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1. 发明申请

WO2012166906A1 CELL-DIRECTED SYNTHESIS OF MULTIFUNCTIONAL NANOPATTERNS AND NANOMATERIALS 审中-公开
标题翻译：细胞指导的多功能纳米生物和纳米生物的合成
公开(公告)号：WO2012166906A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040191
申请日：2012-05-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LU, Timothy, Kuan Ta , CHEN, Allen, Yuyin
发明人： LU, Timothy, Kuan Ta , CHEN, Allen, Yuyin
IPC分类号： C07K14/245 , B82Y5/00 , B82Y40/00
CPC分类号： C07K14/245 , B82Y5/00 , B82Y40/00 , C07K14/4711 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/24 , C07K2319/43 , C07K2319/60 , C07K2319/735
摘要： Aspects of the invention relate to the engineering of biological nanostructures and materials.
摘要翻译：本发明的方面涉及生物纳米结构和材料的工程。

2. 发明申请

WO2009137136A3 IN VIVO GENE SENSORS 审中-公开
标题翻译： VIVO基因传感器
公开(公告)号：WO2009137136A3
公开(公告)日：2013-03-21
申请号：PCT/US2009034296
申请日：2009-02-17
申请人： UNIV BOSTON , MASSACHUSETTS INST TECHNOLOGY , COLLINS JAMES J , LU TIMOTHY KUAN-TA
发明人： COLLINS JAMES J , LU TIMOTHY KUAN-TA
IPC分类号： A61K48/00 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/63
CPC分类号： C12N15/1086 , C12N15/111 , C12N15/63 , C12N2310/111 , C12N2320/50
摘要： Described are methods and compositions for the detection of target genes. The inventors have developed a synthetic nucleic acid sensor-effector gene circuit. In cells without a target gene, the circuit suppresses e.g., effector production, but in the presence of the target gene the suppression is subject to competition, such that the synthetic sensor is de-repressed and permits expression of the effector gene. The methods and compositions described further permit the selective expression of an effector gene in those cells expressing the target gene. In this manner, cells expressing a target gene can be selectively targeted for treatment or elimination. In certain aspects, the methods and compositions described permit the selective expression of an agent such as a therapeutic gene product, in a specifically targeted population of cells in an organism.
摘要翻译：描述了用于检测靶基因的方法和组合物。本发明人开发了合成核酸传感器 - 效应子基因电路。在没有靶基因的细胞中，电路抑制例如效应子产生，但是在靶基因的存在下，抑制受到竞争，使得合成传感器被去抑制并且允许效应基因的表达。所描述的方法和组合物进一步允许在表达靶基因的那些细胞中选择性表达效应基因。以这种方式，表达靶基因的细胞可以选择性地靶向用于治疗或消除。在某些方面，所描述的方法和组合允许在生物体中的特定靶细胞群中选择性地表达诸如治疗性基因产物的试剂。

3. 发明申请

WO2011066539A2 BIOLOGICAL ANALOG-TO-DIGITAL AND DIGITAL-TO-ANALOG CONVERTER SWITCHES 审中-公开
标题翻译：生物模拟数字到数字和数字转换器转换开关
公开(公告)号：WO2011066539A2
公开(公告)日：2011-06-03
申请号：PCT/US2010/058335
申请日：2010-11-30
申请人： TRUSTEES OF BOSTON UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , COLLINS, James, J. , LU, Timothy Kuan-Ta
发明人： COLLINS, James, J. , LU, Timothy Kuan-Ta
IPC分类号： H03M1/02 , H03M1/12 , H03M1/66
CPC分类号： G06N3/002 , H03M1/361 , H03M1/74
摘要： Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in these biological converter switches is provided by combining individual modular components, i.e. , SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a variety of network topologies to create circuits that act, for example, as switchboards, and regulate the production of an output product(s) based on the combination and nature of input signals received.
摘要翻译：这里描述的是利用诸如遗传拨动开关和单个转换存储器模块（SIMM）的模块化组件的新型生物转换器开关，用于将模拟输入转换成数字输出，以及在单元和蜂窝系统中将模拟输出的数字输入转换成模拟输出。这些生物转换器开关的灵活性通过将各个模块化组件即SIMM和遗传拨动开关组合在一起来提供。这些生物转换器开关可以组合在各种网络拓扑中以产生例如作为配电板起作用的电路，并且基于所接收的输入信号的组合和性质来调节输出产品的生产。

