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1. 发明申请

WO2012112953A2 MOLECULAR SWITCH FOR NEURONAL OUTGROWTH 审中-公开
标题翻译：分子开关用于神经生物学
公开(公告)号：WO2012112953A2
公开(公告)日：2012-08-23
申请号：PCT/US2012/025738
申请日：2012-02-17
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , FLANAGAN, John G , SHEN, Yingjie , JONES, Edith Yvonne , ARICESCU, Alexandru Radu , COLES, Charlotte Hannah
发明人： FLANAGAN, John G , SHEN, Yingjie , JONES, Edith Yvonne , ARICESCU, Alexandru Radu , COLES, Charlotte Hannah
CPC分类号： A61K31/727 , A61K31/737 , A61K38/177 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase δ (RPTPδ), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPδ and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPδ. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPδ. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.
摘要翻译：本文公开了诱导神经元的神经元生长的方法。所述方法包括使神经元与结合受体蛋白酪氨酸磷酸酶d（RPTPd）的试剂接触，从而诱导神经元的神经元生长。该试剂可诱导RPTPd的聚集和/或抑制硫酸软骨素蛋白聚糖（CSPG）与RPTPd的结合。合适的试剂的实例是硫酸乙酰肝素蛋白聚糖，硫酸乙酰肝素，硫酸乙酰肝素寡糖或肝素低聚糖。还公开了另外的试剂。神经元可以是CNS神经元或外周神经元。本文还公开了治疗受试者神经元损伤的方法，其包括向受试者施用结合RPTPd的药剂。管理可能是神经元损伤的部位，从而在神经元损伤部位诱导神经元生长。

2. 发明申请

WO2012103414A2 RNASCOPE® HPV ASSAY FOR DETERMINING HPV STATUS IN HEAD AND NECK CANCERS AND CERVICAL LESIONS 审中-公开
标题翻译：用于确定头颈部癌症和颈部病变中HPV状态的RNASCOPE®HPV测定
公开(公告)号：WO2012103414A2
公开(公告)日：2012-08-02
申请号：PCT/US2012/022856
申请日：2012-01-27
申请人： ADVANCED CELL DIAGNOSTICS, INC. , MA, Xiao-Jun , FLANAGAN, John , LUO, Yuling
发明人： MA, Xiao-Jun , FLANAGAN, John , LUO, Yuling
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6841 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention provides a method and a kit for determining whether a head and neck cancer is HPV-related. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to head and neck cancer. The present invention also provides a method and a kit for determining whether a cervical lesion is a benign lesion or a cervical intraepithethial neoplasm lesion. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to cervical cancer. The present invention further provides a method for determining the progression of cervical intraepithethial neoplasm based on the spatial pattern and levels of the E6/E7 mRNA of certain high-risk HPV subtypes. The present invention also provides a method for determining the risk of developing cervical cancer in a human diagnosed with cervical intraepithethial neoplasm based on presence and absence of the certain subgroups of high-risk HPV subtypes.
摘要翻译：本发明提供了用于确定头颈部癌症是否与HPV相关的方法和试剂盒。在一个实施方案中，RNAscope＆reg; 设计HPV测定以检测与头颈部癌有关的某些高风险HPV亚型的E6 / E7 mRNA的存在。本发明还提供了用于确定宫颈病变是良性病变还是宫颈上皮内瘤病变的方法和试剂盒。在一个实施方案中，RNAscope＆reg; 设计HPV测定以检测与宫颈癌相关的某些高风险HPV亚型的E6 / E7 mRNA的存在。本发明进一步提供了基于某些高风险HPV亚型的E6 / E7 mRNA的空间模式和水平确定宫颈上皮内肿瘤进展的方法。本发明还提供了基于存在和不存在某些高风险HPV亚型亚组来确定诊断患有宫颈上皮内瘤的人中发展为宫颈癌的风险的方法。

3. 发明申请

WO2011022462A3 NEURAL REGENERATION 审中-公开
标题翻译：神经再生
公开(公告)号：WO2011022462A3
公开(公告)日：2011-06-16
申请号：PCT/US2010045859
申请日：2010-08-18
申请人： HARVARD COLLEGE , FLANAGAN JOHN G , TENNEY ALAN PETER , SHEN YINGJIE
发明人： FLANAGAN JOHN G , TENNEY ALAN PETER , SHEN YINGJIE
IPC分类号： A61K39/395 , A61K38/16 , A61P25/00 , A61P25/28
CPC分类号： A61K38/1709 , C07K2319/30
摘要： A method of promoting neural cell regeneration is carried out by contacting a neural cell with a compound that inhibits the binding of a chondroitin sulfate proteoglycan (CSPG ) to a cellular (e.g., transmembrane) PTPs protein. The neural cell is associated with an injury or neurodegenerative condition.
摘要翻译：通过使神经细胞与抑制硫酸软骨素蛋白聚糖（CSPG）与细胞（例如跨膜）PTPs蛋白的结合的化合物接触来进行促进神经细胞再生的方法。神经细胞与损伤或神经变性疾病有关。

