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1. 发明申请

WO2011139978A1 MOVING MENISCUS RINSING AND MIXING IN CELL STAINING 审中-公开
标题翻译：在细胞染色中移动男士冲洗和混合
公开(公告)号：WO2011139978A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/034826
申请日：2011-05-02
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles , RICHARDS, William, L. , PANG, Lizhen , SHOWALTER, Wayne , REINHARDT, Kurt
发明人： LEMME, Charles , RICHARDS, William, L. , PANG, Lizhen , SHOWALTER, Wayne , REINHARDT, Kurt
IPC分类号： G01N1/31 , G01N1/30 , G01N35/10
CPC分类号： G01N1/312 , B01F11/0017 , B01F11/0071 , G01N2035/00346 , G01N2035/00465
摘要： An automated cell staining apparatus comprises a translatable head and at least one mixing extension. The translatable head is positionable over a slide and has a lower surface. A portion of the lower surface is spaced apart from the slide by a first gap sufficiently small to allow a meniscus of liquid to form from liquid on the slide during translation of the slide. A mixing extension extends from the lower surface of the translatable head, defines a second gap smaller than the first gap between the mixing extension and the slide, and has a lateral dimension less than the width of the slide and sufficient to generate lateral movement in the liquid on the slide during translation of the head in a direction generally extending from the second gap to the first gap.
摘要翻译：自动细胞染色装置包括可平移头部和至少一个混合延伸部。可平移的头部可定位在滑动件上并具有较低的表面。下表面的一部分与滑块隔开足够小的第一间隙，以允许在滑块平移期间液体从液体形成液面。混合延伸部从可平移头部的下表面延伸，限定比混合延伸部和滑动件之间的第一间隙小的第二间隙，并且具有小于滑块宽度的横向尺寸，并足以在在大致从第二间隙延伸到第一间隙的方向平移头部时，滑块上的液体。

2. 发明申请

WO2009009419A2 APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING 审中-公开
标题翻译：用于生物样品处理的装置和方法
公开(公告)号：WO2009009419A2
公开(公告)日：2009-01-15
申请号：PCT/US2008069151
申请日：2008-07-03
申请人： VENTANA MED SYST INC , LEMME CHARLES D , RICHARDS WILLIAM , WARD GLEN , ASHBY AUSTIN , GHUSSON ANDREW , JENSEN-LONG LISA , KNAPP KEVIN , KUGIZAKI RODNEY , LARSON ALAIN , RICHARDS PAUL , SHOWALTER WAYNE , WILKINSON CHAD
发明人： LEMME CHARLES D , RICHARDS WILLIAM , WARD GLEN , ASHBY AUSTIN , GHUSSON ANDREW , JENSEN-LONG LISA , KNAPP KEVIN , KUGIZAKI RODNEY , LARSON ALAIN , RICHARDS PAUL , SHOWALTER WAYNE , WILKINSON CHAD
IPC分类号： B01J19/00 , G01N1/28 , G01N1/30 , G01N25/00 , G05B11/00
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate- supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译：描述了实现多个基板支撑的生物样品的独立且同时处理的设备和方法。在一个实施例中，布置成较小弧度的衬底保持器可在处理位置和访问位置之间独立移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板递送至保持在衬底保持器中的衬底。所公开的设备和方法特别适用于实施生物样品的稀处理。

