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1. 发明申请

WO1994010908A2 COMPACT C-ARM TOMOGRAPHIC BONE SCANNING SYSTEM 审中-公开
标题翻译：紧凑型C-ARM TOMOGRAPHIC骨扫描系统
公开(公告)号：WO1994010908A2
公开(公告)日：1994-05-26
申请号：PCT/US1993010903
申请日：1993-11-12
申请人： LUNAR CORPORATION , MAZESS, Richard, B. , HANSON, James, A. , DELUHERY, James, G. , PELC, Norbert, J.
发明人： LUNAR CORPORATION
IPC分类号： A61B06/00
CPC分类号： A61B6/4441 , A61B6/032 , A61B6/4035 , A61B6/405 , A61B6/4085 , A61B6/4241 , A61B6/482 , A61B6/505 , A61B6/548 , A61B2090/037 , A61F2/28 , A61F2/32 , A61F2/367 , A61F2/3676 , A61F2/44 , A61F2/468 , A61F2002/3008 , A61F2250/0098 , A61F2310/00011 , A61F2310/00179 , G01T1/163 , G06T7/64
摘要： An x-ray imaging system provides both scanning radiography and computed tomography by means of a modified C-arm geometry that provides improved angular rotation. Estimation techniques are used to produce missing projections of the complete tomographic projection set, and a limited size detector (50) reduces the amount of data required for reconstructing tomographic images of compact objects of unique composition within the patient (such as the spine (65)). The introduction of image artifacts caused by external volumes to the field of view is reduced by employing dual energy techniques to isolate the internal structure from the external volumes.
摘要翻译： X射线成像系统通过提供改进的角旋转的改进的C形臂几何提供扫描放射照相术和计算机断层摄影。估计技术用于产生完整层析成像投影集的缺失投影，并且有限尺寸检测器（50）减少重建患者内独特组合的紧凑物体（例如脊柱（65））的层析成像所需的数据量，）。通过采用双能量技术将外部体积引起的图像伪影引入到视野中，从而将内部结构与外部体积隔离开来。

2. 发明申请

WO1992012165A1 METHODS FOR PREPARATION AND USE OF 1'alpha',24-DIHYDROXY VITAMIN D2 审中-公开
标题翻译： 1α，24-二羟基维生素D 2的制备和使用方法
公开(公告)号：WO1992012165A1
公开(公告)日：1992-07-23
申请号：PCT/US1992000313
申请日：1992-01-07
申请人： LUNAR CORPORATION , BISHOP, Charles, W. , JONES, Glenville , KNUTSON, Joyce, C. , MORIARTY, Robert, M. , PENMASTA, Raju , STRUGNELL, Stephen
发明人： LUNAR CORPORATION
IPC分类号： C07J75/00
CPC分类号： A61K31/59 , A61K31/592 , A61K45/06 , C07C401/00 , C07J9/00 , C07J71/0042 , A61K2300/00
摘要： 1 alpha ,24-dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1 alpha ,24-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in five steps to 1 alpha ,24-dihydroxy vitamin D2. The syntheses also produce novel intermediates.
摘要翻译： 1α，24-二羟基维生素D 2，其可用作用于治疗钙代谢紊乱和各种皮肤病症的药物组合物的活性化合物。本发明还包括从麦角甾醇开始合成的1α，24-二羟基维生素D2的制备，其将六步转化为24-羟基麦角固醇。将24-羟基麦角固醇照射并热转化成24-羟基维生素D2，其以5步转化为1α，24-二羟基维生素D2。这些合成物也产生新的中间体。

