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1. 发明申请

WO2013004607A1 RELAXIN FUSION POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译： RELAXIN FUSION POLYPEPTIDES及其用途
公开(公告)号：WO2013004607A1
公开(公告)日：2013-01-10
申请号：PCT/EP2012/062665
申请日：2012-06-29
申请人： BAYER INTELLECTUAL PROPERTY GMBH , WILMEN, Andreas , HAUPTS, Ulrich , FREIBERG, Christoph , TRAUTWEIN, Mark , LINDEN, Lars , LEINEWEBER, Kirsten , TINEL, Hanna
发明人： WILMEN, Andreas , HAUPTS, Ulrich , FREIBERG, Christoph , TRAUTWEIN, Mark , LINDEN, Lars , LEINEWEBER, Kirsten , TINEL, Hanna
IPC分类号： C07K14/64
CPC分类号： C07K14/64 , A61K38/00 , C07K16/18 , C07K2319/31 , C07K2319/75
摘要： The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A-and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides.
摘要翻译：本发明提供了松弛蛋白融合多肽A-L-B与松弛蛋白A链和松弛蛋白B链的非野生型阵列，其中A链和B链通过连接肽连接。本发明进一步提供具有延长的半衰期的松弛素融合多肽。此外，本发明提供了编码前述融合多肽的核酸序列，含有该融合多肽的载体，药物组合物和这种融合多肽的医学应用。

2. 发明申请

WO2012143495A2 NEUE BINDER-WIRKSTOFF KONJUGATE (ADCS) UND IHRE VERWENDUNG 审中-公开
标题翻译：新建合并偶联物ACTIVE（ADC）和它们的用途
公开(公告)号：WO2012143495A2
公开(公告)日：2012-10-26
申请号：PCT/EP2012/057243
申请日：2012-04-20
申请人： BAYER INTELLECTUAL PROPERTY GMBH , BAYER PHARMA AKTIENGESELLSCHAFT , LERCHEN, Hans-Georg , EL SHEIKH, Sherif , BEIER, Rudolf , BRUDER, Sandra , STELTE-LUDWIG, Beatrix , JÖRIßEN, Hannah , MAHLERT, Christoph , GREVEN, Simone , PETRUL, Heike , SCHUHMACHER, Joachim , LINDEN, Lars , WILLUDA, Jörg , KOPITZ, Charotte, Christine , GOLFIER, Sven , HEISLER, Iring , HARRENGA, Axel , THIERAUCH, Karl-Heinz , BORKOWSKI, Sandra
发明人： LERCHEN, Hans-Georg , EL SHEIKH, Sherif , BEIER, Rudolf , BRUDER, Sandra , STELTE-LUDWIG, Beatrix , JÖRIßEN, Hannah , MAHLERT, Christoph , GREVEN, Simone , PETRUL, Heike , SCHUHMACHER, Joachim , LINDEN, Lars , WILLUDA, Jörg , KOPITZ, Charotte, Christine , GOLFIER, Sven , HEISLER, Iring , HARRENGA, Axel , THIERAUCH, Karl-Heinz , BORKOWSKI, Sandra
IPC分类号： A61K47/48 , C07K16/30 , A61P35/00
CPC分类号： A61K47/48715 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , A61K47/6891 , C07K5/06 , C07K5/06052 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/565 , C07K2317/76
摘要： Die vorliegende Anmeldung betrifft neue, gegen das Target Epidermal Growth Factor Receptor (EGFR, GeneID1956) gerichtete Binder- Wirkstoff-Konjuagte (ADCs) von N,N-Dialkylauristatinen, wirksamer Metabolite dieser ADCs, Verfahren zur Herstellung dieser ADCs, die Verwendung dieser ADCs zur Behandlung und/oder Prävention von Krankheiten sowie die Verwendung dieser ADCs zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere von hyperproliferativen und/oder angiogenen Erkrankungen wie beispielsweise Krebserkrankungen. Solche Behandlungen können als Monotherapie oder auch in Kombination mit anderen Arzneimitteln oder weiteren therapeutischen Maßnahmen erfolgen.
摘要翻译：本申请涉及到针对靶表皮生长因子受体新颖（EGFR，GeneID1956）定向的N，N-二Dialkylauristatinen，这些ADC的有效代谢物粘合剂药物Konjuagte器（ADC），用于制备这些ADC，对于使用这些ADC的处理治疗和/或预防的疾病，以及用于制备药物的用于治疗疾病，特别是过度增殖性和/或血管生成性病症如癌症的治疗和/或预防中使用这些ADC的。这样的治疗可以作为单一药剂或与其它药物或其它治疗措施的组合来进行。

