS BIOSCIENCE, INC. , ERLANDER, Mark, G. , MA, Xiao-Jun , WANG, Wei , WITTLIFF, James, L.
发明人： ERLANDER, Mark, G. , MA, Xiao-Jun , WANG, Wei , WITTLIFF, James, L.
IPC分类号： C12Q1/68
摘要： The invention provides for the identification and use of gene expression profiles, or patterns, with clinical relevance to breast cancer. In particular, the invention provides the identities of genes that are correlated with patient survival and breast cancer recurrence. The gene expression profiles may be embodied in nucleic acid expression, protien expression, or other expression formats and used to predict the survival of the subjects afflicted with breast cancer and to predict cancer recurrence and The profiles may also be used in the study and/or diagnosis of breast cancer cells and tissue, including the grading of invasive breast cancer, as well as for the study and/or determination of prognosis of a patient. When used for diagnosis or prognosis, the profiles may be used to determine the treatment of breast cancer based upon the likelihood of life expectancy and recurrence.

9. 发明申请

WO2005001135A2 3’ BIASED DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译： 3'核酸的漂白检测
公开(公告)号：WO2005001135A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/017572
申请日：2004-06-02
申请人： ARCTURUS BIOSCIENCE, INC. , ELANDER, Mark, G. , MA, Xiao-Jun , BAER, Thomas, M.
发明人： ELANDER, Mark, G. , MA, Xiao-Jun , BAER, Thomas, M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
摘要： The invention provides materials and methods for the detection of nucleic acid expression via the 3' portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3' end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3' end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a "transcriptome").
摘要翻译：本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列，以及通过使用基于定量PCR（Q-PCR）的扩增在3'末端发现的序列的表达序列。本发明可用于检测编码特定基因产物（“转录组”中存在的序列）的表达的核酸的存在。

10. 发明申请

WO2012103414A3 RNASCOPE® HPV ASSAY FOR DETERMINING HPV STATUS IN HEAD AND NECK CANCERS AND CERVICAL LESIONS 审中-公开
标题翻译：用于确定头颈部和颈部癌症和宫颈癌HPV状态的RNASCOPE®HPV测定
公开(公告)号：WO2012103414A3
公开(公告)日：2012-10-11
申请号：PCT/US2012022856
申请日：2012-01-27
申请人： ADVANCED CELL DIAGNOSTICS INC , MA XIAO-JUN , FLANAGAN JOHN , LUO YULING
发明人： MA XIAO-JUN , FLANAGAN JOHN , LUO YULING
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6841 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention provides a method and a kit for determining whether a head and neck cancer is HPV-related. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to head and neck cancer. The present invention also provides a method and a kit for determining whether a cervical lesion is a benign lesion or a cervical intraepithethial neoplasm lesion. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to cervical cancer. The present invention further provides a method for determining the progression of cervical intraepithethial neoplasm based on the spatial pattern and levels of the E6/E7 mRNA of certain high-risk HPV subtypes. The present invention also provides a method for determining the risk of developing cervical cancer in a human diagnosed with cervical intraepithethial neoplasm based on presence and absence of the certain subgroups of high-risk HPV subtypes.
摘要翻译：本发明提供了一种用于确定头颈癌是否与HPV相关的方法和试剂盒。在一个实施方案中，设计了RNA检测HPV检测来检测某些与头颈癌相关的高危HPV亚型的E6 / E7 mRNA的存在。本发明还提供了一种用于确定子宫颈病变是否是良性病变或子宫颈上皮内肿瘤病变的方法和试剂盒。在一个实施方案中，设计了RNA检测HPV检测来检测与子宫颈癌相关的某些高危HPV亚型的E6 / E7 mRNA的存在。本发明还提供了一种基于某些高风险HPV亚型的E6 / E7 mRNA的空间格局和水平来确定子宫颈上皮内肿瘤进展的方法。本发明还提供了一种基于存在和不存在某些亚型的高风险HPV亚型的方法来确定诊断为宫颈上皮内瘤的人的宫颈癌发生风险的方法。

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