4. 发明申请

WO2010096535A1 METHOD FOR DIAGNOSING POMPE DISEASE 审中-公开
标题翻译：诊断疾病的方法
公开(公告)号：WO2010096535A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/024553
申请日：2010-02-18
申请人： AMICUS THERAPEUTICS, INC. , DO, Hung, V. , RANE, Brian, E. , FLANAGAN, John
发明人： DO, Hung, V. , RANE, Brian, E. , FLANAGAN, John
IPC分类号： C12Q1/00 , G01N33/573 , C12Q1/34
CPC分类号： C12Q1/34 , G01N33/5047 , G01N33/577 , G01N2333/924 , G01N2800/042 , G01N2800/52
摘要： Provided is a method for diagnosing Pompe disease in a patient by measuring acid α-glucosidase activity in a sample from the patient. The invention also provides a method for monitoring the treatment of Pompe disease with specific pharmacological chaperones by measuring acid α-glucosidase activity in a sample from the patient.
摘要翻译：提供了一种通过测量来自患者的样品中的酸性α-葡萄糖苷酶活性来诊断患者庞波病的方法。本发明还提供了通过测量来自患者的样品中的酸性α-葡萄糖苷酶活性来监测具有特定药理学分子伴侣的庞毕病治疗的方法。

5. 发明申请

WO2009102895A2 METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES 审中-公开
标题翻译：预防药物治疗疾病的方法
公开(公告)号：WO2009102895A2
公开(公告)日：2009-08-20
申请号：PCT/US2009/033963
申请日：2009-02-12
申请人： AMICUS THERAPEUTICS, INC. , BENJAMIN, Elfrida , DO, Hung, V. , WU, Xiaoyang , FLANAGAN, John , WUSTMAN, Brandon
发明人： BENJAMIN, Elfrida , DO, Hung, V. , WU, Xiaoyang , FLANAGAN, John , WUSTMAN, Brandon
IPC分类号： A61K31/45 , C12Q1/37
CPC分类号： A61K31/445 , C07K14/00 , C12Q1/34 , G01N33/6893 , G01N2333/47 , G01N2333/94 , G01N2800/38 , G01N2800/52
摘要： The present invention provides methods to determine whether a patient with a lysosomal storage disorder will benefit from treatment with a specific pharmacological chaperone. The present invention exemplifies an in vitro method for determining α-galactosidase A responsiveness to a pharmacological chaperone such as 1-deoxygalactonojirimycin in a cell line expressing a mutant from of α- galactosidase A. The invention also provides a method for diagnosing Fabry disease in patients suspected of having Fabry disease.
摘要翻译：本发明提供了确定具有溶酶体储存障碍的患者是否将受益于用特定药物伴侣的治疗的方法。本发明举例说明了在表达来自β-半乳糖苷酶A的突变体的细胞系中测定α-半乳糖苷酶A对药物分子伴侣如1-脱氧半乳糖吉非霉素的反应性的体外方法。本发明还提供了用于诊断患者中法布里病的方法怀疑患有法布里病。

6. 发明申请

WO2009101057A1 PROVIDING INDIRECT DATA ADDRESSING FOR A CONTROL BLOCK AT A CHANNEL SUBSYSTEM OF AN I/O PROCESSING SYSTEM 审中-公开
标题翻译：在I / O处理系统的通道子系统中为控制块提供间接数据寻址
公开(公告)号：WO2009101057A1
公开(公告)日：2009-08-20
申请号：PCT/EP2009/051462
申请日：2009-02-09
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , CASPER, Daniel , FLANAGAN, John , HUANG, Catherine , KALOS, Matthew , NJOKU, Ugochukwu , RIEDY, Dale , SITTMANN III, Gustav
发明人： CASPER, Daniel , FLANAGAN, John , HUANG, Catherine , KALOS, Matthew , NJOKU, Ugochukwu , RIEDY, Dale , SITTMANN III, Gustav
IPC分类号： G06F13/38 , G06F3/06
CPC分类号： G06F3/0659 , G06F3/061 , G06F13/126 , G06F13/385
摘要： An computer program product, apparatus, and method for facilitating input/output (I/O) processing for an I/O operation at a host computer system configured for communication with a control unit. The computer program product includes a tangible storage medium readable by a processing circuit and storing instructions for execution by the processing circuit for performing a method. The method includes the host computer system obtaining a transport command word (TCW) for an I/O operation. The TCW specifies a location of one or more I/O commands and a flag. The flag is set to indicate that the location is an indirect address. The host computer system extracts the location of the one or more I/O commands and the flag from the TCW. The host computer system gathers the one or more I/O commands responsive to the location specified by the TCW and the flag, and then forwards the one or more I/O commands to the control unit for execution.
摘要翻译：一种用于便于在被配置为与控制单元进行通信的主计算机系统上进行I / O操作的输入/输出（I / O）处理的计算机程序产品，装置和方法。计算机程序产品包括可由处理电路读取的有形存储介质，并且存储由处理电路执行以执行方法的指令。该方法包括主计算机系统获得用于I / O操作的传输命令字（TCW）。 TCW指定一个或多个I / O命令和标志的位置。该标志设置为指示该位置是间接地址。主计算机系统从TCW提取一个或多个I / O命令的位置和标志。主计算机系统根据TCW和标志指定的位置收集一个或多个I / O命令，然后将一个或多个I / O命令转发到控制单元执行。

