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1. 发明申请

WO2012124890A2 METHOD FOR PREPARING MESO-2,3-BUTANEDIOL 审中-公开
标题翻译：制备MESO-2,3-丁醇的方法
公开(公告)号：WO2012124890A2
公开(公告)日：2012-09-20
申请号：PCT/KR2012000436
申请日：2012-01-18
申请人： UNIV SOGANG IND UNIV COOP FOUN , LEE JIN WON , LEE SOO JIN , KIM BO-RIM , CHOI WOO JOO
发明人： LEE JIN WON , LEE SOO JIN , KIM BO-RIM , CHOI WOO JOO
IPC分类号： C12N1/21 , C12N15/53 , C12N15/60 , C12N15/70 , C12P7/16
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/88 , C12Y101/01001 , C12Y101/01004 , C12Y401/01005 , Y02E50/10
摘要： The present invention relates to a method for preparing meso-2,3-butanediol. More particularly, the present invention relates to colon bacillus for overexpressing meso-2,3-butaediol, which is cotransformed to an expression vector including at least one nucleotide SEQ ID selected from the group consisting of the following nucleotide SEQ IDs: (a) nucleotide-coding acetoin reductase having an amino acid sequence described in SEQ ID 5 of a sequence listing; (b) nucleotide-coding acetolactate decarboxylase; and (c) nucleotide-coding alcohol dehydrogenase. The cotransformed colon bacillus of the present invention can produce 2,3-butanediol, which could not be obtained from wild species. Therefore, it is possible to biosynthesize a large amount of meso-2,3-butanediol through the biosynthesis path expression of meso-2,3-butanediol from glucose, and through metabolic flux change by means of the insertion of the genes of other species.
摘要翻译：本发明涉及一种制备内消旋-2,3-丁二醇的方法。更具体地，本发明涉及用于过表达内切-2,3-丁二醇的大肠杆菌，其被共转化成包含至少一个选自以下核苷酸SEQ ID的核苷酸SEQ ID的核苷酸SEQ ID：（a）核苷酸 - 具有序列表的SEQ ID 5所示的氨基酸序列的乙偶姻还原酶; （b）核苷酸编码乙酰乳酸脱羧酶; 和（c）核苷酸编码的醇脱氢酶。本发明的共转化大肠杆菌可以产生不能从野生种获得的2,3-丁二醇。因此，可以通过葡萄糖的内消旋-2,3-丁二醇的生物合成途径表达生物合成大量的内消旋-2,3-丁二醇，通过其他物种的基因插入代谢通量变化是可能的。

2. 发明申请

WO2014052920A3 METHODS OF PRODUCING ACETOIN AND 2,3-BUTANEDIOL USING PHOTOSYNTHETIC MICROORGANISMS 审中-公开
标题翻译：使用光合微生物生产乙酰胆碱和2,3-丁二醇的方法
公开(公告)号：WO2014052920A3
公开(公告)日：2014-06-26
申请号：PCT/US2013062459
申请日：2013-09-27
申请人： UNIV CALIFORNIA
发明人： ATSUMI SHOTA , OLIVER JOHN W K , MACHADO IARA M P
IPC分类号： C12P7/16 , A61K35/74 , C12N1/20
CPC分类号： C12P7/26 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12P7/18 , C12Y101/98 , C12Y202/01006 , C12Y401/01005 , Y02P20/52
摘要： The present disclosure provides recombinant cyanobacteria having acetolactate synthase activity and acetolactate decarboxylase activity, as well as recombinant cyanobacteria having acetolactate synthase activity, acetolactate decarboxylase activity, and secondary alcohol dehydrogenase activity. Methods for the production of the recombinant cyanobacteria, as well as methods for use thereof for production of acetoin and 2,3- butanediol from carbon dioxide and light are also provided.
摘要翻译：本发明提供具有乙酰乳酸合酶活性和乙酰乳酸脱羧酶活性的重组蓝藻，以及具有乙酰乳酸合酶活性，乙酰乳酸脱羧酶活性和仲醇脱氢酶活性的重组蓝藻。还提供了用于生产重组蓝藻的方法，以及其用于从二氧化碳和光生产乙偶姻和2,3-丁二醇的方法。