4. 发明申请

WO2009137136A9 IN VIVO GENE SENSORS 审中-公开
标题翻译：体内基因传感器
公开(公告)号：WO2009137136A9
公开(公告)日：2009-12-30
申请号：PCT/US2009034296
申请日：2009-02-17
申请人： UNIV BOSTON , MASSACHUSETTS INST TECHNOLOGY , COLLINS JAMES J , LU TIMOTHY KUAN-TA
发明人： COLLINS JAMES J , LU TIMOTHY KUAN-TA
IPC分类号： C12Q1/68
CPC分类号： C12N15/1086 , C12N15/111 , C12N15/63 , C12N2310/111 , C12N2320/50
摘要： Described are methods and compositions for the detection of target genes. The inventors have developed a synthetic nucleic acid sensor-effector gene circuit. In cells without a target gene, the circuit suppresses e.g., effector production, but in the presence of the target gene the suppression is subject to competition, such that the synthetic sensor is de-repressed and permits expression of the effector gene. The methods and compositions described further permit the selective expression of an effector gene in those cells expressing the target gene. In this manner, cells expressing a target gene can be selectively targeted for treatment or elimination. In certain aspects, the methods and compositions described permit the selective expression of an agent such as a therapeutic gene product, in a specifically targeted population of cells in an organism.
摘要翻译：描述了用于检测靶基因的方法和组合物。本发明人开发了合成的核酸传感器 - 效应基因电路。在没有靶基因的细胞中，电路抑制例如效应物产生，但是在靶基因存在下抑制受到竞争，使得合成传感器解除抑制并允许效应子基因表达。所描述的方法和组合物还允许在表达靶基因的那些细胞中选择性表达效应基因。以这种方式，表达靶基因的细胞可以选择性地靶向治疗或消除。在某些方面，所述的方法和组合物允许在生物体中特定靶向的细胞群中选择性表达诸如治疗性基因产物的试剂。

5. 发明申请

WO2011066539A3 BIOLOGICAL ANALOG-TO-DIGITAL AND DIGITAL-TO-ANALOG CONVERTER SWITCHES 审中-公开
标题翻译：生物模拟 - 数字和数字 - 模拟转换器开关
公开(公告)号：WO2011066539A3
公开(公告)日：2011-10-20
申请号：PCT/US2010058335
申请日：2010-11-30
申请人： UNIV BOSTON , MASSACHUSETTS INST TECHNOLOGY , COLLINS JAMES J , LU TIMOTHY KUAN-TA
发明人： COLLINS JAMES J , LU TIMOTHY KUAN-TA
IPC分类号： H03M1/02 , H03M1/12 , H03M1/66
CPC分类号： G06N3/002 , H03M1/361 , H03M1/74
摘要： Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in these biological converter switches is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a variety of network topologies to create circuits that act, for example, as switchboards, and regulate the production of an output product(s) based on the combination and nature of input signals received.
摘要翻译：本文描述了新颖的生物转换器开关，其在单元和蜂窝系统中利用模块化组件（诸如遗传切换开关和单转换存储器模块（SIMM））将模拟输入转换为数字输出，并将数字输入转换为模拟输出。这些生物转换器开关的灵活性是通过将各个模块化部件，即SIMM和遗传切换开关组合在一起提供的。这些生物转换器开关可以组合在各种网络拓扑中以创建例如作为配电盘的电路，并且基于所接收的输入信号的组合和性质来调节输出产品的生产。