7. 发明申请

WO2009101053A1 BI-DIRECTIONAL DATA TRANSFER WITHIN A SINGLE I/O OPERATION 审中-公开
标题翻译：单向I / O操作中的双向数据传输
公开(公告)号：WO2009101053A1
公开(公告)日：2009-08-20
申请号：PCT/EP2009/051450
申请日：2009-02-09
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , CASPER, Daniel , FLANAGAN, John , KALOS, Matthew , SITTMANN III, Gustav , HUANG, Catherine , NJOKU, Ugochukwu , RIEDY, Dale
发明人： CASPER, Daniel , FLANAGAN, John , KALOS, Matthew , SITTMANN III, Gustav , HUANG, Catherine , NJOKU, Ugochukwu , RIEDY, Dale
IPC分类号： G06F13/10
CPC分类号： G06F3/0613 , G06F3/0659 , G06F3/0673 , G06F13/126
摘要： An article of manufacture, apparatus, and a method for facilitating input/output (I/O) processing for an I/O operation at a host computer system configured for communication with a control unit. The method includes the host computer system obtaining a transport command word (TCW) for an I/O operation having both input and output data. The TCW specifies a location of the output data and a location for storing the input data. The host computer system forwards the I/O operation to the control unit for execution. The host computer system gathers the output data responsive to the location of the output data specified by the TCW, and then forwards the output data to the control unit for use in the execution of the I/O operation. The host computer system receives the input data from the control unit and stores the input data at the location specified by the TCW.
摘要翻译：一种制造装置和方法，用于在被配置为与控制单元进行通信的主计算机系统上促进用于I / O操作的输入/输出（I / O）处理。该方法包括主计算机系统获得具有输入和输出数据的I / O操作的传输命令字（TCW）。 TCW指定输出数据的位置和存储输入数据的位置。主计算机系统将I / O操作转发到控制单元以执行。主计算机系统根据TCW指定的输出数据的位置收集输出数据，然后将输出数据转发到控制单元，以用于执行I / O操作。主计算机系统从控制单元接收输入数据，并将输入数据存储在TCW指定的位置。

8. 发明申请

WO2012115978A8 ELECTROCHEMICAL CELL HAVING AIR CATHODE PARTIALLY INFUSED WITH CARBON DIOXIDE 审中-公开
标题翻译：具有二氧化碳的部分地输入的空气阴极的电化学细胞
公开(公告)号：WO2012115978A8
公开(公告)日：2013-03-28
申请号：PCT/US2012025968
申请日：2012-02-21
申请人： JOHNSON IP HOLDING LLC , JOHNSON LONNIE G , FLANAGAN JOHN S , CAMPBELL TEDRIC D
发明人： JOHNSON LONNIE G , FLANAGAN JOHN S , CAMPBELL TEDRIC D
IPC分类号： H01M2/02 , H01M2/16 , H01M10/052 , H01M10/0563 , H01M10/0568 , H01M10/0569 , H01M12/06
CPC分类号： H01M12/06 , H01M2/025 , H01M2/16 , H01M10/052 , H01M10/0563 , H01M10/0568 , H01M10/0569
摘要： An electrochemical cell (10) has a cell assembly (20) that has an anode (22), an air cathode (24) infused with a liquid electrolyte, an ionically- conductive separator medium (26) disposed between and coupling said anode (22) and said air cathode (24), a housing enclosing said anode, said cathode, and said ionically-conductive separator medium, and a mixture of oxygen and carbon dioxide disposed within said housing in gaseous communication with said air cathode, wherein said carbon dioxide comprises from about 0.04% to about 95% molar fraction of said mixture of oxygen and carbon dioxide.
摘要翻译：电化学电池（10）具有电池组件（20），其具有阳极（22），注入液体电解质的空气阴极（24），设置在所述阳极（22）和耦合所述阳极（22）之间的离子导电隔离介质）和所述空气阴极（24），包围所述阳极，所述阴极和所述离子导电隔离介质的壳体以及与所述空气阴极气体连通地设置在所述壳体内的氧气和二氧化碳的混合物，其中所述二氧化碳包括氧和二氧化碳混合物的约0.04％至约95％的摩尔分数。