3. 发明申请

WO2006012498A1 METHOD AND APPARATUS FOR APPLYING FLUIDS TO A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于将液体应用于生物样品的方法和装置
公开(公告)号：WO2006012498A1
公开(公告)日：2006-02-02
申请号：PCT/US2005/026014
申请日：2005-07-21
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , REINHARDT, Kurt
发明人： LEMME, Charles, D. , REINHARDT, Kurt
IPC分类号： G01N33/53
CPC分类号： B01L3/0293 , B01L2300/0822 , B01L2400/0406 , B01L2400/0475 , G01N1/2813 , G01N1/30 , G01N1/312 , G01N33/543 , G01N33/54366 , Y10T436/112499
摘要： The invention is directed to a method of contacting a biological sample with a solution, comprising the steps of moving a curved surface wetted with the solution in proximity to the biological sample whereby the distance separating the wetted curved surface and the biological sample is sufficient to form a moving liquid meniscus layer between the two. The invention is also directed to an apparatus for contacting a biological sample suspected of containing a biomarker with a solution, comprising a platform for supporting a microscope slide having a biological sample thereon; a translating cap having a curved lower surface positioned above the platform, the curved lower surface being in proximity to a biological sample when in operation; means for moving the translating cap back and forth over the biological sample; and means for applying and removing liquid to and from the cap.
摘要翻译：本发明涉及一种使生物样品与溶液接触的方法，包括以下步骤：将溶液润湿的曲面移动到生物样品附近，由此分开润湿曲面和生物样品的距离足以形成两者之间移动的液体弯月面层。本发明还涉及一种用于将怀疑含有生物标志物的生物样品与溶液接触的装置，包括用于支撑其上具有生物样品的显微镜载片的平台; 平移盖，其具有位于所述平台上方的弯曲下表面，所述弯曲下表面在操作时接近生物样品; 用于将翻译盖来回移动到生物样品上的装置; 以及用于施加和去除帽子上的液体的装置。

4. 发明申请

WO2011008415A2 COVER TILE FOR TREATING A SUBSTRATE WITH A FLUID 审中-公开
标题翻译：用于处理具有流体的基板的盖子
公开(公告)号：WO2011008415A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/039229
申请日：2010-06-18
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , WARD, Glen , KRAM, Brian, H. , RICHARDS, William, L.
发明人： LEMME, Charles, D. , WARD, Glen , KRAM, Brian, H. , RICHARDS, William, L.
IPC分类号： G01N35/00 , G01N1/28
CPC分类号： G01N1/312 , G02B21/34
摘要： A cover tile/substrate construct that includes a cover tile having an upper surface, an opposing lower surface, a proximal edge, a distal edge, and a longitudinal direction extending from the proximal edge to the distal edge, wherein the lower surface defines a three-dimensional surface that includes a protrusion that extends in the longitudinal direction; a substantially planar substrate having an upper surface and an opposing lower surface; and wherein the cover tile is juxtaposed over the substrate so that the lower surface of the cover tile and the upper surface of the substrate together define a wedge-shaped capillary fluid flow gap and the longitudinally extended protrusion of the lower surface of the cover tile protrudes towards the upper surface of the substrate.
摘要翻译：一种覆盖瓦片/基底构造，其包括具有上表面，相对的下表面，近端边缘，远侧边缘和从近端边缘延伸到远端边缘的纵向方向的覆盖瓦，其中下表面限定三包括沿纵向方向延伸的突起的三维表面; 具有上表面和相对的下表面的基本平坦的基板; 并且其中所述覆盖瓦片并置在所述基板上，使得所述覆盖瓦片的下表面和所述基板的上表面一起限定楔形毛细流体流动间隙，并且所述盖板的下表面的纵向延伸的突出部突出朝向基板的上表面。

5. 发明申请

WO2010078177A1 ROBOTIC PIPETTE SYSTEM 审中-公开
标题翻译：机载管系统
公开(公告)号：WO2010078177A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069348
申请日：2009-12-22
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , RICHARDS, William
发明人： LEMME, Charles, D. , RICHARDS, William
IPC分类号： G01N35/00 , G01N35/10 , G01N1/31
CPC分类号： G01N35/1002 , G01N35/0099 , G01N35/025 , G01N2035/00039 , G01N2035/00138 , G01N2035/0434
摘要： A robotic pipette system is used to process specimen-bearing microscope slides. The system includes a filling station, carousels, and a transport apparatus that loads pipettes filled at the filling station into the carousels. The carousels position the pipettes above the specimen-bearing slides such that fluids dispensed from the pipettes are applied to the specimens. Each carousel can hold a series of pipettes that are used to perform a multi-step process.
摘要翻译：机器人移液器系统用于处理承载载玻片的载玻片。该系统包括一个加油站，转盘和运送装置，将装载在加油站的移液管装载到转盘中。转盘将移液器放置在载体载玻片上方，以便将从移液器分配的流体施加到样品上。每个转盘可以容纳一系列用于执行多步骤过程的移液器。