3. 发明申请

WO1992005130A1 NOVEL 1'alpha'-HYDROXY VITAMIN D4 AND NOVEL INTERMEDIATES AND ANALOGUES 审中-公开
标题翻译：新型1α-羟基维生素D4和新型中间体和类似物
公开(公告)号：WO1992005130A1
公开(公告)日：1992-04-02
申请号：PCT/US1991006865
申请日：1991-09-20
申请人： LUNAR CORPORATION , KNUTSON, Joyce, C. , BISHOP, Charles, W. , MORIARTY, Robert, M.
发明人： LUNAR CORPORATION
IPC分类号： C07C09/00
CPC分类号： A61K31/592 , C07C35/21 , C07C401/00
摘要： Novel 1 alpha -hydroxy vitamin D4 and novel analogues, 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4 which are useful as active compounds of pharmaceutical compositions for the treatment of disorders of calcium metabolism. Preparation of the novel 1 alpha -hydroxy vitamin D4 starts from ergosterol which is converted in six steps to 22,23-dihydroergosterol. 22,23-dihydroergosterol was irradiated to yield vitamin D4 which is converted in four steps to 1 alpha -hydroxy vitamin D4 using a cyclovitamin procedure which produces the novel intermediates, vitamin D4 tosylate, 3,5 cyclovitamin D4 and 1 alpha -hydroxy cyclovitamin D4. 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4 are isolated as biological products of the metabolism of novel 1 alpha -hydroxy vitamin D4 using cultured human liver cells.
摘要翻译：新型1α-羟基维生素D4和新型类似物，1,25二羟基维生素D4和1,24二羟基维生素D4，其可用作治疗钙代谢紊乱的药物组合物的活性化合物。新型1α-羟基维生素D4的制备从麦角甾醇开始，其被六步转化为22,23-二氢麦角甾醇。 22,23-二氢麦角甾醇被照射以产生维生素D4，其使用环维生素方法四步转化为1α-羟基维生素D4，其产生新的中间体维生素D4甲苯磺酸酯，3,5环维生素D4和1α-羟基环维生素D4 。使用培养的人肝细胞分离1,25二羟基维生素D4和1,24二羟基维生素D4作为新型1α-羟基维生素D4的代谢的生物产物。

4. 发明申请

WO1996015719A1 BONE DENSITOMETER WITH FILM CASSETTE 审中-公开
标题翻译：骨密度计与薄膜CASSETTE
公开(公告)号：WO1996015719A1
公开(公告)日：1996-05-30
申请号：PCT/US1995014265
申请日：1995-10-19
申请人： LUNAR CORPORATION
发明人： LUNAR CORPORATION , MAZESS, Richard, B.
IPC分类号： A61B06/00
CPC分类号： A61B6/505 , A61B6/4042 , A61B6/482 , G06T7/60 , G06T2207/30012 , G06T2207/30172
摘要： A dual energy densitometer (10) includes a solid state linear x-ray detector (13) which may be swept across the patient with the movement of a poly-energetic fan beam (23) of x-rays to produce a digital bone density image. A broad spectrum film plate (25) interposed between the detector (13) and the patient simultaneously provides a full spectrum radiographic image of high resolution and low parallax such as may be used for morphometric studies. Intervertebral spaces (40) may be used to measure vertebrate heights which may be statistically combined to provide a standard against which crush fractures may be detected.
摘要翻译：双能量密度计（10）包括固态线性X射线检测器（13），其可以通过多能量扇形光束（23）的X射线的移动而扫过患者，以产生数字骨密度图像。介于检测器（13）和患者之间的广谱膜片（25）同时提供高分辨率和低视差的全频谱放射照相图像，例如可用于形态学研究。可以使用椎间隙（40）来测量脊椎动物高度，其可以被统计学合并以提供可以检测到挤压骨折的标准。

5. 发明申请

WO1996003078A1 RADIOGRAPHIC GANTRY WITH SOFTWARE COLLISION AVOIDANCE 审中-公开
标题翻译：具有软件冲突避免的放射性药物
公开(公告)号：WO1996003078A1
公开(公告)日：1996-02-08
申请号：PCT/US1995008717
申请日：1995-07-14
申请人： LUNAR CORPORATION
发明人： LUNAR CORPORATION , HINTON, Corydon, A. , SZEJNA, Glenn
IPC分类号： A61B06/10
CPC分类号： B25J9/1666 , A61B6/102 , A61G2203/72
摘要： Computer control of a multi-axis radiographic instrument (10) is utilized to prevent contact between moving surfaces of the instrument based on soft limits. The soft limits are established from a legal space table (51) incorporating all combinations of axis movement of the equipment and relating those combinations to contacting (53) or non-contacting (55) surfaces. The legal space table (51) may be used to map efficient paths between a start (sp) and ending position (dp) and may be augmented with non-contacting transducers (57) which may sense patient movement not incorporated into the legal space table (51).
摘要翻译：利用多轴射线照相仪器（10）的计算机控制来防止基于软限制的仪器的移动表面之间的接触。软限制是从法律空间表（51）建立的，包括设备的轴运动的所有组合，并将这些组合与接触（53）或非接触（55）表面相关联。合法空间表（51）可以用于映射开始（sp）和结束位置（dp）之间的有效路径，并且可以用非接触式换能器（57）进行增强，所述非接触换能器可以感测未并入到合法空间表中的患者运动（51）。