3. 发明申请

WO2012098089A1 BINDING PROTEINS TO INHIBITORS OF COAGULATION FACTORS 审中-公开
标题翻译：绑定蛋白与凝血因子的抑制剂
公开(公告)号：WO2012098089A1
公开(公告)日：2012-07-26
申请号：PCT/EP2012/050595
申请日：2012-01-17
申请人： BAYER PHARMA AKTIENGESELLSCHAFT , DITTMER, Frank , BUCHMÜLLER, Anja , GERDES, Christoph , TERSTEEGEN, Adrian , GNOTH, Mark, Jean , LINDEN, Lars , HARRENGA, Axel , GRUDZINSKA, Joanna , JESKE, Mario , SCHÄFER, Martina , BIRKENFELD, Jörg , PAULSEN, Holger , FINNERN, Ricarda , MAYER-BARTSCHMID, Anke , EICKER, Andrea , GREVEN, Simone , STEINIG, Susanne
发明人： DITTMER, Frank , BUCHMÜLLER, Anja , GERDES, Christoph , TERSTEEGEN, Adrian , GNOTH, Mark, Jean , LINDEN, Lars , HARRENGA, Axel , GRUDZINSKA, Joanna , JESKE, Mario , SCHÄFER, Martina , BIRKENFELD, Jörg , PAULSEN, Holger , FINNERN, Ricarda , MAYER-BARTSCHMID, Anke , EICKER, Andrea , GREVEN, Simone , STEINIG, Susanne
IPC分类号： C07K16/44 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , A61K2300/00 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FX a inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译：本发明涉及抗原结合区，抗体，抗原结合抗体片段和抗体模拟物的鉴定和用途，其中和抗凝血剂在体外和/或体内的抗凝血作用。本发明的抗体和功能片段和抗体模拟物可用于特异性地逆转抗凝血剂的药理学作用。 FX治疗（解毒剂）和/或诊断目的的抑制剂。本发明还提供了编码前述分子的核酸序列，含有该分子的载体，药物组合物和具有使用说明书的试剂盒。

4. 发明申请

WO2012143499A3 NOVEL BINDER-DRUG CONJUGATES (ADCS) AND THEIR USE 审中-公开
标题翻译：新建合并偶联物ACTIVE（ADC）和它们的用途
公开(公告)号：WO2012143499A3
公开(公告)日：2012-12-13
申请号：PCT/EP2012057249
申请日：2012-04-20
申请人： BAYER IP GMBH , BAYER PHARMA AG , LERCHEN HANS-GEORG , STELTE-LUDWIG BEATRIX , GOLFIER SVEN , KOPITZ CHARLOTTE CHRISTINE , BEIER RUDOLF , EL SHEIKH SHERIF , HEISLER IRING , HARRENGA AXEL , THIERAUCH KARL-HEINZ , SCHUHMACHER JOACHIM , BRUDER SANDRA , GREVEN SIMONE , LINDEN LARS , WILLUDA JOERG , MAHLERT CHRISTOPH , PETRUL HEIKE , JOERISEN HANNAH , BORKOWSKI SANDRA
发明人： LERCHEN HANS-GEORG , STELTE-LUDWIG BEATRIX , GOLFIER SVEN , KOPITZ CHARLOTTE CHRISTINE , BEIER RUDOLF , EL SHEIKH SHERIF , HEISLER IRING , HARRENGA AXEL , THIERAUCH KARL-HEINZ , SCHUHMACHER JOACHIM , BRUDER SANDRA , GREVEN SIMONE , LINDEN LARS , WILLUDA JOERG , MAHLERT CHRISTOPH , PETRUL HEIKE , JOERISEN HANNAH , BORKOWSKI SANDRA
IPC分类号： A61K47/48 , A61P35/00 , C07K16/30
CPC分类号： A61K47/48715 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , A61K47/6891 , C07K5/06 , C07K5/06052 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/565 , C07K2317/76
摘要： The present application relates to novel, anti-mesothelin binder-drug conjugates (ADCs) of N,N-dialkyl auristatins, to effective metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for treating and/or preventing diseases, and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
摘要翻译：本申请涉及新的，直接针对的N，N-二Dialkylauristatinen，这些ADC的有效代谢物的靶标间皮素粘结剂 - 药物偶联物（ADC），用于制备这些ADC，对于疾病的治疗和/或预防中使用这些ADC的处理和使用这些ADC的用于制备药物的用于治疗疾病，特别是过度增殖性和/或血管生成性病症如癌症的治疗和/或预防。这样的治疗可以作为单一药剂或与其它药物或其它治疗措施的组合来进行。

