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1. 发明申请

WO2012124890A2 METHOD FOR PREPARING MESO-2,3-BUTANEDIOL 审中-公开
标题翻译：制备MESO-2,3-丁醇的方法
公开(公告)号：WO2012124890A2
公开(公告)日：2012-09-20
申请号：PCT/KR2012000436
申请日：2012-01-18
申请人： UNIV SOGANG IND UNIV COOP FOUN , LEE JIN WON , LEE SOO JIN , KIM BO-RIM , CHOI WOO JOO
发明人： LEE JIN WON , LEE SOO JIN , KIM BO-RIM , CHOI WOO JOO
IPC分类号： C12N1/21 , C12N15/53 , C12N15/60 , C12N15/70 , C12P7/16
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/88 , C12Y101/01001 , C12Y101/01004 , C12Y401/01005 , Y02E50/10
摘要： The present invention relates to a method for preparing meso-2,3-butanediol. More particularly, the present invention relates to colon bacillus for overexpressing meso-2,3-butaediol, which is cotransformed to an expression vector including at least one nucleotide SEQ ID selected from the group consisting of the following nucleotide SEQ IDs: (a) nucleotide-coding acetoin reductase having an amino acid sequence described in SEQ ID 5 of a sequence listing; (b) nucleotide-coding acetolactate decarboxylase; and (c) nucleotide-coding alcohol dehydrogenase. The cotransformed colon bacillus of the present invention can produce 2,3-butanediol, which could not be obtained from wild species. Therefore, it is possible to biosynthesize a large amount of meso-2,3-butanediol through the biosynthesis path expression of meso-2,3-butanediol from glucose, and through metabolic flux change by means of the insertion of the genes of other species.
摘要翻译：本发明涉及一种制备内消旋-2,3-丁二醇的方法。更具体地，本发明涉及用于过表达内切-2,3-丁二醇的大肠杆菌，其被共转化成包含至少一个选自以下核苷酸SEQ ID的核苷酸SEQ ID的核苷酸SEQ ID：（a）核苷酸 - 具有序列表的SEQ ID 5所示的氨基酸序列的乙偶姻还原酶; （b）核苷酸编码乙酰乳酸脱羧酶; 和（c）核苷酸编码的醇脱氢酶。本发明的共转化大肠杆菌可以产生不能从野生种获得的2,3-丁二醇。因此，可以通过葡萄糖的内消旋-2,3-丁二醇的生物合成途径表达生物合成大量的内消旋-2,3-丁二醇，通过其他物种的基因插入代谢通量变化是可能的。

2. 发明申请

WO2011002200A3 NOVEL GUANOSINE-RICH MODIFIED OLIGONUCLEOTIDES AND ANTIPROLIFERATIVE ACTIVITY THEREOF 审中-公开
标题翻译：新型冠心病修饰寡核苷酸及其抗增殖活性
公开(公告)号：WO2011002200A3
公开(公告)日：2011-09-29
申请号：PCT/KR2010004202
申请日：2010-06-29
申请人： APTABIO THERAPEUTICS INC , LEE SOO JIN , MOON SUNG HWAN
发明人： LEE SOO JIN , MOON SUNG HWAN
IPC分类号： A61K31/7115 , C07H19/06 , A61P35/00 , C07H21/00 , C07H21/02 , C12N15/11
CPC分类号： C07H19/173 , C07H21/00
摘要： The present invention relates to a novel modified oligonucleotide comprising at least one guanosine molecule and a modified nucleic acid with therapeutic efficacies. The present invention also relates to a pharmaceutical composition having cell apoptotic activity against cancer cells for preventing or treating cancer comprising a guanosine-rich modified oligonucleotide with at least one therapeutically effective modified nucleic acid (N), or its pharmaceutically acceptable salt as active ingredient.
摘要翻译：本发明涉及包含至少一种鸟苷分子和具有治疗功效的经修饰的核酸的新型修饰寡核苷酸。本发明还涉及具有至少一种治疗有效的修饰核酸（N）或其药学上可接受的盐作为活性成分的具有用于预防或治疗癌症的癌细胞的细胞凋亡活性的药物组合物，其包含富含鸟嘌呤的修饰的寡核苷酸。

3. 发明申请

WO2005116032A3 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 审中-公开
标题翻译：反向转换和相关的方法
公开(公告)号：WO2005116032A3
公开(公告)日：2006-04-13
申请号：PCT/US2005012799
申请日：2005-04-15
申请人： CHOONGWAE PHARMA CORP , MOON SUNG HWAN , CHUNG JAE UK , LEE SUNG CHAN , EGUCHI MASAKATSU , KAHN MICHAEL , JEONG KWANG WON , NGUYEN CU , LEE SOO JIN
发明人： MOON SUNG HWAN , CHUNG JAE UK , LEE SUNG CHAN , EGUCHI MASAKATSU , KAHN MICHAEL , JEONG KWANG WON , NGUYEN CU , LEE SOO JIN
IPC分类号： C07D487/04 , A61K31/5513 , A61K45/06 , A61P35/00 , C07D487/00
CPC分类号： C07D487/04 , A61K31/4985
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
摘要翻译：公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