6. 发明申请

WO1996002501A1 SYNTHESIS OF 1'alpha'-HYDROXY VITAMIN D 审中-公开
标题翻译： 1α-羟基维生素D的合成
公开(公告)号：WO1996002501A1
公开(公告)日：1996-02-01
申请号：PCT/US1994008002
申请日：1994-07-18
申请人： LUNAR CORPORATION , MORIARTY, Robert, M. , GUO, Liang , PENMASTA, Raju, A.
发明人： LUNAR CORPORATION
IPC分类号： C07C401/00
CPC分类号： C07C401/00
摘要： A method for 1 alpha -hydroxylation of vitamin D compounds using the appropriate vitamin D as the starting material. The method requires no separatory procedures prior to the actual hydroxylation step.
摘要翻译：使用适当的维生素D作为起始原料1维生素D化合物的1α-羟基化的方法。该方法在实际羟基化步骤之前不需要分离操作。

7. 发明申请

WO1994005630A1 1'alpha',24(S)-DIHYDROXY VITAMIN D2, ITS FORMATION AND USE 审中-公开
标题翻译： 1α，24（S）-DIHYDROXY维生素D2，其形成和用途
公开(公告)号：WO1994005630A1
公开(公告)日：1994-03-17
申请号：PCT/US1993008141
申请日：1993-08-30
申请人： LUNAR CORPORATION
发明人： LUNAR CORPORATION , BISHOP, Charles, W. , HORST, Ronald, L. , JONES, Glenville , KOSZEWSKI, Nicholas, J. , KNUTSON, Joyce, C. , MORIARTY, Robert, M. , REINHARDT, Timothy, A. , MENMASTA, Raju , STRUGNELL, Stephen , GUO, Liang , SINGHAL, Sanjay, K. , ZHAO, Lei
IPC分类号： C07C401/00
CPC分类号： C07J9/00 , A61K31/59 , C07C401/00 , C07J71/0042
摘要： 1 alpha ,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of symthetic 1 alpha ,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1 alpha ,24(S)-dihydroxy vitamin D2. The syntheses also produce novel intermediates.
摘要翻译： 1α，24（S） - 二羟基维生素D 2，其可用作用于治疗钙代谢紊乱和各种皮肤病症的药物组合物的活性化合物。本发明还包括从麦角甾醇开始的合成1α，24（S） - 二羟基维生素D2的制备，其以六步转化为24-羟基麦角固醇。将24-羟基麦角固醇照射并热转化成24-羟基维生素D 2，其以6步转化为1α，24（S） - 二羟基维生素D 2。这些合成物也产生新的中间体。

