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1. 发明申请

WO2005100998A3 MEMBRANE MARKERS FOR USE IN CANCER DIAGNOSIS AND THERAPY 审中-公开
标题翻译：用于癌症诊断和治疗的膜标记
公开(公告)号：WO2005100998A3
公开(公告)日：2008-06-12
申请号：PCT/EP2005004153
申请日：2005-04-15
申请人： EUROPROTEOME AG , TORTOLA-PEREZ SILVIA , LAMER STEPHANIE , HEIM STEFFEN , FUCHS MIRIAM , BUSCHMANN THOMAS , SEIBERT VOLKER , FOTIADIS NIKOLETA-KYRIAKI , STEDRONSKY KATRIN , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , ILYNIA TATIANA , FELS LUEDER
发明人： TORTOLA-PEREZ SILVIA , LAMER STEPHANIE , HEIM STEFFEN , FUCHS MIRIAM , BUSCHMANN THOMAS , SEIBERT VOLKER , FOTIADIS NIKOLETA-KYRIAKI , STEDRONSKY KATRIN , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , ILYNIA TATIANA , FELS LUEDER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The invention relates to agents and methods for the diagnosis, prognosis and treatment of non-steroid dependent cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding plasma membrane proteins of the invention that are differentially expressed in tumour tissues for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of such proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of the proteins plasma membrane proteins of the invention, including using agents identified in screening assays described herein, as well as molecules that are complementary to polynucleotide sequences encoding plasmas membrane proteins of the invention and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
摘要翻译：本发明涉及用于诊断，预后和治疗非类固醇依赖性癌症的药剂和方法。具体地说，本发明涉及编码在肿瘤组织中差异表达的本发明的质膜蛋白的核酸和氨基酸序列用于诊断早期和晚期非类固醇特异性癌症，癌症预后以及筛选用于调节这些蛋白质的基因表达和/或生物活性的治疗剂。本发明还涉及设计用于抑制本发明的蛋白质质膜蛋白质的基因表达和/或生物活性的生物学技术，包括使用本文所述的筛选测定中鉴定的试剂，以及与编码的多核苷酸序列互补的分子本发明的血浆膜蛋白和所述蛋白的靶向抗体。在具体实施方案中，蛋白质是人源的。

2. 发明申请

WO2005026735A3 DIFFERENTIALLY EXPRESSED TUMOUR-SPECIFIC POLYPEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF CANCER 审中-公开
标题翻译：差异表达的肿瘤特异性多肽用于癌症的诊断和治疗
公开(公告)号：WO2005026735A3
公开(公告)日：2005-11-03
申请号：PCT/EP2004010780
申请日：2004-09-20
申请人： GENMAB AS , BUSCHMANN THOMAS , FOTIADIS NIKOLETA-KYRIAKI , FUCHS MIRIAM , HEIM STEFFEN , ILYNIA TATIANA , LAMER STEPHANIE , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , SEIBERT VOLKER , PEREZ SILVIA TORTOLA
发明人： BUSCHMANN THOMAS , FOTIADIS NIKOLETA-KYRIAKI , FUCHS MIRIAM , HEIM STEFFEN , ILYNIA TATIANA , LAMER STEPHANIE , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , SEIBERT VOLKER , PEREZ SILVIA TORTOLA
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/57407 , G01N33/6893 , G01N2500/00
摘要： The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
摘要翻译：本发明涉及用于癌症的诊断，预后和治疗的药剂和方法。具体而言，本发明涉及编码跨膜超家族成员6（TM4SF6），突触泡蛋白样蛋白（SYPL），类胃蛋白样2（STOML2），Ras相关GTP结合蛋白RAGA），核苷酸敏感性氯化物通道1A （CLNS1A），朊病毒蛋白（p27-30）（PRNP），鸟嘌呤核苷酸结合蛋白β2样1（GNB2L1），鸟嘌呤核苷酸结合蛋白4（GNG4），整合膜蛋白2B（ITM2B），整合膜蛋白1 ITM1），跨膜9超家族成员2（TM9SF2），阿片受体样1蛋白（OPRL1），低密度脂蛋白受体相关蛋白4（LRP4），人肾小球上皮蛋白1（GLEPP1），toll样受体3（TLR3 ）和/或透明带球菌糖蛋白3A（ZP3），用于诊断早期和晚期非类固醇特异性癌症，癌症预后，以及筛选调节所述蛋白质的基因表达和/或生物学活性的治疗剂。本发明进一步涉及设计用于抑制所述蛋白质的基因表达和/或生物学活性的生物技术，包括使用在本文描述的筛选测定法中鉴定的试剂，反义多核苷酸序列的载体递送和所述蛋白质的抗体靶向。在具体的实施方案中，蛋白质是人源的。

