发明申请
WO0202593A3 MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF
审中-公开
基本信息:
- 专利标题： MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF
- 专利标题（中）：细胞增殖和血管生成的调节剂，其使用和鉴定方法
- 申请号：PCT/US0120849 申请日：2001-06-29
- 公开(公告)号：WO0202593A3 公开(公告)日：2003-08-07
- 发明人： PILLARISETTI SIVARAM , GOLDBERG ITZHAK D
- 申请人： LONG ISLAND JEWISH RES INST , PILLARISETTI SIVARAM , GOLDBERG ITZHAK D
- 专利权人： LONG ISLAND JEWISH RES INST,PILLARISETTI SIVARAM,GOLDBERG ITZHAK D
- 当前专利权人： LONG ISLAND JEWISH RES INST,PILLARISETTI SIVARAM,GOLDBERG ITZHAK D
- 优先权： US60662800 2000-06-29; US27617001 2001-03-15
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/12 ; A61K31/121 ; A61K31/415 ; A61K31/4155 ; A61K31/4178 ; A61K31/42 ; A61K31/422 ; A61K31/4704 ; A61K31/505 ; A61K38/00 ; A61K38/08 ; A61K38/10 ; A61K38/16 ; A61K45/00 ; A61K48/00 ; A61K49/00 ; A61P7/00 ; A61P9/00 ; A61P9/10 ; A61P13/12 ; A61P15/00 ; A61P17/00 ; A61P17/02 ; A61P17/06 ; A61P27/02 ; A61P29/00 ; A61P35/00 ; A61P35/04 ; A61P43/00 ; C07D215/22 ; C07D239/42 ; C07D261/18 ; C07D409/06 ; C07D413/06 ; C07K7/06 ; C07K7/08 ; C07K14/00 ; C07K14/47 ; C07K14/475 ; C07K19/00 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/11 ; C12N15/63 ; G01N33/68
摘要：
The invention is directed to small organic molecules and peptides having the ability to mimic or agonize hepatocyte growth factor/ scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.
摘要（中）：
本发明涉及具有模拟或激动肝细胞生长因子/分散因子（HGF / SF）活性或抑制或拮抗HGF / SF活性的能力的小有机分子和肽，前者可用于促进例如血管生成 用于促进伤口或组织愈合的组织或器官，或增加或恢复心肌梗死后心脏等缺血组织的血流。 抑制细胞生长或增殖在治疗例如炎性关节和皮肤疾病等炎性疾病以及诸如癌症的增生性增生性疾病中是有益的。