3. 发明申请

WO2012174430A2 METHODS OF MAKING NYLON INTERMEDIATES FROM GLYCEROL 审中-公开
标题翻译：从甘油制备尼龙中间体的方法
公开(公告)号：WO2012174430A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042747
申请日：2012-06-15
申请人： INVISTA TECHNOLOGIES S.A.R.L. , PEARLMAN, Paul, S. , CHEN, Changlin , BOTES, Adriana, L.
发明人： PEARLMAN, Paul, S. , CHEN, Changlin , BOTES, Adriana, L.
IPC分类号： C12P7/04 , C12P7/42 , C12P7/46 , C12P13/02 , C12P13/00 , C12P5/02 , C07K14/195 , C07K14/37 , C07K14/405 , C07K14/415 , C12N1/32 , C12N9/10 , C12N9/78 , C12N9/88 , C12N9/00
CPC分类号： C12P13/005 , C07K14/195 , C07K14/37 , C12N1/32 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1029 , C12N9/1096 , C12N9/78 , C12N9/88 , C12N15/52 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/46 , C12P13/001 , C12P13/02 , C12P17/10 , C12Y101/01004 , C12Y101/01157 , C12Y202/01006 , C12Y203/01009 , C12Y401/01005
摘要： Embodiments of the invention relate to the enzymatic conversion of bioderived feedstocks to commercially valuable chemicals. The enzymatic conversions of the embodiments of the invention offer the potential for lower cost routes to these value-added chemicals. Some of the chemicals that are useful include nylon intermediates such as caprolactam, adipic acid, 1,6-hexamethylene diamine; butanediols such as 1,4-butanediol, 1,3-butanediol, and 2,3-butanediol; butanols such as 1-butanol, and 2-butanol; succinic acid, butadiene, isoprene, and 3-hydroxypropanoic acid.
摘要翻译：本发明的实施方案涉及生物活性原料的酶转化为商业上有价值的化学品。本发明实施方案的酶促转化提供了对这些增值化学品的较低成本路线的潜力。一些有用的化学物质包括尼龙中间体如己内酰胺，己二酸，1,6-六亚甲基二胺; 丁二醇如1,4-丁二醇，1,3-丁二醇和2,3-丁二醇; 丁醇如1-丁醇和2-丁醇; 琥珀酸，丁二烯，异戊二烯和3-羟基丙酸。

4. 发明申请

WO2016094334A1 RECOMBINANT MICROORGANISMS EXHIBITING INCREASED FLUX THROUGH A FERMENTATION PATHWAY 审中-公开
标题翻译：重组微生物通过发酵途径展现出增加的通量
公开(公告)号：WO2016094334A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064351
申请日：2015-12-07
申请人： LANZATECH NEW ZEALAND LIMITED , KOEPKE, Michael , MUELLER, Alexander Paul , TRAN, Loan Phuong
发明人： KOEPKE, Michael , MUELLER, Alexander Paul , TRAN, Loan Phuong
IPC分类号： C12N15/74 , C12N9/02 , C12N9/10 , C12N9/88 , C12P1/04 , C12P7/18 , C12R1/145
CPC分类号： C12N9/88 , C12N9/0008 , C12N9/1022 , C12N15/52 , C12P7/18 , C12Y102/07001 , C12Y202/01006 , C12Y401/01005 , Y02E50/17
摘要： The invention provides a recombinant, carboxydotrophic Clostridium bacterium that expresses one or more of pyruvate:ferredoxin oxidoreductase (EC 1.2.7.1), acetolactate synthase (EC 2.2.1.6), and acetolactate decarboxylase (EC 4.1.1.5). The invention further provides a method of producing a fermentation product by fermenting the recombinant bacterium in the presence of a gaseous substrate comprising CO to produce one or more of ethanol, butanol, isopropanol, isobutanol, higher alcohols, butanediol, 2,3-butanediol, succinate, isoprenoids, fatty acids, biopolymers, and mixtures thereof.
摘要翻译：本发明提供了表达丙酮酸：铁氧还蛋白氧化还原酶（EC 1.2.7.1），乙酰乳酸合酶（EC 2.2.1.6）和乙酰乳酸脱羧酶（EC 4.1.1.5）中的一种或多种的重组，羧基营养梭菌细菌。本发明还提供一种通过在包含CO的气态底物的存在下发酵重组细菌以产生乙醇，丁醇，异丙醇，异丁醇，高级醇，丁二醇，2,3-丁二醇，琥珀酸盐，类异戊二烯，脂肪酸，生物聚合物及其混合物。

