专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO9938003A9 MICROFABRICATED APERTURE-BASED SENSOR 审中-公开
标题翻译：基于微孔的基于孔径的传感器
公开(公告)号：WO9938003A9
公开(公告)日：1999-10-21
申请号：PCT/US9901375
申请日：1999-01-21
申请人： I STAT CORP , DAVIS GRAHAM , LIN CHAO , LAUKS IMANTS R , PIERCE RAYMOND J
发明人： DAVIS GRAHAM , LIN CHAO , LAUKS IMANTS R , PIERCE RAYMOND J
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/26
CPC分类号： C12Q1/004 , C12Q1/002 , Y10S435/817
摘要： A chemical sensor includes an enzyme layer (62), a diffusion layer (68) and an analyte barrier layer (60) positioned over the diffusion layer. Apertures (64) are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.
摘要翻译：化学传感器包括位于扩散层上的酶层（62），扩散层（68）和分析物阻挡层（60）。孔径（64）通过在分析物阻挡层中的微细加工形成，以允许受控的分析物通量到扩散层。

2. 发明申请

WO02099407A3 PLANAR ELECTRODE MODULE FOR USE IN A DIAGNOSTIC DEVICE 审中-公开
标题翻译：用于诊断设备的平面电极模块
公开(公告)号：WO02099407A3
公开(公告)日：2003-04-03
申请号：PCT/CA0200827
申请日：2002-06-04
申请人： EPOCAL INC , LAUKS IMANTS R
发明人： LAUKS IMANTS R
IPC分类号： G01N27/27 , G01N27/30 , G01N27/327 , G01N27/403 , G01N27/414 , G01N27/447
CPC分类号： G01N27/307 , G01N27/403 , H01L2224/48091 , H01L2924/3011 , H01L2924/00014 , H01L2924/00
摘要： Planar devices incorporating electrodes for performing chemical analyses are disclosed. The device include an electrode module in a fluidic housing. The electrode module includes a carrier module and at least one electrode thereon. More specifically, the electrode module includes a planar carrier module made of laminate of a metal layer and an insulator layer, which metal layer is divided into at least two metal conductor elements; and at least one electrode formed directly on the carrier module and including a membrane element for imparting chemical sensitivity to the electrode, the membrane element being applied to the insulator layer to be in electrical contact with one of the metal conductor elements through the insulator layer. The insulator layer preferably has die cut perforations through which the membrane element extends into electrical contact with the conductor layer. In the most economical embodiment, the carrier module is a common chip carrier according to ISO 7816-2. The devices of cheaper construction than prior art chemical analysis chips, especially since they are of much simplified construction and of standardized format which allows the use of readily available low cost components.
摘要翻译：公开了包含用于进行化学分析的电极的平面装置。该装置包括在流体壳体中的电极模块。电极模块包括载体模块和其上的至少一个电极。更具体地，电极模块包括由金属层和绝缘体层的层压制成的平面载体模块，该金属层被分成至少两个金属导体元件; 以及至少一个直接形成在所述载体模块上的电极，并且包括用于赋予所述电极化学敏感性的膜元件，所述膜元件被施加到所述绝缘体层，以通过所述绝缘体层与所述金属导体元件中的一个电接触。绝缘体层优选地具有切割穿孔，膜元件通过该切割穿孔与导体层电接触。在最经济的实施例中，载波模块是根据ISO 7816-2的公共芯片载体。比现有技术化学分析芯片更便宜的设备，特别是因为它们的结构非常简单，并且允许使用容易获得的低成本部件的标准化格式。

3. 发明申请

WO2002100261A3 POINT-OF-CARE IN-VITRO BLOOD ANALYSIS SYSTEM 审中-公开
公开(公告)号：WO2002100261A3
公开(公告)日：2002-12-19
申请号：PCT/CA2002/000825
申请日：2002-06-04
申请人： EPOCAL INC. , LAUKS, Imants, R.
发明人： LAUKS, Imants, R.
IPC分类号： G01N33/487
摘要： Devices for cost-effectively performing in-vitro diagnostic chemical analyses at multiple distributed locations within a medical institution are disclosed. One object of this invention is to provide a network of distributed sensory devices that acquire sensor signals from blood specimens and deliver those signals through a connection to a central location for analysis by a general-purpose computer and generation of an analysis result. The analysis result is then sent to numerous locations on a network for display, including also possibly back to the location of signal acquisition. Cost-effective mobile sensing devices are also sdisclosed. The present system includes blood-sensor signal acquisition devices distributed throughout the hospital. The sensory signal-acquisition devices are card readers that acquire raw sensory signals from diagnostic cards inserted therein. These diagnostic cards are smart card-like devices modified for blood collection that contain sensory elements such as electrodes adapted to provide a raw sensory signal. The signal acquisition devices are modified smart card readers, which acquire the raw sensory data from an inserted smart card through a standardized contact arrangement and provide the raw data to data processing devices such as data acquisition cards. The system includes multiple remote ports for acquiring blood sensor signals. One or more card reader, when connected to a mobile general-purpose computer, can be converted into a complete mobile blood analyzer.

