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1. 发明申请

WO2004040298A2 TUMOR MARKER PROTEINS FOR DIAGNOSIS AND THERAPY OF CANCER AND CANCER RISK ASSESSMENT 审中-公开
标题翻译：肿瘤标记蛋白用于诊断和治疗癌症和癌症风险评估
公开(公告)号：WO2004040298A2
公开(公告)日：2004-05-13
申请号：PCT/EP0312162
申请日：2003-10-31
申请人： EUROPROTEOME AG , SEIBERT VOLKER , LAMER STEPHANIE , ROTHMANN-COSIC KIRSTEN , PEREZ SILVIA TORTOLA , ILYINA TATIANA , HEIM STEFFEN , MEUER JOERN , BUSCHMANN THOMAS , FOGERON MARIE-LAURE , VAN DER LINDEN MARK
发明人： SEIBERT VOLKER , LAMER STEPHANIE , ROTHMANN-COSIC KIRSTEN , PEREZ SILVIA TORTOLA , ILYINA TATIANA , HEIM STEFFEN , MEUER JOERN , BUSCHMANN THOMAS , FOGERON MARIE-LAURE , VAN DER LINDEN MARK
IPC分类号： A61K38/17 , A61K38/44 , G01N33/574 , G01N33/48
CPC分类号： A61K38/1709 , A61K38/43 , G01N33/574
摘要： The invention relates to agents and methods for the diagnosis and therapy of cancer and further to the identification of cancer associated marker. The following tumor marker were identified: S-100type calcium binding protein A14 (BC005019) NCBI 10190712, unknown(BC007716)/GTP-specific succinyl-CoA synthetase beta subunit (AF058954) NCBI 14043451, ATP Synthase D Chain O75947, Cathepsin E Precursor P07339, Cathepsin E Precursor/Gastricin precursor (Pepsonogen C) P14091, Complement Component 1, Q Subcomponent Binding Protein Q07021, Dihydrolipoamide Dehydrogenase, mitochondrial precursor P09622, Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase Q16134, Fumarate Hydratase, mitochondrial precursor P07954, IgG Fc binding protein NCBI 4321127, Myosin Light Chain Alkali, non muscle isoform/Myosin Light Chain Alkali, smooth-muscle P16475/P24572, Myosin regulatory light chain 2, smooth muscle isoform/Myosin regulatory light chain 2, nonsarcomeric P19105/P24844, NADH-Ubiquinone Oxidoreductase 42 kda Subunit O95299, PDZ and LIM Domain Protein 1 O00151, Poly(RC)-Binding Protein 1 Q15365, NCBI 4506237, Proteasome activator hPA28 subunit beta Q15365, NCBI 4506237, S 100 calcium-binding protein A14/Calgizzarin (91% identity) O60417/P31949 and/or Succinate Dehydrogenase [ubiquinone] Flavoprotein P31040.
摘要翻译：本发明涉及用于诊断和治疗癌症以及进一步鉴定癌症相关标志物的药剂和方法。鉴定出以下肿瘤标志物：S-100型钙结合蛋白A14（BC005019）NCBI 10190712，未知（BC007716）/ GTP特异性琥珀酰-CoA合成酶β亚基（AF058954）NCBI 14043451，ATP合酶D链O75947，组织蛋白酶E前体P07339 ，组织蛋白酶E前体/胃素前体（Pepsonogen C）P14091，补体成分1，Q子组分结合蛋白Q07021，二氢硫辛酰胺脱氢酶，线粒体前体P09622，电子转移黄素蛋白 - 泛醌氧化还原酶Q16134，富马酸水合酶，线粒体前体P07954，IgG Fc结合蛋白NCBI 4321127，肌球蛋白轻链碱，非肌肉同种型/肌球蛋白轻链碱，平滑肌P16475 / P24572，肌球蛋白调节轻链2，平滑肌同种型/肌球蛋白调节轻链2，非糖尿病P19105 / P24844，NADH-泛醌氧化还原酶42kda 亚基O95299，PDZ和LIM结构域蛋白1 O00151，聚（RC）结合蛋白1 Q15365，NCBI 4506237，蛋白酶体激活剂hPA28亚基 βQ15365，NCBI 4506237，S100蛋白结合蛋白A14 / Calgizzarin（91％同一性）O60417 / P31949和/或琥珀酸脱氢酶[泛醌]黄素蛋白P31040。