9. 发明申请

WO2013000603A1 FACILITATING TRANSPORT MODE INPUT/OUTPUT OPERATIONS BETWEEN A CHANNEL SUBSYSTEM AND INPUT/OUTPUT DEVICES 审中-公开
标题翻译：促进通道子系统和输入/输出设备之间的运输模式输入/输出操作
公开(公告)号：WO2013000603A1
公开(公告)日：2013-01-03
申请号：PCT/EP2012/058104
申请日：2012-05-03
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , HATHORN, Roger , FLANAGAN, John , RICCI, Louis , CARLSON, Scott , KALOS, Matthew, Joseph , YUDENFRIEND, Harry , RIEDY, Dale , CASPER, Daniel, Francis , CANDELARIA, Susan, Kay
发明人： HATHORN, Roger , FLANAGAN, John , RICCI, Louis , CARLSON, Scott , KALOS, Matthew, Joseph , YUDENFRIEND, Harry , RIEDY, Dale , CASPER, Daniel, Francis , CANDELARIA, Susan, Kay
IPC分类号： G06F13/12
CPC分类号： G06F3/0659 , G06F3/061 , G06F3/0683 , G06F13/42
摘要： A computer program product is configured for performing a method including: generating at least one command message by a channel subsystem of the host computer system, the at least one command message including one or more device command words (DCWs), wherein at least one DCW of the one or more DCWs includes a suppress-length indication (SLI) configured to instruct a control unit to continue to perform the I/O operation in response to the control unit detecting that the data count does not match an amount of data required; receiving an incorrect length (IL) value, the IL value being a first IL value in response to the SLI being a first SLI value and the data count not matching the amount of data required; and responsive to receiving the IL value from the control unit, storing an IL indicator in a subchannel-status word.
摘要翻译：计算机程序产品被配置用于执行一种方法，包括：通过主计算机系统的信道子系统生成至少一个命令消息，所述至少一个命令消息包括一个或多个设备命令字（DCW），其中至少一个DCW 所述一个或多个DCW包括抑制长度指示（SLI），其被配置为指示控制单元响应于所述控制单元检测到所述数据计数与所需数据量不匹配而继续执行所述I / O操作; 接收到不正确的长度（IL）值，IL值是响应于SLI是第一SLI值并且数据计数不匹配所需数据量的第一IL值; 并且响应于从所述控制单元接收到IL值，将IL指示符存储在子信道状态字中。

10. 发明申请

WO2012164428A1 FIBRE CHANNEL INPUT/OUTPUT DATA ROUTING SYSTEM AND METHOD 审中-公开
标题翻译：光纤通道输入/输出数据路由系统和方法
公开(公告)号：WO2012164428A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/052489
申请日：2012-05-17
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , IBM (China) Investment Company Limited , FLANAGAN, John , BUBB, Clinton , CASPER, Daniel, Francis
发明人： FLANAGAN, John , BUBB, Clinton , CASPER, Daniel, Francis
IPC分类号： G06F13/38
CPC分类号： H04L49/9068
摘要： On embodiment includes a computer program product for performing a method including: obtaining information relating to an I/O operation at a channel subsystem in a host computer system; generating addressing information and forwarding the addressing information from at least one channel to a network interface between the channel subsystem and at least one I/O device, the addressing information specifying a location in a local channel memory; forwarding an I/O command message to the at least one I/O device via the network interface; responsive to the I/O command message, receiving a data transfer request from the network interface that includes the addressing information; responsive to receiving the data transfer request, accessing one of a plurality of address control words (ACWs), each ACW specifying an address of a location in a host computer memory; and routing the data transfer request to the host memory location specified in the ACW.
摘要翻译：实施例包括用于执行方法的计算机程序产品，包括：获得与主计算机系统中的通道子系统处的I / O操作有关的信息; 产生寻址信息并将寻址信息从至少一个信道转发到信道子系统与至少一个I / O设备之间的网络接口，寻址信息指定本地信道存储器中的位置; 经由所述网络接口将I / O命令消息转发到所述至少一个I / O设备; 响应于I / O命令消息，从包括寻址信息的网络接口接收数据传输请求; 响应于接收到所述数据传输请求，访问多个地址控制字（ACW）中的一个，每个ACW指定主计算机存储器中的位置的地址; 并将数据传输请求路由到ACW中指定的主机存储器位置。

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