5. 发明申请

WO2012163932A1 NEUTRALIZING PROLACTIN RECEPTOR ANTIBODY MAT3 AND ITS THERAPEUTIC USE 审中-公开
标题翻译：中性促乳素受体抗体MAT3及其治疗用途
公开(公告)号：WO2012163932A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/060078
申请日：2012-05-31
申请人： BAYER INTELLECTUAL PROPERTY GMBH , FREIBERG, Christoph , OTTO, Christiane , LINDEN, Lars , HARRENGA, Axel , TRAUTWEIN, Mark , GREVEN, Simone , WILMEN, Andreas
发明人： FREIBERG, Christoph , OTTO, Christiane , LINDEN, Lars , HARRENGA, Axel , TRAUTWEIN, Mark , GREVEN, Simone , WILMEN, Andreas
IPC分类号： C07K16/28 , A61K39/395 , A61P5/00
CPC分类号： C07K16/2869 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The neutralizing prolactin receptor antibody Mat3. and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen - resistant breast cancer. The antibody blocks prolactin receptor-mediated signalling.
摘要翻译：中和催乳素受体抗体Mat3。和抗原结合片段，含有它们的药物组合物及其用于治疗或预防由催乳素受体介导的良性疾病和适应症的用途，例如子宫内膜异位症，子宫腺肌症，非激素雌性避孕，良性乳腺疾病和乳腺疾病，哺乳期抑制，良性前列腺增生，纤维瘤，高血压和正常泌乳素脱发，以及联合激素治疗中的抑制乳腺上皮细胞增殖和治疗和预防抗雌激素耐药性乳腺癌的联合治疗。该抗体阻断催乳素受体介导的信号传导。

