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1. 发明申请

WO9707788A3 COMPOSITION FOR SUSTAINED RELEASE OF AN AGENT 审中-公开
标题翻译：用于持续发行代理的组合物
公开(公告)号：WO9707788A3
公开(公告)日：1997-04-17
申请号：PCT/US9613787
申请日：1996-08-29
申请人： ALKERMES INC , LEE HYE JUNG , JOHNSON OLUFUNMI L , ZALE STEPHEN E , TRACY MARK A
发明人： LEE HYE-JUNG , JOHNSON OLUFUNMI L , ZALE STEPHEN E , TRACY MARK A
IPC分类号： A61K9/54 , A61K9/16 , A61K9/50 , A61K9/52 , A61K47/30
CPC分类号： A61K9/5084 , A61K9/1647
摘要： Composition for the sustained release of a biologically active agent in vivo. The composition comprises microcarriers containing a first solid-phase biocompatible material and a biologically active agent, wherein said microcarriers sustain in vivo release of the biologically active agent. The composition also contains particles of a second biocompatible solid-phase material wherein the second solid-phase material further sustains the in vivo release of the biologically active agent. The invention also relates to a method for sustaining effective serum levels of a biologically active agent in a subject, including forming an injectable dose containing an effective amount of a biologically active agent, wherein the agent is contained in a microcarrier, with a release-period sustaining amount of a solid-phase material. The method further includes administering the injectable dose to the subject.

2. 发明申请

WO1997007788A2 COMPOSITION FOR SUSTAINED RELEASE OF AN AGENT 审中-公开
标题翻译：用于持续发行代理的组合物
公开(公告)号：WO1997007788A2
公开(公告)日：1997-03-06
申请号：PCT/US1996013787
申请日：1996-08-29
申请人： ALKERMES CONTROLLED THERAPEUTICS, INC. , LEE, Hye-Jung , JOHNSON, OluFunmi, L. , ZALE, Stephen, E. , TRACY, Mark, A.
发明人： ALKERMES CONTROLLED THERAPEUTICS, INC.
IPC分类号： A61K09/54
CPC分类号： A61K9/5084 , A61K9/1647
摘要： Composition for the sustained release of a biologically active agent in vivo. The composition comprises microcarriers containing a first solid-phase biocompatible material and a biologically active agent, wherein said microcarriers sustain in vivo release of the biologically active agent. The composition also contains particles of a second biocompatible solid-phase material wherein the second solid-phase material further sustains the in vivo release of the biologically active agent. The invention also relates to a method for sustaining effective serum levels of a biologically active agent in a subject, including forming an injectable dose containing an effective amount of a biologically active agent, wherein the agent is contained in a microcarrier, with a release-period sustaining amount of a solid-phase material. The method further includes administering the injectable dose to the subject.
摘要翻译：用于体内持续释放生物活性剂的组合物。该组合物包含含有第一固相生物相容性材料和生物活性剂的微载体，其中所述微载体维持生物活性剂的体内释放。该组合物还含有第二生物相容性固相材料的颗粒，其中第二固相材料进一步维持生物活性剂的体内释放。本发明还涉及一种用于维持受试者中生物活性剂有效血清水平的方法，包括形成含有有效量的生物活性剂的可注射剂量，其中所述试剂包含在微载体中，释放期维持量的固相材料。该方法还包括向受试者施用可注射剂量。

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