4. 发明申请

WO2002099407A2 ELECTRODE MODULE 审中-公开
标题翻译：电极模块
公开(公告)号：WO2002099407A2
公开(公告)日：2002-12-12
申请号：PCT/CA2002/000827
申请日：2002-06-04
申请人： EPOCAL INC. , LAUKS, Imants, R.
发明人： LAUKS, Imants, R.
IPC分类号： G01N27/30
CPC分类号： G01N27/307 , G01N27/403 , H01L2224/48091 , H01L2924/3011 , H01L2924/00014 , H01L2924/00
摘要： Planar devices incorporating electrodes for performing chemical analyses are disclosed. The device include an electrode module in a fluidic housing. The electrode module includes a carrier module and at least one electrode thereon. More specifically, the electrode module includes a planar carrier module made of laminate of a metal layer and an insulator layer, which metal layer is divided into at least two metal conductor elements; and at least one electrode formed directly on the carrier module and including a membrane element for imparting chemical sensitivity to the electrode, the membrane element being applied to the insulator layer to be in electrical contact with one of the metal conductor elements through the insulator layer. The insulator layer preferably has die cut perforations through which the membrane element extends into electrical contact with the conductor layer. In the most economical embodiment, the carrier module is a common chip carrier according to ISO 7816-2. The devices of cheaper construction than prior art chemical analysis chips, especially since they are of much simplified construction and of standardized format which allows the use of readily available low cost components.
摘要翻译：公开了包含用于进行化学分析的电极的平面装置。该装置包括在流体壳体中的电极模块。电极模块包括载体模块和其上的至少一个电极。更具体地，电极模块包括由金属层和绝缘体层的层压制成的平面载体模块，该金属层被分成至少两个金属导体元件; 以及至少一个直接形成在所述载体模块上的电极，并且包括用于赋予所述电极化学敏感性的膜元件，所述膜元件被施加到所述绝缘体层，以通过所述绝缘体层与所述金属导体元件中的一个电接触。绝缘体层优选地具有切割穿孔，膜元件通过该切割穿孔与导体层电接触。在最经济的实施例中，载波模块是根据ISO 7816-2的公共芯片载体。比现有技术化学分析芯片更便宜的设备，特别是因为它们的结构非常简单，并且允许使用容易获得的低成本部件的标准化格式。

5. 发明申请

WO03076937A9 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 审中-公开
标题翻译：用于分析测量和免疫测定的装置和方法
公开(公告)号：WO03076937A9
公开(公告)日：2004-04-22
申请号：PCT/US0306820
申请日：2003-03-05
申请人： I STAT CORP , DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
发明人： DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
IPC分类号： B01L3/00 , C12M1/34 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/543 , G01N35/04 , G01N35/08 , G01N33/483
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

6. 发明申请

WO2003076937A3 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 审中-公开
公开(公告)号：WO2003076937A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006820
申请日：2003-03-05
申请人： I-STAT CORPORATION , DAVIS, Graham , LAUKS, Imants, R. , LIN, Chao , MILLER, Cary, James
发明人： DAVIS, Graham , LAUKS, Imants, R. , LIN, Chao , MILLER, Cary, James
IPC分类号： G01N33/483
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

7. 发明申请

WO03076937A2 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 审中-公开
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：WO03076937A2
公开(公告)日：2003-09-18
申请号：PCT/US0306820
申请日：2003-03-05
申请人： I STAT CORP , DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
发明人： DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
IPC分类号： B01L3/00 , C12M1/34 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/543 , G01N35/04 , G01N35/08 , G01N33/53
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于进行液体样品中分析物测定的各种测定的装置，并且涉及用于这种测定的方法。具体而言，本发明涉及设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案测定生物样品中分析物的测定。该盒提供用于处理样本的计量部分的新颖特征，用于精确且灵活地控制样本或第二流体在盒内的移动，用于在测定期间修改具有额外化合物的溶液以及构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法享有比现有技术显着的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定以及使操作者和患者的污染风险最小化的一次性使用方法。所公开的发明适用于即时临床诊断领域，包括在事故现场，急诊室，手术室，养老院，重症监护室和非医疗环境中的使用。