5. 发明申请

WO2016012557A1 MICROORGANISM STRAINS FOR THE PRODUCTION OF 2.3- BUTANEDIOL 审中-公开
标题翻译：用于生产2.3-丁醇的微生物菌株
公开(公告)号：WO2016012557A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066920
申请日：2015-07-23
申请人： ALDERYS
发明人： BREMOND, Mélanie , JAILLARDON, Karine , LOUIS, Dominique , THOMAS, Dominique
IPC分类号： C12P7/16
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0036 , C12N9/1022 , C12N9/88 , C12N15/52 , C12Y101/01004 , C12Y106/03 , C12Y202/01006 , C12Y401/01001 , C12Y401/01005
摘要： A recombinant yeast having a rcduced pyruvate decarboxylase activity, in the génome of which has been inserted: - one or more nucleic acids encoding an acetolactate synthase or ALS, - one or more nucleic acids encoding an acetolactate decarboxylase or ALD, - one or more nucleic acids encoding a butancdiol dehydrogenase or BDH, and - one or more copies of a nucleic acids encoding a NADH oxidase or NOXE.
摘要翻译：一种重组酵母，其具有一种或多种编码乙酰乳酸合酶或ALS的核酸， - 编码乙酰乳酸脱羧酶或ALD的一种或多种核酸， - 一种或多种核酸编码丁二醇脱氢酶或BDH的酸，以及编码NADH氧化酶或NOXE的核酸的一个或多个拷贝。

6. 发明申请

WO2016191169A1 ACETOLACTATE DECARBOXYLASE 审中-公开
标题翻译：醋酸十八烷酸
公开(公告)号：WO2016191169A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/033028
申请日：2016-05-18
申请人： DUPONT NUTRITION BIOSCIENCES APS , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： CRAMER, Jacob Flyvholm , JENSEN, Lene Bojsen , KELLETTSMITH, Anja Hemmingsen , BLADT, Tove , LEE, Sang-Kye
IPC分类号： C12N9/88
CPC分类号： C12N9/96 , C12C5/00 , C12C5/004 , C12G1/0203 , C12G2200/15 , C12N1/38 , C12N9/88 , C12Y401/01005
摘要： The present disclosure provides methods, compositions, apparatuses and kits comprising ALDC enzymes having a better stability and/or activity, and, optionally, the yield of ALDC enzymes which can be recovered from microorganisms is improved. In some embodiments, the present disclosure provides methods, apparatuses, compositions and kits for the use of metal ions to increase stability and/or activity, and which further can be used to recover the enzymes from microorganisms in improved yields.
摘要翻译：本公开提供了包含具有更好的稳定性和/或活性的ALDC酶的方法，组合物，装置和试剂盒，并且任选地，可以从微生物中回收的ALDC酶的产率得到改善。在一些实施方案中，本公开提供了用于使用金属离子增加稳定性和/或活性的方法，装置，组合物和试剂盒，并且其还可用于以提高的产率从微生物中回收酶。