3. 发明申请

WO2004003564A2 TUMOUR MARKER AND THE USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF TUMOUR DISEASES 审中-公开
标题翻译：肿瘤标志物及其用途的诊断和肿瘤疾病治疗
公开(公告)号：WO2004003564A2
公开(公告)日：2004-01-08
申请号：PCT/EP0306748
申请日：2003-06-26
申请人： EUROPROTEOME AG , LAMER STEPHANIE , FOGERON MARIE-LAURE , LAGE HERMANN , KELLNER UDO
发明人： LAMER STEPHANIE , FOGERON MARIE-LAURE , LAGE HERMANN , KELLNER UDO
IPC分类号： A61K38/00 , C07K1/28 , G01N33/68 , C07K14/435
CPC分类号： C07K1/28 , A61K38/00
摘要： The invention relates to the use of the type II membrane protein NP 055070 (respectively Swiss-Prot number), NHP2-type protein 1 P55769, pre-mRNA cleavage factor Im (25kD) NP008937, Lysyl-tRNA synthetase Q15046, UNR-interacting protein Q9Y3F4, nucleic transport factor 2 P13662, erythrocyte phosphatase1 isoenzyme F P24666, Prefoldin sub-unit 2 Q9UHV9, heterogeneous nuclear ribonucleoprotein C1/C2 P07910, transitional endoplasmic reticulum-ATPase P55072, bifunctional methylenetetrahydrofolic acid dehydrogenase P13995, 47 kDa heat-shock protein precursor P29043, ubiquinol-cytochrome C reductase complex core protein P31930, the fragments thereof, detector substances targeting the same, and/or nucleic acids coding for the same, for producing a means for diagnosing tumours and for the prophylactic or therapeutic treatment of tumours.
摘要翻译：它是，UNR相互作用蛋白Q9Y3F4使用II型膜蛋白NP 055070（二者SWISS-PROT。号），NHP 2样蛋白1 P55769，前mRNA裂解因子IM（25kD的）NP008937，赖氨酰tRNA合成酶Q15046的，核运输因子2 P13662，Erytrozytenphosphatase1同工酶˚FP24666，Prefoldin亚基2 Q9UHV9，不均一核核糖核蛋白C1 / C2 P07910，transitionale内质网ATP酶P55072，双功能Methylenetetrahydrofolsäure脱氢酶P13995，47 kDa热休克蛋白前体P29043，泛醇细胞色素C的Reductasekomplex核心蛋白P31930其针对这些识别物质和/或编码它们的制备用于肿瘤的诊断，预防或治疗性治疗的药剂的核酸片段建议。