8. 发明申请

WO2002100261A2 POINT-OF-CARE IN-VITRO BLOOD ANALYSIS SYSTEM 审中-公开
标题翻译：要点血管内血液分析系统
公开(公告)号：WO2002100261A2
公开(公告)日：2002-12-19
申请号：PCT/CA2002/000825
申请日：2002-06-04
申请人： EPOCAL INC. , LAUKS, Imants, R.
发明人： LAUKS, Imants, R.
IPC分类号： A61B5/00
CPC分类号： G01N33/49
摘要： Devices for cost-effectively performing in-vitro diagnostic chemical analyses at multiple distributed locations within a medical institution are disclosed. One object of this invention is to provide a network of distributed sensory devices that acquire sensor signals from blood specimens and deliver those signals through a connection to a central location for analysis by a general-purpose computer and generation of an analysis result. The analysis result is then sent to numerous locations on a network for display, including also possibly back to the location of signal acquisition. Cost-effective mobile sensing devices are also sdisclosed. The present system includes blood-sensor signal acquisition devices distributed throughout the hospital. The sensory signal-acquisition devices are card readers that acquire raw sensory signals from diagnostic cards inserted therein. These diagnostic cards are smart card-like devices modified for blood collection that contain sensory elements such as electrodes adapted to provide a raw sensory signal. The signal acquisition devices are modified smart card readers, which acquire the raw sensory data from an inserted smart card through a standardized contact arrangement and provide the raw data to data processing devices such as data acquisition cards. The system includes multiple remote ports for acquiring blood sensor signals. One or more card reader, when connected to a mobile general-purpose computer, can be converted into a complete mobile blood analyzer.
摘要翻译：公开了用于在医疗机构内的多个分布位置进行成本有效地进行体外诊断化学分析的装置。本发明的一个目的是提供一种分布式感觉装置的网络，其从血液样本获取传感器信号，并通过连接到中心位置传送这些信号，以便通用计算机进行分析并产生分析结果。然后将分析结果发送到网络上的多个位置进行显示，包括也可能返回到信号采集的位置。成本效益高的移动传感设备也被披露。本系统包括分布在整个医院的血液传感器信号采集装置。感觉信号采集装置是从插入其中的诊断卡获取原始感觉信号的读卡器。这些诊断卡是用于血液收集修改的智能卡状设备，其包含感觉元件，例如适于提供原始感觉信号的电极。信号采集装置是改进的智能卡读卡器，其通过标准化的接触装置从插入的智能卡获取原始感觉数据，并将原始数据提供给数据处理装置，例如数据采集卡。该系统包括用于采集血液传感器信号的多个远程端口。一个或多个读卡器连接到移动通用计算机时，可以转换成完整的移动血液分析仪。

9. 发明申请

WO2002098554A1 INTEGRATED ELECTROKINETIC DEVICES AND METHODS OF MANUFACTURE 审中-公开
标题翻译：综合电动装置及其制造方法
公开(公告)号：WO2002098554A1
公开(公告)日：2002-12-12
申请号：PCT/CA2002/000826
申请日：2002-06-04
申请人： EPOCAL INC. , LAUKS, Imants, R.
发明人： LAUKS, Imants, R.
IPC分类号： B01J19/00
CPC分类号： B01L3/50273 , B01J2219/00783 , B01J2219/00831 , B01J2219/00853 , B01J2219/0086 , B01L3/502707 , B01L3/502753 , B01L2200/12 , B01L2200/16 , B01L2300/0645 , B01L2300/0825 , B01L2300/10 , B01L2400/0415 , B01L2400/0418 , G01N2035/00158
摘要： Devices with electrokinetic elements are disclosed as well as their method of microfabrication for use in micro-scale analysis, mixture separation and reaction. The devices consist of solid hydrophilic-matrix films (2) that have been microfabricated into a variety of micro-scale structures. These structures include hydrophilic-matrix conductors (2) for electrokinetic species transport and separation. They also include hydrophilic-matrix cladding containing chemical species adjacent to either an open conduit or a hydrophilic matrix conductor. Also described are other integrated microstructures consisting of hydrophilic-matrix materials (2) such as micro-reaction zones for retaining chemical species for on-chip chemical reactions and integrated detection structures for on-chip species detection. In general, a hydrophilic matrix on a substrate (1) functions as a conductor that is covered by an electrically insulating, preferably water permeable material (3).
摘要翻译：公开了具有电动元件的装置以及它们用于微尺度分析，混合物分离和反应的微细加工方法。该装置由已经微加工成各种微尺度结构的固体亲水基质膜（2）组成。这些结构包括用于电动物质输送和分离的亲水基质导体（2）。它们还包括含有与开放导管或亲水基质导体相邻的化学物质的亲水基质包层。还描述了由亲水基质材料（2）组成的其它集成微结构，例如用于保留用于片上化学反应的化学物质的微反应区和用于片上物种检测的集成检测结构。通常，基材（1）上的亲水基质用作被电绝缘的，优选水可渗透的材料（3）覆盖的导体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式