6. 发明申请

WO2012143497A3 NOVEL BINDER-DRUG CONJUGATES (ADCS) AND THEIR USE 审中-公开
标题翻译：新建合并偶联物ACTIVE（ADC）和它们的用途
公开(公告)号：WO2012143497A3
公开(公告)日：2013-03-21
申请号：PCT/EP2012057247
申请日：2012-04-20
申请人： BAYER IP GMBH , BAYER PHARMA AG , LERCHEN HANS-GEORG , LINDEN LARS , EL SHEIKH SHERIF , WILLUDA JOERG , KOPITZ CHARLOTTE CHRISTINE , SCHUHMACHER JOACHIM , GREVEN SIMONE , MAHLERT CHRISTOPH , STELTE-LUDWIG BEATRIX , GOLFIER SVEN , BEIER RUDOLF , HEISLER IRING , HARRENGA AXEL , THIERAUCH KARL-HEINZ , BRUDER SANDRA , PETRUL HEIKE , JOERISEN HANNAH , BORKOWSKI SANDRA
发明人： LERCHEN HANS-GEORG , LINDEN LARS , EL SHEIKH SHERIF , WILLUDA JOERG , KOPITZ CHARLOTTE CHRISTINE , SCHUHMACHER JOACHIM , GREVEN SIMONE , MAHLERT CHRISTOPH , STELTE-LUDWIG BEATRIX , GOLFIER SVEN , BEIER RUDOLF , HEISLER IRING , HARRENGA AXEL , THIERAUCH KARL-HEINZ , BRUDER SANDRA , PETRUL HEIKE , JOERISEN HANNAH , BORKOWSKI SANDRA
IPC分类号： A61K47/48 , A61P35/00 , C07K16/30
CPC分类号： A61K47/48715 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , A61K47/6891 , C07K5/06 , C07K5/06052 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/565 , C07K2317/76
摘要： The present application relates to novel, anti-C4,4a binder-drug conjugates (ADCs) of N,N-dialkyl auristatins, to effective metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for treating and/or preventing diseases, and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
摘要翻译：本申请涉及新的，针对靶的N，N-二Dialkylauristatinen，这些ADC的有效代谢物C4,4a粘合剂 - 药物Konjuagte器（ADC），用于制备这些ADC，用于治疗和/或预防的使用这些ADC的处理疾病以及用于制备药物的用于治疗疾病，特别是过度增殖性和/或血管生成性病症如癌症的治疗和/或预防中使用这些ADC的。这样的治疗可以作为单一药剂或与其它药物或其它治疗措施的组合来进行。

7. 发明申请

WO2012143497A2 NEUE BINDER-WIRKSTOFF KONJUGATE (ADCS) UND IHRE VERWENDUNG 审中-公开
标题翻译：新建合并偶联物ACTIVE（ADC）和它们的用途
公开(公告)号：WO2012143497A2
公开(公告)日：2012-10-26
申请号：PCT/EP2012/057247
申请日：2012-04-20
申请人： BAYER INTELLECTUAL PROPERTY GMBH , BAYER PHARMA AKTIENGESELLSCHAFT , LERCHEN, Hans-Georg , LINDEN, Lars , EL SHEIKH, Sherif , WILLUDA, Jörg , KOPITZ, Charlotte, Christine , SCHUHMACHER, Joachim , GREVEN, Simone , MAHLERT, Christoph , STELTE-LUDWIG, Beatrix , GOLFIER, Sven , BEIER, Rudolf , HEISLER, Iring , HARRENGA, Axel , THIERAUCH, Karl-Heinz , BRUDER, Sandra , PETRUL, Heike , JÖRIßEN, Hannah , BORKOWSKI, Sandra
发明人： LERCHEN, Hans-Georg , LINDEN, Lars , EL SHEIKH, Sherif , WILLUDA, Jörg , KOPITZ, Charlotte, Christine , SCHUHMACHER, Joachim , GREVEN, Simone , MAHLERT, Christoph , STELTE-LUDWIG, Beatrix , GOLFIER, Sven , BEIER, Rudolf , HEISLER, Iring , HARRENGA, Axel , THIERAUCH, Karl-Heinz , BRUDER, Sandra , PETRUL, Heike , JÖRIßEN, Hannah , BORKOWSKI, Sandra
IPC分类号： A61K47/48 , A61K47/00
CPC分类号： A61K47/48715 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , A61K47/6891 , C07K5/06 , C07K5/06052 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/565 , C07K2317/76
摘要： Die vorliegende Anmeldung betrifft neue, gegen das Target C4,4a gerichtete Binder-Wirkstoff-Konjuagte (ADCs) von N,N-Dialkylauristatinen, wirksamer Metabolite dieser ADCs, Verfahren zur Herstellung dieser ADCs, die Verwendung dieser ADCs zur Behandlung und/oder Prävention von Krankheiten sowie die Verwendung dieser ADCs zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere von hyperproliferativen und/oder angiogenen Erkrankungen wie beispielsweise Krebserkrankungen. Solche Behandlungen können als Monotherapie oder auch in Kombination mit anderen Arzneimitteln oder weiteren therapeutischen Maßnahmen erfolgen.
摘要翻译：本申请涉及新的，针对靶的N，N-二Dialkylauristatinen，这些ADC的有效代谢物C4,4a粘合剂 - 药物Konjuagte器（ADC），用于制备这些ADC，用于治疗和/或预防的使用这些ADC的处理疾病以及用于制备药物的用于治疗疾病，特别是过度增殖性和/或血管生成性病症如癌症的治疗和/或预防中使用这些ADC的。这样的治疗可以作为单一药剂或与其它药物或其它治疗措施的组合来进行。