4. 发明申请

WO0044392A3 IDENTIFICATION OF SPECIFIC DIFFERENTIALLY EXPRESSED MYCOBACTERIAL ANTIGENS 审中-公开
标题翻译：特异性差异表达的MYCOBACTERIAL抗原的鉴定
公开(公告)号：WO0044392A3
公开(公告)日：2000-12-07
申请号：PCT/EP0000690
申请日：2000-01-28
申请人： CHIRON BEHRING GMBH & CO , JUNGBLUT PETER , KAUFMANN STEFAN H E , SCHAIBLE ULRICH , MOLLENKOPF HANS , RAUPACH BAERBEL , ZIMNY ARNDT URSULA , LAMER STEPHANIE , MATTOW JENS
发明人： JUNGBLUT PETER , KAUFMANN STEFAN H E , SCHAIBLE ULRICH , MOLLENKOPF HANS , RAUPACH BAERBEL , ZIMNY-ARNDT URSULA , LAMER STEPHANIE , MATTOW JENS
IPC分类号： G01N33/569 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K38/16 , A61K38/44 , A61K38/46 , A61K38/53 , A61K39/04 , A61K39/395 , A61K39/40 , A61P11/00 , A61P17/02 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/08 , A61P35/00 , C07K14/35 , C07K16/12 , C07K19/00 , C12N1/21 , C12N9/00 , C12N15/09 , C12N15/31 , C12N15/62 , C12P21/02 , C12R1/32
CPC分类号： A61K39/04 , A61K2039/53 , C07K14/35 , C07K2319/00
摘要： The present invention relates to compositions useful in immunization against pathogenic organisms of the genus Mycobacterium and for diagnostic purposes. In particular, the present invention relates to a composition comprising at least one protein which is differentially expressed in a virulent strain as compared to an avirulent strain of Mycobacteria. Furthermore, the invention relates to compositions comprising fusion proteins, antigenic fragments, nucleic acid molecules encoding the aforementioned proteinaceous compounds and/or antibodies thereto. Additionally, the invention relates to pharmaceutical and diagnostic compositions comprising or employing compounds of the invention. In addition, the present invention relates to the use of the compounds of the invention for the treatment of Mycobacterium induced diseases and/or for the preparation of a vaccine for vaccination against Mycobacterium induced diseases.
摘要翻译：本发明涉及可用于针对分枝杆菌属的病原微生物免疫的组合物和用于诊断目的。特别地，本发明涉及一种组合物，其包含至少一种与分枝杆菌的无毒力菌株相比在毒力菌株中差异表达的蛋白质。此外，本发明涉及包含融合蛋白，抗原性片段，编码上述蛋白质化合物的核酸分子和/或其抗体的组合物。另外，本发明涉及包含或使用本发明化合物的药物和诊断组合物。此外，本发明涉及本发明化合物用于治疗分枝杆菌诱导的疾病和/或用于制备针对分枝杆菌诱导的疾病的疫苗接种的用途。

5. 发明申请

WO2004040298A3 TUMOR MARKER PROTEINS FOR DIAGNOSIS AND THERAPY OF CANCER AND CANCER RISK ASSESSMENT 审中-公开
公开(公告)号：WO2004040298A3
公开(公告)日：2004-05-13
申请号：PCT/EP2003/012162
申请日：2003-10-31
申请人： EUROPROTEOME AG , SEIBERT, Volker , LAMER, Stephanie , ROTHMANN-COSIC, Kirsten , PÈREZ, Silvia, Tòrtola , ILYINA, Tatiana , HEIM, Steffen , MEUER, Jörn , BUSCHMANN, Thomas , FOGERON, Marie-Laure , VAN DER LINDEN, Mark
发明人： SEIBERT, Volker , LAMER, Stephanie , ROTHMANN-COSIC, Kirsten , PÈREZ, Silvia, Tòrtola , ILYINA, Tatiana , HEIM, Steffen , MEUER, Jörn , BUSCHMANN, Thomas , FOGERON, Marie-Laure , VAN DER LINDEN, Mark
IPC分类号： G01N33/574
摘要： The invention relates to agents and methods for the diagnosis and therapy of cancer and further to the identification of cancer associated marker. The following tumor marker were identified: S-100type calcium binding protein A14 (BC005019) NCBI 10190712, unknown(BC007716)/GTP-specific succinyl-CoA synthetase beta subunit (AF058954) NCBI 14043451, ATP Synthase D Chain O75947, Cathepsin E Precursor P07339, Cathepsin E Precursor/Gastricin precursor (Pepsonogen C) P14091, Complement Component 1, Q Subcomponent Binding Protein Q07021, Dihydrolipoamide Dehydrogenase, mitochondrial precursor P09622, Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase Q16134, Fumarate Hydratase, mitochondrial precursor P07954, IgG Fc binding protein NCBI 4321127, Myosin Light Chain Alkali, non muscle isoform/Myosin Light Chain Alkali, smooth-muscle P16475/P24572, Myosin regulatory light chain 2, smooth muscle isoform/Myosin regulatory light chain 2, nonsarcomeric P19105/P24844, NADH-Ubiquinone Oxidoreductase 42 kda Subunit O95299, PDZ and LIM Domain Protein 1 O00151, Poly(RC)-Binding Protein 1 Q15365, NCBI 4506237, Proteasome activator hPA28 subunit beta Q15365, NCBI 4506237, S 100 calcium-binding protein A14/Calgizzarin (91% identity) O60417/P31949 and/or Succinate Dehydrogenase [ubiquinone] Flavoprotein P31040.