6. 发明申请

WO0218980A2 OPTICAL SYSTEM FOR IMAGING DISTORTIONS IN MOVING REFLECTIVE SHEETS 审中-公开
标题翻译：用于在移动反射片中成像失真的光学系统
公开(公告)号：WO0218980A2
公开(公告)日：2002-03-07
申请号：PCT/US0127280
申请日：2001-08-30
申请人： APPLIED PROCESS TECHNOLOGIES , MADOCKS JOHN E , ABBOTT MARK M , LEMME CHARLES D
发明人： MADOCKS JOHN E , ABBOTT MARK M , LEMME CHARLES D
IPC分类号： G01B11/30 , G02B
CPC分类号： G01N21/896 , G01B11/306
摘要： An inspection apparatus for detecting the surface distortion in a sheet of reflective material such as tempered glass includes an improved optical system. The optical system includes a light source spanning the entire width of an industrial glass conveyor, directing a striped image at the glass. The image is reflected from the glass and detected by a series of image capture devices such as CCD cameras, for example, imaging the entire width of the conveyor. A plurality of images are captured in real time across the width of the conveyor as the glass travels through the reflected image. The image data is used to measure the distance from high points (peaks) on the glass to low points (valleys). This approach tolerates substantial vibration and movement of the glass sheet inherent in such an industrial environment. Because the method is comparative, no standard value and therefore no periodic calibration are required.
摘要翻译：用于检测诸如钢化玻璃的反光材料片中的表面变形的检查装置包括改进的光学系统。光学系统包括跨越工业玻璃输送机的整个宽度的光源，将条纹图像引导到玻璃杯。该图像从玻璃反射并通过诸如CCD照相机的一系列图像捕获装置进行检测，例如对输送机的整个宽度进行成像。随着玻璃穿过反射图像，多个图像在传送带的宽度上实时捕获。图像数据用于测量从玻璃上的高点（峰值）到低点（谷）的距离。这种方法允许在这种工业环境中固有的玻璃板的实质振动和移动。因为该方法是比较的，因此不需要标准值，因此不需要定期校准。

7. 发明申请

WO2005066640A1 METHOD FOR MODIFYING PRESSURE WITHIN A FLUID DISPENSER 审中-公开
标题翻译：用于在流体分配器中修改压力的方法
公开(公告)号：WO2005066640A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/040190
申请日：2004-12-01
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles , RIZZO, Vince, R., Jr. , GHUSSON, Andrew
发明人： LEMME, Charles , RIZZO, Vince, R., Jr. , GHUSSON, Andrew
IPC分类号： G01N35/10
CPC分类号： G01N1/312 , B01L3/0203 , B01L2200/0605 , G01N35/1002 , Y10T436/2575
摘要： A fluid dispenser useful in methods and apparatuses for automated biological reaction systems including a barrel (408), a coupler (428), a piston (454) associated with the barrel (408), and a sealing surface that seals the inner diameter against fluid flow at the lower extent of the piston (454).
摘要翻译：一种用于自动生物反应系统的方法和装置的流体分配器，包括筒体（408），联接器（428），与筒体（408）相关联的活塞（454）以及密封内径免受流体在活塞的下部（454）处流动。