7. 发明申请

WO2015187087A3 NOVEL COMBINATIONS FOR ANTIGEN BASED THERAPY 审中-公开
标题翻译：基于抗原治疗的新型组合
公开(公告)号：WO2015187087A3
公开(公告)日：2016-01-28
申请号：PCT/SE2015050651
申请日：2015-06-04
申请人： DIAMYD MEDICAL AB
发明人： ESSEN-MÖLLER ANDERS , LUDVIGSSON JOHNNY
IPC分类号： A61K39/00 , A61K31/592 , A61K31/593 , A61K38/28 , A61P3/10
CPC分类号： A61K39/0008 , A61K9/0019 , A61K31/192 , A61K31/197 , A61K31/592 , A61K31/593 , A61K38/1793 , A61K38/191 , A61K38/28 , A61K38/43 , A61K45/06 , A61K2039/54 , A61K2039/55505 , A61K2039/577 , C12Y401/01005 , A61K2300/00
摘要： The present invention relates to a method for prevention and/or treatment of an autoimmune disease, comprising administering a composition, said composition comprising at least one beta cell autoantigen, to a subject The subject may have a serum vitamin-D level above 50 nanomole/liter or the composition may be administered by intralymphatic injection or injection directly into a lymph node, or over a period of weeks, months, or years. The invention also relates to a composition comprising a plurality of particles, each having immobilised on its surface at least one first and at least one second antigen, wherein the first antigen is a beta cell autoantigen, and the second antigen is either a tolerogen or a beta cell autoantigen, andto composition comprising i) at least one beta cell autoantigen, and at least one of iia) an IL-10 inducing compound selected from the group consisting of vitamin-D, vitamin-D analogs, tyrosine kinase inhibitors, gamma-amino butyric acid, and gamma-amino butyric acid analogs; and iib) a compound that reduces the dendritic cells' ability to activate naïve CD4+ Tcells, such as a cyclooxygenase inhibitor, a CTLA-4 compound or a TNF alpha inhibitor. The invention also relates to pharmaceutical kits and to medical use of beta cell autoantigens.
摘要翻译：本发明涉及一种预防和/或治疗自身免疫性疾病的方法，包括向受试者施用包含至少一种β细胞自身抗原的所述组合物。所述受试者可具有高于50纳摩尔/ 或者组合物可以通过淋巴内注射或直接注射到淋巴结中，或在数周，数月或数年的时间内施用。本发明还涉及包含多个颗粒的组合物，每个颗粒在其表面上固定有至少一个第一和至少一个第二抗原，其中第一抗原是β细胞自身抗原，第二抗原是耐受原或 β细胞自身抗原，以及组合物，其包含i）至少一种β细胞自身抗原，和iia中的至少一种，IL-10诱导化合物，其选自维生素D，维生素-D类似物，酪氨酸激酶抑制剂，氨基丁酸和γ-氨基丁酸类似物; 和iib）降低树突状细胞激活初始CD4 + T细胞的能力的化合物，例如环氧合酶抑制剂，CTLA-4化合物或TNFα抑制剂。本发明还涉及药物试剂盒和β细胞自身抗原的医疗用途。

8. 发明申请

WO2015187087A2 NOVEL COMBINATIONS FOR ANTIGEN BASED THERAPY 审中-公开
标题翻译：基于抗原治疗的新型组合
公开(公告)号：WO2015187087A2
公开(公告)日：2015-12-10
申请号：PCT/SE2015/050651
申请日：2015-06-04
申请人： DIAMYD MEDICAL AB
发明人： ESSEN-MÖLLER, Anders , LUDVIGSSON, Johnny
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K9/0019 , A61K31/192 , A61K31/197 , A61K31/592 , A61K31/593 , A61K38/1793 , A61K38/191 , A61K38/28 , A61K38/43 , A61K45/06 , A61K2039/54 , A61K2039/55505 , A61K2039/577 , C12Y401/01005 , A61K2300/00
摘要： The present invention relates to a method for prevention and/or treatment of an autoimmune disease, comprising administering a composition, said composition comprising at least one beta cell autoantigen, to a subject The subject may have a serum vitamin-D level above 50 nanomole/liter or the composition may be administered by intralymphatic injection or injection directly into a lymph node, or over a period of weeks, months, or years. The invention also relates to a composition comprising a plurality of particles, each having immobilised on its surface at least one first and at least one second antigen, wherein the first antigen is a beta cell autoantigen, and the second antigen is either a tolerogen or a beta cell autoantigen, andto composition comprising i) at least one beta cell autoantigen, and at least one of iia) an IL-10 inducing compound selected from the group consisting of vitamin-D, vitamin-D analogs, tyrosine kinase inhibitors, gamma-amino butyric acid, and gamma-amino butyric acid analogs; and iib) a compound that reduces the dendritic cells' ability to activate naïve CD4+ Tcells, such as a cyclooxygenase inhibitor, a CTLA-4 compound or a TNF alpha inhibitor. The invention also relates to pharmaceutical kits and to medical use of beta cell autoantigens.
摘要翻译：本发明涉及一种预防和/或治疗自身免疫性疾病的方法，包括向受试者施用包含至少一种β细胞自身抗原的所述组合物。所述受试者可具有高于50纳摩尔/ 或者组合物可以通过淋巴内注射或直接注射到淋巴结中，或在数周，数月或数年的时间内施用。本发明还涉及包含多个颗粒的组合物，每个颗粒在其表面上固定有至少一个第一和至少一个第二抗原，其中第一抗原是β细胞自身抗原，第二抗原是耐受原或 β细胞自身抗原，以及组合物，其包含i）至少一种β细胞自身抗原，和iia中的至少一种，IL-10诱导化合物，其选自维生素D，维生素-D类似物，酪氨酸激酶抑制剂，氨基丁酸和γ-氨基丁酸类似物; 和iib）降低树突状细胞激活初始CD4 + T细胞的能力的化合物，例如环氧合酶抑制剂，CTLA-4化合物或TNFα抑制剂。本发明还涉及药物试剂盒和β细胞自身抗原的医疗用途。