6. 发明申请

WO2005026735A2 DIFFERENTIALLY EXPRESSED TUMOUR-SPECIFIC POLYPEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF CANCER 审中-公开
标题翻译：用于诊断和治疗癌症的差异显着的肿瘤特异性多聚体
公开(公告)号：WO2005026735A2
公开(公告)日：2005-03-24
申请号：PCT/EP2004/010780
申请日：2004-09-20
申请人： EUROPROTEOME AG , BUSCHMANN, Thomas , FOTIADIS, Nikoleta-Kyriaki , FUCHS, Miriam , HEIM, Steffen , ILYNIA, Tatiana , LAMER, Stephanie , MEUER, Jörn , ROTHMANN-COSIC, Kirsten , SEIBERT, Volker , PÉREZ, Silvia, Tortola
发明人： BUSCHMANN, Thomas , FOTIADIS, Nikoleta-Kyriaki , FUCHS, Miriam , HEIM, Steffen , ILYNIA, Tatiana , LAMER, Stephanie , MEUER, Jörn , ROTHMANN-COSIC, Kirsten , SEIBERT, Volker , PÉREZ, Silvia, Tortola
IPC分类号： G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/57407 , G01N33/6893 , G01N2500/00
摘要： The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
摘要翻译：本发明涉及用于诊断，预后和治疗癌症的药剂和方法。具体而言，本发明涉及编码跨膜超家族成员6（TM4SF6），突触素样蛋白（SYPL），2号孔蛋白（STOML2），Ras相关GTP结合蛋白RAGA）的核酸和氨基酸序列，核苷酸敏感性氯通道1A （CLNS1A），朊病毒蛋白（p27-30）（PRNP），鸟嘌呤核苷酸结合蛋白β2-样1（GNB2L1），鸟嘌呤核苷酸结合蛋白4（GNG4），整合膜蛋白2B（ITM2B），整合膜蛋白1 ITM1），跨膜9超家族成员2（TM9SF2），阿片受体样1蛋白（OPRL1），低密度脂蛋白受体相关蛋白4（LRP4），人肾小球上皮蛋白1（GLEPP1），toll样受体3（TLR3 ）和/或透明带糖蛋白3A（ZP3），用于诊断早期和晚期非类固醇特异性癌症，癌症预后，以及筛选调节所述蛋白质的基因表达和/或生物活性的治疗剂。本发明还涉及设计用于抑制所述蛋白质的基因表达和/或生物活性的生物学技术，包括使用本文所述的筛选测定中鉴定的试剂，反义多核苷酸序列的载体递送和所述蛋白质的抗体靶向。在具体实施方案中，蛋白质是人源的。

7. 发明申请

WO2004005928A2 AGENTS AND METHODS FOR DIAGNOSIS AND THERAPY OF CANCER AND CANCER RISK ASSESSMENT 审中-公开
标题翻译：用于癌症诊断和治疗以及癌症风险评估的试剂和方法
公开(公告)号：WO2004005928A2
公开(公告)日：2004-01-15
申请号：PCT/EP2003/007339
申请日：2003-07-08
申请人： EUROPROTEOME AG , HEIM, Steffen , SEIBERT, Volker , LAMER, Stephanie , FOGERON, Marie-Laure , TÓRTOLA-PÉREZ, Silvia , ROTHMANN, Kirsten , BUSCHMANN, Thomas , MEUER, Jörn , ILYNIA, Tatiana , VAN DER LINDEN, Mark
发明人： SEIBERT, Volker , LAMER, Stephanie , FOGERON, Marie-Laure , TÓRTOLA-PÉREZ, Silvia , ROTHMANN, Kirsten , BUSCHMANN, Thomas , MEUER, Jörn , ILYNIA, Tatiana , VAN DER LINDEN, Mark
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57484
摘要： The invention relates to agents and methods for the diagnosis and therapy of cancer and further to the identification of cancer associated marker. The following tumor marker were identified: Q14259 Enhancer of rudimentary homolog, O00151 PDZ and LIM Domain Protein 1, P55072 Transitional Endolasmatic Reticulum ATPase, P47756 F-Actin Capping Protein Beta subunit, P11021 78 kDa Glucose regulated protein precursor, Q9Y4L1 150 kD Oxygen-regulated Protein Precursor.
摘要翻译：本发明涉及用于癌症的诊断和治疗的试剂和方法，并进一步涉及鉴定癌症相关标志物。鉴定了以下肿瘤标志物：Q14259基础同系物的增强子，O00151 PDZ和LIM域蛋白1，P55072过渡型Endolamatic Reticulum ATP酶，P47756 F-肌动蛋白加帽蛋白β亚基，P11021 78kDa葡萄糖调节的蛋白质前体，Q9Y4L1 150kD氧调节的蛋白质前体。

