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1. 发明申请

WO2019178267A2 INDUCTIVE REGENERATION OF THE AIRWAY BY TRANSCRIPTIONAL FACTOR MODULATION OF GLANDULAR MYOEPITHELIAL STEM CELLS 审中-公开
公开(公告)号：WO2019178267A2
公开(公告)日：2019-09-19
申请号：PCT/US2019/022106
申请日：2019-03-13
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , ENGELHARDT, John, F. , LYNCH, Thomas, J. , ANDERSON, Preston, J. , SHAHIN, Weam
发明人： ENGELHARDT, John, F. , LYNCH, Thomas, J. , ANDERSON, Preston, J. , SHAHIN, Weam
IPC分类号： C12N5/07 , C12N5/0789
摘要： Compositions and methods to modulate Lef-1/TCF/Wnt signaling ex vivo or in vivo, and assays to detect those modulators, are described.

2. 发明申请

WO2017100329A1 INVERSE EMULSION COMPOSITIONS 审中-公开
标题翻译：反相乳液组合物
公开(公告)号：WO2017100329A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065394
申请日：2016-12-07
申请人： KEMIRA OYJ , JACKSON, Logan , LYNCH, Thomas, J. , ROBINSON, Ronald , FOURNIER, Frances , YANG, Hong , AUJILA, Sukhjit , KIM, Do, Hoon , ALEXIS, Dennis, Arun
发明人： JACKSON, Logan , LYNCH, Thomas, J. , ROBINSON, Ronald , FOURNIER, Frances , YANG, Hong , AUJILA, Sukhjit , KIM, Do, Hoon , ALEXIS, Dennis, Arun
IPC分类号： C08F20/56 , C09K8/26
CPC分类号： C08F20/56 , C08F220/56 , C09K8/36 , C09K8/584 , C08F220/06 , C08F2220/585
摘要： An inverse emulsion composition comprising: one or more hydrophobic liquids having a boiling point at least about 100 °C; up to about 38% by weight of one or more acrylamide-(co)polymers; one or more emulsifier surfactants; and one or more inverting surfactants; wherein, when the composition is inverted in an aqueous solution, it provides an inverted solution having a filter ratio using a 1.2 micron filter (FR 1.2) of about 1.5 or less.
摘要翻译：反相乳液组合物，其包含：一种或多种沸点至少约为100℃的疏水性液体; 至多约38重量％的一种或多种丙烯酰胺 - （共）聚合物; 一种或多种乳化剂表面活性剂; 和一种或多种反相表面活性剂; 其中当组合物在水溶液中倒置时，其提供具有约1.5或更小的1.2微米过滤器（FR1.2）的过滤比的倒置溶液。

3. 发明申请

WO2017100327A1 LIQUID POLYMER COMPOSITIONS 审中-公开
标题翻译：液体聚合物组合物
公开(公告)号：WO2017100327A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065391
申请日：2016-12-07
申请人： KEMIRA OYJ , JACKSON, Logan , LYNCH, Thomas, J. , ROBINSON, Ronald , FOURNIER, Frances , YANG, Hong , AUJILA, Sukhjit , KIM, Do, Hoon , ALEXIS, Dennis, Arun
发明人： JACKSON, Logan , LYNCH, Thomas, J. , ROBINSON, Ronald , FOURNIER, Frances , YANG, Hong , AUJILA, Sukhjit , KIM, Do, Hoon , ALEXIS, Dennis, Arun
IPC分类号： E21B43/00 , E21B43/16 , C08F2/32 , C08F26/00 , C09K8/588 , C08J3/09
CPC分类号： C08F2/24 , C09K8/588 , C08F220/06 , C08F220/56
摘要： Liquid polymer compositions comprising: one or more hydrophobic liquids having a boiling point at least about 100 °C; at least about 39% by weight of one or more acrylamide-(co)polymers; one or more emulsifier surfactants; and one or more inverting surfactants; wherein, when the composition is inverted in an aqueous solution, it provides an inverted solution having a filter ratio using a 1.2 micron filter (FR1.2) of about 1.5 or less.
摘要翻译：液体聚合物组合物，其包含：一种或多种沸点至少约为100℃的疏水性液体; 至少约39重量％的一种或多种丙烯酰胺 - （共）聚合物; 一种或多种乳化剂表面活性剂; 和一种或多种反相表面活性剂; 其中当该组合物在水溶液中倒置时，其提供具有约1.5或更小的1.2微米过滤器（FR1.2）的过滤比的倒置溶液。