9. 发明申请

WO2014052920A2 METHODS OF PRODUCING ACETOIN AND 2,3-BUTANEDIOL USING PHOTOSYNTHETIC MICROORGANISMS 审中-公开
标题翻译：使用光合微生物生产乙酰胆碱和2,3-丁二醇的方法
公开(公告)号：WO2014052920A2
公开(公告)日：2014-04-03
申请号：PCT/US2013/062459
申请日：2013-09-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： ATSUMI, Shota , OLIVER, John, W. K. , MACHADO, Iara, M.P.
IPC分类号： C12N1/21
CPC分类号： C12P7/26 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12P7/18 , C12Y101/98 , C12Y202/01006 , C12Y401/01005 , Y02P20/52
摘要： The present disclosure provides recombinant cyanobacteria having acetolactate synthase activity and acetolactate decarboxylase activity, as well as recombinant cyanobacteria having acetolactate synthase activity, acetolactate decarboxylase activity, and secondary alcohol dehydrogenase activity. Methods for the production of the recombinant cyanobacteria, as well as methods for use thereof for production of acetoin and 2,3- butanediol from carbon dioxide and light are also provided.
摘要翻译：本公开提供具有乙酰乳酸合酶活性和乙酰乳酸脱羧酶活性的重组蓝细菌，以及具有乙酰乳酸合酶活性，乙酰乳酸脱羧酶活性和仲醇脱氢酶活性的重组蓝细菌。还提供了用于生产重组蓝细菌的方法，以及其用于从二氧化碳和光产生乙偶姻和2,3-丁二醇的方法。

10. 发明申请

WO2013115659A3 RECOMBINANT MICROORGANISMS AND METHODS OF USE THEREOF 审中-公开
标题翻译：重组微生物及其使用方法
公开(公告)号：WO2013115659A3
公开(公告)日：2013-10-03
申请号：PCT/NZ2013000012
申请日：2013-01-31
申请人： LANZATECH NEW ZEALAND LTD , KOEPKE MICHAEL , NAGARAJU SHILPA , CHEN WENDY
发明人： KOEPKE MICHAEL , NAGARAJU SHILPA , CHEN WENDY
IPC分类号： C12N1/21 , C12N15/52 , C12N15/53 , C12N15/74 , C12P7/06 , C12P7/40
CPC分类号： C12P7/065 , C12N1/20 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12N15/00 , C12N15/52 , C12N15/74 , C12N2510/02 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/50 , C12P7/56 , C12P13/06 , C12P13/08 , C12Y101/01004 , C12Y202/01006 , C12Y401/01005 , Y02E50/17
摘要： The invention relates to methods for the production of chemical compounds, particularly but not exclusively ethanol, by microbial fermentation. Also described are genetically modified micro-organisms capable of using carbon monoxide to produce one or more products, particularly but not exclusively ethanol as a main product, and producing a reduced amount or substantially no 2,3-butanediol and/or a precursor thereof.
摘要翻译：本发明涉及通过微生物发酵来生产化学化合物，特别是但不限于乙醇的方法。还描述了能够使用一氧化碳来产生一种或多种产品的遗传修饰的微生物，特别是但不限于乙醇作为主要产品，并且产生减少量或基本上不产生2,3-丁二醇和/或其前体。

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