8. 发明申请

WO2012143495A3 NOVEL BINDER-DRUG CONJUGATES (ADCS) AND THEIR USE 审中-公开
标题翻译：新建合并偶联物ACTIVE（ADC）和它们的用途
公开(公告)号：WO2012143495A3
公开(公告)日：2012-12-13
申请号：PCT/EP2012057243
申请日：2012-04-20
申请人： BAYER IP GMBH , BAYER PHARMA AG , LERCHEN HANS-GEORG , EL SHEIKH SHERIF , BEIER RUDOLF , BRUDER SANDRA , STELTE-LUDWIG BEATRIX , JOERISEN HANNAH , MAHLERT CHRISTOPH , GREVEN SIMONE , PETRUL HEIKE , SCHUHMACHER JOACHIM , LINDEN LARS , WILLUDA JOERG , KOPITZ CHAROTTE CHRISTINE , GOLFIER SVEN , HEISLER IRING , HARRENGA AXEL , THIERAUCH KARL-HEINZ , BORKOWSKI SANDRA
发明人： LERCHEN HANS-GEORG , EL SHEIKH SHERIF , BEIER RUDOLF , BRUDER SANDRA , STELTE-LUDWIG BEATRIX , JOERISEN HANNAH , MAHLERT CHRISTOPH , GREVEN SIMONE , PETRUL HEIKE , SCHUHMACHER JOACHIM , LINDEN LARS , WILLUDA JOERG , KOPITZ CHAROTTE CHRISTINE , GOLFIER SVEN , HEISLER IRING , HARRENGA AXEL , THIERAUCH KARL-HEINZ , BORKOWSKI SANDRA
IPC分类号： A61K47/48 , A61P35/00 , C07K16/30
CPC分类号： A61K47/48715 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , A61K47/6891 , C07K5/06 , C07K5/06052 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/565 , C07K2317/76
摘要： The present application relates to novel, anti-Target Epidermal Growth Factor Receptor (EGFR, GeneID1956) binder-drug conjugates (ADCs) of N,N-dialkyl auristatins, to effective metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for treating and/or preventing diseases, and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
摘要翻译：本申请涉及新的抗靶表皮生长因子受体（EGFR，GeneID1956）定向N个粘合剂 - 药物偶联物（ADC），N-Dialkylauristatinen，这些ADC的有效代谢物，用于制备这些ADC，对于使用这些ADC的处理治疗和/或预防的疾病，以及用于制备药物的用于治疗疾病，特别是过度增殖性和/或血管生成性病症如癌症的治疗和/或预防中使用这些ADC的。这样的治疗可以作为单一药剂或与其它药物或其它治疗措施的组合来进行。

9. 发明申请

WO1996013022A1 METHOD AND APPARATUS FOR WATCHING/SUPERVISING AND ALERTING STATIONARY AND/OR MOBILE OBJECTS 审中-公开
标题翻译：观察/监督和指示静态和/或移动对象的方法和装置
公开(公告)号：WO1996013022A1
公开(公告)日：1996-05-02
申请号：PCT/SE1995001243
申请日：1995-10-20
申请人： HARJU, Bert , LINDEN, Lars
IPC分类号： G08B25/10
CPC分类号： G08B25/10
摘要： A method and an apparatus for watching one or more stationary or mobile objects by means of an apparatus comprising a central unit (1), any optional number of detector modules (2) and one or more communication modules (3), whereby any optional combination of detector modules (2) can be connected to the central unit (1), and any optional combination of communication modules (3) can likewise be connected to the central unit (1), and in which apparatus the central unit (1) receives and eventually treats information of existing irregularities in the detector modules and passes on such irregularities in the form of alarm from two or more of the communication modules, namely both by a convention sound and/or light alarm, and also via a telephone module and/or via a car mobile telephone and/or via a satellite telephone module and/or via a radio link and/or via a GPS module.
摘要翻译：一种用于通过包括中央单元（1），任何可选数量的检测器模块（2）和一个或多个通信模块（3）的装置观看一个或多个固定或移动对象的方法和装置，由此任何可选组合检测器模块（2）可以连接到中央单元（1），并且通信模块（3）的任何可选组合同样可以连接到中央单元（1），并且中央单元（1）在哪个设备中接收并且最终处理在检测器模块中的现有不规则的信息，并且以两种或多种通信模块的方式传递诸如警报形式的这种不规则性，即通过常规声音和/或光警报，并且还经由电话模块和/ 或经由汽车移动电话和/或经由卫星电话模块和/或经由无线电链路和/或经由GPS模块。

