发明申请
WO2012103414A3 RNASCOPE® HPV ASSAY FOR DETERMINING HPV STATUS IN HEAD AND NECK CANCERS AND CERVICAL LESIONS
审中-公开
基本信息:
- 专利标题： RNASCOPE® HPV ASSAY FOR DETERMINING HPV STATUS IN HEAD AND NECK CANCERS AND CERVICAL LESIONS
- 专利标题（中）：用于确定头颈部和颈部癌症和宫颈癌HPV状态的RNASCOPE®HPV测定
- 申请号：PCT/US2012022856 申请日：2012-01-27
- 公开(公告)号：WO2012103414A3 公开(公告)日：2012-10-11
- 发明人： MA XIAO-JUN , FLANAGAN JOHN , LUO YULING
- 申请人： ADVANCED CELL DIAGNOSTICS INC , MA XIAO-JUN , FLANAGAN JOHN , LUO YULING
- 专利权人： ADVANCED CELL DIAGNOSTICS INC,MA XIAO-JUN,FLANAGAN JOHN,LUO YULING
- 当前专利权人： ADVANCED CELL DIAGNOSTICS INC,MA XIAO-JUN,FLANAGAN JOHN,LUO YULING
- 优先权： US201161437337 2011-01-28
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/70
摘要：
The present invention provides a method and a kit for determining whether a head and neck cancer is HPV-related. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to head and neck cancer. The present invention also provides a method and a kit for determining whether a cervical lesion is a benign lesion or a cervical intraepithethial neoplasm lesion. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to cervical cancer. The present invention further provides a method for determining the progression of cervical intraepithethial neoplasm based on the spatial pattern and levels of the E6/E7 mRNA of certain high-risk HPV subtypes. The present invention also provides a method for determining the risk of developing cervical cancer in a human diagnosed with cervical intraepithethial neoplasm based on presence and absence of the certain subgroups of high-risk HPV subtypes.
摘要（中）：
本发明提供了一种用于确定头颈癌是否与HPV相关的方法和试剂盒。 在一个实施方案中，设计了RNA检测HPV检测来检测某些与头颈癌相关的高危HPV亚型的E6 / E7 mRNA的存在。 本发明还提供了一种用于确定子宫颈病变是否是良性病变或子宫颈上皮内肿瘤病变的方法和试剂盒。 在一个实施方案中，设计了RNA检测HPV检测来检测与子宫颈癌相关的某些高危HPV亚型的E6 / E7 mRNA的存在。 本发明还提供了一种基于某些高风险HPV亚型的E6 / E7 mRNA的空间格局和水平来确定子宫颈上皮内肿瘤进展的方法。 本发明还提供了一种基于存在和不存在某些亚型的高风险HPV亚型的方法来确定诊断为宫颈上皮内瘤的人的宫颈癌发生风险的方法。