8. 发明申请

WO2004003564A3 TUMORMARKER UND IHRE VERWENDUNG ZUR DIAGNOSE UND THERAPIE VON TUMORERKRANKUNGEN 审中-公开
公开(公告)号：WO2004003564A3
公开(公告)日：2004-01-08
申请号：PCT/EP2003/006748
申请日：2003-06-26
申请人： EUROPROTEOME AG , LAMER, Stephanie , FOGERON, Marie-Laure , LAGE, Hermann , KELLNER, Udo
发明人： LAMER, Stephanie , FOGERON, Marie-Laure , LAGE, Hermann , KELLNER, Udo
IPC分类号： G01N33/68
摘要： Es wird die Verwendung von Typ II Membranprotein NP 055070 (jeweils Swiss-Prot. Nummer), NHP2-ähnliches Protein 1 P55769, pre-mRNA cleavage factor Im (25kD) NP008937, Lysyl-tRNA Synthetase Q15046, UNR-interagierendes Protein Q9Y3F4, nukleärer Transportfaktor 2 P13662, Erytrozytenphosphatase1 Isoenzyme F P24666, Prefoldin Untereinheit 2 Q9UHV9, heterogenes nukleäres Ribonucleoprotein C1/C2 P07910, transitionale endoplasmische Retikulum-ATPase P55072, bifunktionelle Methylenetetrahydrofolsäure Dehydrogenase P13995, 47 kDa Hitzeschockprotein Vorstufe P29043, Ubichinol-Cytochrom C Reductasekomplex core Protein P31930, deren Fragmente, gegen diese gerichtete Erkennungssubstanzen und/oder diese codierende Nucleinsäuren zur Herstellung eines Mittels zur Diagnose, prophylaktischen oder therapeutischen Behandlung von Tumoren vorgeschlagen.

9. 发明申请

WO2005100998A2 MEMBRANE MARKERS FOR USE IN CANCER DIAGNOSIS AND THERAPY 审中-公开
标题翻译：用于癌症诊断和治疗的膜标记
公开(公告)号：WO2005100998A2
公开(公告)日：2005-10-27
申请号：PCT/EP2005/004153
申请日：2005-04-15
申请人： EUROPROTEOME AG , TÓRTOLA-PÉREZ, Silvia , LAMER, Stephanie , HEIM, Steffen , FUCHS, Miriam , BUSCHMANN, Thomas , SEIBERT, Volker , FOTIADIS, Nikoleta-Kyriaki , STEDRONSKY, Katrin , MEUER, Jörn , ROTHMANN-COSIC, Kirsten , ILYNIA, tatiana , FELS, Lüder
发明人： TÓRTOLA-PÉREZ, Silvia , LAMER, Stephanie , HEIM, Steffen , FUCHS, Miriam , BUSCHMANN, Thomas , SEIBERT, Volker , FOTIADIS, Nikoleta-Kyriaki , STEDRONSKY, Katrin , MEUER, Jörn , ROTHMANN-COSIC, Kirsten , ILYNIA, tatiana , FELS, Lüder
IPC分类号： G01N33/574
CPC分类号： C12Q1/6897 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The invention relates to agents and methods for the diagnosis, prognosis and treatment of non-steroid dependent cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding plasma membrane proteins of the invention that are differentially expressed in tumour tissues for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of such proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of the proteins plasma membrane proteins of the invention, including using agents identified in screening assays described herein, as well as molecules that are complementary to polynucleotide sequences encoding plasmas membrane proteins of the invention and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
摘要翻译：本发明涉及用于诊断，预后和治疗非类固醇依赖性癌症的药剂和方法。具体地说，本发明涉及编码在肿瘤组织中差异表达的本发明的质膜蛋白的核酸和氨基酸序列用于诊断早期和晚期非类固醇特异性癌症，癌症预后以及筛选用于调节这些蛋白质的基因表达和/或生物活性的治疗剂。本发明还涉及设计用于抑制本发明的蛋白质质膜蛋白质的基因表达和/或生物活性的生物学技术，包括使用本文所述的筛选测定中鉴定的试剂，以及与编码的多核苷酸序列互补的分子本发明的血浆膜蛋白和所述蛋白的靶向抗体。在具体实施方案中，蛋白质是人源的。