8. 发明申请

WO2003091710A1 AUTOMATED MOLECULAR PATHOLOGY APPARATUS HAVING FIXED SLIDE PLATFORMS 审中-公开
标题翻译：具有固定滑动平台的自动分子病理学设备
公开(公告)号：WO2003091710A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012947
申请日：2003-04-28
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , BRYANT, David , CAMPBELL, Devon , GHUSSON, Andrew , REINHARDT, Kurt , RICHARDS, William , RIZZO, Vincent , SHOWALTER, Wayne
发明人： LEMME, Charles, D. , BRYANT, David , CAMPBELL, Devon , GHUSSON, Andrew , REINHARDT, Kurt , RICHARDS, William , RIZZO, Vincent , SHOWALTER, Wayne
IPC分类号： G01N21/00
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed positions, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions are brought to the slides. The apparatus includes a reagent support (1300), nozzle support (1100), and reagent dispensers (1302).
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂，洗涤和盖玻片溶液带到载玻片上。或者，将幻灯片保持在固定位置，同时将试剂，洗涤和盖玻片溶液带到载玻片上。该装置包括试剂支架（1300），喷嘴支架（1100）和试剂分配器（1302）。

9. 发明申请

WO2003089140A1 AUTOMATED HIGH VOLUME SLIDE STAINING SYSTEM 审中-公开
标题翻译：自动化高容量滑块系统
公开(公告)号：WO2003089140A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/011651
申请日：2003-04-15
申请人： VENTANA MEDICAL SYSTEMS, INC. , REINHARDT, Kurt , LEMME, Charles, D. , WARD, Glen , RICHARDS, William , SHOWALTER, Wayne
发明人： REINHARDT, Kurt , LEMME, Charles, D. , WARD, Glen , RICHARDS, William , SHOWALTER, Wayne
IPC分类号： B01L3/02
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus (20) includes a plurality of work stations (120, 140, 160, 180) arranged in a stack, and a transport/elevator (52) for transporting slides between the various work stations. In particular the device is for deparaffinizing, staining and coverslipping a plurality of biological specimen bearing slides (56), in a fully automated and integrated system.
摘要翻译：自动滑块处理装置（20）包括以堆叠方式布置的多个工作站（120,140,160,180）和用于在各个工作站之间传送滑块的运输/升降机（52）。特别地，该装置用于在完全自动化和集成的系统中脱蜡，染色和覆盖多个生物样品轴承滑块（56）。

10. 发明申请

WO2011008415A3 COVER TILE FOR TREATING A SUBSTRATE WITH A FLUID 审中-公开
标题翻译：用流体处理基板的盖板
公开(公告)号：WO2011008415A3
公开(公告)日：2011-04-14
申请号：PCT/US2010039229
申请日：2010-06-18
申请人： VENTANA MED SYST INC , LEMME CHARLES D , WARD GLEN , KRAM BRIAN H , RICHARDS WILLIAM L
发明人： LEMME CHARLES D , WARD GLEN , KRAM BRIAN H , RICHARDS WILLIAM L
IPC分类号： G01N35/00 , G01N1/28
CPC分类号： G01N1/312 , G02B21/34
摘要： A cover tile/substrate construct that includes a cover tile having an upper surface, an opposing lower surface, a proximal edge, a distal edge, and a longitudinal direction extending from the proximal edge to the distal edge, wherein the lower surface defines a three-dimensional surface that includes a protrusion that extends in the longitudinal direction; a substantially planar substrate having an upper surface and an opposing lower surface; and wherein the cover tile is juxtaposed over the substrate so that the lower surface of the cover tile and the upper surface of the substrate together define a wedge-shaped capillary fluid flow gap and the longitudinally extended protrusion of the lower surface of the cover tile protrudes towards the upper surface of the substrate.
摘要翻译：包括具有上表面，相对的下表面，近侧边缘，远侧边缘和从近侧边缘延伸到远侧边缘的纵向方向的覆盖瓦片的覆盖瓦片/基底构造，其中下表面限定三个所述三维表面包括在所述纵向方向上延伸的突起; 基本上平面的基底，其具有上表面和相对的下表面; 并且其中所述盖瓦并置在所述基板上，使得所述盖瓦的下表面和所述基板的上表面一起限定楔形毛细流体流动间隙，并且所述盖瓦的下表面的纵向延伸突出部突出朝向衬底的上表面。

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