4. 发明申请

WO2021211385A1 A NUTRACEUTICAL COMPOSITION FOR MULTIMODAL PROPHYLAXIS AGAINST AND TREATMENT OF VIRAL AND BACTERIAL INFECTION AND INFLAMMATION 审中-公开
公开(公告)号：WO2021211385A1
公开(公告)日：2021-10-21
申请号：PCT/US2021/026715
申请日：2021-04-09
申请人： CUDDEBACK, David A. , LYNCH, Thomas J.
发明人： CUDDEBACK, David A. , LYNCH, Thomas J.
IPC分类号： A23L19/00 , A23L33/105 , A61K31/37
摘要： A nutraceutical composition for protection against a wide spectrum of viral and bacterial infections and for treatment of established infection and infectious inflammation. The nutraceutical composition includes a novel combination of vitamin, mineral and herbal or other natural and organic supplements. The composition of supplements may be compounded as a pill, tablet, powder, capsule or liquid be taken orally one or more times per day. Vitamin C and vitamin E along with zinc complexed with pyrithione or citrate are used in conjunction with nutraceuticals provided as immune boosters and antiviral agents along with possible anti-inflammatory herbs or other anti-inflammatory substances.

5. 发明申请

WO2019178267A3 INDUCTIVE REGENERATION OF THE AIRWAY BY TRANSCRIPTIONAL FACTOR MODULATION OF GLANDULAR MYOEPITHELIAL STEM CELLS 审中-公开
公开(公告)号：WO2019178267A3
公开(公告)日：2019-09-19
申请号：PCT/US2019/022106
申请日：2019-03-13
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , ENGELHARDT, John, F. , LYNCH, Thomas, J. , ANDERSON, Preston, J. , SHAHIN, Weam
发明人： ENGELHARDT, John, F. , LYNCH, Thomas, J. , ANDERSON, Preston, J. , SHAHIN, Weam
IPC分类号： C12N5/07 , C12N5/0789
摘要： Compositions and methods to modulate Lef-1/TCF/Wnt signaling ex vivo or in vivo, and assays to detect those modulators, are described.

6. 发明申请

WO2005010091A1 FILM FORMING COATING COMPOSITION CONTAINING SURFACE TREATED BARIUM SULFATE AND METHODS OF USE 审中-公开
标题翻译：包含表面处理的硫酸钡的成膜涂料组合物及其使用方法
公开(公告)号：WO2005010091A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/011044
申请日：2004-04-08
申请人： J.M. HUBER CORPORATION , LYNCH, Thomas, J.
发明人： LYNCH, Thomas, J.
IPC分类号： C08K9/06
CPC分类号： C08K9/04
摘要： A coating composition comprising, in admixture, a resin and aminosilane surface-treated barium sulfate particles, and methods of using it as a film forming coating. Low blistering, highly corrosion resistant and low viscosity coating compositions are provided.
摘要翻译：一种涂料组合物，其包含树脂和氨基硅烷表面处理的硫酸钡颗粒的混合物，以及将其用作成膜涂层的方法。提供低起泡，高耐腐蚀和低粘度涂料组合物。