10. 发明申请

WO2004040298A2 TUMOR MARKER PROTEINS FOR DIAGNOSIS AND THERAPY OF CANCER AND CANCER RISK ASSESSMENT 审中-公开
标题翻译：肿瘤标记蛋白用于诊断和治疗癌症和癌症风险评估
公开(公告)号：WO2004040298A2
公开(公告)日：2004-05-13
申请号：PCT/EP0312162
申请日：2003-10-31
申请人： EUROPROTEOME AG , SEIBERT VOLKER , LAMER STEPHANIE , ROTHMANN-COSIC KIRSTEN , PEREZ SILVIA TORTOLA , ILYINA TATIANA , HEIM STEFFEN , MEUER JOERN , BUSCHMANN THOMAS , FOGERON MARIE-LAURE , VAN DER LINDEN MARK
发明人： SEIBERT VOLKER , LAMER STEPHANIE , ROTHMANN-COSIC KIRSTEN , PEREZ SILVIA TORTOLA , ILYINA TATIANA , HEIM STEFFEN , MEUER JOERN , BUSCHMANN THOMAS , FOGERON MARIE-LAURE , VAN DER LINDEN MARK
IPC分类号： A61K38/17 , A61K38/44 , G01N33/574 , G01N33/48
CPC分类号： A61K38/1709 , A61K38/43 , G01N33/574
摘要： The invention relates to agents and methods for the diagnosis and therapy of cancer and further to the identification of cancer associated marker. The following tumor marker were identified: S-100type calcium binding protein A14 (BC005019) NCBI 10190712, unknown(BC007716)/GTP-specific succinyl-CoA synthetase beta subunit (AF058954) NCBI 14043451, ATP Synthase D Chain O75947, Cathepsin E Precursor P07339, Cathepsin E Precursor/Gastricin precursor (Pepsonogen C) P14091, Complement Component 1, Q Subcomponent Binding Protein Q07021, Dihydrolipoamide Dehydrogenase, mitochondrial precursor P09622, Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase Q16134, Fumarate Hydratase, mitochondrial precursor P07954, IgG Fc binding protein NCBI 4321127, Myosin Light Chain Alkali, non muscle isoform/Myosin Light Chain Alkali, smooth-muscle P16475/P24572, Myosin regulatory light chain 2, smooth muscle isoform/Myosin regulatory light chain 2, nonsarcomeric P19105/P24844, NADH-Ubiquinone Oxidoreductase 42 kda Subunit O95299, PDZ and LIM Domain Protein 1 O00151, Poly(RC)-Binding Protein 1 Q15365, NCBI 4506237, Proteasome activator hPA28 subunit beta Q15365, NCBI 4506237, S 100 calcium-binding protein A14/Calgizzarin (91% identity) O60417/P31949 and/or Succinate Dehydrogenase [ubiquinone] Flavoprotein P31040.
摘要翻译：本发明涉及用于诊断和治疗癌症以及进一步鉴定癌症相关标志物的药剂和方法。鉴定出以下肿瘤标志物：S-100型钙结合蛋白A14（BC005019）NCBI 10190712，未知（BC007716）/ GTP特异性琥珀酰-CoA合成酶β亚基（AF058954）NCBI 14043451，ATP合酶D链O75947，组织蛋白酶E前体P07339 ，组织蛋白酶E前体/胃素前体（Pepsonogen C）P14091，补体成分1，Q子组分结合蛋白Q07021，二氢硫辛酰胺脱氢酶，线粒体前体P09622，电子转移黄素蛋白 - 泛醌氧化还原酶Q16134，富马酸水合酶，线粒体前体P07954，IgG Fc结合蛋白NCBI 4321127，肌球蛋白轻链碱，非肌肉同种型/肌球蛋白轻链碱，平滑肌P16475 / P24572，肌球蛋白调节轻链2，平滑肌同种型/肌球蛋白调节轻链2，非糖尿病P19105 / P24844，NADH-泛醌氧化还原酶42kda 亚基O95299，PDZ和LIM结构域蛋白1 O00151，聚（RC）结合蛋白1 Q15365，NCBI 4506237，蛋白酶体激活剂hPA28亚基 βQ15365，NCBI 4506237，S100蛋白结合蛋白A14 / Calgizzarin（91％同一性）O60417 / P31949和/或琥珀酸脱氢酶[泛醌]黄素蛋白P31040。

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