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1. 发明申请

WO2011003063A3 ENZYMES AND METHODS FOR RESOLVING AMINO VINYL CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：分离氨基乙烯基环丙烷羧酸衍生物的酶和方法
公开(公告)号：WO2011003063A3
公开(公告)日：2011-04-28
申请号：PCT/US2010040900
申请日：2010-07-02
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , TAYLOR IAN N , LLOYD MICHAEL C , HESELTINE ADRIAN
发明人： TAYLOR IAN N , LLOYD MICHAEL C , HESELTINE ADRIAN
IPC分类号： C07C229/32 , C07C227/04 , C07C227/14 , C07C227/40 , C12P13/04
CPC分类号： C07C229/48 , C07B2200/07 , C07C227/18 , C07C229/24 , C07C249/02 , C07C2601/02 , C12N9/18 , C12P13/04 , C12P41/005 , C07C251/24
摘要： Preparation and isolation of amino vinyl cyclopropane carboxylic acid derivatives and salts thereof, methods of resolving enantiomers, and methods of identifying compositions and/or enzymes that are capable of resolving racemic or partially enantiomerically enriched mixtures.
摘要翻译：氨基乙烯基环丙烷羧酸衍生物及其盐的制备和分离，拆分对映体的方法以及鉴定能够拆分外消旋或部分对映体富集的混合物的组合物和/或酶的方法。

2. 发明申请

WO2011003063A2 ENZYMES AND METHODS FOR RESOLVING AMINO VINYL CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：用于分解氨基乙烯基环丙烷羧酸衍生物的酶和方法
公开(公告)号：WO2011003063A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040900
申请日：2010-07-02
申请人： DR. REDDY'S LABORATORIES LTD. , DR. REDDY'S LABORATORIES, INC. , TAYLOR, Ian N. , LLOYD, Michael C. , HESELTINE, Adrian
发明人： TAYLOR, Ian N. , LLOYD, Michael C. , HESELTINE, Adrian
IPC分类号： C07C229/32 , C07C227/14 , C07C227/04 , C07C227/40 , C12P13/04
CPC分类号： C07C229/48 , C07B2200/07 , C07C227/18 , C07C229/24 , C07C249/02 , C07C2601/02 , C12N9/18 , C12P13/04 , C12P41/005 , C07C251/24
摘要： Preparation and isolation of amino vinyl cyclopropane carboxylic acid derivatives and salts thereof, methods of resolving enantiomers, and methods of identifying compositions and/or enzymes that are capable of resolving racemic or partially enantiomerically enriched mixtures.
摘要翻译：氨基乙烯基环丙烷羧酸衍生物及其盐的制备和分离，拆分对映异构体的方法以及鉴定能够拆分外消旋或部分对映体富集的混合物的组合物和/或酶的方法。

3. 发明申请

WO2007084545A1 PROCESS FOR MAKING AMINO ACIDS 审中-公开
标题翻译：制备氨基酸的方法
公开(公告)号：WO2007084545A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/001207
申请日：2007-01-17
申请人： DOW GLOBAL TECHNOLOGIES INC. , LLOYD, Michael, C. , DAUGS, Edward, D. , RAND, Cynthia, L. , PENG, Wei-jun
发明人： LLOYD, Michael, C. , DAUGS, Edward, D. , RAND, Cynthia, L. , PENG, Wei-jun
IPC分类号： C07C227/32 , C07D317/30 , C12P41/00
CPC分类号： C07C227/32 , C07D317/30 , C12P13/04 , C12P41/006
摘要： A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds comprising a masked amino acid derivative which may be selected from the group consisting of amino nitrile, N-acyl amino acid, amino amide, hydantoin and amino ester; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R 1 and R 2 are the same or different alkyl groups and wherein R 1 and R 2 may be fused.
摘要翻译：通过以下步骤制备氨基酸的方法：（a）使式I化合物与加氢甲酰化催化剂和合成气接触以产生包含式IIa，IIb和IIc的醛化合物的混合物; （b）使来自步骤（a）的醛化合物的混合物反应以产生包含可以选自氨基腈，N-酰基氨基酸，氨基酰胺，乙内酰脲和氨基酯; （c）在水存在下将来自步骤（b）的衍生化合物的混合物与对映选择性水解酶接触以产生具有式IV的L-氨基酸; （d）以基本上纯的形式分离具有式IV的氨基酸，其中在式I，IIa，IIb，IIc，IIIa，IIIb，IIIc和IV中，R是H，烷基或芳基，R 1， SO 2和R 2是相同或不同的烷基，其中R 1和R 2和R 2可以是稠合的。

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