4. 发明申请

WO2011002200A2 NOVEL GUANOSINE-RICH MODIFIED OLIGONUCLEOTIDES AND ANTIPROLIFERATIVE ACTIVITY THEREOF 审中-公开
标题翻译：新型富含核糖核酸的修饰寡核苷酸及其抗增殖活性
公开(公告)号：WO2011002200A2
公开(公告)日：2011-01-06
申请号：PCT/KR2010/004202
申请日：2010-06-29
申请人： APTABIO THERAPEUTICS INC. , LEE, Soo Jin , MOON, Sung Hwan
发明人： LEE, Soo Jin , MOON, Sung Hwan
IPC分类号： C07H19/06
CPC分类号： C07H19/173 , C07H21/00
摘要： The present invention relates to a novel modified oligonucleotide comprising at least one guanosine molecule and a modified nucleic acid with therapeutic efficacies. The present invention also relates to a pharmaceutical composition having cell apoptotic activity against cancer cells for preventing or treating cancer comprising a guanosine-rich modified oligonucleotide with at least one therapeutically effective modified nucleic acid (N), or its pharmaceutically acceptable salt as active ingredient.
摘要翻译：本发明涉及新的修饰的寡核苷酸，其包含至少一个鸟苷分子和具有治疗功效的修饰的核酸。本发明还涉及用于预防或治疗癌症的具有细胞凋亡活性的药物组合物，其包含富含鸟苷的修饰的寡核苷酸和至少一种治疗有效的修饰的核酸（N）或其药学上可接受的盐作为活性成分。

5. 发明申请

WO2010002099A3 FPC CONNECTOR FOR ELECTRICALLY CONNECTING AN FPC TO PCB AND FPC-CONNECTOIN METHOD USING THE SAME 审中-公开
标题翻译：用于将FPC电连接到PCB的FPC连接器和使用相同的FPC连接方法
公开(公告)号：WO2010002099A3
公开(公告)日：2010-02-25
申请号：PCT/KR2009002350
申请日：2009-05-04
申请人： LEE SOO-JIN
发明人： LEE SOO-JIN
IPC分类号： H01R12/24 , H01R12/26 , H01R12/38
CPC分类号： H01R12/79 , H01R12/613 , H01R12/62 , H01R12/85 , H01R12/88 , H05K3/365 , H05K2201/10189 , H05K2201/10265 , H05K2201/10393 , Y10T29/49124
摘要： The present invention relates to an FPC connector for electrically connecting an FPC to a connecting unit of a wire printed on a PCB, and to an FPC connection method using the same, wherein an FPC (10) is inserted into a casing (110) so that a wire connection unit in the FPC (10) may face and come in direct contact with a wire connection unit (2a) in the PCB, and an FPC pressurizing member is inserted into the casing (110) in order to pressurize the upper plane of the FPC (10) which faces and comes in direct contact with the wire connection unit (2a) of the PCB (1).
摘要翻译：本发明涉及一种用于将FPC电连接到印刷在PCB上的导线的连接单元的FPC连接器以及使用该FPC连接方法的FPC连接方法，其中将FPC（10）插入壳体（110） FPC（10）中的电线连接单元可以面对并直接接触PCB中的电线连接单元（2a），并且FPC加压构件插入壳体（110）中以便对上平面（1）的导线连接单元（2a）面对并直接接触的FPC（10）。

6. 发明申请

WO2005116032A2 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 审中-公开
标题翻译：反转模拟法和与之相关的方法
公开(公告)号：WO2005116032A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/012799
申请日：2005-04-15
申请人： CHOONGWAE PHARMA CORPORATION , MOON, Sung Hwan , CHUNG, Jae Uk , LEE, Sung Chan , EGUCHI, Masakatsu , KAHN, Michael , JEONG, Kwang Won , NGUYEN, Cu , LEE, Soo Jin
发明人： MOON, Sung Hwan , CHUNG, Jae Uk , LEE, Sung Chan , EGUCHI, Masakatsu , KAHN, Michael , JEONG, Kwang Won , NGUYEN, Cu , LEE, Soo Jin
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , A61K31/4985 , Y02A50/467
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
摘要翻译：公开了模拟生物活性肽和蛋白质的逆转区二级结构的构象约束化合物。这种反转模拟结构可用于广泛的领域，包括用作诊断剂和治疗剂。还公开了含有本发明的反向模拟结构的文库以及筛选它们以鉴定生物活性成员的方法。本发明还涉及这些化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术相关的再狭窄，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化症复合体，阿尔茨海默病，过多的头发生长或脱落，或溃疡性结肠炎。

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