6. 发明申请

WO2011014693A2 BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOF 审中-公开
标题翻译：表达淀粉样肽的噬菌体及其用途
公开(公告)号：WO2011014693A2
公开(公告)日：2011-02-03
申请号：PCT/US2010/043770
申请日：2010-07-29
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , TRUSTEES OF BOSTON UNIVERSITY , LU, Timothy Kuan-Ta , LINDQUIST, Susan , KRISHNAN, Rajaraman , COLLINS, James , O'DONNELL, Charles W , LEIGHTON, Bonnie Berger , DEVADAS, Srinivas
发明人： LU, Timothy Kuan-Ta , LINDQUIST, Susan , KRISHNAN, Rajaraman , COLLINS, James , O'DONNELL, Charles W , LEIGHTON, Bonnie Berger , DEVADAS, Srinivas
IPC分类号： C12N15/63 , C12N15/12 , C12N7/01 , C07K14/47 , A61K38/17 , A61P25/28
CPC分类号： C07K14/4711 , A61K35/76 , A61K38/00 , C07K2319/735 , C12N2795/10232 , C12N2795/10243 , C12N2795/14132 , C12N2795/14143 , Y02A50/475 , A61K2300/00
摘要： The present invention generally relates to engineered bacteriophages which express amyloid peptides for the modulation (e.g. increase or decrease) of protein aggregates and amyloid formation. In some embodiments, the engineered bacteriophages express anti-amyloid peptides for inhibiting protein aggregation and amyloid formation, which can be useful in the treatment and prevention of and bacterial infections and biofilms. In some embodiments, the engineered bacteriophages express amyloid peptides for promoting amyloid formation, which are useful for increasing amyloid formation such as promoting bacterial biofilms. Other aspects relate to methods to inhibit bacteria biofilms, and methods for the treatment of amyloid related disorders, e.g., Alzheimer's disease using an anti-amyloid peptide engineered bacteriophages. Other aspects of the invention relate to engineered bacteriophages to express the amyloid peptides on the bacteriophage surface and/or secrete the amyloid peptides, e.g., anti-amyloid peptides and pro-amyloid peptides, and uses thereof for modulating protein aggregates and amyloid formation.
摘要翻译：本发明一般涉及表达淀粉样蛋白肽用于调节（例如增加或减少）蛋白质聚集体和淀粉样蛋白形成的工程化噬菌体。在一些实施方案中，工程改造的噬菌体表达用于抑制蛋白质聚集和淀粉样蛋白形成的抗淀粉样肽，其可用于治疗和预防细菌感染和生物膜。在一些实施方案中，工程改造的噬菌体表达促淀粉样蛋白形成的淀粉样肽，其可用于增加淀粉样蛋白形成，例如促进细菌生物膜。其它方面涉及抑制细菌生物膜的方法，以及使用抗淀粉样肽工程改造的噬菌体治疗淀粉样蛋白相关病症例如阿尔茨海默病的方法。本发明的其它方面涉及在噬菌体表面上表达淀粉样肽和/或分泌淀粉样肽（例如抗淀粉样肽和淀粉样前肽）的工程化噬菌体，以及其用于调节蛋白质聚集体和淀粉样蛋白形成的用途。 / p>

7. 发明申请

WO2010141135A2 BACTERIOPHAGES EXPRESSING ANTIMICROBIAL PEPTIDES AND USES THEREOF 审中-公开
标题翻译：表达抗真菌肽的特异性及其用途
公开(公告)号：WO2010141135A2
公开(公告)日：2010-12-09
申请号：PCT/US2010/026357
申请日：2010-03-05
申请人： TRUSTEES OF BOSTON UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , COLLINS, James J. , KOERIS, Michael , LU, Timothy Kuan-Ta , CHAU, Tanguy My , STEPHANOPOULOS, Gregory
发明人： COLLINS, James J. , KOERIS, Michael , LU, Timothy Kuan-Ta , CHAU, Tanguy My , STEPHANOPOULOS, Gregory
IPC分类号： A61K48/00
CPC分类号： C12N7/00 , A61K35/76 , A61K38/1767 , C07K14/43504 , C07K14/43563 , C07K14/463 , C12N9/503 , C12N2795/10221 , C12N2795/10231 , C12N2795/10232 , C12N2795/12032 , C12N2795/12043 , C12N2795/14132 , C12N2795/14143 , Y02A50/401
摘要： The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enymes or fragments thereof for targeting a broad spectum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.
摘要翻译：本发明通常涉及表达抗微生物肽或溶解酶或其片段的工程化噬菌体，用于靶向细菌宿主的宽谱，以及长期抑制细菌噬菌体抗性以减少细菌感染。在一些实施方案中，噬菌体表达从宿主细菌分泌的抗微生物肽或抗微生物多肽（例如噬菌体裂解酶），或者在细菌宿主细胞裂解时释放。本发明的方面还涉及在临床环境和伤口愈合中使用工程化噬菌体来减少细菌感染，在受试者中或用于生物修复目的。