7. 发明申请

WO2009012202A1 MINERAL DISPERSANTS AND METHODS FOR PREPARING MINERAL SLURRIES USING THE SAME 审中-公开
标题翻译：矿物分散剂和使用其制备矿物浆料的方法
公开(公告)号：WO2009012202A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/069937
申请日：2008-07-14
申请人： KEMIRA OYJ , LYNCH, Thomas, J.
发明人： LYNCH, Thomas, J.
IPC分类号： C04B33/00
CPC分类号： C09C1/021 , C01P2004/51 , C01P2004/62 , C01P2006/22 , C09C3/10
摘要： A mineral slurry comprises mineral particles in an amount equal to or greater than about 60 percent by total weight of the slurry, wherein 85 percent of the mineral particles have an average particle size equal to or less than 2 micrometers; a polyelectrolyte dispersant derived from an acrylate polymer formed by reversible addition-fragmentation chain transfer polymerization, wherein the polyelectrolyte dispersant comprises endgroups comprising thio-containing residues derived from a trithiocarbonate chain transfer agent, wherein the polyelectrolyte dispersant is in an amount less than about 35 pounds of the dispersant per ton of dry mineral particles, and wherein the polyelectrolyte dispersant has a molecular weight of 3000 to 10,000 Daltons and a polydispersity of at least 1.0 and less than 1.5; and the remainder water.
摘要翻译：矿物浆料包含等于或大于浆料总重量的约60％的矿物颗粒，其中85％的矿物颗粒具有等于或小于2微米的平均粒度; 衍生自通过可逆加成 - 断裂链转移聚合形成的丙烯酸酯聚合物的聚电解质分散剂，其中所述聚电解质分散剂包含包含衍生自三硫代碳酸酯链转移剂的含硫残基的端基，其中所述聚电解质分散剂的量小于约35磅的分散剂，其中所述聚电解质分散剂的分子量为3000至10,000道尔顿，多分散性为至少1.0且小于1.5; 剩余的水。

8. 发明申请

WO2005094357A2 METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS 审中-公开
标题翻译：确定癌症对肺癌生长因子受体靶向治疗反应的方法
公开(公告)号：WO2005094357A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/010645
申请日：2005-03-31
申请人： THE GENERAL HOSPITAL CORPORATION , DANA-FARBER CANCER INSTITUTE, INC. , BELL, Daphne, Winifred , HABER, Daniel, A. , JANNE, Pasi, Antero , JOHNSON, Bruce, E. , LYNCH, Thomas, J. , MEYERSON, Matthew , PAEZ, Juan, Guillermo , SELLERS, William, R. , SETTLEMAN, Jeffrey, E. , SORDELLA, Raffaella
发明人： BELL, Daphne, Winifred , HABER, Daniel, A. , JANNE, Pasi, Antero , JOHNSON, Bruce, E. , LYNCH, Thomas, J. , MEYERSON, Matthew , PAEZ, Juan, Guillermo , SELLERS, William, R. , SETTLEMAN, Jeffrey, E. , SORDELLA, Raffaella
IPC分类号： C12Q1/48 , G01N33/574 , G01N33/74
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB 1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
摘要翻译：本发明涉及确定癌症对表皮生长因子受体（EGFR）治疗的反应性的方法。在优选的实施方案中，erbB1基因的激酶结构域中存在至少一个方差赋予对酪氨酸激酶抑制剂吉非替尼的敏感性。因此，这些突变的诊断测定将允许对最可能对药物作出反应的那些患者施用吉非替尼，厄洛替尼和其他酪氨酸激酶抑制剂。

9. 发明申请

WO2005094357A3 METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS 审中-公开
标题翻译：确定癌症对肺癌生长因子受体靶向治疗反应的方法
公开(公告)号：WO2005094357A3
公开(公告)日：2008-12-24
申请号：PCT/US2005010645
申请日：2005-03-31
申请人： GEN HOSPITAL CORP , DANA FARBER CANCER INST INC , BELL DAPHNE WINIFRED , HABER DANIEL A , JANNE PASI ANTERO , JOHNSON BRUCE E , LYNCH THOMAS J , MEYERSON MATTHEW , PAEZ JUAN GUILLERMO , SELLERS WILLIAM R , SETTLEMAN JEFFREY E , SORDELLA RAFFAELLA
发明人： BELL DAPHNE WINIFRED , HABER DANIEL A , JANNE PASI ANTERO , JOHNSON BRUCE E , LYNCH THOMAS J , MEYERSON MATTHEW , PAEZ JUAN GUILLERMO , SELLERS WILLIAM R , SETTLEMAN JEFFREY E , SORDELLA RAFFAELLA
IPC分类号： C12Q1/68 , C07H21/04 , C12Q1/48 , G01N33/574 , G01N33/74
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB 1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
摘要翻译：本发明涉及确定癌症对表皮生长因子受体（EGFR）治疗的反应性的方法。在优选的实施方案中，erbB1基因的激酶结构域中存在至少一个方差赋予对酪氨酸激酶抑制剂吉非替尼的敏感性。因此，这些突变的诊断测定将允许对最可能对药物作出反应的那些患者施用吉非替尼，厄洛替尼和其他酪氨酸激酶抑制剂。

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