8. 发明申请

WO1993025146A1 ULTRASONIC DENSITOMETER DEVICE AND METHOD 审中-公开
标题翻译：超声波传感器装置及方法
公开(公告)号：WO1993025146A1
公开(公告)日：1993-12-23
申请号：PCT/US1993005437
申请日：1993-06-08
申请人： LUNAR CORPORATION
发明人： LUNAR CORPORATION , WIENER, Scott, A. , DELUHERY, James, G.
IPC分类号： A61B08/08
CPC分类号： A61B8/4281 , A61B8/0875 , G01N29/07 , G01N29/11 , G01N29/28 , G01N29/348 , G01N2291/011 , G01N2291/015 , G01N2291/02483 , G01N2291/106
摘要： An ultrasound densitometer (100) is disclosed in which ultrasonic transducers (121) are located spaced apart in a water bath (103) into which the heel of a person may be inserted. The transit time of an ultrasonic pulse through the water and heel the attenuation of the pulse may be measured to evaluate the physical properties of the bone in the heel. A central controller (38, 160, 162) coordinates the ultrasonic measurement with the automatic filling and draining of the water bath to ensure hygienic and repeatable operation. The water may be preheated to reduce patient discomfort and to improve the consistency of the result. The delay of preheating is reduced by preheating water in a separate pre-fill chamber (132) during the previous scan. Gravity feed of the water reduces the complexity of the water handling and provides extremely quiet operation. A toe peg (110) in the water bath, which fits between the patient's toes, and a calf support (120) help to reduce patient motion during the measuring.
摘要翻译：公开了一种超声波密度计（100），其中超声波换能器（121）位于水浴（103）中间隔开的位置，可以插入人的脚跟。可以测量超声波脉冲穿过水和脚跟的脉冲的衰减的传播时间，以评估脚后跟骨的物理性质。中央控制器（38,160,162）通过水浴的自动灌装和排水来协调超声波测量，以确保卫生和可重复的操作。可以预热水以减少患者的不适，并提高结果的一致性。在先前的扫描期间，通过在单独的预填充室（132）中预热水来减少预热的延迟。水的重力进料降低了水处理的复杂性，并提供了非常安静的操作。位于患者脚趾之间的水浴中的脚趾钉（110）和小腿支撑件（120）有助于在测量期间减少患者运动。

9. 发明申请

WO1993021826A1 SYSTEM FOR SELECTIVE MATERIAL IMAGING 审中-公开
标题翻译：选择性材料成像系统
公开(公告)号：WO1993021826A1
公开(公告)日：1993-11-11
申请号：PCT/US1993003866
申请日：1993-04-23
申请人： LUNAR CORPORATION
发明人： LUNAR CORPORATION , PELC, Norbert, J.
IPC分类号： A61B06/00
CPC分类号： A61B6/505 , A61B6/4035 , A61B6/482 , H05G1/60
摘要： A dual energy x-ray system (10) for determining bone density and the like compensates for variable flux density associated with the different absorptions and the production of the high and low energies of x-rays by controlling both the voltage biasing the x-ray tube and the relative dwell times during which the x-ray tube is at those voltages, the dwell time being increased for the lower voltage to compensate for lower flux density. Compensation for variations in flux density improves the resultant signal-to-noise ratio of the measurements taken and thereby provides more accurate measurement of materials with minimized examination time.

10. 发明申请

WO1996015720A2 BONE DENSITOMETER WITH IMPROVED POINT CHARACTERIZATION 审中-公开
标题翻译：骨密度测量仪具有改进的点特征
公开(公告)号：WO1996015720A2
公开(公告)日：1996-05-30
申请号：PCT/US1995014269
申请日：1995-10-19
申请人： LUNAR CORPORATION
发明人： LUNAR CORPORATION , MAZESS, Richard, B.
IPC分类号： A61B06/00
CPC分类号： A61B6/505 , A61B6/032 , A61B6/4042 , A61B6/4085 , A61B6/4241 , A61B6/463 , A61B6/482 , A61F2/28 , A61F2/32 , A61F2/367 , A61F2/3676 , A61F2/44 , A61F2/4657 , A61F2/468 , A61F2002/3008 , A61F2240/008 , A61F2250/0098 , A61F2310/00011 , A61F2310/00179 , G01T1/163 , G06T7/60
摘要： A dual energy densitometer (10) includes a solid state linear x-ray detector (13) which may be swept across the patient (16) with the movement of both to produce a matrix (29) of data elements (31) representing attenuation through the patient (16). Each of these data elements (31) may be characterized as to its material type by the use of the data element values, templates representing general rules to be applied to the bone and operator input. The operator input is provided by a cursor (228) controlled paintbrush which changes classifications of individual pixels based on a selected brush type.
摘要翻译：双能量密度计（10）包括固态线性X射线检测器（13），其可以被扫描穿过患者（16），随着两者的移动，以产生表示衰减的数据元素（31）的矩阵（29）患者（16）。这些数据元素（31）中的每一个可以通过使用数据元素值来表征其材料类型，表示要应用于骨骼和操作者输入的一般规则的模板。操作员输入由光标（228）提供，控制画笔根据所选择的画笔类型改变各个像素的分类。

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