8. 发明申请

WO2009108406A2 ENGINEERED BACTERIOPHAGES AS ADJUVANTS FOR ANTIMICROBIAL AGENTS AND COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：工程化杀菌剂作为抗菌药物及其组合物的使用方法及其使用方法
公开(公告)号：WO2009108406A2
公开(公告)日：2009-09-03
申请号：PCT/US2009030755
申请日：2009-01-12
申请人： UNIV BOSTON , MASSACHUSETTS INST TECHNOLOGY , COLLINS JAMES J , LU TIMOTHY KUAN-TA
发明人： COLLINS JAMES J , LU TIMOTHY KUAN-TA
IPC分类号： C12P21/06
CPC分类号： C07K14/005 , A61K35/76 , C12N15/113 , C12N2320/32 , C12N2330/30 , C12N2795/14122 , C12N2795/14132
摘要： The present invention relates to the treatment and prevention of bacteria and bacterial infections. In particular, the present invention relates to engineered bacteriophages used in combination with antimicrobial agents to potentiate the antimicrobial effect and bacterial killing by the antimicrobial agent. The present invention generally relates to methods and compositions comprising engineered bacteriophages and antimicrobial agents for the treatment of bacteria, and more particularly to bacteriophages comprising agents that inhibit antibiotic resistance genes and/or cell survival genes, and/or bacteriophages comprising repressors of SOS response genes or inhibitors of antimicrobial defense genes and/or expressing an agent which increases the sensitivity of bacteria to an antimicrobial agent in combination with at least one antimicrobial agent, and their use thereof.
摘要翻译：本发明涉及细菌和细菌感染的治疗和预防。特别地，本发明涉及与抗微生物剂组合使用的工程化噬菌体，以增强抗微生物效果和抗微生物剂的细菌杀伤作用。本发明一般涉及包含工程化噬菌体和用于治疗细菌的抗微生物剂的方法和组合物，更具体地涉及包含抑制抗生素抗性基因和/或细胞存活基因的试剂和/或包含SOS应答基因阻遏物的噬菌体的噬菌体或抗微生物防御基因的抑制剂和/或表达增加细菌对抗微生物剂与至少一种抗微生物剂的敏感性的试剂及其用途。

9. 发明申请

WO2020097411A1 ENCRYPTION AND STEGANOGRAPHY OF SYNTHETIC GENE CIRCUITS 审中-公开
公开(公告)号：WO2020097411A1
公开(公告)日：2020-05-14
申请号：PCT/US2019/060383
申请日：2019-11-08
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LU, Timothy, Kuan-Ta
发明人： LU, Timothy, Kuan-Ta , SIUTI, Piro , PURCELL, Oliver , WANG, Jerry
IPC分类号： G06N3/00 , G06N3/02 , G06N3/12 , C12N15/09 , C12N15/63
摘要： Disclosed herein are methods of preparing a concealed gene circuit. Also disclosed herein are polynucleic acids and cells comprising said gene circuits and methods of altering the topology of the concealed gene circuits contained therein.

10. 发明申请

WO2010141135A3 BACTERIOPHAGES EXPRESSING ANTIMICROBIAL PEPTIDES AND USES THEREOF 审中-公开
标题翻译：表达抗真菌肽的特异性及其用途
公开(公告)号：WO2010141135A3
公开(公告)日：2014-04-03
申请号：PCT/US2010026357
申请日：2010-03-05
申请人： UNIV BOSTON , MASSACHUSETTS INST TECHNOLOGY , COLLINS JAMES J , KOERIS MICHAEL , LU TIMOTHY KUAN-TA , CHAU TANGUY MY , STEPHANOPOULOS GREGORY
发明人： COLLINS JAMES J , KOERIS MICHAEL , LU TIMOTHY KUAN-TA , CHAU TANGUY MY , STEPHANOPOULOS GREGORY
IPC分类号： C12P21/06 , C07H21/04
CPC分类号： C12N7/00 , A61K35/76 , A61K38/1767 , C07K14/43504 , C07K14/43563 , C07K14/463 , C12N9/503 , C12N2795/10221 , C12N2795/10231 , C12N2795/10232 , C12N2795/12032 , C12N2795/12043 , C12N2795/14132 , C12N2795/14143
摘要： The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enymes or fragments thereof for targeting a broad spectum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.
摘要翻译：本发明通常涉及表达抗微生物肽或溶解酶或其片段的工程化噬菌体，用于靶向细菌宿主的宽谱，以及用于长期抑制细菌噬菌体抗性以减少细菌感染。在一些实施方案中，噬菌体表达从宿主细菌分泌的抗微生物肽或抗微生物多肽（例如噬菌体裂解酶），或者在细菌宿主细胞裂解时释放。本发明的方面还涉及在临床环境和伤口愈合中使用工程化噬菌体来减少细菌感染，在受试者中或用于生物修复目的。

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