2. 发明申请

WO2004005928A3 AGENTS AND METHODS FOR DIAGNOSIS AND THERAPY OF CANCER AND CANCER RISK ASSESSMENT 审中-公开
标题翻译：癌症和癌症风险评估的诊断和治疗方法
公开(公告)号：WO2004005928A3
公开(公告)日：2004-05-06
申请号：PCT/EP0307339
申请日：2003-07-08
申请人： EUROPROTEOME AG , SEIBERT VOLKER , LAMER STEPHANIE , FOGERON MARIE-LAURE , TORTOLA-PEREZ SILVIA , ROTHMANN-COSIC KIRSTEN , BUSCHMANN THOMAS , MEUER JOERN , ILYNIA TATIANA , VAN DER LINDEN MARK , HEIM STEFFEN
发明人： SEIBERT VOLKER , LAMER STEPHANIE , FOGERON MARIE-LAURE , TORTOLA-PEREZ SILVIA , ROTHMANN-COSIC KIRSTEN , BUSCHMANN THOMAS , MEUER JOERN , ILYNIA TATIANA , VAN DER LINDEN MARK , HEIM STEFFEN
IPC分类号： G01N33/574 , C07K14/82 , A61K39/00 , C12N9/02 , C12Q1/68
CPC分类号： G01N33/574 , G01N33/57484
摘要： The invention relates to agents and methods for the diagnosis and therapy of cancer and further to the identification of cancer associated marker. The following tumor marker were identified: Q14259 Enhancer of rudimentary homolog, O00151 PDZ and LIM Domain Protein 1, P55072 Transitional Endolasmatic Reticulum ATPase, P47756 F-Actin Capping Protein Beta subunit, P11021 78 kDa Glucose regulated protein precursor, Q9Y4L1 150 kD Oxygen-regulated Protein Precursor.
摘要翻译：本发明涉及用于诊断和治疗癌症以及进一步鉴定癌症相关标志物的药剂和方法。鉴定了以下肿瘤标志物：Q14259基础同源物的增强子，O00151 PDZ和LIM结构域蛋白1，P55072过渡性内质网络ATP酶，P47756 F-肌动蛋白封端蛋白β亚基，P11021 78kDa葡萄糖调节蛋白前体，Q9Y4L1 150kD氧调节蛋白质前体。

3. 发明申请

WO2005026735A3 DIFFERENTIALLY EXPRESSED TUMOUR-SPECIFIC POLYPEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF CANCER 审中-公开
标题翻译：差异表达的肿瘤特异性多肽用于癌症的诊断和治疗
公开(公告)号：WO2005026735A3
公开(公告)日：2005-11-03
申请号：PCT/EP2004010780
申请日：2004-09-20
申请人： GENMAB AS , BUSCHMANN THOMAS , FOTIADIS NIKOLETA-KYRIAKI , FUCHS MIRIAM , HEIM STEFFEN , ILYNIA TATIANA , LAMER STEPHANIE , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , SEIBERT VOLKER , PEREZ SILVIA TORTOLA
发明人： BUSCHMANN THOMAS , FOTIADIS NIKOLETA-KYRIAKI , FUCHS MIRIAM , HEIM STEFFEN , ILYNIA TATIANA , LAMER STEPHANIE , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , SEIBERT VOLKER , PEREZ SILVIA TORTOLA
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/57407 , G01N33/6893 , G01N2500/00
摘要： The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
摘要翻译：本发明涉及用于癌症的诊断，预后和治疗的药剂和方法。具体而言，本发明涉及编码跨膜超家族成员6（TM4SF6），突触泡蛋白样蛋白（SYPL），类胃蛋白样2（STOML2），Ras相关GTP结合蛋白RAGA），核苷酸敏感性氯化物通道1A （CLNS1A），朊病毒蛋白（p27-30）（PRNP），鸟嘌呤核苷酸结合蛋白β2样1（GNB2L1），鸟嘌呤核苷酸结合蛋白4（GNG4），整合膜蛋白2B（ITM2B），整合膜蛋白1 ITM1），跨膜9超家族成员2（TM9SF2），阿片受体样1蛋白（OPRL1），低密度脂蛋白受体相关蛋白4（LRP4），人肾小球上皮蛋白1（GLEPP1），toll样受体3（TLR3 ）和/或透明带球菌糖蛋白3A（ZP3），用于诊断早期和晚期非类固醇特异性癌症，癌症预后，以及筛选调节所述蛋白质的基因表达和/或生物学活性的治疗剂。本发明进一步涉及设计用于抑制所述蛋白质的基因表达和/或生物学活性的生物技术，包括使用在本文描述的筛选测定法中鉴定的试剂，反义多核苷酸序列的载体递送和所述蛋白质的抗体靶向。在具体的实施方案中，蛋白质是人源的。