10. 发明申请

WO2012143499A2 NEUE BINDER-WIRKSTOFF KONJUGATE (ADCS) UND IHRE VERWENDUNG 审中-公开
标题翻译：新的BINDER活性偶联物（ADCS）及其用途
公开(公告)号：WO2012143499A2
公开(公告)日：2012-10-26
申请号：PCT/EP2012/057249
申请日：2012-04-20
申请人： BAYER INTELLECTUAL PROPERTY GMBH , BAYER PHARMA AKTIENGESELLSCHAFT , LERCHEN, Hans-Georg , STELTE-LUDWIG, Beatrix , GOLFIER, Sven , KOPITZ, Charlotte Christine , BEIER, Rudolf , EL SHEIKH, Sherif , HEISLER, Iring , HARRENGA, Axel , THIERAUCH, Karl-Heinz , SCHUHMACHER, Joachim , BRUDER, Sandra , GREVEN, Simone , LINDEN, Lars , WILLUDA, Jörg , MAHLERT, Christoph , PETRUL, Heike , JÖRIßEN, Hannah , BORKOWSKI, Sandra
发明人： LERCHEN, Hans-Georg , STELTE-LUDWIG, Beatrix , GOLFIER, Sven , KOPITZ, Charlotte Christine , BEIER, Rudolf , EL SHEIKH, Sherif , HEISLER, Iring , HARRENGA, Axel , THIERAUCH, Karl-Heinz , SCHUHMACHER, Joachim , BRUDER, Sandra , GREVEN, Simone , LINDEN, Lars , WILLUDA, Jörg , MAHLERT, Christoph , PETRUL, Heike , JÖRIßEN, Hannah , BORKOWSKI, Sandra
IPC分类号： A61K47/48 , C07K16/30 , A61P35/00
CPC分类号： A61K47/48715 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , A61K47/6891 , C07K5/06 , C07K5/06052 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/565 , C07K2317/76
摘要： Die vorliegende Anmeldung betrifft neue, gegen das Target Mesothelin gerichtete Binder-Wirkstoff-Konjugate (ADCs) von N,N-Dialkylauristatinen, wirksamer Metabolite dieser ADCs, Verfahren zur Herstellung dieser ADCs, die Verwendung dieser ADCs zur Behandlung und/oder Prävention von Krankheiten sowie die Verwendung dieser ADCs zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere von hyperproliferativen und/oder angiogenen Erkrankungen wie beispielsweise Krebserkrankungen. Solche Behandlungen können als Monotherapie oder auch in Kombination mit anderen Arzneimitteln oder weiteren therapeutischen Massnahmen erfolgen.
摘要翻译：
本申请涉及新的，直接针对的N，N-二Dialkylauristatinen，这些ADC的有效代谢物的靶标间皮素粘结剂 - 药物偶联物（ADC），用于制备这些ADC，对于使用这些ADC的处理治疗和/或Pr＆AUML;预防疾病，以及用于药物用于治疗和/或Pr＆AUML的制备中的用途，这些ADC中;预防的疾病，特别是过度增殖性和/或血管生成性病症，如癌症。这种治疗可以作为单一疗法或与其他药物或其他治疗措施结合使用。

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