4. 发明申请

WO2005100998A3 MEMBRANE MARKERS FOR USE IN CANCER DIAGNOSIS AND THERAPY 审中-公开
标题翻译：用于癌症诊断和治疗的膜标记
公开(公告)号：WO2005100998A3
公开(公告)日：2008-06-12
申请号：PCT/EP2005004153
申请日：2005-04-15
申请人： EUROPROTEOME AG , TORTOLA-PEREZ SILVIA , LAMER STEPHANIE , HEIM STEFFEN , FUCHS MIRIAM , BUSCHMANN THOMAS , SEIBERT VOLKER , FOTIADIS NIKOLETA-KYRIAKI , STEDRONSKY KATRIN , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , ILYNIA TATIANA , FELS LUEDER
发明人： TORTOLA-PEREZ SILVIA , LAMER STEPHANIE , HEIM STEFFEN , FUCHS MIRIAM , BUSCHMANN THOMAS , SEIBERT VOLKER , FOTIADIS NIKOLETA-KYRIAKI , STEDRONSKY KATRIN , MEUER JOERN , ROTHMANN-COSIC KIRSTEN , ILYNIA TATIANA , FELS LUEDER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The invention relates to agents and methods for the diagnosis, prognosis and treatment of non-steroid dependent cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding plasma membrane proteins of the invention that are differentially expressed in tumour tissues for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of such proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of the proteins plasma membrane proteins of the invention, including using agents identified in screening assays described herein, as well as molecules that are complementary to polynucleotide sequences encoding plasmas membrane proteins of the invention and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
摘要翻译：本发明涉及用于诊断，预后和治疗非类固醇依赖性癌症的药剂和方法。具体地说，本发明涉及编码在肿瘤组织中差异表达的本发明的质膜蛋白的核酸和氨基酸序列用于诊断早期和晚期非类固醇特异性癌症，癌症预后以及筛选用于调节这些蛋白质的基因表达和/或生物活性的治疗剂。本发明还涉及设计用于抑制本发明的蛋白质质膜蛋白质的基因表达和/或生物活性的生物学技术，包括使用本文所述的筛选测定中鉴定的试剂，以及与编码的多核苷酸序列互补的分子本发明的血浆膜蛋白和所述蛋白的靶向抗体。在具体实施方案中，蛋白质是人源的。

5. 发明申请

WO2004102191A2 SERUM PROTEIN PROFILING FOR THE DIAGNOSIS OF EPITHELIAL CANCERS 审中-公开
标题翻译：用于诊断上皮癌的血清蛋白质谱
公开(公告)号：WO2004102191A2
公开(公告)日：2004-11-25
申请号：PCT/EP2004005295
申请日：2004-05-17
申请人： EUROPROTEOME AG , EBERT MATTHIAS , MEUER JOERN , WIEMER JAN
发明人： EBERT MATTHIAS , MEUER JOERN , WIEMER JAN
IPC分类号： G01N30/88 , G01N33/48 , G01N33/50 , G01N33/574
CPC分类号： G01N33/57488 , G01N30/8655 , G01N33/48 , G01N33/50 , G01N2030/8813 , G01N2030/8831
摘要： The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion, subjects having an epithelial cancer or a metastasised epithelial cancer or subjects having an acute and chronic inflammation of the epithelium. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium.
摘要翻译：本发明提供生物分子和这些生物分子用于上皮癌的鉴别诊断或上皮的急性和慢性炎症的用途。特别地，本发明提供了用于检测测试样品内的生物分子的方法以及包含对于健康受试者，具有癌前病变的受试者，具有上皮癌或转移性上皮癌的受试者或具有转移性上皮癌的受试者的生物分子的质量分布的数据库上皮的急性和慢性炎症。此外，本发明提供了使用气相离子光谱法表征所述生物分子的方法。此外，本发明提供鉴定所述生物分子的方法，只要它们是蛋白质或多肽即可。本发明还提供了用于上皮癌鉴别诊断或上皮的急性和慢性炎症的试剂盒。

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